Incidental Mutation 'R6365:Vmn2r58'
| ID |
512634 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r58
|
| Ensembl Gene |
ENSMUSG00000090383 |
| Gene Name |
vomeronasal 2, receptor 58 |
| Synonyms |
EG628422 |
| MMRRC Submission |
044515-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.377)
|
| Stock # |
R6365 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
41486305-41522094 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 41513607 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Asparagine
at position 345
(K345N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126966
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171671]
|
| AlphaFold |
K7N6V2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171671
AA Change: K345N
PolyPhen 2
Score 0.417 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000126966
Gene: ENSMUSG00000090383
AA Change: K345N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
8e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.8e-23 |
PFAM |
|
Pfam:7tm_3
|
597 |
835 |
2.9e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.0%
- 20x: 93.8%
|
| Validation Efficiency |
98% (57/58) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2900026A02Rik |
G |
T |
5: 113,330,510 (GRCm39) |
R1235S |
probably benign |
Het |
| Abca9 |
T |
A |
11: 110,036,481 (GRCm39) |
I543F |
possibly damaging |
Het |
| Acot6 |
A |
G |
12: 84,156,186 (GRCm39) |
E378G |
probably benign |
Het |
| Adam30 |
T |
C |
3: 98,068,350 (GRCm39) |
L61S |
probably damaging |
Het |
| Agap3 |
T |
A |
5: 24,679,983 (GRCm39) |
L227Q |
probably benign |
Het |
| Ap5m1 |
T |
C |
14: 49,316,285 (GRCm39) |
I285T |
probably benign |
Het |
| Atp2a2 |
A |
G |
5: 122,599,979 (GRCm39) |
Y497H |
probably benign |
Het |
| Bace1 |
C |
T |
9: 45,765,974 (GRCm39) |
Q17* |
probably null |
Het |
| Calcr |
T |
C |
6: 3,711,455 (GRCm39) |
I189V |
probably benign |
Het |
| Cd48 |
A |
T |
1: 171,509,732 (GRCm39) |
Q24L |
probably null |
Het |
| Cnga1 |
T |
C |
5: 72,762,288 (GRCm39) |
I409V |
probably benign |
Het |
| Ctsd |
G |
A |
7: 141,939,314 (GRCm39) |
T37M |
probably benign |
Het |
| Cyp2c29 |
T |
C |
19: 39,296,198 (GRCm39) |
S171P |
probably damaging |
Het |
| Dnaaf11 |
A |
T |
15: 66,325,983 (GRCm39) |
S197R |
probably benign |
Het |
| Dnah8 |
G |
A |
17: 30,967,542 (GRCm39) |
D2585N |
probably benign |
Het |
| Drd2 |
A |
T |
9: 49,318,249 (GRCm39) |
N397I |
probably damaging |
Het |
| Dst |
A |
G |
1: 34,231,008 (GRCm39) |
E3045G |
probably damaging |
Het |
| Dzip3 |
T |
A |
16: 48,751,636 (GRCm39) |
R764S |
probably damaging |
Het |
| Efcab3 |
A |
G |
11: 104,815,412 (GRCm39) |
E3247G |
unknown |
Het |
| Exosc10 |
T |
C |
4: 148,645,562 (GRCm39) |
V114A |
probably benign |
Het |
| Fam234a |
C |
A |
17: 26,439,429 (GRCm39) |
E32* |
probably null |
Het |
| Fbxw11 |
C |
A |
11: 32,670,623 (GRCm39) |
D162E |
possibly damaging |
Het |
| Fcho2 |
A |
T |
13: 98,926,367 (GRCm39) |
M72K |
probably benign |
Het |
| Fech |
T |
C |
18: 64,591,251 (GRCm39) |
N391S |
probably benign |
Het |
| Foxp2 |
T |
C |
6: 15,286,684 (GRCm39) |
L58P |
probably damaging |
Het |
| Gdi2 |
A |
G |
13: 3,615,093 (GRCm39) |
D430G |
possibly damaging |
Het |
| Grm8 |
C |
T |
6: 27,363,226 (GRCm39) |
C763Y |
probably damaging |
Het |
| H2bc6 |
C |
T |
13: 23,769,641 (GRCm39) |
R100H |
probably benign |
Het |
| Hibch |
T |
A |
1: 52,908,096 (GRCm39) |
|
probably null |
Het |
| Ifi44l |
C |
T |
3: 151,467,142 (GRCm39) |
V63I |
unknown |
Het |
| Igf1r |
G |
T |
7: 67,839,798 (GRCm39) |
A702S |
probably benign |
Het |
| Kctd13 |
G |
A |
7: 126,529,862 (GRCm39) |
R101Q |
probably damaging |
Het |
| Klhl33 |
T |
C |
14: 51,129,294 (GRCm39) |
D645G |
probably benign |
Het |
| Mylk |
A |
G |
16: 34,680,961 (GRCm39) |
T74A |
probably benign |
Het |
| Myo1f |
A |
G |
17: 33,805,090 (GRCm39) |
S453G |
probably benign |
Het |
| Naxe |
A |
G |
3: 87,965,298 (GRCm39) |
V105A |
probably damaging |
Het |
| Nid2 |
A |
G |
14: 19,853,201 (GRCm39) |
Y1140C |
probably damaging |
Het |
| Nlrp12 |
T |
C |
7: 3,288,518 (GRCm39) |
T665A |
probably benign |
Het |
| Or51l4 |
T |
A |
7: 103,404,402 (GRCm39) |
H130L |
probably benign |
Het |
| Otud7b |
T |
G |
3: 96,062,567 (GRCm39) |
I602S |
probably benign |
Het |
| Pakap |
G |
T |
4: 57,709,675 (GRCm39) |
G207* |
probably null |
Het |
| Papolg |
T |
C |
11: 23,832,290 (GRCm39) |
D166G |
probably damaging |
Het |
| Pbx4 |
T |
G |
8: 70,324,857 (GRCm39) |
|
probably null |
Het |
| Pdcd4 |
T |
C |
19: 53,910,564 (GRCm39) |
|
probably null |
Het |
| Pde2a |
C |
T |
7: 101,159,570 (GRCm39) |
T800I |
probably damaging |
Het |
| Polk |
A |
T |
13: 96,620,517 (GRCm39) |
V582E |
probably damaging |
Het |
| Prss40 |
A |
G |
1: 34,591,598 (GRCm39) |
|
probably benign |
Het |
| Robo4 |
G |
T |
9: 37,322,008 (GRCm39) |
R597L |
probably benign |
Het |
| Scg2 |
T |
A |
1: 79,413,017 (GRCm39) |
I529F |
probably benign |
Het |
| Sema7a |
T |
C |
9: 57,862,188 (GRCm39) |
F180L |
probably benign |
Het |
| Sowahc |
T |
C |
10: 59,059,349 (GRCm39) |
L495P |
probably damaging |
Het |
| Trf |
A |
G |
9: 103,099,327 (GRCm39) |
V324A |
possibly damaging |
Het |
| Uox |
C |
T |
3: 146,330,332 (GRCm39) |
R163* |
probably null |
Het |
| Vip |
C |
T |
10: 5,594,021 (GRCm39) |
R125* |
probably null |
Het |
| Vmn1r159 |
T |
A |
7: 22,542,826 (GRCm39) |
T69S |
probably damaging |
Het |
| Vmn1r202 |
A |
T |
13: 22,686,374 (GRCm39) |
F14L |
probably benign |
Het |
| Vmn1r53 |
T |
C |
6: 90,201,241 (GRCm39) |
N28D |
probably damaging |
Het |
| Zbtb17 |
G |
A |
4: 141,190,694 (GRCm39) |
G171S |
probably benign |
Het |
| Zbtb8os |
A |
T |
4: 129,236,945 (GRCm39) |
N120I |
possibly damaging |
Het |
| Zfp959 |
T |
A |
17: 56,204,785 (GRCm39) |
L274H |
probably damaging |
Het |
|
| Other mutations in Vmn2r58 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Vmn2r58
|
APN |
7 |
41,513,854 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL00924:Vmn2r58
|
APN |
7 |
41,486,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01291:Vmn2r58
|
APN |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01480:Vmn2r58
|
APN |
7 |
41,514,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01551:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01591:Vmn2r58
|
APN |
7 |
41,514,753 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01940:Vmn2r58
|
APN |
7 |
41,487,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01994:Vmn2r58
|
APN |
7 |
41,486,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02041:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02222:Vmn2r58
|
APN |
7 |
41,513,449 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02317:Vmn2r58
|
APN |
7 |
41,486,765 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02614:Vmn2r58
|
APN |
7 |
41,486,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02673:Vmn2r58
|
APN |
7 |
41,514,082 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03323:Vmn2r58
|
APN |
7 |
41,511,295 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03337:Vmn2r58
|
APN |
7 |
41,513,810 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03380:Vmn2r58
|
APN |
7 |
41,513,874 (GRCm39) |
missense |
probably benign |
0.00 |
|
ANU05:Vmn2r58
|
UTSW |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0138:Vmn2r58
|
UTSW |
7 |
41,487,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0141:Vmn2r58
|
UTSW |
7 |
41,511,309 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0421:Vmn2r58
|
UTSW |
7 |
41,514,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0604:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0854:Vmn2r58
|
UTSW |
7 |
41,486,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Vmn2r58
|
UTSW |
7 |
41,513,387 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1441:Vmn2r58
|
UTSW |
7 |
41,486,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1678:Vmn2r58
|
UTSW |
7 |
41,513,480 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1691:Vmn2r58
|
UTSW |
7 |
41,486,913 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1699:Vmn2r58
|
UTSW |
7 |
41,509,951 (GRCm39) |
missense |
probably benign |
|
|
R1865:Vmn2r58
|
UTSW |
7 |
41,486,682 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2008:Vmn2r58
|
UTSW |
7 |
41,509,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2036:Vmn2r58
|
UTSW |
7 |
41,513,417 (GRCm39) |
missense |
probably benign |
|
|
R2202:Vmn2r58
|
UTSW |
7 |
41,513,594 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3787:Vmn2r58
|
UTSW |
7 |
41,513,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3883:Vmn2r58
|
UTSW |
7 |
41,513,914 (GRCm39) |
nonsense |
probably null |
|
|
R3944:Vmn2r58
|
UTSW |
7 |
41,513,885 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3949:Vmn2r58
|
UTSW |
7 |
41,513,348 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4232:Vmn2r58
|
UTSW |
7 |
41,487,011 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4409:Vmn2r58
|
UTSW |
7 |
41,522,051 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4411:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4413:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4600:Vmn2r58
|
UTSW |
7 |
41,522,046 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4610:Vmn2r58
|
UTSW |
7 |
41,487,117 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r58
|
UTSW |
7 |
41,509,935 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4793:Vmn2r58
|
UTSW |
7 |
41,514,495 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4870:Vmn2r58
|
UTSW |
7 |
41,486,639 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4981:Vmn2r58
|
UTSW |
7 |
41,486,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r58
|
UTSW |
7 |
41,487,176 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5024:Vmn2r58
|
UTSW |
7 |
41,513,746 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5064:Vmn2r58
|
UTSW |
7 |
41,486,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5330:Vmn2r58
|
UTSW |
7 |
41,513,384 (GRCm39) |
nonsense |
probably null |
|
|
R5526:Vmn2r58
|
UTSW |
7 |
41,522,069 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5980:Vmn2r58
|
UTSW |
7 |
41,514,480 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6163:Vmn2r58
|
UTSW |
7 |
41,486,825 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6567:Vmn2r58
|
UTSW |
7 |
41,514,673 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6594:Vmn2r58
|
UTSW |
7 |
41,486,535 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6980:Vmn2r58
|
UTSW |
7 |
41,513,662 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7373:Vmn2r58
|
UTSW |
7 |
41,487,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7458:Vmn2r58
|
UTSW |
7 |
41,487,123 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7630:Vmn2r58
|
UTSW |
7 |
41,513,611 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7807:Vmn2r58
|
UTSW |
7 |
41,521,910 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8114:Vmn2r58
|
UTSW |
7 |
41,511,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8232:Vmn2r58
|
UTSW |
7 |
41,514,076 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8313:Vmn2r58
|
UTSW |
7 |
41,521,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8412:Vmn2r58
|
UTSW |
7 |
41,513,722 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8530:Vmn2r58
|
UTSW |
7 |
41,513,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8851:Vmn2r58
|
UTSW |
7 |
41,487,219 (GRCm39) |
missense |
probably benign |
|
|
R8881:Vmn2r58
|
UTSW |
7 |
41,486,609 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8936:Vmn2r58
|
UTSW |
7 |
41,513,981 (GRCm39) |
missense |
|
|
|
R9045:Vmn2r58
|
UTSW |
7 |
41,487,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9166:Vmn2r58
|
UTSW |
7 |
41,513,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9706:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF006:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
RF027:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Vmn2r58
|
UTSW |
7 |
41,513,789 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACCTTTGGCATATGGTTGG -3'
(R):5'- TGCGACATATTGCACAACTGTTAG -3'
Sequencing Primer
(F):5'- TCTCATGGATACTATAGGCAACAGC -3'
(R):5'- TGCACAACTGTTAGTGACATGG -3'
|
| Posted On |
2018-04-27 |
Incidental Mutation