Incidental Mutation 'FR4449:Cracdl'
ID 511439
Institutional Source Beutler Lab
Gene Symbol Cracdl
Ensembl Gene ENSMUSG00000026090
Gene Name capping protein inhibiting regulator of actin like
Synonyms 2010300C02Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # FR4449 ()
Quality Score 221.999
Status Not validated
Chromosome 1
Chromosomal Location 37650758-37758905 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 37664117 bp (GRCm39)
Zygosity Homozygous
Amino Acid Change Glutamic Acid to Stop codon at position 594 (E594*)
Ref Sequence ENSEMBL: ENSMUSP00000123803 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162875]
AlphaFold E9Q3M9
Predicted Effect probably null
Transcript: ENSMUST00000160023
AA Change: E69*
SMART Domains Protein: ENSMUSP00000125015
Gene: ENSMUSG00000026090
AA Change: E69*

DomainStartEndE-ValueType
internal_repeat_1 2 65 4.52e-24 PROSPERO
internal_repeat_1 65 128 4.52e-24 PROSPERO
low complexity region 181 194 N/A INTRINSIC
low complexity region 223 237 N/A INTRINSIC
low complexity region 263 279 N/A INTRINSIC
low complexity region 441 465 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000162875
AA Change: E594*
SMART Domains Protein: ENSMUSP00000123803
Gene: ENSMUSG00000026090
AA Change: E594*

DomainStartEndE-ValueType
low complexity region 13 43 N/A INTRINSIC
Pfam:DUF4592 130 243 1.8e-33 PFAM
low complexity region 347 366 N/A INTRINSIC
internal_repeat_2 387 461 2.31e-5 PROSPERO
internal_repeat_3 404 474 3.67e-5 PROSPERO
internal_repeat_1 411 526 3.02e-34 PROSPERO
internal_repeat_2 485 559 2.31e-5 PROSPERO
internal_repeat_1 537 652 3.02e-34 PROSPERO
internal_repeat_3 570 698 3.67e-5 PROSPERO
low complexity region 705 718 N/A INTRINSIC
low complexity region 747 761 N/A INTRINSIC
low complexity region 787 803 N/A INTRINSIC
low complexity region 965 989 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.5%
  • 10x: 98.3%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 127 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 GGTATTGCATTTCTTATCT G 5: 4,031,214 (GRCm39) probably benign Homo
Amfr C G 8: 94,731,787 (GRCm39) G30R probably damaging Homo
Anxa7 C T 14: 20,519,479 (GRCm39) G113E probably damaging Homo
Apc AGC AGCCAATAACGC 18: 34,415,058 (GRCm39) probably benign Het
Apc AATAAAGC AATAAAGCCGATAAAGC 18: 34,415,053 (GRCm39) probably benign Het
Apol6 TTT TTTGATT 15: 76,935,643 (GRCm39) probably null Homo
Arid1b CGG CGGTGG 17: 5,045,864 (GRCm39) probably benign Het
B430218F22Rik CGGCG CGGCGATGGCG 13: 118,523,387 (GRCm39) probably benign Homo
Blm CCTCCTCCTCCTCCTCCTCCTCCT CCTCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCT 7: 80,162,656 (GRCm39) probably benign Het
Brd2 CTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA CAAAAAAAAAAAAAAA 17: 34,335,310 (GRCm39) probably benign Het
Btnl10 AAG AAGGAG 11: 58,814,754 (GRCm39) probably benign Homo
Cacna1a ACC ACCCCC 8: 85,365,343 (GRCm39) probably benign Het
Cacna1a ACC ACCGCC 8: 85,365,352 (GRCm39) probably benign Het
Cacna1a ACC ACCCCC 8: 85,365,349 (GRCm39) probably benign Het
Calhm1 TGGC TGGCTGTGGCTGCGGC 19: 47,129,713 (GRCm39) probably benign Het
Ccdc15 C CTTTAT 9: 37,226,454 (GRCm39) probably null Het
Ccdc85c CCG CCGACG 12: 108,240,875 (GRCm39) probably benign Het
Ccnk TTCCCAC T 12: 108,168,766 (GRCm39) probably benign Het
Cdhr2 AGTC AGTCGTC 13: 54,873,737 (GRCm39) probably benign Homo
Cdk15 A ATCTAAAAGG 1: 59,296,982 (GRCm39) probably benign Homo
Cdx1 GCTG GCTGCTCCTG 18: 61,152,953 (GRCm39) probably benign Het
Cfap46 T C 7: 139,218,711 (GRCm39) probably benign Homo
Cgref1 TTC TTCGTC 5: 31,091,120 (GRCm39) probably benign Het
Cgref1 CTT CTTATT 5: 31,091,122 (GRCm39) probably null Homo
Cluh G GACTGAA 11: 74,560,358 (GRCm39) probably benign Het
Cntnap1 AGCCCC AGCCCCCGCCCC 11: 101,080,395 (GRCm39) probably benign Het
Cntnap1 AGCC AGCCCCCGCC 11: 101,080,419 (GRCm39) probably benign Het
Cpne1 CCTACT CCT 2: 155,915,422 (GRCm39) probably benign Homo
Cttnbp2 CTGCTG CTGCTGTTGCTG 6: 18,367,461 (GRCm39) probably benign Het
Cul9 TCC TCCGCC 17: 46,811,782 (GRCm39) probably benign Het
Dbr1 AGGAGG AGGAGGGGGAGG 9: 99,465,727 (GRCm39) probably benign Het
Dbr1 AGGAGG AGGAGGCGGAGG 9: 99,465,739 (GRCm39) probably benign Het
Dbr1 GGAGGA GGAGGAAGAGGA 9: 99,465,749 (GRCm39) probably benign Het
Dhx8 CG CGAGACAG 11: 101,629,020 (GRCm39) probably benign Homo
Dhx8 CG CGAGACAG 11: 101,629,032 (GRCm39) probably benign Het
Dhx8 G GAGACCC 11: 101,629,033 (GRCm39) probably benign Het
Dhx8 AGACCG AGACCGTGACCG 11: 101,629,010 (GRCm39) probably benign Homo
Dhx8 AGACCGGGACCGGGACCGGGACCGGGAC AGACCGGGACCGGGAC 11: 101,629,016 (GRCm39) probably benign Het
Dspp CGACAGCAGTGACAGCAGCGACAGCAGCGACAGCAGTGACAGCAG CGACAGCAGCGACAGCAGCGACAGCAGTGACAGCAG 5: 104,326,254 (GRCm39) probably benign Het
Dusp10 G T 1: 183,769,253 (GRCm39) C73F probably damaging Homo
Erich3 GA GAGAA 3: 154,469,150 (GRCm39) probably benign Homo
Ermn CTT CTTGTT 2: 57,938,086 (GRCm39) probably benign Het
Fgd6 GGAT G 10: 93,880,182 (GRCm39) probably benign Homo
G530012D18Rik GAGAGAGAGAGAGAGAGACAGAGA GAGAGA 1: 85,504,901 (GRCm39) probably benign Homo
Gar1 GCCGCCTCCGCC GCCGCC 3: 129,624,353 (GRCm39) probably benign Homo
Gatad2b AGAC A 3: 90,249,224 (GRCm39) probably benign Het
Gigyf2 C T 1: 87,356,307 (GRCm39) probably benign Het
Gm16519 A AGAT 17: 71,236,333 (GRCm39) probably benign Homo
Gm4340 AGC AGCGGC 10: 104,031,946 (GRCm39) probably benign Het
Gm4340 GCA GCATCA 10: 104,031,947 (GRCm39) probably benign Het
Gm4340 AGC AGCGGC 10: 104,031,943 (GRCm39) probably benign Het
Gpatch11 AGGAAG AGGAAGCGGAAG 17: 79,149,597 (GRCm39) probably benign Het
Gpatch11 GAAGAG GAAGAGCAAGAG 17: 79,149,605 (GRCm39) probably benign Het
Gpatch11 GG GGCAGACG 17: 79,149,610 (GRCm39) probably benign Het
Hoxa10 T A 6: 52,211,166 (GRCm39) Q250L possibly damaging Homo
Igkv12-89 GCA GCAGCAGCAACA 6: 68,812,264 (GRCm39) probably benign Homo
Igsf10 G A 3: 59,226,531 (GRCm39) R2381C probably damaging Homo
Il17rd GGC GGCAGC 14: 26,804,635 (GRCm39) probably benign Het
Ints5 G A 19: 8,874,594 (GRCm39) R851Q probably benign Het
Isg20l2 AGA AGAGGA 3: 87,839,020 (GRCm39) probably benign Het
Kcng4 G T 8: 120,360,258 (GRCm39) Y39* probably null Homo
Kifc5b A C 17: 27,143,191 (GRCm39) E321A probably benign Het
Klra2 TCCACAG TCCACAGAAACCCACAG 6: 131,198,809 (GRCm39) probably null Homo
Kmt2b TCCTCC TCCTCCCCCTCC 7: 30,285,794 (GRCm39) probably benign Het
Kmt2b CCTCCT CCTCCTGCTCCT 7: 30,285,786 (GRCm39) probably benign Het
Kmt2b TCCTCC TCCTCCACCTCC 7: 30,285,791 (GRCm39) probably benign Het
Krt10 ACC ACCACCTCC 11: 99,280,093 (GRCm39) probably benign Het
Las1l GA GAGAA X: 94,984,438 (GRCm39) probably benign Het
Lce1m AC ACTGCTGCTGCCGC 3: 92,925,459 (GRCm39) probably benign Het
Leo1 GTACCATGCA G 9: 75,357,855 (GRCm39) probably benign Het
Lkaaear1 CA CATCTCCAGCTCTA 2: 181,339,364 (GRCm39) probably benign Het
Maml2 ACAGCAGCAGCAACAGCAGCAGCAGCAGCA ACAGCAACAGCAGCAGCAGCAGCA 9: 13,532,752 (GRCm39) probably benign Homo
Med12l CAG CAGTAG 3: 59,183,384 (GRCm39) probably null Het
Mgat4e GTCGTAGTCATCGT GTCGT 1: 134,468,735 (GRCm39) probably benign Homo
Mn1 GCA GCAACA 5: 111,567,576 (GRCm39) probably benign Het
Morn4 AGGCAGTGAG AGGCAGTGAGTCTGGCAGTGAG 19: 42,064,548 (GRCm39) probably benign Het
Nat8f2 T A 6: 85,844,668 (GRCm39) L231F possibly damaging Homo
Noc2l C CTGA 4: 156,324,558 (GRCm39) probably benign Het
Nrg3 T TAGACAC 14: 38,119,228 (GRCm39) probably benign Het
Or8b41 A G 9: 38,054,484 (GRCm39) I13V probably benign Homo
Piezo1 G A 8: 123,222,308 (GRCm39) R503W probably damaging Homo
Pih1d2 CTCTTGCGAGGATC CTC 9: 50,532,927 (GRCm39) probably null Homo
Pik3ap1 G GGAA 19: 41,270,385 (GRCm39) probably benign Het
Ppp1r3f C A X: 7,426,575 (GRCm39) G562V probably damaging Homo
Ptms TTC TTCGTC 6: 124,891,422 (GRCm39) probably benign Het
Ptpn23 G T 9: 110,216,701 (GRCm39) P1052T probably benign Homo
Qrich2 AACT A 11: 116,347,025 (GRCm39) probably benign Homo
Raet1d A ATATCCTCTCTGG 10: 22,246,814 (GRCm39) probably benign Het
Rbm33 AGCAGCAGCAGCACCAGCCGCAGCAGCAGCA AGCAGCAGCAGCA 5: 28,599,166 (GRCm39) probably benign Homo
Rrbp1 TGCTTCTCAAAGGTGGCTGCCTTGGCTTC TGCTTC 2: 143,809,376 (GRCm39) probably null Het
Sbp CAACAAAGATGCTGA CAACAAAGATGCTGAGAACAAAGATGCTGA 17: 24,164,338 (GRCm39) probably benign Het
Setd1a G A 7: 127,384,498 (GRCm39) probably benign Het
Sfswap CCCACTCAG CCCACTCAGTCCACTCAG 5: 129,646,812 (GRCm39) probably benign Het
Sfswap CCACTCAGC CCACTCAGCTCACTCAGC 5: 129,646,813 (GRCm39) probably benign Het
Sh3pxd2b T TGTCTGC 11: 32,373,065 (GRCm39) probably benign Homo
Six3 CGG CGGGGG 17: 85,928,790 (GRCm39) probably benign Het
Slc12a1 C CTTTGGCCACAACACG 2: 124,996,136 (GRCm39) probably benign Homo
Slc26a8 CTCTCTG C 17: 28,857,290 (GRCm39) probably benign Het
Spata31h1 TTCAGT TT 10: 82,121,303 (GRCm39) probably null Homo
Srebf2 G T 15: 82,069,536 (GRCm39) A693S probably damaging Homo
Sry ACTG ACTGCTG Y: 2,662,818 (GRCm39) probably benign Het
Sry TGCTG TGCTGCTG Y: 2,662,832 (GRCm39) probably benign Homo
Ston1 G A 17: 88,942,953 (GRCm39) V120M probably benign Homo
Supt20 CAGCAG CAGCAGGAGCAG 3: 54,635,070 (GRCm39) probably benign Het
Tbl3 TG TGTGG 17: 24,921,518 (GRCm39) probably benign Homo
Tctn3 AG AGAAGCCG 19: 40,595,646 (GRCm39) probably benign Het
Tesk1 CCC CCCACC 4: 43,447,002 (GRCm39) probably benign Homo
Tmc2 T G 2: 130,082,116 (GRCm39) V433G probably damaging Het
Tmprss13 G A 9: 45,239,856 (GRCm39) A55T unknown Het
Tnfaip8 ACACACACTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC AC 18: 50,179,906 (GRCm39) probably null Homo
Tob1 CAG CAGAAG 11: 94,105,294 (GRCm39) probably benign Het
Tob1 AGC AGCCGC 11: 94,105,301 (GRCm39) probably benign Het
Tpsab1 TTGCACCTCCT TT 17: 25,562,756 (GRCm39) probably benign Homo
Triobp GTC GTCTTC 15: 78,877,589 (GRCm39) probably benign Het
Ubtf CCT CCTACT 11: 102,197,774 (GRCm39) probably null Het
Vps13b G T 15: 35,847,103 (GRCm39) A2629S probably damaging Homo
Xpnpep3 G C 15: 81,311,623 (GRCm39) D110H possibly damaging Het
Zc3h13 CGAGATGTG CGAGATGTGTGAGATGTG 14: 75,561,041 (GRCm39) probably null Homo
Zfhx3 GCAACAGCA GCAACAGCAACAACAGCA 8: 109,682,726 (GRCm39) probably benign Homo
Zfp26 C A 9: 20,349,842 (GRCm39) A241S probably benign Homo
Zfp335 CTC CTCATC 2: 164,749,397 (GRCm39) probably benign Het
Zfp335 CTCT CTCTTCT 2: 164,749,403 (GRCm39) probably benign Het
Zfp598 ACCACC ACCACCTCCACC 17: 24,899,750 (GRCm39) probably benign Het
Zfp598 ACCACC ACCACCCCCACC 17: 24,899,759 (GRCm39) probably benign Het
Zfp831 TCC TCCACC 2: 174,487,264 (GRCm39) probably benign Het
Zfp831 CTC CTCGTC 2: 174,487,275 (GRCm39) probably benign Het
Zfp978 G T 4: 147,475,401 (GRCm39) S316I probably benign Het
Other mutations in Cracdl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01376:Cracdl APN 1 37,667,425 (GRCm39) missense probably damaging 0.99
IGL01413:Cracdl APN 1 37,651,387 (GRCm39) missense possibly damaging 0.85
IGL01812:Cracdl APN 1 37,664,446 (GRCm39) missense probably benign 0.06
IGL02183:Cracdl APN 1 37,664,459 (GRCm39) missense possibly damaging 0.93
IGL02498:Cracdl APN 1 37,662,926 (GRCm39) missense probably benign
IGL02713:Cracdl APN 1 37,663,218 (GRCm39) missense possibly damaging 0.72
IGL02736:Cracdl APN 1 37,676,954 (GRCm39) missense probably damaging 1.00
FR4449:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4548:Cracdl UTSW 1 37,664,183 (GRCm39) missense probably damaging 0.96
FR4548:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4548:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4737:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4737:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4976:Cracdl UTSW 1 37,664,183 (GRCm39) missense probably damaging 0.96
FR4976:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4976:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
R0022:Cracdl UTSW 1 37,667,326 (GRCm39) missense probably damaging 1.00
R0022:Cracdl UTSW 1 37,667,326 (GRCm39) missense probably damaging 1.00
R0055:Cracdl UTSW 1 37,663,337 (GRCm39) missense probably benign 0.18
R0153:Cracdl UTSW 1 37,663,720 (GRCm39) missense probably benign
R0523:Cracdl UTSW 1 37,683,710 (GRCm39) start codon destroyed probably null 0.94
R0699:Cracdl UTSW 1 37,651,411 (GRCm39) missense possibly damaging 0.85
R0928:Cracdl UTSW 1 37,663,663 (GRCm39) missense possibly damaging 0.85
R1457:Cracdl UTSW 1 37,665,093 (GRCm39) nonsense probably null
R1759:Cracdl UTSW 1 37,664,791 (GRCm39) missense probably benign 0.00
R1888:Cracdl UTSW 1 37,663,364 (GRCm39) missense possibly damaging 0.53
R1888:Cracdl UTSW 1 37,663,364 (GRCm39) missense possibly damaging 0.53
R2289:Cracdl UTSW 1 37,651,342 (GRCm39) missense possibly damaging 0.53
R2421:Cracdl UTSW 1 37,652,556 (GRCm39) missense probably benign 0.33
R2422:Cracdl UTSW 1 37,652,556 (GRCm39) missense probably benign 0.33
R2509:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R2510:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R2511:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R3893:Cracdl UTSW 1 37,670,539 (GRCm39) missense probably benign 0.00
R4351:Cracdl UTSW 1 37,663,993 (GRCm39) missense probably benign
R4454:Cracdl UTSW 1 37,663,834 (GRCm39) missense probably damaging 1.00
R4788:Cracdl UTSW 1 37,670,556 (GRCm39) missense probably damaging 1.00
R4798:Cracdl UTSW 1 37,664,046 (GRCm39) missense probably benign 0.12
R5599:Cracdl UTSW 1 37,652,424 (GRCm39) missense possibly damaging 0.53
R5920:Cracdl UTSW 1 37,677,062 (GRCm39) missense probably damaging 1.00
R6051:Cracdl UTSW 1 37,663,306 (GRCm39) missense probably damaging 0.98
R6106:Cracdl UTSW 1 37,652,493 (GRCm39) missense possibly damaging 0.53
R6794:Cracdl UTSW 1 37,676,936 (GRCm39) splice site probably null
R6828:Cracdl UTSW 1 37,663,898 (GRCm39) missense possibly damaging 0.53
R6930:Cracdl UTSW 1 37,664,026 (GRCm39) missense possibly damaging 0.73
R7044:Cracdl UTSW 1 37,651,361 (GRCm39) missense possibly damaging 0.85
R7069:Cracdl UTSW 1 37,670,982 (GRCm39) missense probably damaging 1.00
R7149:Cracdl UTSW 1 37,651,352 (GRCm39) nonsense probably null
R7296:Cracdl UTSW 1 37,653,699 (GRCm39) missense possibly damaging 0.53
R7698:Cracdl UTSW 1 37,664,452 (GRCm39) missense probably benign 0.12
R7714:Cracdl UTSW 1 37,663,858 (GRCm39) missense probably benign 0.33
R8071:Cracdl UTSW 1 37,663,010 (GRCm39) nonsense probably null
R8205:Cracdl UTSW 1 37,664,047 (GRCm39) missense probably benign 0.06
R8443:Cracdl UTSW 1 37,652,537 (GRCm39) missense probably benign 0.33
R8720:Cracdl UTSW 1 37,652,522 (GRCm39) missense possibly damaging 0.53
R8917:Cracdl UTSW 1 37,676,993 (GRCm39) missense probably damaging 0.99
R9056:Cracdl UTSW 1 37,663,553 (GRCm39) missense possibly damaging 0.91
R9158:Cracdl UTSW 1 37,670,442 (GRCm39) missense probably damaging 0.99
R9290:Cracdl UTSW 1 37,663,634 (GRCm39) missense probably damaging 0.97
R9483:Cracdl UTSW 1 37,670,496 (GRCm39) missense probably damaging 1.00
R9641:Cracdl UTSW 1 37,663,592 (GRCm39) missense possibly damaging 0.85
X0025:Cracdl UTSW 1 37,664,026 (GRCm39) missense probably benign 0.33
Predicted Primers
Posted On 2018-04-05