Incidental Mutation 'IGL01149:Cdcp2'
ID50989
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdcp2
Ensembl Gene ENSMUSG00000047636
Gene NameCUB domain containing protein 2
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.115) question?
Stock #IGL01149
Quality Score
Status
Chromosome4
Chromosomal Location107096891-107113125 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 107107111 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Serine at position 386 (F386S)
Ref Sequence ENSEMBL: ENSMUSP00000061401 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062495] [ENSMUST00000221740]
Predicted Effect probably benign
Transcript: ENSMUST00000062495
AA Change: F386S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000061401
Gene: ENSMUSG00000047636
AA Change: F386S

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
CUB 30 143 1.74e-42 SMART
CUB 145 255 2.37e-35 SMART
CUB 257 373 9.57e-31 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000221740
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4632415L05Rik A G 3: 19,895,112 noncoding transcript Het
Adcy1 A C 11: 7,137,385 N420H probably damaging Het
Avp T C 2: 130,580,673 probably benign Het
B3galnt2 A T 13: 13,980,685 I216F probably benign Het
Cdc42bpa T C 1: 180,074,572 S465P probably damaging Het
Cdc42bpg T A 19: 6,312,205 probably benign Het
Cdh4 A G 2: 179,874,144 T372A probably damaging Het
Clspn T G 4: 126,573,178 M612R probably damaging Het
Dll4 T C 2: 119,331,109 C391R probably damaging Het
Dll4 T C 2: 119,332,745 Y616H probably damaging Het
Exoc1 A G 5: 76,542,244 probably benign Het
F830045P16Rik A G 2: 129,460,312 probably null Het
Fhod1 A G 8: 105,347,807 probably benign Het
Fign T C 2: 63,979,760 R389G possibly damaging Het
Gm13941 T A 2: 111,101,137 E50V unknown Het
Gm436 T C 4: 144,673,779 D143G probably benign Het
Kit C T 5: 75,610,876 T231M probably damaging Het
Neu3 T C 7: 99,813,880 H212R probably benign Het
Nup214 G T 2: 32,034,700 S1747I probably damaging Het
Olfr1289 T C 2: 111,484,101 S224P probably damaging Het
Olfr735 G T 14: 50,345,614 A276E probably damaging Het
Olfr870 G T 9: 20,171,530 L14I probably damaging Het
Secisbp2 T C 13: 51,676,455 probably null Het
Slc26a10 G A 10: 127,174,177 probably benign Het
Slc7a6 T C 8: 106,179,600 S155P probably damaging Het
Slf1 A T 13: 77,112,648 I173N probably damaging Het
Tedc1 C T 12: 113,163,188 R357* probably null Het
Tkfc A G 19: 10,600,651 L38P probably damaging Het
Tubgcp4 A G 2: 121,184,783 D324G probably null Het
Zfyve16 T C 13: 92,508,283 H1137R probably damaging Het
Other mutations in Cdcp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02041:Cdcp2 APN 4 107107189 intron probably benign
IGL03396:Cdcp2 APN 4 107107172 nonsense probably null
R0128:Cdcp2 UTSW 4 107106707 splice site probably benign
R0130:Cdcp2 UTSW 4 107106707 splice site probably benign
R0519:Cdcp2 UTSW 4 107107192 intron probably benign
R0543:Cdcp2 UTSW 4 107097676 unclassified probably null
R1376:Cdcp2 UTSW 4 107102759 missense possibly damaging 0.93
R1376:Cdcp2 UTSW 4 107102759 missense possibly damaging 0.93
R1606:Cdcp2 UTSW 4 107102513 missense probably damaging 1.00
R1866:Cdcp2 UTSW 4 107107000 missense probably damaging 0.99
R1887:Cdcp2 UTSW 4 107102702 missense probably damaging 1.00
R2944:Cdcp2 UTSW 4 107102558 missense possibly damaging 0.88
R4620:Cdcp2 UTSW 4 107106730 missense probably damaging 0.99
R4816:Cdcp2 UTSW 4 107106772 missense probably damaging 1.00
R5298:Cdcp2 UTSW 4 107106985 missense probably benign 0.01
R5646:Cdcp2 UTSW 4 107105142 missense probably damaging 1.00
R5979:Cdcp2 UTSW 4 107105281 missense probably damaging 1.00
R6062:Cdcp2 UTSW 4 107102492 missense probably damaging 1.00
R6702:Cdcp2 UTSW 4 107107086 missense probably benign
Posted On2013-06-21