Incidental Mutation 'IGL01143:Zyg11b'
| ID |
50978 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zyg11b
|
| Ensembl Gene |
ENSMUSG00000034636 |
| Gene Name |
zyg-ll family member B, cell cycle regulator |
| Synonyms |
1110046I03Rik, 2810482G21Rik, D4Mgi23, LOC242610 |
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.710)
|
| Stock # |
IGL01143
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
108086921-108158293 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 108102191 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 510
(V510E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000043844
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043616]
|
| AlphaFold |
Q3UFS0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000043616
AA Change: V510E
PolyPhen 2
Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000043844
Gene: ENSMUSG00000034636
AA Change: V510E
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1jdha_
|
370 |
722 |
3e-16 |
SMART |
|
Blast:ARM
|
480 |
526 |
1e-17 |
BLAST |
|
Blast:ARM
|
528 |
570 |
3e-19 |
BLAST |
|
Blast:ARM
|
638 |
679 |
3e-10 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130508
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abtb3 |
A |
T |
10: 85,490,335 (GRCm39) |
|
probably benign |
Het |
| Adgrl4 |
A |
G |
3: 151,205,866 (GRCm39) |
|
probably null |
Het |
| Adgrv1 |
A |
C |
13: 81,567,470 (GRCm39) |
D5234E |
probably benign |
Het |
| Bmp7 |
G |
T |
2: 172,721,275 (GRCm39) |
H267N |
probably benign |
Het |
| Ccdc113 |
T |
C |
8: 96,260,888 (GRCm39) |
V30A |
probably damaging |
Het |
| Ccdc185 |
A |
T |
1: 182,575,417 (GRCm39) |
L424Q |
probably damaging |
Het |
| Cep192 |
T |
A |
18: 67,937,445 (GRCm39) |
D58E |
probably damaging |
Het |
| Ces1f |
C |
T |
8: 93,998,458 (GRCm39) |
|
probably null |
Het |
| Chaf1a |
T |
A |
17: 56,370,336 (GRCm39) |
D600E |
possibly damaging |
Het |
| Cndp2 |
A |
G |
18: 84,695,442 (GRCm39) |
|
probably null |
Het |
| Dnah11 |
T |
A |
12: 117,976,475 (GRCm39) |
D2727V |
probably damaging |
Het |
| Dync1li2 |
T |
C |
8: 105,156,085 (GRCm39) |
D252G |
probably damaging |
Het |
| Ephx2 |
C |
T |
14: 66,326,971 (GRCm39) |
R408Q |
probably damaging |
Het |
| Fat1 |
C |
A |
8: 45,488,569 (GRCm39) |
T3427K |
possibly damaging |
Het |
| Gal3st4 |
A |
G |
5: 138,269,664 (GRCm39) |
M1T |
probably null |
Het |
| Gm5828 |
T |
C |
1: 16,840,172 (GRCm39) |
|
noncoding transcript |
Het |
| Gm7694 |
C |
T |
1: 170,130,394 (GRCm39) |
M1I |
probably null |
Het |
| Gpatch1 |
A |
G |
7: 35,000,997 (GRCm39) |
|
probably benign |
Het |
| Grik1 |
G |
T |
16: 87,754,488 (GRCm39) |
|
probably null |
Het |
| Gtf2ird2 |
A |
G |
5: 134,225,394 (GRCm39) |
T161A |
possibly damaging |
Het |
| Hk2 |
T |
C |
6: 82,706,533 (GRCm39) |
I790V |
possibly damaging |
Het |
| Ints9 |
G |
A |
14: 65,274,870 (GRCm39) |
V609I |
probably benign |
Het |
| Kcnq4 |
T |
G |
4: 120,555,820 (GRCm39) |
D585A |
probably damaging |
Het |
| Large2 |
T |
C |
2: 92,196,684 (GRCm39) |
Y464C |
probably damaging |
Het |
| Lpar6 |
G |
A |
14: 73,476,077 (GRCm39) |
D13N |
probably damaging |
Het |
| Morn1 |
T |
C |
4: 155,176,761 (GRCm39) |
Y132H |
probably damaging |
Het |
| Nphp1 |
C |
T |
2: 127,622,056 (GRCm39) |
V24I |
probably benign |
Het |
| Or5b104 |
A |
T |
19: 13,072,476 (GRCm39) |
F179I |
probably damaging |
Het |
| Or5w17 |
T |
C |
2: 87,584,278 (GRCm39) |
N20D |
probably benign |
Het |
| Or8b1c |
G |
T |
9: 38,384,338 (GRCm39) |
M98I |
possibly damaging |
Het |
| Pcdhb13 |
T |
C |
18: 37,575,690 (GRCm39) |
W23R |
probably benign |
Het |
| Plekhg3 |
T |
C |
12: 76,611,756 (GRCm39) |
|
probably null |
Het |
| Slx4 |
T |
C |
16: 3,808,752 (GRCm39) |
K396R |
probably benign |
Het |
| Snx13 |
A |
G |
12: 35,182,159 (GRCm39) |
D736G |
probably damaging |
Het |
| Spag17 |
A |
G |
3: 99,846,614 (GRCm39) |
D46G |
probably benign |
Het |
| Spata31 |
T |
G |
13: 65,068,630 (GRCm39) |
Y259* |
probably null |
Het |
| Synj1 |
T |
C |
16: 90,748,864 (GRCm39) |
E1064G |
probably damaging |
Het |
| Tom1 |
A |
G |
8: 75,785,085 (GRCm39) |
T81A |
probably benign |
Het |
| Ttc23l |
A |
G |
15: 10,530,775 (GRCm39) |
I279T |
probably damaging |
Het |
| Ttc39a |
T |
C |
4: 109,300,010 (GRCm39) |
|
probably null |
Het |
| Vmn2r108 |
C |
A |
17: 20,682,727 (GRCm39) |
A826S |
possibly damaging |
Het |
|
| Other mutations in Zyg11b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01080:Zyg11b
|
APN |
4 |
108,094,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01627:Zyg11b
|
APN |
4 |
108,107,985 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02517:Zyg11b
|
APN |
4 |
108,123,515 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03166:Zyg11b
|
APN |
4 |
108,123,086 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0326:Zyg11b
|
UTSW |
4 |
108,129,450 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0345:Zyg11b
|
UTSW |
4 |
108,123,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0396:Zyg11b
|
UTSW |
4 |
108,112,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Zyg11b
|
UTSW |
4 |
108,117,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0718:Zyg11b
|
UTSW |
4 |
108,099,273 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1426:Zyg11b
|
UTSW |
4 |
108,108,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1495:Zyg11b
|
UTSW |
4 |
108,123,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1829:Zyg11b
|
UTSW |
4 |
108,123,290 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1907:Zyg11b
|
UTSW |
4 |
108,112,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1916:Zyg11b
|
UTSW |
4 |
108,129,480 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1980:Zyg11b
|
UTSW |
4 |
108,123,127 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2070:Zyg11b
|
UTSW |
4 |
108,108,016 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2495:Zyg11b
|
UTSW |
4 |
108,101,921 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4717:Zyg11b
|
UTSW |
4 |
108,099,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5889:Zyg11b
|
UTSW |
4 |
108,094,577 (GRCm39) |
nonsense |
probably null |
|
|
R5957:Zyg11b
|
UTSW |
4 |
108,102,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6606:Zyg11b
|
UTSW |
4 |
108,093,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7151:Zyg11b
|
UTSW |
4 |
108,102,119 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7316:Zyg11b
|
UTSW |
4 |
108,107,699 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7488:Zyg11b
|
UTSW |
4 |
108,123,655 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8936:Zyg11b
|
UTSW |
4 |
108,109,356 (GRCm39) |
missense |
|
|
|
R9291:Zyg11b
|
UTSW |
4 |
108,108,014 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9642:Zyg11b
|
UTSW |
4 |
108,117,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0022:Zyg11b
|
UTSW |
4 |
108,093,298 (GRCm39) |
missense |
probably benign |
|
|
X0067:Zyg11b
|
UTSW |
4 |
108,112,543 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Zyg11b
|
UTSW |
4 |
108,112,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-06-21 |
Incidental Mutation