Incidental Mutation 'R6336:Mok'
ID 510772
Institutional Source Beutler Lab
Gene Symbol Mok
Ensembl Gene ENSMUSG00000056458
Gene Name MOK protein kinase
Synonyms Rage, Stk30, MOK, MAPK/MAK/MRK/ overlapping kinase
MMRRC Submission 044490-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.129) question?
Stock # R6336 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 110774232-110807373 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 110800558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135791 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070565] [ENSMUST00000084974] [ENSMUST00000177224]
AlphaFold Q9WVS4
Predicted Effect noncoding transcript
Transcript: ENSMUST00000021701
Predicted Effect probably null
Transcript: ENSMUST00000070565
SMART Domains Protein: ENSMUSP00000068904
Gene: ENSMUSG00000056458

DomainStartEndE-ValueType
S_TKc 4 285 6.78e-85 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000084974
SMART Domains Protein: ENSMUSP00000082041
Gene: ENSMUSG00000056458

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 1 138 8.4e-20 PFAM
Pfam:Pkinase 1 168 4.9e-36 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000177224
SMART Domains Protein: ENSMUSP00000135791
Gene: ENSMUSG00000056458

DomainStartEndE-ValueType
Pfam:Pkinase 4 70 2e-6 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 98% (45/46)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik G T 5: 113,331,349 (GRCm39) P955Q possibly damaging Het
Adgrv1 T C 13: 81,534,100 (GRCm39) N5827S probably benign Het
Akt3 T C 1: 176,859,278 (GRCm39) D431G probably damaging Het
Anapc16 A T 10: 59,824,651 (GRCm39) V76D possibly damaging Het
Ankib1 A T 5: 3,750,377 (GRCm39) Y755* probably null Het
Ankrd6 A G 4: 32,860,411 (GRCm39) S11P probably damaging Het
Card6 T A 15: 5,128,646 (GRCm39) K917* probably null Het
Ccdc152 T C 15: 3,330,611 (GRCm39) I21M probably damaging Het
Ccdc40 A G 11: 119,122,819 (GRCm39) E207G possibly damaging Het
Clca3a2 G T 3: 144,512,239 (GRCm39) A499E probably benign Het
Cntnap5b C T 1: 100,286,394 (GRCm39) A383V probably benign Het
Ddo T C 10: 40,509,027 (GRCm39) V89A probably damaging Het
Depdc5 T C 5: 33,121,851 (GRCm39) 176 probably null Het
Dlgap1 T A 17: 71,122,284 (GRCm39) D904E probably damaging Het
Ephb4 T A 5: 137,370,347 (GRCm39) L849H probably damaging Het
Fbxl13 A G 5: 21,728,545 (GRCm39) probably null Het
Fer1l6 C A 15: 58,431,081 (GRCm39) Y245* probably null Het
Foxred2 A G 15: 77,839,964 (GRCm39) Y109H probably damaging Het
Gabarapl1 A G 6: 129,514,491 (GRCm39) D43G probably benign Het
Gabrb1 A C 5: 72,187,241 (GRCm39) E178A possibly damaging Het
Gbp11 A G 5: 105,473,355 (GRCm39) Het
Grin3b C A 10: 79,812,295 (GRCm39) A845E probably damaging Het
Hoxd4 A G 2: 74,557,705 (GRCm39) Y28C probably damaging Het
Igsf10 G A 3: 59,237,760 (GRCm39) T807M probably benign Het
Kcnt1 A G 2: 25,778,767 (GRCm39) probably null Het
Kdm5a C A 6: 120,375,939 (GRCm39) T565K probably damaging Het
Map7d1 A G 4: 126,130,475 (GRCm39) S412P probably damaging Het
Mto1 A T 9: 78,381,117 (GRCm39) I73F probably damaging Het
Mtss2 G A 8: 111,458,796 (GRCm39) D310N probably damaging Het
Ncf2 T C 1: 152,709,821 (GRCm39) Y393H probably damaging Het
Or13c25 A T 4: 52,911,459 (GRCm39) C112S probably damaging Het
Or2f1b T C 6: 42,739,591 (GRCm39) S202P probably damaging Het
Or2y14 G T 11: 49,405,369 (GRCm39) K301N probably damaging Het
Or4f47 A C 2: 111,972,751 (GRCm39) I154L probably benign Het
Or4k49 A G 2: 111,494,964 (GRCm39) H131R possibly damaging Het
Or52z1 T C 7: 103,437,452 (GRCm39) T11A possibly damaging Het
Phxr2 T A 10: 98,961,952 (GRCm39) probably benign Het
Potefam3f A G 8: 20,499,951 (GRCm39) K242E unknown Het
Rnf17 A G 14: 56,658,626 (GRCm39) probably null Het
Serpinb9d T C 13: 33,378,677 (GRCm39) M41T probably damaging Het
Slc12a5 T A 2: 164,834,384 (GRCm39) probably null Het
Slc22a6 G A 19: 8,599,494 (GRCm39) R331H probably benign Het
Spg11 G C 2: 121,943,440 (GRCm39) probably null Het
Src T A 2: 157,299,075 (GRCm39) V24E probably benign Het
Srgap1 A T 10: 121,761,846 (GRCm39) Y101N probably benign Het
Vmn2r30 T A 7: 7,337,307 (GRCm39) T110S probably benign Het
Vwa3a A G 7: 120,361,646 (GRCm39) E119G possibly damaging Het
Whamm T A 7: 81,241,512 (GRCm39) D274E probably damaging Het
Other mutations in Mok
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Mok APN 12 110,774,631 (GRCm39) unclassified probably benign
IGL01925:Mok APN 12 110,774,646 (GRCm39) missense probably benign 0.15
IGL02660:Mok APN 12 110,794,499 (GRCm39) missense probably damaging 0.99
R0256:Mok UTSW 12 110,774,539 (GRCm39) missense probably damaging 1.00
R1797:Mok UTSW 12 110,774,479 (GRCm39) missense probably benign 0.28
R2022:Mok UTSW 12 110,778,257 (GRCm39) missense probably benign 0.00
R2175:Mok UTSW 12 110,781,634 (GRCm39) missense probably benign 0.01
R3840:Mok UTSW 12 110,781,591 (GRCm39) missense probably benign 0.04
R3841:Mok UTSW 12 110,781,591 (GRCm39) missense probably benign 0.04
R4645:Mok UTSW 12 110,774,873 (GRCm39) unclassified probably benign
R5711:Mok UTSW 12 110,774,503 (GRCm39) missense probably damaging 1.00
R6084:Mok UTSW 12 110,781,380 (GRCm39) missense probably benign 0.01
R6544:Mok UTSW 12 110,777,189 (GRCm39) missense probably damaging 1.00
R7403:Mok UTSW 12 110,781,563 (GRCm39) critical splice donor site probably null
R7557:Mok UTSW 12 110,774,833 (GRCm39) missense probably benign
R7789:Mok UTSW 12 110,778,261 (GRCm39) missense probably damaging 1.00
R8011:Mok UTSW 12 110,781,351 (GRCm39) utr 3 prime probably benign
R8169:Mok UTSW 12 110,774,799 (GRCm39) missense probably benign 0.00
R8487:Mok UTSW 12 110,776,341 (GRCm39) critical splice donor site probably null
R9437:Mok UTSW 12 110,774,659 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGGTAGTCACTGACATTACCACC -3'
(R):5'- GTTGTCGTGAAATTACGCAGAG -3'

Sequencing Primer
(F):5'- GTCACTGACATTACCACCAACTTGG -3'
(R):5'- TTACGCAGAGGAAAAAGTCTGTAGTG -3'
Posted On 2018-04-02