Incidental Mutation 'R6321:Zfp451'
ID 510324
Institutional Source Beutler Lab
Gene Symbol Zfp451
Ensembl Gene ENSMUSG00000042197
Gene Name zinc finger protein 451
Synonyms 4930515K21Rik, Kiaa0576-hp, 4933435G09Rik
MMRRC Submission 044418-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6321 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 33800626-33853676 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 33852816 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 33 (F33L)
Ref Sequence ENSEMBL: ENSMUSP00000137992 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019861] [ENSMUST00000044455] [ENSMUST00000139143] [ENSMUST00000194656]
AlphaFold Q8C0P7
Predicted Effect probably benign
Transcript: ENSMUST00000019861
AA Change: F33L

PolyPhen 2 Score 0.233 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000019861
Gene: ENSMUSG00000042197
AA Change: F33L

DomainStartEndE-ValueType
coiled coil region 81 109 N/A INTRINSIC
ZnF_C2H2 169 195 1.63e1 SMART
ZnF_C2H2 212 232 1.18e2 SMART
ZnF_C2H2 253 277 1.73e0 SMART
ZnF_C2H2 315 335 2.03e2 SMART
ZnF_C2H2 362 385 3.75e1 SMART
ZnF_C2H2 494 517 2.91e-2 SMART
ZnF_C2H2 527 550 5.4e1 SMART
low complexity region 558 577 N/A INTRINSIC
ZnF_C2H2 604 629 1.55e1 SMART
ZnF_C2H2 634 657 2.29e0 SMART
ZnF_C2H2 665 687 1.64e-1 SMART
ZnF_C2H2 751 774 6.75e0 SMART
ZnF_C2H2 787 810 4.94e0 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000044455
AA Change: F33L

PolyPhen 2 Score 0.678 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000044372
Gene: ENSMUSG00000042197
AA Change: F33L

DomainStartEndE-ValueType
low complexity region 92 98 N/A INTRINSIC
Pfam:LAP2alpha 344 499 2.5e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125723
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130376
SMART Domains Protein: ENSMUSP00000118047
Gene: ENSMUSG00000042197

DomainStartEndE-ValueType
ZnF_C2H2 30 56 1.63e1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000139143
AA Change: F33L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect possibly damaging
Transcript: ENSMUST00000194656
AA Change: F33L

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000141813
Gene: ENSMUSG00000042197
AA Change: F33L

DomainStartEndE-ValueType
ZnF_C2H2 127 153 6.9e-2 SMART
ZnF_C2H2 170 190 5e-1 SMART
ZnF_C2H2 211 235 7.2e-3 SMART
Meta Mutation Damage Score 0.0710 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.8%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actbl2 G T 13: 111,391,915 (GRCm39) M83I probably damaging Het
Adgra2 T A 8: 27,604,190 (GRCm39) M460K probably benign Het
Aldh16a1 G A 7: 44,799,189 (GRCm39) A31V probably damaging Het
Ank2 T C 3: 126,740,587 (GRCm39) probably benign Het
Arrdc4 C A 7: 68,398,793 (GRCm39) D8Y probably benign Het
Auts2 A G 5: 131,494,953 (GRCm39) Y110H probably damaging Het
Blnk A T 19: 40,922,903 (GRCm39) Y405N probably damaging Het
Capsl T C 15: 9,461,855 (GRCm39) F84L probably damaging Het
Cdcp3 T C 7: 130,858,735 (GRCm39) probably null Het
Cenpl T C 1: 160,902,465 (GRCm39) S46P probably benign Het
Chd1l G A 3: 97,494,483 (GRCm39) A399V probably damaging Het
Chrnd C T 1: 87,119,951 (GRCm39) R90C probably damaging Het
Cyfip2 A T 11: 46,182,347 (GRCm39) M37K probably benign Het
Dnah11 T C 12: 118,106,027 (GRCm39) E625G possibly damaging Het
Dnah5 T G 15: 28,372,557 (GRCm39) V2936G probably damaging Het
Dock9 A G 14: 121,783,433 (GRCm39) M2055T probably damaging Het
Epb41l2 A T 10: 25,344,026 (GRCm39) R274S probably damaging Het
Erich3 A T 3: 154,433,139 (GRCm39) H371L probably damaging Het
Evi5l C A 8: 4,253,080 (GRCm39) P454T probably benign Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Golgb1 T A 16: 36,738,559 (GRCm39) C2299* probably null Het
Heca G C 10: 17,790,991 (GRCm39) probably null Het
Hecw1 C T 13: 14,697,414 (GRCm39) A9T probably benign Het
Hs3st6 T A 17: 24,977,542 (GRCm39) W341R probably damaging Het
Kidins220 C T 12: 25,107,533 (GRCm39) S1571L probably benign Het
Klk1b9 A G 7: 43,443,732 (GRCm39) E82G probably damaging Het
Ltbp3 C A 19: 5,795,685 (GRCm39) H180Q probably benign Het
Mecom A G 3: 30,034,741 (GRCm39) Y502H probably damaging Het
Mfsd2a A G 4: 122,843,165 (GRCm39) V372A probably benign Het
Mrgprd A G 7: 144,875,879 (GRCm39) D250G probably benign Het
Muc2 A G 7: 141,287,397 (GRCm39) D191G probably benign Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Naip6 C A 13: 100,436,909 (GRCm39) S538I probably benign Het
Or4f59 A G 2: 111,873,113 (GRCm39) V88A probably benign Het
Or52w1 A G 7: 105,018,109 (GRCm39) Y192C probably damaging Het
Pnpla6 T C 8: 3,594,015 (GRCm39) V1342A probably benign Het
Ppp1r9a A G 6: 5,115,151 (GRCm39) E789G probably damaging Het
Prkdc A G 16: 15,532,783 (GRCm39) T1471A probably benign Het
Scarb1 T A 5: 125,381,395 (GRCm39) S50C probably damaging Het
Slc4a8 C T 15: 100,687,045 (GRCm39) T283M probably damaging Het
Smc2 C A 4: 52,462,814 (GRCm39) D601E probably benign Het
Snx6 C A 12: 54,798,798 (GRCm39) V221F probably damaging Het
Spag17 A C 3: 99,995,743 (GRCm39) K1794T probably benign Het
Tpo A G 12: 30,153,107 (GRCm39) W416R probably damaging Het
Ttc13 C A 8: 125,409,930 (GRCm39) K427N probably damaging Het
Upf3a A T 8: 13,837,466 (GRCm39) N137I possibly damaging Het
Ush2a C T 1: 188,581,243 (GRCm39) Q3708* probably null Het
Zbtb17 G A 4: 141,190,694 (GRCm39) G171S probably benign Het
Zfp454 A G 11: 50,763,876 (GRCm39) F408L probably damaging Het
Zfp639 T C 3: 32,571,237 (GRCm39) Y40H probably damaging Het
Other mutations in Zfp451
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00225:Zfp451 APN 1 33,825,621 (GRCm39) intron probably benign
IGL00423:Zfp451 APN 1 33,816,660 (GRCm39) missense probably benign 0.44
IGL00925:Zfp451 APN 1 33,815,342 (GRCm39) unclassified probably benign
IGL00971:Zfp451 APN 1 33,822,234 (GRCm39) missense probably benign 0.01
IGL01521:Zfp451 APN 1 33,816,412 (GRCm39) splice site probably null
IGL01672:Zfp451 APN 1 33,801,247 (GRCm39) missense probably benign 0.33
IGL01826:Zfp451 APN 1 33,821,243 (GRCm39) missense probably damaging 1.00
IGL02298:Zfp451 APN 1 33,812,002 (GRCm39) missense probably damaging 0.98
IGL02343:Zfp451 APN 1 33,815,574 (GRCm39) missense probably damaging 1.00
IGL03150:Zfp451 APN 1 33,816,535 (GRCm39) missense probably damaging 1.00
IGL03257:Zfp451 APN 1 33,816,129 (GRCm39) missense possibly damaging 0.90
R0006:Zfp451 UTSW 1 33,841,861 (GRCm39) intron probably benign
R0068:Zfp451 UTSW 1 33,816,706 (GRCm39) missense probably damaging 1.00
R0068:Zfp451 UTSW 1 33,816,706 (GRCm39) missense probably damaging 1.00
R0358:Zfp451 UTSW 1 33,816,810 (GRCm39) missense probably damaging 1.00
R0441:Zfp451 UTSW 1 33,816,126 (GRCm39) missense probably damaging 0.96
R0483:Zfp451 UTSW 1 33,809,991 (GRCm39) splice site probably benign
R0745:Zfp451 UTSW 1 33,809,929 (GRCm39) nonsense probably null
R1469:Zfp451 UTSW 1 33,808,894 (GRCm39) missense possibly damaging 0.93
R1469:Zfp451 UTSW 1 33,808,894 (GRCm39) missense possibly damaging 0.93
R1486:Zfp451 UTSW 1 33,816,808 (GRCm39) missense probably damaging 0.99
R1774:Zfp451 UTSW 1 33,852,849 (GRCm39) missense probably benign 0.02
R1929:Zfp451 UTSW 1 33,822,937 (GRCm39) missense probably benign 0.12
R1929:Zfp451 UTSW 1 33,821,274 (GRCm39) missense probably damaging 1.00
R1933:Zfp451 UTSW 1 33,816,903 (GRCm39) missense probably damaging 1.00
R2108:Zfp451 UTSW 1 33,818,248 (GRCm39) missense possibly damaging 0.93
R2225:Zfp451 UTSW 1 33,809,988 (GRCm39) splice site probably benign
R2372:Zfp451 UTSW 1 33,819,133 (GRCm39) splice site probably null
R3923:Zfp451 UTSW 1 33,818,126 (GRCm39) missense probably null 1.00
R4295:Zfp451 UTSW 1 33,816,836 (GRCm39) missense probably damaging 0.99
R4409:Zfp451 UTSW 1 33,816,494 (GRCm39) missense probably damaging 1.00
R4617:Zfp451 UTSW 1 33,841,752 (GRCm39) intron probably benign
R4757:Zfp451 UTSW 1 33,804,939 (GRCm39) missense probably damaging 0.98
R4777:Zfp451 UTSW 1 33,821,186 (GRCm39) missense possibly damaging 0.80
R4906:Zfp451 UTSW 1 33,844,465 (GRCm39) missense probably damaging 1.00
R4964:Zfp451 UTSW 1 33,816,942 (GRCm39) missense probably damaging 1.00
R5128:Zfp451 UTSW 1 33,842,014 (GRCm39) intron probably benign
R5129:Zfp451 UTSW 1 33,842,014 (GRCm39) intron probably benign
R5383:Zfp451 UTSW 1 33,852,887 (GRCm39) missense probably damaging 1.00
R5446:Zfp451 UTSW 1 33,816,609 (GRCm39) missense probably damaging 1.00
R6154:Zfp451 UTSW 1 33,842,627 (GRCm39) intron probably benign
R6228:Zfp451 UTSW 1 33,842,219 (GRCm39) intron probably benign
R6272:Zfp451 UTSW 1 33,842,325 (GRCm39) intron probably benign
R6296:Zfp451 UTSW 1 33,808,898 (GRCm39) nonsense probably null
R6445:Zfp451 UTSW 1 33,812,092 (GRCm39) missense probably damaging 1.00
R6528:Zfp451 UTSW 1 33,816,862 (GRCm39) missense probably damaging 1.00
R6562:Zfp451 UTSW 1 33,801,260 (GRCm39) missense possibly damaging 0.90
R6739:Zfp451 UTSW 1 33,842,675 (GRCm39) intron probably benign
R6911:Zfp451 UTSW 1 33,842,537 (GRCm39) intron probably benign
R7042:Zfp451 UTSW 1 33,816,474 (GRCm39) missense probably damaging 1.00
R7044:Zfp451 UTSW 1 33,841,248 (GRCm39) intron probably benign
R7071:Zfp451 UTSW 1 33,815,825 (GRCm39) missense possibly damaging 0.96
R7082:Zfp451 UTSW 1 33,811,972 (GRCm39) critical splice donor site probably null
R7123:Zfp451 UTSW 1 33,815,950 (GRCm39) missense probably damaging 1.00
R7149:Zfp451 UTSW 1 33,816,405 (GRCm39) missense probably damaging 1.00
R7179:Zfp451 UTSW 1 33,841,651 (GRCm39) missense unknown
R7185:Zfp451 UTSW 1 33,808,974 (GRCm39) missense probably damaging 1.00
R7228:Zfp451 UTSW 1 33,842,475 (GRCm39) missense unknown
R7402:Zfp451 UTSW 1 33,852,843 (GRCm39) missense probably benign
R7462:Zfp451 UTSW 1 33,816,094 (GRCm39) missense probably damaging 1.00
R7488:Zfp451 UTSW 1 33,818,221 (GRCm39) missense probably benign 0.22
R7507:Zfp451 UTSW 1 33,808,840 (GRCm39) missense probably damaging 1.00
R7774:Zfp451 UTSW 1 33,844,474 (GRCm39) missense probably benign 0.20
R7835:Zfp451 UTSW 1 33,812,060 (GRCm39) missense probably damaging 1.00
R7979:Zfp451 UTSW 1 33,821,219 (GRCm39) missense probably benign 0.01
R8123:Zfp451 UTSW 1 33,801,248 (GRCm39) missense possibly damaging 0.92
R8137:Zfp451 UTSW 1 33,821,156 (GRCm39) missense possibly damaging 0.57
R8938:Zfp451 UTSW 1 33,842,063 (GRCm39) intron probably benign
R8974:Zfp451 UTSW 1 33,816,535 (GRCm39) missense probably damaging 1.00
R9036:Zfp451 UTSW 1 33,815,562 (GRCm39) missense probably damaging 1.00
RF005:Zfp451 UTSW 1 33,815,873 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACTCCAATTGTTCAGGTAGCC -3'
(R):5'- AGTTCCCTGGGCTGGATTTC -3'

Sequencing Primer
(F):5'- ATTGTTCAGGTAGCCCCAAG -3'
(R):5'- GCTGGATTTCCGCTTGGTCC -3'
Posted On 2018-04-02