Mutagenetix > Incidental Mutation

Incidental Mutation 'R6315:Dnah6'

510587

Institutional Source

Beutler Lab

Gene Symbol

Dnah6

Ensembl Gene

ENSMUSG00000052861

Gene Name

dynein, axonemal, heavy chain 6

Synonyms

A730004I20Rik, Dnahc6

MMRRC Submission

044472-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

R6315 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

72994589-73198634 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 73168588 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 445 (Q445R)

Ref Sequence

ENSEMBL: ENSMUSP00000144791 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064948] [ENSMUST00000114040] [ENSMUST00000204053]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000064948
AA Change: Q445R

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000068758
Gene: ENSMUSG00000052861
AA Change: Q445R

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000114040
AA Change: Q445R

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000109674
Gene: ENSMUSG00000052861
AA Change: Q445R

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	873	1300	2.2e-135	PFAM
AAA	1407	1510	2.76e-1	SMART
AAA	1688	1829	5.25e-1	SMART
low complexity region	1905	1915	N/A	INTRINSIC
AAA	2031	2184	1.01e-3	SMART
AAA	2382	2540	3.08e0	SMART
low complexity region	2555	2566	N/A	INTRINSIC
low complexity region	2593	2604	N/A	INTRINSIC
Pfam:MT	2633	2967	1.1e-53	PFAM
Pfam:AAA_9	2984	3214	1e-58	PFAM
Pfam:Dynein_heavy	3344	4089	2.2e-213	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000204053
AA Change: Q445R

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000144791
Gene: ENSMUSG00000052861
AA Change: Q445R

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

97% (64/66)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca15	T	C	7: 119,945,315 (GRCm39)	Y464H	probably damaging	Het
Ahnak	T	C	19: 8,983,990 (GRCm39)	M1758T	probably damaging	Het
Ak9	A	T	10: 41,282,837 (GRCm39)	D1201V	possibly damaging	Het
Amdhd2	A	C	17: 24,377,330 (GRCm39)	H203Q	probably benign	Het
Ano3	A	G	2: 110,527,384 (GRCm39)	M608T	probably damaging	Het
Arhgef4	G	A	1: 34,762,558 (GRCm39)	A605T	unknown	Het
Atp1a2	C	G	1: 172,116,903 (GRCm39)	R238P	probably damaging	Het
Atp8b1	C	A	18: 64,664,550 (GRCm39)	R1206L	probably damaging	Het
B4galt5	A	T	2: 167,147,729 (GRCm39)	N215K	probably damaging	Het
Bpifa1	A	G	2: 153,987,996 (GRCm39)	K180E	possibly damaging	Het
Cadm1	C	T	9: 47,721,417 (GRCm39)	T269M	probably damaging	Het
Cadm3	T	C	1: 173,171,919 (GRCm39)	D252G	probably benign	Het
Ccdc18	A	G	5: 108,309,448 (GRCm39)	R348G	probably benign	Het
Cers4	G	A	8: 4,566,980 (GRCm39)	C94Y	probably benign	Het
Cfap58	G	A	19: 47,929,716 (GRCm39)	R59H	probably benign	Het
Col19a1	C	T	1: 24,565,533 (GRCm39)	G266D	unknown	Het
Col6a5	G	T	9: 105,759,169 (GRCm39)	F2012L	probably damaging	Het
Dsg3	A	G	18: 20,657,643 (GRCm39)	S238G	probably benign	Het
E130308A19Rik	G	A	4: 59,691,132 (GRCm39)	S322N	probably benign	Het
Eif5b	A	G	1: 38,057,114 (GRCm39)	D57G	unknown	Het
Fbn2	T	C	18: 58,188,025 (GRCm39)		probably null	Het
Fbxo38	A	T	18: 62,669,218 (GRCm39)	C77*	probably null	Het
Fgb	T	A	3: 82,952,362 (GRCm39)	Q169L	probably benign	Het
Fut9	A	T	4: 25,619,774 (GRCm39)	Y347N	probably damaging	Het
Gabrg2	T	C	11: 41,862,688 (GRCm39)	K132R	probably damaging	Het
Gpn3	C	T	5: 122,510,638 (GRCm39)		probably benign	Het
Helz2	A	G	2: 180,874,995 (GRCm39)	L1833P	probably damaging	Het
Hk3	C	T	13: 55,158,970 (GRCm39)	D484N	probably benign	Het
Icam4	T	C	9: 20,941,248 (GRCm39)	V129A	probably damaging	Het
Impdh2	T	C	9: 108,440,638 (GRCm39)	S280P	possibly damaging	Het
Impg1	C	A	9: 80,301,356 (GRCm39)	G267V	probably benign	Het
Iqgap1	C	T	7: 80,449,638 (GRCm39)	V39M	possibly damaging	Het
Lyst	A	G	13: 13,818,089 (GRCm39)	N1253S	probably benign	Het
Mgat4b	T	A	11: 50,122,591 (GRCm39)	V195E	probably damaging	Het
Mrgprb8	C	T	7: 48,038,983 (GRCm39)	T218I	probably damaging	Het
Myrfl	T	G	10: 116,658,724 (GRCm39)	E411A	possibly damaging	Het
Myt1l	T	C	12: 29,877,797 (GRCm39)	S483P	unknown	Het
Neil2	A	G	14: 63,420,920 (GRCm39)	V80A	possibly damaging	Het
Nfe2l2	G	T	2: 75,507,163 (GRCm39)	D312E	probably damaging	Het
Nin	A	T	12: 70,092,389 (GRCm39)	L640Q	probably damaging	Het
Nup205	T	A	6: 35,213,804 (GRCm39)	I1732N	probably damaging	Het
Nup42	T	C	5: 24,372,502 (GRCm39)	S97P	probably damaging	Het
Or5b114-ps1	T	C	19: 13,352,769 (GRCm39)	C148R	unknown	Het
Or5k16	A	C	16: 58,736,609 (GRCm39)	Y132D	probably damaging	Het
Plcb1	A	T	2: 135,188,261 (GRCm39)	T785S	probably benign	Het
Plch1	C	T	3: 63,688,811 (GRCm39)	W131*	probably null	Het
Ppp1r1b	A	G	11: 98,246,216 (GRCm39)	E66G	probably damaging	Het
Ros1	A	T	10: 51,994,306 (GRCm39)	W1325R	probably benign	Het
Sec14l5	A	C	16: 4,998,141 (GRCm39)	E500A	possibly damaging	Het
Sirpb1c	A	G	3: 15,886,470 (GRCm39)	V302A	possibly damaging	Het
Spata19	T	C	9: 27,312,133 (GRCm39)	Y107H	possibly damaging	Het
Sv2a	G	A	3: 96,095,502 (GRCm39)	M298I	probably benign	Het
Tdrd6	A	T	17: 43,937,229 (GRCm39)	M1273K	probably benign	Het
Tectb	A	G	19: 55,179,904 (GRCm39)	H250R	possibly damaging	Het
Trip11	T	G	12: 101,851,837 (GRCm39)	E742D	possibly damaging	Het
Tslp	A	G	18: 32,950,143 (GRCm39)	T71A	probably benign	Het
Usp20	C	T	2: 30,907,770 (GRCm39)	R711C	possibly damaging	Het
Vmn1r181	G	A	7: 23,684,183 (GRCm39)	R216Q	probably benign	Het
Vmn2r8	A	T	5: 108,949,757 (GRCm39)	F363L	probably benign	Het
Vsnl1	T	A	12: 11,382,156 (GRCm39)	N75I	probably damaging	Het
Wdr55	A	T	18: 36,895,122 (GRCm39)	D96V	probably damaging	Het
Wls	T	A	3: 159,640,007 (GRCm39)		probably null	Het
Zc3h13	A	G	14: 75,546,355 (GRCm39)	D152G	probably damaging	Het
Zc3h18	A	G	8: 123,110,604 (GRCm39)	E151G	probably benign	Het
Zfat	A	G	15: 67,956,311 (GRCm39)	S1174P	probably damaging	Het
Zfyve9	T	A	4: 108,531,685 (GRCm39)	T416S	probably damaging	Het

Other mutations in Dnah6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Dnah6	APN	6	73,172,720 (GRCm39)	missense	probably benign	0.00
IGL00488:Dnah6	APN	6	73,063,190 (GRCm39)	missense	possibly damaging	0.95
IGL00497:Dnah6	APN	6	73,172,744 (GRCm39)	missense	probably damaging	1.00
IGL00557:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00561:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00563:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00755:Dnah6	APN	6	73,189,417 (GRCm39)	critical splice donor site	probably null
IGL00756:Dnah6	APN	6	73,100,754 (GRCm39)	missense	possibly damaging	0.76
IGL00764:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00895:Dnah6	APN	6	73,133,333 (GRCm39)	missense	possibly damaging	0.67
IGL00922:Dnah6	APN	6	73,010,509 (GRCm39)	splice site	probably benign
IGL00972:Dnah6	APN	6	73,060,140 (GRCm39)	splice site	probably benign
IGL00975:Dnah6	APN	6	73,150,373 (GRCm39)	missense	possibly damaging	0.94
IGL01014:Dnah6	APN	6	73,051,764 (GRCm39)	splice site	probably benign
IGL01307:Dnah6	APN	6	73,042,708 (GRCm39)	missense	probably damaging	1.00
IGL01353:Dnah6	APN	6	73,150,439 (GRCm39)	missense	probably benign	0.01
IGL01362:Dnah6	APN	6	73,069,161 (GRCm39)	missense	probably damaging	1.00
IGL01373:Dnah6	APN	6	73,051,731 (GRCm39)	missense	probably benign	0.10
IGL01559:Dnah6	APN	6	73,001,235 (GRCm39)	critical splice donor site	probably null
IGL01622:Dnah6	APN	6	73,121,701 (GRCm39)	missense	probably damaging	1.00
IGL01623:Dnah6	APN	6	73,121,701 (GRCm39)	missense	probably damaging	1.00
IGL01682:Dnah6	APN	6	73,052,785 (GRCm39)	missense	probably damaging	1.00
IGL01735:Dnah6	APN	6	73,053,643 (GRCm39)	nonsense	probably null
IGL01736:Dnah6	APN	6	73,165,360 (GRCm39)	missense	probably benign	0.06
IGL01825:Dnah6	APN	6	73,042,759 (GRCm39)	missense	probably damaging	1.00
IGL01835:Dnah6	APN	6	73,112,784 (GRCm39)	missense	probably damaging	1.00
IGL01870:Dnah6	APN	6	73,009,552 (GRCm39)	missense	probably benign	0.04
IGL01935:Dnah6	APN	6	73,037,126 (GRCm39)	missense	probably benign
IGL02126:Dnah6	APN	6	73,080,149 (GRCm39)	missense	probably benign	0.01
IGL02191:Dnah6	APN	6	72,994,780 (GRCm39)	missense	probably benign	0.00
IGL02293:Dnah6	APN	6	73,110,633 (GRCm39)	splice site	probably benign
IGL02316:Dnah6	APN	6	73,145,894 (GRCm39)	missense	probably benign	0.19
IGL02339:Dnah6	APN	6	73,078,881 (GRCm39)	missense	probably benign	0.00
IGL02380:Dnah6	APN	6	73,053,623 (GRCm39)	missense	probably benign	0.12
IGL02458:Dnah6	APN	6	73,004,431 (GRCm39)	missense	probably benign	0.43
IGL02499:Dnah6	APN	6	72,998,210 (GRCm39)	missense	probably benign	0.12
IGL02652:Dnah6	APN	6	73,072,087 (GRCm39)	missense	probably damaging	1.00
IGL02668:Dnah6	APN	6	73,098,806 (GRCm39)	missense	possibly damaging	0.61
IGL02858:Dnah6	APN	6	73,185,582 (GRCm39)	missense	probably benign	0.03
IGL02875:Dnah6	APN	6	73,115,698 (GRCm39)	missense	probably damaging	0.99
IGL02878:Dnah6	APN	6	73,009,570 (GRCm39)	missense	probably benign	0.01
IGL02989:Dnah6	APN	6	73,046,403 (GRCm39)	missense	probably damaging	1.00
IGL03001:Dnah6	APN	6	73,126,123 (GRCm39)	missense	probably benign	0.19
IGL03135:Dnah6	APN	6	73,121,987 (GRCm39)	missense	probably benign	0.00
IGL03145:Dnah6	APN	6	73,018,037 (GRCm39)	missense	probably damaging	1.00
IGL03202:Dnah6	APN	6	73,121,683 (GRCm39)	missense	probably damaging	1.00
IGL03282:Dnah6	APN	6	73,030,630 (GRCm39)	splice site	probably benign
IGL03286:Dnah6	APN	6	73,060,068 (GRCm39)	missense	probably damaging	1.00
IGL03372:Dnah6	APN	6	73,052,833 (GRCm39)	missense	probably benign	0.15
P0025:Dnah6	UTSW	6	73,140,487 (GRCm39)	missense	probably benign	0.00
PIT4305001:Dnah6	UTSW	6	73,042,738 (GRCm39)	missense	probably benign	0.03
PIT4466001:Dnah6	UTSW	6	73,185,624 (GRCm39)	missense	probably benign	0.00
PIT4480001:Dnah6	UTSW	6	73,078,863 (GRCm39)	missense	probably benign	0.00
PIT4515001:Dnah6	UTSW	6	73,091,565 (GRCm39)	missense	probably damaging	1.00
PIT4651001:Dnah6	UTSW	6	73,037,243 (GRCm39)	missense	probably benign	0.02
R0103:Dnah6	UTSW	6	73,069,155 (GRCm39)	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73,069,155 (GRCm39)	missense	probably damaging	1.00
R0105:Dnah6	UTSW	6	73,132,262 (GRCm39)	missense	probably damaging	0.99
R0105:Dnah6	UTSW	6	73,132,262 (GRCm39)	missense	probably damaging	0.99
R0127:Dnah6	UTSW	6	73,015,717 (GRCm39)	splice site	probably benign
R0164:Dnah6	UTSW	6	73,165,518 (GRCm39)	splice site	probably benign
R0165:Dnah6	UTSW	6	72,998,306 (GRCm39)	missense	probably benign	0.01
R0183:Dnah6	UTSW	6	73,059,906 (GRCm39)	missense	probably damaging	1.00
R0200:Dnah6	UTSW	6	73,046,403 (GRCm39)	missense	probably damaging	1.00
R0304:Dnah6	UTSW	6	73,136,098 (GRCm39)	missense	probably damaging	1.00
R0324:Dnah6	UTSW	6	73,150,541 (GRCm39)	missense	possibly damaging	0.86
R0335:Dnah6	UTSW	6	73,046,382 (GRCm39)	splice site	probably benign
R0345:Dnah6	UTSW	6	72,998,240 (GRCm39)	missense	probably benign	0.12
R0357:Dnah6	UTSW	6	73,165,342 (GRCm39)	missense	probably benign
R0362:Dnah6	UTSW	6	73,185,592 (GRCm39)	missense	probably benign	0.06
R0377:Dnah6	UTSW	6	73,098,975 (GRCm39)	missense	possibly damaging	0.93
R0386:Dnah6	UTSW	6	73,060,107 (GRCm39)	missense	probably damaging	0.99
R0547:Dnah6	UTSW	6	73,021,757 (GRCm39)	missense	probably benign	0.15
R0639:Dnah6	UTSW	6	72,999,395 (GRCm39)	missense	probably benign	0.02
R0673:Dnah6	UTSW	6	73,100,794 (GRCm39)	missense	probably benign	0.01
R0690:Dnah6	UTSW	6	73,106,457 (GRCm39)	missense	probably benign	0.01
R0708:Dnah6	UTSW	6	73,189,605 (GRCm39)	missense	probably benign	0.05
R0711:Dnah6	UTSW	6	73,064,585 (GRCm39)	missense	probably damaging	0.99
R0718:Dnah6	UTSW	6	73,012,276 (GRCm39)	missense	possibly damaging	0.80
R0894:Dnah6	UTSW	6	73,101,740 (GRCm39)	missense	probably benign	0.00
R0972:Dnah6	UTSW	6	73,136,176 (GRCm39)	missense	possibly damaging	0.94
R1263:Dnah6	UTSW	6	73,121,948 (GRCm39)	missense	probably damaging	0.99
R1298:Dnah6	UTSW	6	73,136,118 (GRCm39)	missense	probably damaging	1.00
R1300:Dnah6	UTSW	6	73,101,692 (GRCm39)	missense	probably benign	0.22
R1301:Dnah6	UTSW	6	73,185,528 (GRCm39)	critical splice donor site	probably null
R1341:Dnah6	UTSW	6	73,168,602 (GRCm39)	missense	probably benign	0.09
R1509:Dnah6	UTSW	6	73,004,425 (GRCm39)	missense	probably damaging	1.00
R1519:Dnah6	UTSW	6	73,026,031 (GRCm39)	missense	probably damaging	0.97
R1533:Dnah6	UTSW	6	73,128,536 (GRCm39)	missense	probably benign
R1557:Dnah6	UTSW	6	73,026,114 (GRCm39)	nonsense	probably null
R1591:Dnah6	UTSW	6	73,053,583 (GRCm39)	missense	probably benign	0.01
R1602:Dnah6	UTSW	6	73,044,452 (GRCm39)	missense	probably damaging	1.00
R1610:Dnah6	UTSW	6	73,121,946 (GRCm39)	missense	probably benign	0.09
R1616:Dnah6	UTSW	6	73,077,095 (GRCm39)	missense	probably benign	0.10
R1643:Dnah6	UTSW	6	73,021,735 (GRCm39)	missense	possibly damaging	0.85
R1644:Dnah6	UTSW	6	73,132,279 (GRCm39)	missense	probably benign	0.18
R1655:Dnah6	UTSW	6	73,182,715 (GRCm39)	missense	possibly damaging	0.88
R1661:Dnah6	UTSW	6	73,101,761 (GRCm39)	missense	probably benign	0.00
R1665:Dnah6	UTSW	6	73,101,761 (GRCm39)	missense	probably benign	0.00
R1675:Dnah6	UTSW	6	73,106,523 (GRCm39)	missense	probably damaging	1.00
R1734:Dnah6	UTSW	6	73,021,744 (GRCm39)	missense	probably damaging	0.98
R1757:Dnah6	UTSW	6	73,137,965 (GRCm39)	missense	probably damaging	1.00
R1794:Dnah6	UTSW	6	73,001,941 (GRCm39)	missense	probably damaging	0.99
R1831:Dnah6	UTSW	6	73,158,780 (GRCm39)	missense	possibly damaging	0.76
R1866:Dnah6	UTSW	6	73,077,071 (GRCm39)	missense	probably benign	0.00
R1897:Dnah6	UTSW	6	73,158,745 (GRCm39)	missense	probably benign	0.30
R1951:Dnah6	UTSW	6	73,061,704 (GRCm39)	nonsense	probably null
R1978:Dnah6	UTSW	6	73,098,953 (GRCm39)	missense	possibly damaging	0.51
R1987:Dnah6	UTSW	6	73,072,027 (GRCm39)	missense	probably damaging	0.96
R1988:Dnah6	UTSW	6	73,069,175 (GRCm39)	missense	probably damaging	1.00
R2012:Dnah6	UTSW	6	73,044,449 (GRCm39)	missense	probably damaging	1.00
R2014:Dnah6	UTSW	6	73,150,402 (GRCm39)	missense	probably damaging	0.98
R2022:Dnah6	UTSW	6	73,004,405 (GRCm39)	missense	probably benign
R2041:Dnah6	UTSW	6	73,050,422 (GRCm39)	missense	probably damaging	1.00
R2068:Dnah6	UTSW	6	72,998,165 (GRCm39)	missense	probably benign	0.23
R2114:Dnah6	UTSW	6	73,121,018 (GRCm39)	missense	probably damaging	1.00
R2152:Dnah6	UTSW	6	73,026,149 (GRCm39)	missense	probably benign	0.32
R2163:Dnah6	UTSW	6	73,066,729 (GRCm39)	splice site	probably null
R2193:Dnah6	UTSW	6	73,115,623 (GRCm39)	missense	probably damaging	1.00
R2235:Dnah6	UTSW	6	73,077,068 (GRCm39)	missense	probably damaging	0.96
R2276:Dnah6	UTSW	6	73,090,564 (GRCm39)	missense	probably benign	0.15
R2292:Dnah6	UTSW	6	72,998,092 (GRCm39)	missense	probably damaging	1.00
R2355:Dnah6	UTSW	6	73,133,404 (GRCm39)	missense	possibly damaging	0.95
R2395:Dnah6	UTSW	6	73,068,950 (GRCm39)	splice site	probably null
R2436:Dnah6	UTSW	6	73,126,156 (GRCm39)	missense	probably benign	0.05
R2847:Dnah6	UTSW	6	73,106,314 (GRCm39)	missense	probably benign	0.41
R2848:Dnah6	UTSW	6	73,106,314 (GRCm39)	missense	probably benign	0.41
R3033:Dnah6	UTSW	6	73,150,333 (GRCm39)	missense	probably benign	0.03
R3429:Dnah6	UTSW	6	73,098,797 (GRCm39)	missense	possibly damaging	0.95
R3430:Dnah6	UTSW	6	73,098,797 (GRCm39)	missense	possibly damaging	0.95
R3499:Dnah6	UTSW	6	73,009,616 (GRCm39)	missense	probably benign	0.21
R3811:Dnah6	UTSW	6	73,168,481 (GRCm39)	missense	probably benign	0.00
R3852:Dnah6	UTSW	6	73,104,910 (GRCm39)	missense	possibly damaging	0.82
R3975:Dnah6	UTSW	6	73,098,975 (GRCm39)	missense	possibly damaging	0.93
R4164:Dnah6	UTSW	6	73,066,575 (GRCm39)	nonsense	probably null
R4246:Dnah6	UTSW	6	73,106,431 (GRCm39)	missense	probably benign	0.00
R4367:Dnah6	UTSW	6	73,126,467 (GRCm39)	missense	possibly damaging	0.95
R4378:Dnah6	UTSW	6	73,095,009 (GRCm39)	missense	probably benign	0.01
R4405:Dnah6	UTSW	6	73,106,274 (GRCm39)	missense	probably benign	0.00
R4420:Dnah6	UTSW	6	73,168,462 (GRCm39)	missense	probably benign
R4486:Dnah6	UTSW	6	73,015,729 (GRCm39)	missense	probably damaging	1.00
R4512:Dnah6	UTSW	6	73,155,399 (GRCm39)	missense	probably damaging	1.00
R4547:Dnah6	UTSW	6	73,169,388 (GRCm39)	missense	probably benign
R4573:Dnah6	UTSW	6	73,063,164 (GRCm39)	missense	probably damaging	1.00
R4574:Dnah6	UTSW	6	73,063,164 (GRCm39)	missense	probably damaging	1.00
R4590:Dnah6	UTSW	6	73,129,695 (GRCm39)	missense	probably damaging	0.99
R4604:Dnah6	UTSW	6	73,106,643 (GRCm39)	missense	possibly damaging	0.92
R4652:Dnah6	UTSW	6	73,047,580 (GRCm39)	missense	probably benign
R4653:Dnah6	UTSW	6	73,050,440 (GRCm39)	missense	possibly damaging	0.76
R4669:Dnah6	UTSW	6	73,014,671 (GRCm39)	missense	probably damaging	1.00
R4674:Dnah6	UTSW	6	73,169,405 (GRCm39)	missense	probably benign	0.04
R4712:Dnah6	UTSW	6	73,001,995 (GRCm39)	critical splice acceptor site	probably null
R4788:Dnah6	UTSW	6	73,106,513 (GRCm39)	missense	probably damaging	1.00
R4791:Dnah6	UTSW	6	73,072,057 (GRCm39)	missense	probably benign	0.11
R4792:Dnah6	UTSW	6	73,066,651 (GRCm39)	missense	probably damaging	0.99
R4801:Dnah6	UTSW	6	73,066,681 (GRCm39)	missense	probably damaging	1.00
R4802:Dnah6	UTSW	6	73,066,681 (GRCm39)	missense	probably damaging	1.00
R4817:Dnah6	UTSW	6	72,999,407 (GRCm39)	missense	probably benign	0.02
R4830:Dnah6	UTSW	6	73,021,745 (GRCm39)	missense	possibly damaging	0.85
R4862:Dnah6	UTSW	6	73,098,771 (GRCm39)	missense	probably damaging	0.99
R4916:Dnah6	UTSW	6	73,169,659 (GRCm39)	intron	probably benign
R4948:Dnah6	UTSW	6	73,030,672 (GRCm39)	missense	probably benign	0.00
R4953:Dnah6	UTSW	6	73,165,366 (GRCm39)	missense	probably benign	0.19
R5000:Dnah6	UTSW	6	73,121,798 (GRCm39)	missense	probably benign	0.26
R5036:Dnah6	UTSW	6	73,021,674 (GRCm39)	missense	probably benign
R5044:Dnah6	UTSW	6	73,014,605 (GRCm39)	missense	probably benign	0.41
R5143:Dnah6	UTSW	6	73,158,744 (GRCm39)	missense	possibly damaging	0.91
R5157:Dnah6	UTSW	6	73,172,617 (GRCm39)	missense	probably benign
R5186:Dnah6	UTSW	6	73,044,410 (GRCm39)	missense	probably damaging	1.00
R5201:Dnah6	UTSW	6	73,172,715 (GRCm39)	missense	possibly damaging	0.82
R5249:Dnah6	UTSW	6	73,090,471 (GRCm39)	missense	probably damaging	1.00
R5272:Dnah6	UTSW	6	73,104,844 (GRCm39)	critical splice donor site	probably null
R5330:Dnah6	UTSW	6	73,051,573 (GRCm39)	missense	probably damaging	1.00
R5331:Dnah6	UTSW	6	73,051,573 (GRCm39)	missense	probably damaging	1.00
R5340:Dnah6	UTSW	6	73,189,603 (GRCm39)	missense	probably benign
R5343:Dnah6	UTSW	6	73,189,599 (GRCm39)	missense	probably benign
R5375:Dnah6	UTSW	6	73,100,838 (GRCm39)	missense	probably damaging	1.00
R5380:Dnah6	UTSW	6	73,014,598 (GRCm39)	missense	probably damaging	1.00
R5435:Dnah6	UTSW	6	73,037,121 (GRCm39)	missense	probably benign	0.00
R5455:Dnah6	UTSW	6	73,052,717 (GRCm39)	missense	probably benign	0.00
R5458:Dnah6	UTSW	6	73,063,168 (GRCm39)	missense	probably damaging	1.00
R5463:Dnah6	UTSW	6	73,069,140 (GRCm39)	missense	probably benign	0.04
R5484:Dnah6	UTSW	6	73,069,099 (GRCm39)	missense	possibly damaging	0.95
R5513:Dnah6	UTSW	6	73,167,402 (GRCm39)	missense	probably null	0.00
R5527:Dnah6	UTSW	6	73,136,212 (GRCm39)	missense	probably benign
R5541:Dnah6	UTSW	6	73,169,971 (GRCm39)	missense	possibly damaging	0.91
R5548:Dnah6	UTSW	6	73,128,672 (GRCm39)	missense	probably damaging	1.00
R5680:Dnah6	UTSW	6	73,126,508 (GRCm39)	missense	probably damaging	1.00
R5689:Dnah6	UTSW	6	72,998,210 (GRCm39)	missense	probably benign	0.12
R5966:Dnah6	UTSW	6	73,037,262 (GRCm39)	missense	probably benign	0.00
R5980:Dnah6	UTSW	6	73,158,705 (GRCm39)	missense	probably benign	0.01
R6049:Dnah6	UTSW	6	73,063,149 (GRCm39)	missense	probably benign	0.38
R6092:Dnah6	UTSW	6	73,091,680 (GRCm39)	missense	possibly damaging	0.61
R6130:Dnah6	UTSW	6	73,165,477 (GRCm39)	missense	probably benign	0.16
R6279:Dnah6	UTSW	6	73,042,798 (GRCm39)	missense	probably damaging	1.00
R6300:Dnah6	UTSW	6	73,042,798 (GRCm39)	missense	probably damaging	1.00
R6301:Dnah6	UTSW	6	73,063,200 (GRCm39)	missense	probably damaging	1.00
R6394:Dnah6	UTSW	6	73,132,401 (GRCm39)	nonsense	probably null
R6470:Dnah6	UTSW	6	73,051,569 (GRCm39)	missense	probably damaging	1.00
R6526:Dnah6	UTSW	6	73,051,687 (GRCm39)	missense	probably benign	0.05
R6545:Dnah6	UTSW	6	73,021,715 (GRCm39)	missense	probably damaging	1.00
R6583:Dnah6	UTSW	6	73,150,516 (GRCm39)	missense	probably benign	0.02
R6609:Dnah6	UTSW	6	73,030,678 (GRCm39)	missense	possibly damaging	0.52
R6638:Dnah6	UTSW	6	73,012,263 (GRCm39)	splice site	probably null
R6640:Dnah6	UTSW	6	73,001,276 (GRCm39)	missense	probably damaging	1.00
R6647:Dnah6	UTSW	6	73,115,743 (GRCm39)	missense	probably damaging	1.00
R6744:Dnah6	UTSW	6	73,014,532 (GRCm39)	missense	probably damaging	0.97
R6767:Dnah6	UTSW	6	73,110,591 (GRCm39)	missense	probably benign	0.29
R6845:Dnah6	UTSW	6	73,110,525 (GRCm39)	missense	probably damaging	1.00
R6913:Dnah6	UTSW	6	73,189,505 (GRCm39)	missense	probably benign	0.00
R6918:Dnah6	UTSW	6	73,158,738 (GRCm39)	nonsense	probably null
R6929:Dnah6	UTSW	6	73,021,756 (GRCm39)	missense	probably damaging	0.96
R6981:Dnah6	UTSW	6	72,998,161 (GRCm39)	missense	probably benign	0.00
R7065:Dnah6	UTSW	6	73,064,545 (GRCm39)	missense	possibly damaging	0.87
R7139:Dnah6	UTSW	6	73,112,663 (GRCm39)	missense	probably damaging	1.00
R7169:Dnah6	UTSW	6	73,015,729 (GRCm39)	missense	probably damaging	1.00
R7202:Dnah6	UTSW	6	73,158,688 (GRCm39)	critical splice donor site	probably null
R7203:Dnah6	UTSW	6	73,150,528 (GRCm39)	missense	probably benign	0.00
R7315:Dnah6	UTSW	6	73,061,743 (GRCm39)	missense	probably damaging	1.00
R7329:Dnah6	UTSW	6	73,121,705 (GRCm39)	nonsense	probably null
R7387:Dnah6	UTSW	6	73,189,595 (GRCm39)	nonsense	probably null
R7388:Dnah6	UTSW	6	73,169,300 (GRCm39)	missense	possibly damaging	0.47
R7454:Dnah6	UTSW	6	73,189,475 (GRCm39)	missense	probably damaging	1.00
R7520:Dnah6	UTSW	6	73,104,887 (GRCm39)	missense	probably benign	0.04
R7524:Dnah6	UTSW	6	73,095,082 (GRCm39)	missense	probably damaging	1.00
R7548:Dnah6	UTSW	6	73,004,423 (GRCm39)	missense	probably damaging	1.00
R7570:Dnah6	UTSW	6	73,126,413 (GRCm39)	missense	probably benign	0.01
R7604:Dnah6	UTSW	6	73,069,151 (GRCm39)	missense	probably damaging	1.00
R7615:Dnah6	UTSW	6	73,072,189 (GRCm39)	missense	possibly damaging	0.85
R7622:Dnah6	UTSW	6	73,101,742 (GRCm39)	missense	possibly damaging	0.94
R7690:Dnah6	UTSW	6	73,146,063 (GRCm39)	splice site	probably null
R7735:Dnah6	UTSW	6	73,046,412 (GRCm39)	missense	probably damaging	1.00
R7754:Dnah6	UTSW	6	73,002,703 (GRCm39)	missense	probably benign	0.41
R7829:Dnah6	UTSW	6	73,104,902 (GRCm39)	nonsense	probably null
R7904:Dnah6	UTSW	6	73,112,450 (GRCm39)	splice site	probably null
R8034:Dnah6	UTSW	6	73,106,208 (GRCm39)	missense	probably damaging	1.00
R8093:Dnah6	UTSW	6	73,137,896 (GRCm39)	missense	probably damaging	1.00
R8120:Dnah6	UTSW	6	73,002,769 (GRCm39)	missense	probably damaging	1.00
R8178:Dnah6	UTSW	6	73,037,208 (GRCm39)	missense	probably benign	0.16
R8206:Dnah6	UTSW	6	73,014,549 (GRCm39)	nonsense	probably null
R8214:Dnah6	UTSW	6	73,021,711 (GRCm39)	missense	probably damaging	1.00
R8269:Dnah6	UTSW	6	73,145,810 (GRCm39)	critical splice donor site	probably null
R8273:Dnah6	UTSW	6	73,172,664 (GRCm39)	missense	probably benign	0.00
R8273:Dnah6	UTSW	6	73,053,582 (GRCm39)	missense	probably benign	0.31
R8331:Dnah6	UTSW	6	73,001,983 (GRCm39)	missense	probably benign	0.10
R8350:Dnah6	UTSW	6	73,172,798 (GRCm39)	missense	probably benign	0.41
R8428:Dnah6	UTSW	6	73,051,634 (GRCm39)	missense	probably benign	0.15
R8447:Dnah6	UTSW	6	73,115,757 (GRCm39)	missense	probably damaging	0.99
R8450:Dnah6	UTSW	6	73,172,798 (GRCm39)	missense	probably benign	0.41
R8517:Dnah6	UTSW	6	73,155,440 (GRCm39)	missense	probably benign	0.16
R8523:Dnah6	UTSW	6	73,072,171 (GRCm39)	missense	probably damaging	1.00
R8691:Dnah6	UTSW	6	73,145,850 (GRCm39)	missense	probably damaging	1.00
R8700:Dnah6	UTSW	6	73,052,873 (GRCm39)	intron	probably benign
R8737:Dnah6	UTSW	6	73,044,428 (GRCm39)	missense	possibly damaging	0.83
R8762:Dnah6	UTSW	6	73,156,811 (GRCm39)	missense	possibly damaging	0.83
R8804:Dnah6	UTSW	6	73,042,756 (GRCm39)	missense	probably benign
R8809:Dnah6	UTSW	6	73,009,546 (GRCm39)	missense	possibly damaging	0.94
R8813:Dnah6	UTSW	6	73,104,937 (GRCm39)	missense	probably damaging	1.00
R8849:Dnah6	UTSW	6	73,121,156 (GRCm39)	critical splice acceptor site	probably null
R8867:Dnah6	UTSW	6	72,998,131 (GRCm39)	missense	probably damaging	1.00
R8882:Dnah6	UTSW	6	73,155,481 (GRCm39)	missense	probably benign	0.05
R8973:Dnah6	UTSW	6	73,121,734 (GRCm39)	missense	probably benign	0.39
R9049:Dnah6	UTSW	6	73,119,275 (GRCm39)	missense	probably damaging	1.00
R9053:Dnah6	UTSW	6	73,061,640 (GRCm39)	missense	possibly damaging	0.94
R9064:Dnah6	UTSW	6	73,126,156 (GRCm39)	missense	probably benign	0.00
R9077:Dnah6	UTSW	6	73,121,029 (GRCm39)	nonsense	probably null
R9102:Dnah6	UTSW	6	73,044,469 (GRCm39)	missense	probably benign
R9106:Dnah6	UTSW	6	73,121,752 (GRCm39)	missense	probably damaging	1.00
R9119:Dnah6	UTSW	6	73,037,186 (GRCm39)	missense	possibly damaging	0.95
R9124:Dnah6	UTSW	6	73,098,882 (GRCm39)	missense	possibly damaging	0.78
R9165:Dnah6	UTSW	6	73,121,924 (GRCm39)	missense	probably damaging	1.00
R9182:Dnah6	UTSW	6	73,121,688 (GRCm39)	nonsense	probably null
R9200:Dnah6	UTSW	6	73,004,497 (GRCm39)	missense	probably benign	0.06
R9265:Dnah6	UTSW	6	73,060,040 (GRCm39)	missense	probably benign	0.02
R9368:Dnah6	UTSW	6	72,998,261 (GRCm39)	missense	probably benign	0.22
R9378:Dnah6	UTSW	6	73,189,513 (GRCm39)	missense	probably benign
R9439:Dnah6	UTSW	6	73,012,330 (GRCm39)	missense	possibly damaging	0.66
R9506:Dnah6	UTSW	6	73,119,299 (GRCm39)	missense	probably damaging	1.00
R9645:Dnah6	UTSW	6	73,115,750 (GRCm39)	missense	possibly damaging	0.82
R9731:Dnah6	UTSW	6	73,168,589 (GRCm39)	missense	probably benign	0.00
RF002:Dnah6	UTSW	6	73,078,872 (GRCm39)	missense	probably benign
RF020:Dnah6	UTSW	6	73,095,040 (GRCm39)	missense	probably benign	0.00
W0251:Dnah6	UTSW	6	73,155,501 (GRCm39)	missense	possibly damaging	0.95
X0025:Dnah6	UTSW	6	73,168,483 (GRCm39)	missense	probably benign	0.01
X0025:Dnah6	UTSW	6	73,014,656 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah6	UTSW	6	73,110,542 (GRCm39)	missense	probably benign
Z1176:Dnah6	UTSW	6	73,064,766 (GRCm39)	missense	possibly damaging	0.79
Z1177:Dnah6	UTSW	6	73,009,509 (GRCm39)	missense	probably damaging	0.99
Z1177:Dnah6	UTSW	6	72,998,220 (GRCm39)	missense	probably benign	0.13
Z1177:Dnah6	UTSW	6	73,132,255 (GRCm39)	missense	possibly damaging	0.92
Z1177:Dnah6	UTSW	6	73,018,121 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGACATAGAGATGCCCCTCG -3'
(R):5'- TGCTTTCAGGAGAAGGACG -3'

Sequencing Primer
(F):5'- TCGCTCGATAAACACCCAGATATCTG -3'
(R):5'- GGACGGCTAAGAACAATTCTAAAC -3'

Posted On

2018-04-02