Incidental Mutation 'R6320:Ptgr2'
ID 510115
Institutional Source Beutler Lab
Gene Symbol Ptgr2
Ensembl Gene ENSMUSG00000072946
Gene Name prostaglandin reductase 2
Synonyms Zadh1, 9630002F03Rik, B830026H24Rik, 1810016I24Rik, PGR-2
MMRRC Submission 044475-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # R6320 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 84332011-84362606 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 84349111 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 150 (I150K)
Ref Sequence ENSEMBL: ENSMUSP00000114766 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000123614] [ENSMUST00000123693] [ENSMUST00000135001] [ENSMUST00000146377] [ENSMUST00000147363]
AlphaFold Q8VDQ1
Predicted Effect probably benign
Transcript: ENSMUST00000123614
AA Change: I150K

PolyPhen 2 Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000115704
Gene: ENSMUSG00000072946
AA Change: I150K

DomainStartEndE-ValueType
Pfam:ADH_N_2 4 165 5.4e-40 PFAM
Pfam:ADH_zinc_N 166 287 1.3e-15 PFAM
Pfam:ADH_zinc_N_2 200 343 4.5e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000123693
SMART Domains Protein: ENSMUSP00000115506
Gene: ENSMUSG00000072946

DomainStartEndE-ValueType
Pfam:ADH_N_2 4 56 1.3e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128158
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128541
Predicted Effect probably benign
Transcript: ENSMUST00000135001
AA Change: I150K

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000114559
Gene: ENSMUSG00000072946
AA Change: I150K

DomainStartEndE-ValueType
Pfam:ADH_zinc_N 166 283 7.4e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138733
Predicted Effect probably benign
Transcript: ENSMUST00000146377
AA Change: I150K

PolyPhen 2 Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000119981
Gene: ENSMUSG00000072946
AA Change: I150K

DomainStartEndE-ValueType
Pfam:ADH_zinc_N 166 283 1.4e-16 PFAM
Pfam:ADH_zinc_N_2 200 343 6.9e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000147363
AA Change: I150K

PolyPhen 2 Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000114766
Gene: ENSMUSG00000072946
AA Change: I150K

DomainStartEndE-ValueType
Pfam:ADH_zinc_N 166 283 1.2e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150720
Meta Mutation Damage Score 0.2414 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 100% (63/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agtr1b G T 3: 20,369,943 (GRCm39) A221D probably benign Het
Aldh18a1 A T 19: 40,559,005 (GRCm39) D280E probably benign Het
Apob G A 12: 8,039,194 (GRCm39) D475N probably benign Het
Bmi1 C T 2: 18,689,186 (GRCm39) T290I probably benign Het
Brd8 A T 18: 34,746,292 (GRCm39) D139E possibly damaging Het
Cacna1e C A 1: 154,317,270 (GRCm39) V1467F possibly damaging Het
Cdh15 A G 8: 123,591,086 (GRCm39) D445G probably benign Het
Ceacam5 T A 7: 17,481,123 (GRCm39) L290H probably damaging Het
Celsr1 G T 15: 85,785,160 (GRCm39) Q3025K probably benign Het
Chi3l1 T A 1: 134,109,996 (GRCm39) M1K probably null Het
Crybg2 T C 4: 133,808,737 (GRCm39) S1404P probably damaging Het
Cubn C A 2: 13,285,006 (GRCm39) C3470F probably damaging Het
Cyp20a1 T C 1: 60,391,331 (GRCm39) probably null Het
Cyp24a1 G T 2: 170,328,704 (GRCm39) T408K probably benign Het
Cyp2a12 A T 7: 26,730,577 (GRCm39) I181F possibly damaging Het
Dnm1l A T 16: 16,149,952 (GRCm39) I268N probably damaging Het
Eif2a A G 3: 58,464,517 (GRCm39) probably null Het
Epg5 T C 18: 78,005,613 (GRCm39) F701S probably damaging Het
Fbxo46 T C 7: 18,870,466 (GRCm39) S362P possibly damaging Het
Fgf22 A G 10: 79,592,830 (GRCm39) probably benign Het
Fhod1 A C 8: 106,063,982 (GRCm39) probably benign Het
Flnc T A 6: 29,459,062 (GRCm39) V2448D probably damaging Het
Gm2696 G T 10: 77,671,972 (GRCm39) probably benign Het
Gmpr T C 13: 45,685,874 (GRCm39) S214P possibly damaging Het
Krt6a A G 15: 101,600,744 (GRCm39) V308A probably damaging Het
Lig3 T A 11: 82,684,833 (GRCm39) probably null Het
Lrrc37a T A 11: 103,394,877 (GRCm39) N183Y probably benign Het
Mapk8ip3 C A 17: 25,125,879 (GRCm39) G422V probably damaging Het
Mks1 T C 11: 87,746,325 (GRCm39) S97P probably benign Het
Mphosph9 A T 5: 124,463,024 (GRCm39) V7E probably damaging Het
Msh5 A G 17: 35,248,900 (GRCm39) L711P probably damaging Het
Naga T A 15: 82,216,404 (GRCm39) probably null Het
Nherf4 A G 9: 44,159,980 (GRCm39) V380A probably benign Het
Nlrp10 T A 7: 108,524,953 (GRCm39) T176S possibly damaging Het
Nqo1 T C 8: 108,115,582 (GRCm39) N232D probably benign Het
Or1j21 C G 2: 36,683,585 (GRCm39) N112K possibly damaging Het
Or2b6 T A 13: 21,823,418 (GRCm39) I92L probably damaging Het
P2ry6 A G 7: 100,587,603 (GRCm39) F252S probably damaging Het
P3h3 G A 6: 124,831,835 (GRCm39) R317W probably benign Het
Pakap T A 4: 57,710,173 (GRCm39) C373S probably damaging Het
Phkb T A 8: 86,602,327 (GRCm39) D39E probably benign Het
Psg16 G A 7: 16,822,112 (GRCm39) G23D probably damaging Het
Ptprf A G 4: 118,070,011 (GRCm39) V1457A probably benign Het
Sart3 A T 5: 113,889,301 (GRCm39) Y508N probably benign Het
Sh3bp1 C T 15: 78,795,715 (GRCm39) P615S probably damaging Het
Ska3 A T 14: 58,054,148 (GRCm39) N267K probably benign Het
Slc26a7 A G 4: 14,524,498 (GRCm39) I462T probably benign Het
Slu7 C T 11: 43,332,316 (GRCm39) A244V probably benign Het
Smarca4 C T 9: 21,548,671 (GRCm39) P319L probably damaging Het
Smg9 A G 7: 24,120,286 (GRCm39) D420G probably benign Het
Strc T A 2: 121,205,439 (GRCm39) D25V probably benign Het
Syne2 T G 12: 76,108,424 (GRCm39) V936G probably damaging Het
Tbc1d7 C T 13: 43,306,409 (GRCm39) probably benign Het
Terb1 C A 8: 105,173,831 (GRCm39) D751Y probably damaging Het
Trpc1 A G 9: 95,603,303 (GRCm39) Y410H probably damaging Het
Ush2a A G 1: 188,089,043 (GRCm39) N333D probably benign Het
Usp34 T C 11: 23,402,520 (GRCm39) S2438P probably damaging Het
Vps35l T C 7: 118,353,072 (GRCm39) V189A probably benign Het
Zbtb17 G A 4: 141,190,694 (GRCm39) G171S probably benign Het
Zfp7 G A 15: 76,774,810 (GRCm39) G284D possibly damaging Het
Zfyve26 A G 12: 79,286,776 (GRCm39) S2271P probably damaging Het
Zscan18 G A 7: 12,509,147 (GRCm39) probably benign Het
Other mutations in Ptgr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02382:Ptgr2 APN 12 84,360,722 (GRCm39) missense probably damaging 0.99
IGL03176:Ptgr2 APN 12 84,354,668 (GRCm39) missense probably damaging 1.00
R1914:Ptgr2 UTSW 12 84,349,096 (GRCm39) missense probably benign 0.11
R1915:Ptgr2 UTSW 12 84,349,096 (GRCm39) missense probably benign 0.11
R4624:Ptgr2 UTSW 12 84,355,128 (GRCm39) missense possibly damaging 0.70
R5827:Ptgr2 UTSW 12 84,342,110 (GRCm39) critical splice donor site probably null
R5978:Ptgr2 UTSW 12 84,342,032 (GRCm39) nonsense probably null
R5986:Ptgr2 UTSW 12 84,355,120 (GRCm39) missense possibly damaging 0.85
R6019:Ptgr2 UTSW 12 84,344,920 (GRCm39) missense probably damaging 1.00
R6526:Ptgr2 UTSW 12 84,360,726 (GRCm39) missense probably damaging 1.00
R7369:Ptgr2 UTSW 12 84,339,080 (GRCm39) start gained probably benign
R7401:Ptgr2 UTSW 12 84,339,103 (GRCm39) start gained probably benign
R7463:Ptgr2 UTSW 12 84,339,072 (GRCm39) start gained probably benign
R7583:Ptgr2 UTSW 12 84,355,179 (GRCm39) missense probably damaging 1.00
R7793:Ptgr2 UTSW 12 84,354,575 (GRCm39) missense probably damaging 1.00
R8172:Ptgr2 UTSW 12 84,360,783 (GRCm39) missense possibly damaging 0.93
R9005:Ptgr2 UTSW 12 84,344,873 (GRCm39) missense possibly damaging 0.86
R9495:Ptgr2 UTSW 12 84,354,647 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCAAGATTGAGGTTCTGGAACAT -3'
(R):5'- GCACTCTAGCAAATGAGCCATG -3'

Sequencing Primer
(F):5'- CTCTTTCAGCTTGCAGGAAAAGGAC -3'
(R):5'- AATGAGCCATGTCACCGG -3'
Posted On 2018-04-02