Incidental Mutation 'R5902:Wnt5b'
ID 512249
Institutional Source Beutler Lab
Gene Symbol Wnt5b
Ensembl Gene ENSMUSG00000030170
Gene Name wingless-type MMTV integration site family, member 5B
Synonyms Wnt-5b
MMRRC Submission 044100-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5902 (G1)
Quality Score 54
Status Validated
Chromosome 6
Chromosomal Location 119409492-119521308 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 119425199 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 6 (H6L)
Ref Sequence ENSEMBL: ENSMUSP00000112448 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117171] [ENSMUST00000118120] [ENSMUST00000119369] [ENSMUST00000178696]
AlphaFold P22726
Predicted Effect probably benign
Transcript: ENSMUST00000117171
SMART Domains Protein: ENSMUSP00000113188
Gene: ENSMUSG00000030170

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
WNT1 50 359 3.47e-215 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000118120
SMART Domains Protein: ENSMUSP00000112819
Gene: ENSMUSG00000030170

DomainStartEndE-ValueType
WNT1 12 321 3.47e-215 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000119369
AA Change: H6L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000112448
Gene: ENSMUSG00000030170
AA Change: H6L

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
WNT1 63 372 3.47e-215 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000178696
SMART Domains Protein: ENSMUSP00000137065
Gene: ENSMUSG00000030170

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
WNT1 50 359 3.47e-215 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.4%
  • 20x: 92.1%
Validation Efficiency 99% (81/82)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik A G 2: 68,539,281 (GRCm39) M1V probably null Het
Abca13 T A 11: 9,247,177 (GRCm39) L2308H probably damaging Het
Abcc8 T C 7: 45,764,463 (GRCm39) T1161A probably benign Het
Acin1 T A 14: 54,901,130 (GRCm39) T659S probably benign Het
Actl7a G T 4: 56,743,827 (GRCm39) R118L probably damaging Het
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Alkbh8 A G 9: 3,385,414 (GRCm39) K569E probably benign Het
Anxa3 A T 5: 96,960,712 (GRCm39) K39* probably null Het
Aoc2 A G 11: 101,220,072 (GRCm39) E659G probably damaging Het
Atg7 C T 6: 114,650,639 (GRCm39) T83M possibly damaging Het
AU022252 T C 4: 119,084,101 (GRCm39) D104G probably benign Het
Car6 T C 4: 150,271,956 (GRCm39) Y231C possibly damaging Het
Cdh10 T G 15: 18,985,341 (GRCm39) probably null Het
Cebpz A C 17: 79,233,366 (GRCm39) M787R probably benign Het
Chst2 A G 9: 95,287,662 (GRCm39) L228P probably damaging Het
Clic4 T C 4: 134,999,869 (GRCm39) K11R probably benign Het
Col6a3 C T 1: 90,729,921 (GRCm39) probably null Het
Commd7 T A 2: 153,463,737 (GRCm39) T144S probably damaging Het
Ctla2a T A 13: 61,082,834 (GRCm39) *138Y probably null Het
Dhx33 A T 11: 70,879,957 (GRCm39) V351D probably damaging Het
Dnah9 G A 11: 65,916,013 (GRCm39) T2313I probably benign Het
Dspp A T 5: 104,325,977 (GRCm39) D780V unknown Het
Dync1li1 A G 9: 114,546,929 (GRCm39) probably null Het
E2f3 C T 13: 30,169,250 (GRCm39) probably benign Het
Fan1 T C 7: 64,023,070 (GRCm39) probably null Het
Gart A G 16: 91,425,415 (GRCm39) S617P probably damaging Het
Ggcx A G 6: 72,406,979 (GRCm39) N705S possibly damaging Het
Gm4841 A T 18: 60,403,868 (GRCm39) V75E probably damaging Het
Greb1l A G 18: 10,538,302 (GRCm39) E1105G probably benign Het
Hr C A 14: 70,795,231 (GRCm39) Q288K probably benign Het
Hus1 T C 11: 8,960,669 (GRCm39) probably benign Het
Ifi47 C A 11: 48,986,213 (GRCm39) probably null Het
Irf2bp1 T C 7: 18,738,372 (GRCm39) V4A probably benign Het
Kprp C T 3: 92,731,835 (GRCm39) C405Y unknown Het
Lacc1 T C 14: 77,272,239 (GRCm39) I186V possibly damaging Het
Lifr A G 15: 7,220,231 (GRCm39) T954A probably benign Het
Lonrf2 T C 1: 38,846,174 (GRCm39) M333V probably benign Het
Mthfd1 A T 12: 76,337,826 (GRCm39) H400L probably benign Het
Myh4 A G 11: 67,141,733 (GRCm39) K864R possibly damaging Het
Nup50 C T 15: 84,819,641 (GRCm39) A305V probably benign Het
Or4a74 T A 2: 89,439,595 (GRCm39) I284L probably damaging Het
Or4k44 C T 2: 111,367,739 (GRCm39) M298I probably benign Het
Pax4 G T 6: 28,447,126 (GRCm39) Q3K probably benign Het
Pced1b T G 15: 97,282,970 (GRCm39) Y336* probably null Het
Postn C A 3: 54,279,510 (GRCm39) N329K probably benign Het
Prickle1 T C 15: 93,408,553 (GRCm39) E82G probably null Het
Prtn3 T C 10: 79,718,766 (GRCm39) Y241H probably damaging Het
Rasgrf2 A T 13: 92,068,011 (GRCm39) I260K probably damaging Het
Sh3glb1 T C 3: 144,418,431 (GRCm39) N44S possibly damaging Het
Sis A T 3: 72,867,589 (GRCm39) probably null Het
Slc4a9 A G 18: 36,662,386 (GRCm39) probably null Het
Slc4a9 A T 18: 36,664,560 (GRCm39) D406V probably damaging Het
Slc8a1 C T 17: 81,715,511 (GRCm39) G841R probably damaging Het
Smn1 C T 13: 100,263,412 (GRCm39) P60L probably benign Het
Snai1 G A 2: 167,383,930 (GRCm39) C241Y probably damaging Het
Spock3 A G 8: 63,808,336 (GRCm39) D411G unknown Het
Szt2 T A 4: 118,248,700 (GRCm39) T607S probably benign Het
Tcap A T 11: 98,274,673 (GRCm39) M1L probably benign Het
Tex29 A T 8: 11,905,723 (GRCm39) probably benign Het
Tex29 C A 8: 11,904,276 (GRCm39) probably benign Het
Tex29 C T 8: 11,904,277 (GRCm39) probably benign Het
Tln2 T C 9: 67,269,999 (GRCm39) T467A probably benign Het
Trim34a C T 7: 103,910,328 (GRCm39) Q377* probably null Het
Ube2q1 T A 3: 89,683,487 (GRCm39) L144* probably null Het
Vps13c A G 9: 67,841,729 (GRCm39) E1917G probably benign Het
Wdr19 T A 5: 65,384,482 (GRCm39) N525K probably benign Het
Wdr3 A T 3: 100,051,807 (GRCm39) probably benign Het
Yju2 A G 17: 56,269,077 (GRCm39) T62A probably damaging Het
Zdbf2 T C 1: 63,345,685 (GRCm39) S1355P possibly damaging Het
Zfp11 T A 5: 129,734,976 (GRCm39) I162F probably damaging Het
Zpbp T C 11: 11,365,332 (GRCm39) T172A probably benign Het
Other mutations in Wnt5b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01590:Wnt5b APN 6 119,417,515 (GRCm39) missense possibly damaging 0.70
IGL01822:Wnt5b APN 6 119,410,433 (GRCm39) missense probably damaging 1.00
Blizzard UTSW 6 119,423,319 (GRCm39) missense probably damaging 1.00
Invierno UTSW 6 119,417,272 (GRCm39) missense probably damaging 1.00
luftmensch UTSW 6 119,410,813 (GRCm39) missense probably damaging 0.97
R0557:Wnt5b UTSW 6 119,410,779 (GRCm39) missense probably damaging 1.00
R0732:Wnt5b UTSW 6 119,423,543 (GRCm39) nonsense probably null
R1472:Wnt5b UTSW 6 119,410,442 (GRCm39) missense probably damaging 1.00
R1673:Wnt5b UTSW 6 119,423,315 (GRCm39) missense probably benign 0.19
R4202:Wnt5b UTSW 6 119,417,272 (GRCm39) missense probably damaging 1.00
R5100:Wnt5b UTSW 6 119,417,449 (GRCm39) missense probably benign 0.20
R5264:Wnt5b UTSW 6 119,410,813 (GRCm39) missense probably damaging 0.97
R5393:Wnt5b UTSW 6 119,417,394 (GRCm39) missense probably damaging 1.00
R5394:Wnt5b UTSW 6 119,417,283 (GRCm39) missense probably damaging 0.98
R5482:Wnt5b UTSW 6 119,423,392 (GRCm39) missense probably benign 0.19
R5741:Wnt5b UTSW 6 119,410,690 (GRCm39) missense probably damaging 1.00
R6005:Wnt5b UTSW 6 119,410,615 (GRCm39) missense probably benign 0.04
R6061:Wnt5b UTSW 6 119,410,603 (GRCm39) missense probably damaging 0.98
R6208:Wnt5b UTSW 6 119,423,473 (GRCm39) missense probably damaging 1.00
R6405:Wnt5b UTSW 6 119,410,457 (GRCm39) missense probably benign 0.06
R6478:Wnt5b UTSW 6 119,410,751 (GRCm39) missense probably damaging 1.00
R6482:Wnt5b UTSW 6 119,410,573 (GRCm39) missense possibly damaging 0.88
R7047:Wnt5b UTSW 6 119,425,217 (GRCm39) start gained probably benign
R7338:Wnt5b UTSW 6 119,425,092 (GRCm39) splice site probably null
R8044:Wnt5b UTSW 6 119,423,319 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCACTCACCACCAGGATTTG -3'
(R):5'- AGTGCTGAATTCCTCTGGGG -3'

Sequencing Primer
(F):5'- CAGGATTTGGGTCCAGGCTAGAC -3'
(R):5'- GGGACCGAATTTGCTTTCAG -3'
Posted On 2018-04-12