Incidental Mutation 'R6310:Dhx58'
ID 509554
Institutional Source Beutler Lab
Gene Symbol Dhx58
Ensembl Gene ENSMUSG00000017830
Gene Name DExH-box helicase 58
Synonyms D11Lgp2e, B430001I08Rik, LPG2
MMRRC Submission 044414-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.201) question?
Stock # R6310 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 100585710-100595097 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 100590193 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 364 (S364G)
Ref Sequence ENSEMBL: ENSMUSP00000017974 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017974]
AlphaFold Q99J87
Predicted Effect probably benign
Transcript: ENSMUST00000017974
AA Change: S364G

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000017974
Gene: ENSMUSG00000017830
AA Change: S364G

DomainStartEndE-ValueType
DEXDc 2 207 2.86e-22 SMART
HELICc 387 475 3.85e-14 SMART
Blast:HELICc 497 543 4e-12 BLAST
Pfam:RIG-I_C-RD 552 667 1.5e-37 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126167
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132930
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137154
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140543
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149869
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150656
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.5%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to EMCV infection and decreased susceptibility to VSV infection. Mice homozygous for a different knock-out allele exhibit increased susceptibility to WNV infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acly C G 11: 100,373,046 (GRCm39) G856A possibly damaging Het
Adgrb3 T A 1: 25,150,799 (GRCm39) M1145L probably benign Het
Akap13 A T 7: 75,398,941 (GRCm39) H2673L probably damaging Het
Bmpr1b A G 3: 141,570,297 (GRCm39) S131P probably damaging Het
Cep72 A C 13: 74,201,144 (GRCm39) S175A possibly damaging Het
Chd2 C T 7: 73,102,912 (GRCm39) E1358K probably damaging Het
Cmip T C 8: 118,156,549 (GRCm39) I308T possibly damaging Het
Cps1 A T 1: 67,182,140 (GRCm39) N118I probably benign Het
Cux1 C T 5: 136,304,018 (GRCm39) G1265D probably benign Het
Ddx24 C A 12: 103,390,166 (GRCm39) R275L probably damaging Het
Dis3l A C 9: 64,229,857 (GRCm39) V274G probably benign Het
Fryl A T 5: 73,349,104 (GRCm39) probably benign Het
Gbf1 A G 19: 46,268,444 (GRCm39) H1272R probably damaging Het
Gjb3 A G 4: 127,220,433 (GRCm39) V33A probably damaging Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gm9964 T C 11: 79,187,476 (GRCm39) probably benign Het
Grk5 T C 19: 61,069,349 (GRCm39) I342T probably damaging Het
Hnf1b T A 11: 83,795,737 (GRCm39) C527S probably damaging Het
Hoxd4 G T 2: 74,558,734 (GRCm39) A186S possibly damaging Het
Ighv1-78 G A 12: 115,832,584 (GRCm39) H54Y probably benign Het
Intu T A 3: 40,655,721 (GRCm39) L936* probably null Het
Kcp G A 6: 29,493,257 (GRCm39) R89W probably damaging Het
Kctd3 T C 1: 188,704,435 (GRCm39) T779A probably benign Het
Muc16 G A 9: 18,553,246 (GRCm39) P4349L probably benign Het
Nedd9 T C 13: 41,471,928 (GRCm39) T178A probably benign Het
Nuak2 G T 1: 132,257,699 (GRCm39) A204S probably damaging Het
Or51f1 T A 7: 102,506,412 (GRCm39) I26F probably benign Het
Or6c214 T C 10: 129,590,528 (GRCm39) R264G probably benign Het
Pcdhac2 C A 18: 37,278,824 (GRCm39) Y601* probably null Het
Pla2g4a T A 1: 149,717,977 (GRCm39) D624V possibly damaging Het
Plxnb1 T C 9: 108,938,796 (GRCm39) V1386A probably damaging Het
Plxnd1 T A 6: 115,953,697 (GRCm39) L623F possibly damaging Het
Pms2 T A 5: 143,860,401 (GRCm39) S71R probably benign Het
Prkg1 T C 19: 30,546,651 (GRCm39) D683G probably damaging Het
Rasgrp3 T A 17: 75,801,204 (GRCm39) Y45N probably damaging Het
Rfc4 T C 16: 22,933,459 (GRCm39) I233M probably benign Het
Sema3a G A 5: 13,606,986 (GRCm39) G274S probably damaging Het
Sesn1 T C 10: 41,772,074 (GRCm39) L201P probably damaging Het
Setx G A 2: 29,066,947 (GRCm39) V2363I possibly damaging Het
Sh3glb1 A G 3: 144,403,228 (GRCm39) S81P probably damaging Het
Sik3 A G 9: 46,089,784 (GRCm39) S218G probably damaging Het
Slc12a2 C G 18: 58,048,578 (GRCm39) F781L probably damaging Het
Slc12a6 A T 2: 112,166,184 (GRCm39) I188F probably damaging Het
Slc34a2 A G 5: 53,222,139 (GRCm39) probably null Het
Slc35f4 A G 14: 49,559,914 (GRCm39) C44R probably damaging Het
Sytl1 G A 4: 132,988,309 (GRCm39) P16S probably benign Het
Taok3 C T 5: 117,394,003 (GRCm39) T592M possibly damaging Het
Tgfb1i1 T C 7: 127,852,009 (GRCm39) F303L probably damaging Het
Txk T C 5: 72,893,760 (GRCm39) S7G probably benign Het
Utp4 T C 8: 107,645,253 (GRCm39) V550A probably benign Het
Vmn1r229 G A 17: 21,034,976 (GRCm39) D74N probably benign Het
Zfp638 A G 6: 83,844,212 (GRCm39) D25G possibly damaging Het
Zfp646 T C 7: 127,483,079 (GRCm39) V1752A probably benign Het
Other mutations in Dhx58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01395:Dhx58 APN 11 100,594,752 (GRCm39) missense probably damaging 0.97
IGL02476:Dhx58 APN 11 100,593,090 (GRCm39) missense probably benign 0.00
R0103:Dhx58 UTSW 11 100,586,096 (GRCm39) missense probably damaging 1.00
R0103:Dhx58 UTSW 11 100,586,096 (GRCm39) missense probably damaging 1.00
R0137:Dhx58 UTSW 11 100,587,823 (GRCm39) missense probably damaging 0.99
R0164:Dhx58 UTSW 11 100,586,150 (GRCm39) missense probably benign 0.42
R0164:Dhx58 UTSW 11 100,586,150 (GRCm39) missense probably benign 0.42
R0369:Dhx58 UTSW 11 100,592,374 (GRCm39) critical splice donor site probably null
R0390:Dhx58 UTSW 11 100,590,090 (GRCm39) missense probably damaging 1.00
R0606:Dhx58 UTSW 11 100,593,077 (GRCm39) missense probably benign 0.00
R1710:Dhx58 UTSW 11 100,594,400 (GRCm39) missense probably benign 0.20
R1816:Dhx58 UTSW 11 100,593,978 (GRCm39) missense probably damaging 0.98
R1993:Dhx58 UTSW 11 100,594,316 (GRCm39) splice site probably null
R2281:Dhx58 UTSW 11 100,588,980 (GRCm39) critical splice donor site probably null
R3176:Dhx58 UTSW 11 100,587,805 (GRCm39) missense probably damaging 1.00
R3276:Dhx58 UTSW 11 100,587,805 (GRCm39) missense probably damaging 1.00
R4651:Dhx58 UTSW 11 100,592,185 (GRCm39) missense probably damaging 1.00
R4652:Dhx58 UTSW 11 100,592,185 (GRCm39) missense probably damaging 1.00
R4716:Dhx58 UTSW 11 100,587,797 (GRCm39) splice site probably null
R5030:Dhx58 UTSW 11 100,586,963 (GRCm39) missense probably damaging 1.00
R5082:Dhx58 UTSW 11 100,587,802 (GRCm39) missense probably benign 0.29
R5098:Dhx58 UTSW 11 100,585,999 (GRCm39) missense probably benign
R5394:Dhx58 UTSW 11 100,589,034 (GRCm39) missense probably benign 0.00
R5397:Dhx58 UTSW 11 100,594,746 (GRCm39) missense probably damaging 1.00
R5787:Dhx58 UTSW 11 100,592,145 (GRCm39) missense possibly damaging 0.91
R5975:Dhx58 UTSW 11 100,593,035 (GRCm39) missense probably damaging 0.98
R6935:Dhx58 UTSW 11 100,589,232 (GRCm39) splice site probably null
R7311:Dhx58 UTSW 11 100,588,997 (GRCm39) missense probably benign
R7908:Dhx58 UTSW 11 100,586,130 (GRCm39) missense probably damaging 0.99
R8317:Dhx58 UTSW 11 100,594,388 (GRCm39) missense probably damaging 1.00
R8821:Dhx58 UTSW 11 100,594,806 (GRCm39) missense probably damaging 1.00
R8831:Dhx58 UTSW 11 100,594,806 (GRCm39) missense probably damaging 1.00
R9717:Dhx58 UTSW 11 100,592,133 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GTATGGAAAACCCTGTTCCCC -3'
(R):5'- CAGGTGTCTTCTCTGCCAAC -3'

Sequencing Primer
(F):5'- TGTGAAATGCCTCCAGCC -3'
(R):5'- TGCCAACAACTGTCCTGCG -3'
Posted On 2018-04-02