Incidental Mutation 'R6365:Vip'
ID 512646
Institutional Source Beutler Lab
Gene Symbol Vip
Ensembl Gene ENSMUSG00000019772
Gene Name vasoactive intestinal polypeptide
Synonyms PHI, peptide histidine isoleucine
MMRRC Submission 044515-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.232) question?
Stock # R6365 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 5589218-5597617 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 5594021 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 125 (R125*)
Ref Sequence ENSEMBL: ENSMUSP00000019906 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019906]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000019906
AA Change: R125*
SMART Domains Protein: ENSMUSP00000019906
Gene: ENSMUSG00000019772
AA Change: R125*

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
GLUCA 82 108 2.87e-11 SMART
GLUCA 126 152 6.39e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217331
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 93.8%
Validation Efficiency 98% (57/58)
MGI Phenotype FUNCTION: This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous null mutants display abnormal circadian rhythyms with a shorter period, abnormal phase, and in 1/4 arrhythmic circadian persistence. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik G T 5: 113,330,510 (GRCm39) R1235S probably benign Het
Abca9 T A 11: 110,036,481 (GRCm39) I543F possibly damaging Het
Acot6 A G 12: 84,156,186 (GRCm39) E378G probably benign Het
Adam30 T C 3: 98,068,350 (GRCm39) L61S probably damaging Het
Agap3 T A 5: 24,679,983 (GRCm39) L227Q probably benign Het
Ap5m1 T C 14: 49,316,285 (GRCm39) I285T probably benign Het
Atp2a2 A G 5: 122,599,979 (GRCm39) Y497H probably benign Het
Bace1 C T 9: 45,765,974 (GRCm39) Q17* probably null Het
Calcr T C 6: 3,711,455 (GRCm39) I189V probably benign Het
Cd48 A T 1: 171,509,732 (GRCm39) Q24L probably null Het
Cnga1 T C 5: 72,762,288 (GRCm39) I409V probably benign Het
Ctsd G A 7: 141,939,314 (GRCm39) T37M probably benign Het
Cyp2c29 T C 19: 39,296,198 (GRCm39) S171P probably damaging Het
Dnaaf11 A T 15: 66,325,983 (GRCm39) S197R probably benign Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Drd2 A T 9: 49,318,249 (GRCm39) N397I probably damaging Het
Dst A G 1: 34,231,008 (GRCm39) E3045G probably damaging Het
Dzip3 T A 16: 48,751,636 (GRCm39) R764S probably damaging Het
Efcab3 A G 11: 104,815,412 (GRCm39) E3247G unknown Het
Exosc10 T C 4: 148,645,562 (GRCm39) V114A probably benign Het
Fam234a C A 17: 26,439,429 (GRCm39) E32* probably null Het
Fbxw11 C A 11: 32,670,623 (GRCm39) D162E possibly damaging Het
Fcho2 A T 13: 98,926,367 (GRCm39) M72K probably benign Het
Fech T C 18: 64,591,251 (GRCm39) N391S probably benign Het
Foxp2 T C 6: 15,286,684 (GRCm39) L58P probably damaging Het
Gdi2 A G 13: 3,615,093 (GRCm39) D430G possibly damaging Het
Grm8 C T 6: 27,363,226 (GRCm39) C763Y probably damaging Het
H2bc6 C T 13: 23,769,641 (GRCm39) R100H probably benign Het
Hibch T A 1: 52,908,096 (GRCm39) probably null Het
Ifi44l C T 3: 151,467,142 (GRCm39) V63I unknown Het
Igf1r G T 7: 67,839,798 (GRCm39) A702S probably benign Het
Kctd13 G A 7: 126,529,862 (GRCm39) R101Q probably damaging Het
Klhl33 T C 14: 51,129,294 (GRCm39) D645G probably benign Het
Mylk A G 16: 34,680,961 (GRCm39) T74A probably benign Het
Myo1f A G 17: 33,805,090 (GRCm39) S453G probably benign Het
Naxe A G 3: 87,965,298 (GRCm39) V105A probably damaging Het
Nid2 A G 14: 19,853,201 (GRCm39) Y1140C probably damaging Het
Nlrp12 T C 7: 3,288,518 (GRCm39) T665A probably benign Het
Or51l4 T A 7: 103,404,402 (GRCm39) H130L probably benign Het
Otud7b T G 3: 96,062,567 (GRCm39) I602S probably benign Het
Pakap G T 4: 57,709,675 (GRCm39) G207* probably null Het
Papolg T C 11: 23,832,290 (GRCm39) D166G probably damaging Het
Pbx4 T G 8: 70,324,857 (GRCm39) probably null Het
Pdcd4 T C 19: 53,910,564 (GRCm39) probably null Het
Pde2a C T 7: 101,159,570 (GRCm39) T800I probably damaging Het
Polk A T 13: 96,620,517 (GRCm39) V582E probably damaging Het
Prss40 A G 1: 34,591,598 (GRCm39) probably benign Het
Robo4 G T 9: 37,322,008 (GRCm39) R597L probably benign Het
Scg2 T A 1: 79,413,017 (GRCm39) I529F probably benign Het
Sema7a T C 9: 57,862,188 (GRCm39) F180L probably benign Het
Sowahc T C 10: 59,059,349 (GRCm39) L495P probably damaging Het
Trf A G 9: 103,099,327 (GRCm39) V324A possibly damaging Het
Uox C T 3: 146,330,332 (GRCm39) R163* probably null Het
Vmn1r159 T A 7: 22,542,826 (GRCm39) T69S probably damaging Het
Vmn1r202 A T 13: 22,686,374 (GRCm39) F14L probably benign Het
Vmn1r53 T C 6: 90,201,241 (GRCm39) N28D probably damaging Het
Vmn2r58 T A 7: 41,513,607 (GRCm39) K345N probably benign Het
Zbtb17 G A 4: 141,190,694 (GRCm39) G171S probably benign Het
Zbtb8os A T 4: 129,236,945 (GRCm39) N120I possibly damaging Het
Zfp959 T A 17: 56,204,785 (GRCm39) L274H probably damaging Het
Other mutations in Vip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01018:Vip APN 10 5,592,480 (GRCm39) missense probably benign 0.28
IGL02182:Vip APN 10 5,593,561 (GRCm39) missense probably benign 0.01
R0082:Vip UTSW 10 5,594,953 (GRCm39) makesense probably null
R0267:Vip UTSW 10 5,594,004 (GRCm39) missense possibly damaging 0.67
R1776:Vip UTSW 10 5,594,992 (GRCm39) critical splice donor site probably null
R3973:Vip UTSW 10 5,592,590 (GRCm39) missense possibly damaging 0.57
R4803:Vip UTSW 10 5,594,099 (GRCm39) missense probably damaging 0.99
R5898:Vip UTSW 10 5,593,988 (GRCm39) missense probably damaging 0.96
R9571:Vip UTSW 10 5,590,661 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GTCATTGAGGAAAACACATCAGACC -3'
(R):5'- CAGTGTCCAAATAGAGCTCAAC -3'

Sequencing Primer
(F):5'- ACCTAGGGTGAGATAGAGGTTTTG -3'
(R):5'- GTGTCCAAATAGAGCTCAACATGTG -3'
Posted On 2018-04-27