Incidental Mutation 'R6303:Lingo4'
ID 509142
Institutional Source Beutler Lab
Gene Symbol Lingo4
Ensembl Gene ENSMUSG00000044505
Gene Name leucine rich repeat and Ig domain containing 4
Synonyms LERN4, Lrrn6d, A530050P17Rik
MMRRC Submission 044410-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R6303 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 94306526-94311820 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 94310513 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 484 (G484R)
Ref Sequence ENSEMBL: ENSMUSP00000058050 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050975] [ENSMUST00000197040]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000050975
AA Change: G484R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000058050
Gene: ENSMUSG00000044505
AA Change: G484R

DomainStartEndE-ValueType
LRRNT 55 89 1.23e-4 SMART
LRR 88 107 2.76e2 SMART
LRR_TYP 108 131 1.02e-6 SMART
LRR_TYP 132 155 7.26e-3 SMART
LRR 156 179 1.33e1 SMART
LRR_TYP 180 203 5.42e-2 SMART
LRR 204 227 4.45e1 SMART
LRR 228 251 3.27e1 SMART
LRR 300 323 4.83e0 SMART
LRR 324 347 3.07e-1 SMART
LRR 348 371 3.36e1 SMART
LRRCT 383 436 5.24e-5 SMART
IGc2 451 516 3.53e-13 SMART
transmembrane domain 560 582 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000197040
SMART Domains Protein: ENSMUSP00000143763
Gene: ENSMUSG00000028150

DomainStartEndE-ValueType
ZnF_C4 7 78 7.2e-37 SMART
low complexity region 95 112 N/A INTRINSIC
HOLI 299 453 3.78e-22 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198829
Meta Mutation Damage Score 0.4725 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency 98% (43/44)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apol9b T A 15: 77,619,504 (GRCm39) V100E probably damaging Het
Bin3 A G 14: 70,374,625 (GRCm39) D218G possibly damaging Het
Cobll1 A T 2: 64,928,377 (GRCm39) M982K possibly damaging Het
Crybg2 T C 4: 133,814,898 (GRCm39) V1593A possibly damaging Het
Ctsh A G 9: 89,944,796 (GRCm39) S76G possibly damaging Het
Dnajc10 T G 2: 80,181,008 (GRCm39) D767E probably benign Het
Elapor1 A C 3: 108,368,572 (GRCm39) C806W probably damaging Het
Etaa1 A C 11: 17,897,505 (GRCm39) M204R probably damaging Het
Fbxw16 A T 9: 109,278,169 (GRCm39) I3N probably benign Het
Fndc1 T C 17: 7,977,317 (GRCm39) E1394G probably damaging Het
Gm19410 T C 8: 36,274,714 (GRCm39) C1512R possibly damaging Het
Gramd4 A G 15: 86,019,120 (GRCm39) E596G possibly damaging Het
Hephl1 C A 9: 15,001,448 (GRCm39) V226F possibly damaging Het
Ilf3 G A 9: 21,314,432 (GRCm39) probably benign Het
Kcnh3 T C 15: 99,124,919 (GRCm39) V123A probably benign Het
Kdm2b A G 5: 123,019,807 (GRCm39) S260P probably benign Het
Lrrc10b T C 19: 10,434,342 (GRCm39) Q113R probably benign Het
Lrrc8c A T 5: 105,756,475 (GRCm39) N750I probably benign Het
Mtcl2 T C 2: 156,882,684 (GRCm39) N456S possibly damaging Het
Nlrp2 A G 7: 5,340,760 (GRCm39) L18P probably damaging Het
Nrp2 T C 1: 62,784,565 (GRCm39) L238P probably damaging Het
Nup155 T C 15: 8,147,526 (GRCm39) S262P probably damaging Het
Or51k1 G A 7: 103,661,238 (GRCm39) L224F probably damaging Het
Pappa G A 4: 65,122,891 (GRCm39) G742D probably damaging Het
Pclo A T 5: 14,727,907 (GRCm39) probably benign Het
Phyhipl A G 10: 70,395,387 (GRCm39) probably null Het
Plcg1 A G 2: 160,603,383 (GRCm39) T1185A possibly damaging Het
Plscr5 A T 9: 92,087,609 (GRCm39) I193F probably benign Het
Polr1b G A 2: 128,957,682 (GRCm39) R579H probably damaging Het
Polr2a A T 11: 69,637,739 (GRCm39) W202R probably damaging Het
Ppp4r1 A G 17: 66,131,724 (GRCm39) K489E probably benign Het
Qser1 G A 2: 104,593,175 (GRCm39) T1704I probably damaging Het
Sik1 A G 17: 32,065,270 (GRCm39) V776A probably damaging Het
Spata31h1 T A 10: 82,126,202 (GRCm39) K2269N possibly damaging Het
Spice1 A G 16: 44,191,060 (GRCm39) M305V probably benign Het
Taf4b T C 18: 14,940,412 (GRCm39) I297T probably damaging Het
Trim14 C A 4: 46,522,118 (GRCm39) M186I probably benign Het
Usp49 C A 17: 47,991,747 (GRCm39) Q670K probably damaging Het
Usp54 T C 14: 20,611,036 (GRCm39) D1260G possibly damaging Het
Vmn1r224 T A 17: 20,640,028 (GRCm39) S202T possibly damaging Het
Vmn1r3 T A 4: 3,184,975 (GRCm39) T111S probably damaging Het
Zfp985 A G 4: 147,668,232 (GRCm39) I367V probably benign Het
Other mutations in Lingo4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01074:Lingo4 APN 3 94,310,595 (GRCm39) missense probably benign 0.00
IGL02662:Lingo4 APN 3 94,309,124 (GRCm39) unclassified probably benign
IGL02687:Lingo4 APN 3 94,309,404 (GRCm39) missense probably damaging 1.00
IGL02711:Lingo4 APN 3 94,310,700 (GRCm39) missense probably benign
IGL03001:Lingo4 APN 3 94,309,703 (GRCm39) missense probably damaging 1.00
IGL03260:Lingo4 APN 3 94,309,250 (GRCm39) missense probably benign
PIT4449001:Lingo4 UTSW 3 94,309,239 (GRCm39) missense probably benign
R0088:Lingo4 UTSW 3 94,309,340 (GRCm39) missense probably benign 0.39
R0616:Lingo4 UTSW 3 94,310,388 (GRCm39) missense probably benign 0.00
R1455:Lingo4 UTSW 3 94,306,699 (GRCm39) unclassified probably benign
R1733:Lingo4 UTSW 3 94,310,485 (GRCm39) missense probably benign 0.00
R2001:Lingo4 UTSW 3 94,310,382 (GRCm39) missense probably damaging 1.00
R2085:Lingo4 UTSW 3 94,309,552 (GRCm39) missense probably damaging 1.00
R3793:Lingo4 UTSW 3 94,309,685 (GRCm39) missense probably benign
R3805:Lingo4 UTSW 3 94,309,407 (GRCm39) missense probably damaging 1.00
R3806:Lingo4 UTSW 3 94,309,407 (GRCm39) missense probably damaging 1.00
R4438:Lingo4 UTSW 3 94,310,204 (GRCm39) missense possibly damaging 0.79
R4660:Lingo4 UTSW 3 94,310,672 (GRCm39) missense probably benign 0.00
R4724:Lingo4 UTSW 3 94,310,183 (GRCm39) nonsense probably null
R4981:Lingo4 UTSW 3 94,306,761 (GRCm39) missense probably benign 0.18
R4994:Lingo4 UTSW 3 94,310,308 (GRCm39) missense probably benign 0.02
R4994:Lingo4 UTSW 3 94,309,848 (GRCm39) missense probably benign
R5600:Lingo4 UTSW 3 94,309,220 (GRCm39) missense probably benign
R6188:Lingo4 UTSW 3 94,310,157 (GRCm39) missense probably damaging 1.00
R6267:Lingo4 UTSW 3 94,310,697 (GRCm39) missense probably benign 0.02
R6304:Lingo4 UTSW 3 94,310,513 (GRCm39) missense probably damaging 1.00
R6789:Lingo4 UTSW 3 94,306,662 (GRCm39) unclassified probably benign
R7313:Lingo4 UTSW 3 94,310,451 (GRCm39) missense possibly damaging 0.95
R7329:Lingo4 UTSW 3 94,310,162 (GRCm39) missense probably benign
R7631:Lingo4 UTSW 3 94,306,767 (GRCm39) missense possibly damaging 0.93
R7908:Lingo4 UTSW 3 94,309,541 (GRCm39) missense probably benign 0.19
R8277:Lingo4 UTSW 3 94,309,931 (GRCm39) missense possibly damaging 0.61
R8848:Lingo4 UTSW 3 94,310,840 (GRCm39) missense probably benign
R9257:Lingo4 UTSW 3 94,310,676 (GRCm39) missense probably benign 0.05
R9753:Lingo4 UTSW 3 94,309,493 (GRCm39) nonsense probably null
X0054:Lingo4 UTSW 3 94,310,683 (GRCm39) missense possibly damaging 0.54
Z1177:Lingo4 UTSW 3 94,310,301 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCCAACATGTCCAAGGGAAGAG -3'
(R):5'- ATCCCTGGCATAGTGATGTTGG -3'

Sequencing Primer
(F):5'- GAGCCTAAGGGAGTTTTCAGACATTC -3'
(R):5'- GGGTCAGACAGAGTGCCATTTG -3'
Posted On 2018-04-02