Incidental Mutation 'R6301:Usp31'
ID 509097
Institutional Source Beutler Lab
Gene Symbol Usp31
Ensembl Gene ENSMUSG00000063317
Gene Name ubiquitin specific peptidase 31
Synonyms 6330567E21Rik
MMRRC Submission 044466-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R6301 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 121241244-121306476 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 121247499 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 1315 (S1315T)
Ref Sequence ENSEMBL: ENSMUSP00000040037 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046929]
AlphaFold E9Q6Y8
Predicted Effect possibly damaging
Transcript: ENSMUST00000046929
AA Change: S1315T

PolyPhen 2 Score 0.764 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000040037
Gene: ENSMUSG00000063317
AA Change: S1315T

DomainStartEndE-ValueType
low complexity region 6 17 N/A INTRINSIC
low complexity region 29 58 N/A INTRINSIC
low complexity region 64 75 N/A INTRINSIC
low complexity region 90 120 N/A INTRINSIC
Pfam:UCH 122 755 2.5e-64 PFAM
Pfam:UCH_1 562 737 1.3e-12 PFAM
low complexity region 763 777 N/A INTRINSIC
low complexity region 792 811 N/A INTRINSIC
low complexity region 831 847 N/A INTRINSIC
low complexity region 869 881 N/A INTRINSIC
low complexity region 985 996 N/A INTRINSIC
low complexity region 1009 1030 N/A INTRINSIC
low complexity region 1044 1060 N/A INTRINSIC
low complexity region 1072 1127 N/A INTRINSIC
low complexity region 1161 1173 N/A INTRINSIC
low complexity region 1192 1204 N/A INTRINSIC
low complexity region 1245 1258 N/A INTRINSIC
Meta Mutation Damage Score 0.0766 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 100% (66/66)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm2 C T 4: 144,285,224 (GRCm39) A138T probably damaging Het
Acot10 T C 15: 20,666,348 (GRCm39) N131S probably benign Het
Agbl5 A G 5: 31,049,177 (GRCm39) Y220C probably damaging Het
Ankdd1a C T 9: 65,415,343 (GRCm39) A227T possibly damaging Het
Ap3b1 A T 13: 94,664,803 (GRCm39) Q914L unknown Het
Arhgef25 T C 10: 127,021,751 (GRCm39) D216G possibly damaging Het
Bcas2 T A 3: 103,079,187 (GRCm39) probably benign Het
Bpifb5 A C 2: 154,072,139 (GRCm39) H282P possibly damaging Het
Ccdc121rt2 A T 5: 112,598,334 (GRCm39) I294F possibly damaging Het
Ccdc167 A G 17: 29,924,556 (GRCm39) I15T probably damaging Het
Cd248 A G 19: 5,120,009 (GRCm39) N619S probably benign Het
Chrna1 A G 2: 73,400,828 (GRCm39) F234S possibly damaging Het
Clcc1 T G 3: 108,580,682 (GRCm39) M332R probably damaging Het
Cmklr1 T A 5: 113,752,999 (GRCm39) M1L possibly damaging Het
Cntnap5c A G 17: 58,199,032 (GRCm39) M109V probably benign Het
Coq2 A G 5: 100,809,729 (GRCm39) I18T possibly damaging Het
Crybg3 T C 16: 59,350,701 (GRCm39) S880G probably damaging Het
Cubn A G 2: 13,482,889 (GRCm39) C286R probably damaging Het
Defa24 T C 8: 22,225,299 (GRCm39) V63A probably benign Het
Dnah6 C T 6: 73,063,200 (GRCm39) R2634H probably damaging Het
Dusp8 T A 7: 141,636,756 (GRCm39) probably null Het
Elac1 T C 18: 73,871,939 (GRCm39) D352G probably damaging Het
Ermap A T 4: 119,042,800 (GRCm39) V241E probably damaging Het
Fgf10 T A 13: 118,852,047 (GRCm39) M43K probably benign Het
Gabrd A G 4: 155,471,724 (GRCm39) V193A probably damaging Het
Hectd4 T G 5: 121,392,283 (GRCm39) C182W possibly damaging Het
Hook3 C T 8: 26,524,968 (GRCm39) W26* probably null Het
Kif1a C A 1: 92,982,663 (GRCm39) E714* probably null Het
Krt6b T C 15: 101,587,386 (GRCm39) E236G probably damaging Het
Large2 A G 2: 92,199,861 (GRCm39) L209P probably damaging Het
Lats1 A G 10: 7,578,871 (GRCm39) N665S probably benign Het
Lrrc37 A T 11: 103,509,756 (GRCm39) probably benign Het
Lrrtm3 T C 10: 63,925,001 (GRCm39) I55M probably benign Het
Ltk A G 2: 119,582,238 (GRCm39) S838P probably damaging Het
Ltn1 T C 16: 87,217,194 (GRCm39) I348V probably benign Het
Mag T A 7: 30,600,104 (GRCm39) S559C probably damaging Het
Mink1 A G 11: 70,503,120 (GRCm39) H1072R possibly damaging Het
Mycbp2 T A 14: 103,392,862 (GRCm39) Q833L probably damaging Het
Myh4 G A 11: 67,146,159 (GRCm39) E1406K possibly damaging Het
Npc1 C T 18: 12,330,302 (GRCm39) V950I probably benign Het
Npl A G 1: 153,394,627 (GRCm39) probably null Het
Or10w3 A G 19: 13,703,753 (GRCm39) I43V probably benign Het
Or11g27 T A 14: 50,771,711 (GRCm39) F281I probably benign Het
Or2m13 A T 16: 19,226,167 (GRCm39) F200I possibly damaging Het
Or8b36 ATTGCTGTTT ATTGCTGTTTGCTGTTT 9: 37,937,836 (GRCm39) probably null Het
Oxsm A T 14: 16,242,220 (GRCm38) I183N probably damaging Het
Pde7a T C 3: 19,297,327 (GRCm39) I108V probably benign Het
Pgghg A T 7: 140,526,289 (GRCm39) T585S probably damaging Het
Pkhd1l1 G A 15: 44,452,921 (GRCm39) D3949N probably damaging Het
Ralgapa2 A T 2: 146,169,331 (GRCm39) H1777Q possibly damaging Het
Rela G A 19: 5,695,438 (GRCm39) probably null Het
Rilpl1 C A 5: 124,652,602 (GRCm39) G41W probably damaging Het
Rp1 T C 1: 4,417,477 (GRCm39) K1212E probably benign Het
Sgca A C 11: 94,863,393 (GRCm39) L28V probably damaging Het
Ssmem1 A G 6: 30,519,758 (GRCm39) R148G probably damaging Het
St8sia5 A T 18: 77,333,836 (GRCm39) N165Y probably damaging Het
Tbl2 A T 5: 135,188,223 (GRCm39) H339L probably benign Het
Tcof1 G A 18: 60,961,897 (GRCm39) P718L probably damaging Het
Trim72 A T 7: 127,603,786 (GRCm39) E44V possibly damaging Het
Try10 T A 6: 41,332,523 (GRCm39) S60T probably benign Het
Xrn2 A G 2: 146,905,262 (GRCm39) I856V probably benign Het
Other mutations in Usp31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00341:Usp31 APN 7 121,305,893 (GRCm39) missense probably damaging 1.00
IGL00421:Usp31 APN 7 121,247,873 (GRCm39) missense probably damaging 0.96
IGL00657:Usp31 APN 7 121,247,454 (GRCm39) missense probably benign 0.00
IGL01917:Usp31 APN 7 121,278,708 (GRCm39) missense probably benign 0.26
IGL02444:Usp31 APN 7 121,278,718 (GRCm39) missense probably damaging 1.00
IGL03090:Usp31 APN 7 121,278,753 (GRCm39) splice site probably benign
R0334:Usp31 UTSW 7 121,258,185 (GRCm39) missense probably damaging 0.99
R0945:Usp31 UTSW 7 121,269,476 (GRCm39) missense probably damaging 1.00
R1326:Usp31 UTSW 7 121,247,525 (GRCm39) missense probably damaging 1.00
R2116:Usp31 UTSW 7 121,247,919 (GRCm39) missense probably benign 0.39
R3113:Usp31 UTSW 7 121,278,736 (GRCm39) missense probably damaging 1.00
R4072:Usp31 UTSW 7 121,267,005 (GRCm39) splice site probably null
R4075:Usp31 UTSW 7 121,267,005 (GRCm39) splice site probably null
R4076:Usp31 UTSW 7 121,267,005 (GRCm39) splice site probably null
R4306:Usp31 UTSW 7 121,306,152 (GRCm39) missense possibly damaging 0.93
R4675:Usp31 UTSW 7 121,306,548 (GRCm39) unclassified probably benign
R4960:Usp31 UTSW 7 121,247,868 (GRCm39) missense probably damaging 0.99
R5368:Usp31 UTSW 7 121,260,588 (GRCm39) missense probably damaging 1.00
R5396:Usp31 UTSW 7 121,267,005 (GRCm39) splice site probably null
R5456:Usp31 UTSW 7 121,269,500 (GRCm39) missense probably damaging 1.00
R5475:Usp31 UTSW 7 121,250,749 (GRCm39) missense probably damaging 1.00
R5497:Usp31 UTSW 7 121,250,824 (GRCm39) missense probably damaging 1.00
R5872:Usp31 UTSW 7 121,248,698 (GRCm39) missense probably benign 0.05
R6688:Usp31 UTSW 7 121,277,553 (GRCm39) missense probably benign 0.01
R6875:Usp31 UTSW 7 121,248,863 (GRCm39) nonsense probably null
R6895:Usp31 UTSW 7 121,252,399 (GRCm39) missense probably benign 0.00
R7570:Usp31 UTSW 7 121,274,186 (GRCm39) missense probably damaging 1.00
R7633:Usp31 UTSW 7 121,258,185 (GRCm39) missense probably damaging 0.99
R7666:Usp31 UTSW 7 121,248,404 (GRCm39) missense possibly damaging 0.68
R7841:Usp31 UTSW 7 121,276,535 (GRCm39) missense probably damaging 0.96
R7841:Usp31 UTSW 7 121,247,679 (GRCm39) missense probably benign 0.00
R8013:Usp31 UTSW 7 121,248,480 (GRCm39) missense probably damaging 0.99
R8014:Usp31 UTSW 7 121,248,480 (GRCm39) missense probably damaging 0.99
R8118:Usp31 UTSW 7 121,276,485 (GRCm39) missense probably damaging 1.00
R8140:Usp31 UTSW 7 121,248,249 (GRCm39) missense possibly damaging 0.79
R9063:Usp31 UTSW 7 121,306,466 (GRCm39) missense probably benign
R9795:Usp31 UTSW 7 121,247,499 (GRCm39) missense probably benign 0.00
X0062:Usp31 UTSW 7 121,250,737 (GRCm39) missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- TCTCACACAGTCAGGCACATG -3'
(R):5'- AAGTCAGTCAGTAAGAACACTGC -3'

Sequencing Primer
(F):5'- GTCAGGCACATGACCCC -3'
(R):5'- TCAGTCAGTAAGAACACTGCAGATG -3'
Posted On 2018-04-02