Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01070:Vmn2r26'

51253

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

IGL01070

Quality Score

Status

Chromosome

Chromosomal Location

124001717-124038994 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 124038566 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 714 (I714F)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

AlphaFold

Q6TAC4

Predicted Effect

probably benign
Transcript: ENSMUST00000032238
AA Change: I714F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: I714F

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158682

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,834,475 (GRCm39)	V124I	probably damaging	Het
Adamts5	T	C	16: 85,660,021 (GRCm39)	H757R	probably damaging	Het
Aen	G	A	7: 78,557,050 (GRCm39)	M299I	probably damaging	Het
Akap3	A	T	6: 126,842,842 (GRCm39)	E487V	possibly damaging	Het
Bicd2	T	C	13: 49,531,792 (GRCm39)	S271P	probably damaging	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Cma1	A	G	14: 56,180,154 (GRCm39)	S71P	probably benign	Het
Cspp1	T	C	1: 10,158,370 (GRCm39)	Y494H	probably damaging	Het
Cyp39a1	A	G	17: 43,993,913 (GRCm39)	K191R	probably benign	Het
Efr3a	G	A	15: 65,724,927 (GRCm39)	V507I	probably benign	Het
Fam178b	C	T	1: 36,603,484 (GRCm39)	R489Q	possibly damaging	Het
Kcnj4	A	G	15: 79,368,780 (GRCm39)	L400P	probably benign	Het
Kif27	A	G	13: 58,491,907 (GRCm39)	Y411H	probably damaging	Het
Mstn	A	T	1: 53,101,156 (GRCm39)	I78L	possibly damaging	Het
Nrap	T	C	19: 56,317,516 (GRCm39)	D1377G	probably damaging	Het
Pramel5	T	G	4: 143,997,842 (GRCm39)	Y467S	probably damaging	Het
Prkg1	G	A	19: 30,546,743 (GRCm39)		probably benign	Het
Rbfox1	A	C	16: 7,124,307 (GRCm39)	S219R	possibly damaging	Het
Rfng	T	C	11: 120,674,778 (GRCm39)	N71D	probably damaging	Het
Rp1	T	C	1: 4,415,461 (GRCm39)	I1884V	probably damaging	Het
Rptn	T	A	3: 93,305,483 (GRCm39)	Y939N	possibly damaging	Het
Sart1	A	G	19: 5,433,979 (GRCm39)	V322A	probably benign	Het
Shank3	T	C	15: 89,433,619 (GRCm39)	S1455P	probably damaging	Het
Smc5	T	A	19: 23,208,965 (GRCm39)	R703W	possibly damaging	Het
Sptan1	G	A	2: 29,904,185 (GRCm39)		probably null	Het
Tecta	T	C	9: 42,306,299 (GRCm39)	D43G	probably damaging	Het
Tmem67	A	T	4: 12,054,750 (GRCm39)	M685K	probably benign	Het
Trac	A	G	14: 54,458,223 (GRCm39)	T82A	probably benign	Het
Trank1	A	G	9: 111,195,861 (GRCm39)	N1295S	probably damaging	Het
Ttc36	T	C	9: 44,712,887 (GRCm39)		probably null	Het
Utp18	A	T	11: 93,760,674 (GRCm39)	S384T	possibly damaging	Het
Vmn1r64	C	A	7: 5,886,941 (GRCm39)	A201S	probably benign	Het
Vps54	T	A	11: 21,262,268 (GRCm39)	V626D	probably damaging	Het
Wapl	T	C	14: 34,467,579 (GRCm39)		probably benign	Het
Yars2	C	T	16: 16,124,406 (GRCm39)	R338*	probably null	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01370:Vmn2r26	APN	6	124,038,715 (GRCm39)	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124,030,833 (GRCm39)	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124,027,632 (GRCm39)	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124,038,584 (GRCm39)	missense	probably damaging	1.00
IGL02425:Vmn2r26	APN	6	124,038,777 (GRCm39)	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124,003,100 (GRCm39)	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124,003,091 (GRCm39)	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124,016,754 (GRCm39)	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124,027,778 (GRCm39)	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124,016,858 (GRCm39)	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124,038,992 (GRCm39)	makesense	probably null
R0083:Vmn2r26	UTSW	6	124,030,940 (GRCm39)	splice site	probably null
R0682:Vmn2r26	UTSW	6	124,038,129 (GRCm39)	missense	probably damaging	0.97
R1061:Vmn2r26	UTSW	6	124,038,603 (GRCm39)	missense	probably benign	0.12
R1077:Vmn2r26	UTSW	6	124,030,872 (GRCm39)	missense	probably benign	0.00
R1263:Vmn2r26	UTSW	6	124,027,667 (GRCm39)	missense	probably benign
R1579:Vmn2r26	UTSW	6	124,016,706 (GRCm39)	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124,038,431 (GRCm39)	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124,038,369 (GRCm39)	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124,001,730 (GRCm39)	missense	probably benign
R1956:Vmn2r26	UTSW	6	124,030,846 (GRCm39)	missense	probably damaging	1.00
R1996:Vmn2r26	UTSW	6	124,038,144 (GRCm39)	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124,038,196 (GRCm39)	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124,016,708 (GRCm39)	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124,038,309 (GRCm39)	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124,002,938 (GRCm39)	missense	probably benign
R4490:Vmn2r26	UTSW	6	124,027,697 (GRCm39)	missense	possibly damaging	0.47
R4629:Vmn2r26	UTSW	6	124,038,150 (GRCm39)	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124,038,375 (GRCm39)	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124,030,924 (GRCm39)	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124,003,070 (GRCm39)	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124,038,832 (GRCm39)	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124,038,285 (GRCm39)	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124,027,676 (GRCm39)	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124,016,408 (GRCm39)	missense	probably benign	0.00
R5739:Vmn2r26	UTSW	6	124,002,925 (GRCm39)	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124,038,633 (GRCm39)	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124,016,830 (GRCm39)	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124,016,519 (GRCm39)	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124,038,444 (GRCm39)	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124,038,348 (GRCm39)	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124,003,039 (GRCm39)	missense	probably benign	0.17
R6637:Vmn2r26	UTSW	6	124,038,650 (GRCm39)	missense	probably damaging	1.00
R6927:Vmn2r26	UTSW	6	124,016,057 (GRCm39)	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124,016,741 (GRCm39)	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124,038,255 (GRCm39)	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124,016,727 (GRCm39)	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124,038,948 (GRCm39)	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124,002,914 (GRCm39)	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124,016,700 (GRCm39)	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124,016,606 (GRCm39)	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124,016,321 (GRCm39)	missense	probably benign
R7696:Vmn2r26	UTSW	6	124,038,494 (GRCm39)	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124,038,704 (GRCm39)	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124,016,758 (GRCm39)	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124,001,914 (GRCm39)	missense	probably benign	0.00
R8331:Vmn2r26	UTSW	6	124,038,887 (GRCm39)	missense	probably benign	0.22
R8352:Vmn2r26	UTSW	6	124,016,577 (GRCm39)	missense	probably benign	0.09
R8445:Vmn2r26	UTSW	6	124,002,995 (GRCm39)	missense	probably damaging	0.97
R8452:Vmn2r26	UTSW	6	124,016,577 (GRCm39)	missense	probably benign	0.09
R8681:Vmn2r26	UTSW	6	124,001,877 (GRCm39)	missense	probably benign	0.00
R8914:Vmn2r26	UTSW	6	124,038,983 (GRCm39)	missense	probably benign
R9333:Vmn2r26	UTSW	6	124,003,009 (GRCm39)	missense	probably benign	0.13
R9351:Vmn2r26	UTSW	6	124,016,333 (GRCm39)	missense	probably benign
R9436:Vmn2r26	UTSW	6	124,002,826 (GRCm39)	missense	probably damaging	1.00
R9515:Vmn2r26	UTSW	6	124,038,137 (GRCm39)	missense	probably damaging	1.00
RF010:Vmn2r26	UTSW	6	124,016,448 (GRCm39)	missense	possibly damaging	0.90

Posted On

2013-06-21