Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01124:Foxo6'

50942

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Foxo6

Ensembl Gene

ENSMUSG00000052135

Gene Name

forkhead box O6

Synonyms

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.389) question?

Stock #

IGL01124

Quality Score

Status

Chromosome

Chromosomal Location

120124275-120144458 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 120126349 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 149 (T149A)

Ref Sequence

ENSEMBL: ENSMUSP00000099716 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102656]

AlphaFold

Q70KY4

Predicted Effect

probably benign
Transcript: ENSMUST00000102656
AA Change: T149A

PolyPhen 2 Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000099716
Gene: ENSMUSG00000052135
AA Change: T149A

Domain	Start	End	E-Value	Type
low complexity region	33	49	N/A	INTRINSIC
low complexity region	55	69	N/A	INTRINSIC
FH	86	176	1.64e-42	SMART
low complexity region	225	239	N/A	INTRINSIC
low complexity region	255	290	N/A	INTRINSIC
low complexity region	301	319	N/A	INTRINSIC
Pfam:FOXO_KIX_bdg	354	423	1.1e-13	PFAM
Pfam:FOXO-TAD	497	538	7.3e-24	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygotes for a null allele show defective memory consolidation with impaired neuronal synchronization and altered dendritic spine morphology. Homozygotes for another null allele show attenuated gluconeogenesis, improved glucose tolerance and increased insulin sensitivity after high fat feeding. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ascc3	T	C	10: 50,608,569 (GRCm39)	I1477T	probably damaging	Het
Baat	A	G	4: 49,490,391 (GRCm39)	I231T	possibly damaging	Het
Cactin	T	C	10: 81,160,184 (GRCm39)	S426P	possibly damaging	Het
Cfh	A	T	1: 140,110,999 (GRCm39)	F6I	probably benign	Het
Clec4a2	C	T	6: 123,116,037 (GRCm39)		probably benign	Het
Col12a1	A	G	9: 79,611,129 (GRCm39)	S148P	probably damaging	Het
Cubn	G	T	2: 13,482,904 (GRCm39)	Q281K	possibly damaging	Het
Cyp2c65	T	A	19: 39,081,954 (GRCm39)		probably benign	Het
Dennd4b	A	T	3: 90,176,381 (GRCm39)	T243S	possibly damaging	Het
Epha8	C	T	4: 136,663,394 (GRCm39)	G518D	probably damaging	Het
Fmo3	G	A	1: 162,785,830 (GRCm39)	R387C	probably damaging	Het
Fthl17d	T	C	X: 8,852,827 (GRCm39)	E3G	probably benign	Het
Gm10521	A	G	1: 171,724,010 (GRCm39)	Y107C	unknown	Het
Ipo8	T	A	6: 148,678,874 (GRCm39)	E908V	probably benign	Het
Kcnd2	T	C	6: 21,217,216 (GRCm39)	S307P	probably damaging	Het
Klf3	A	G	5: 64,974,123 (GRCm39)	M3V	possibly damaging	Het
Ldb3	T	A	14: 34,266,157 (GRCm39)	E417D	probably damaging	Het
Lrch1	A	T	14: 74,994,503 (GRCm39)	D673E	probably benign	Het
Map3k4	T	C	17: 12,474,087 (GRCm39)	K865E	probably benign	Het
Muc4	G	A	16: 32,589,104 (GRCm39)	V754I	possibly damaging	Het
Nek4	A	G	14: 30,692,219 (GRCm39)	N223D	probably benign	Het
Nell2	G	A	15: 95,194,060 (GRCm39)	T551M	probably damaging	Het
Nup155	T	A	15: 8,183,163 (GRCm39)	M1241K	probably damaging	Het
Or2t49	A	T	11: 58,393,020 (GRCm39)	S121T	possibly damaging	Het
Or5i1	T	C	2: 87,613,720 (GRCm39)	F279L	probably benign	Het
Orc1	T	C	4: 108,445,984 (GRCm39)		probably benign	Het
Pclo	T	C	5: 14,764,343 (GRCm39)	I4272T	unknown	Het
Ppp1r12c	A	G	7: 4,500,344 (GRCm39)		probably benign	Het
Prcp	A	G	7: 92,559,416 (GRCm39)	E160G	probably benign	Het
Prl3d3	G	A	13: 27,343,090 (GRCm39)	R92Q	possibly damaging	Het
Prl6a1	T	A	13: 27,500,347 (GRCm39)	M106K	possibly damaging	Het
Slc22a1	T	A	17: 12,869,749 (GRCm39)		probably benign	Het
Slco3a1	A	G	7: 73,934,295 (GRCm39)	Y626H	probably damaging	Het
Smtn	A	G	11: 3,476,326 (GRCm39)		probably null	Het
Snx30	T	C	4: 59,886,404 (GRCm39)		probably benign	Het
Spock2	A	G	10: 59,967,209 (GRCm39)	D393G	unknown	Het
Trem3	T	G	17: 48,556,829 (GRCm39)	L100R	probably damaging	Het
Trpm2	A	T	10: 77,781,659 (GRCm39)		probably benign	Het
Ubr1	T	C	2: 120,745,386 (GRCm39)	M901V	probably benign	Het
Usp28	T	A	9: 48,948,513 (GRCm39)	S873T	probably damaging	Het
Vmn1r86	T	C	7: 12,836,856 (GRCm39)	I7V	probably benign	Het
Xirp2	T	C	2: 67,338,959 (GRCm39)	L400P	probably damaging	Het

Other mutations in Foxo6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02441:Foxo6	APN	4	120,125,232 (GRCm39)	missense	possibly damaging	0.52
R0284:Foxo6	UTSW	4	120,126,199 (GRCm39)	missense	probably benign	0.01
R2044:Foxo6	UTSW	4	120,144,166 (GRCm39)	missense	probably benign	0.40
R2152:Foxo6	UTSW	4	120,125,811 (GRCm39)	missense	probably benign	0.03
R2568:Foxo6	UTSW	4	120,125,961 (GRCm39)	missense	probably benign	0.11
R3008:Foxo6	UTSW	4	120,125,961 (GRCm39)	missense	probably benign	0.11
R7352:Foxo6	UTSW	4	120,125,448 (GRCm39)	missense	probably benign	0.02
R8724:Foxo6	UTSW	4	120,144,109 (GRCm39)	missense	probably damaging	1.00
R8951:Foxo6	UTSW	4	120,125,133 (GRCm39)	missense	unknown
Z1187:Foxo6	UTSW	4	120,144,332 (GRCm39)	missense	possibly damaging	0.93
Z1188:Foxo6	UTSW	4	120,144,332 (GRCm39)	missense	possibly damaging	0.93

Posted On

2013-06-21