Incidental Mutation 'R6354:Vmn2r65'
ID 512964
Institutional Source Beutler Lab
Gene Symbol Vmn2r65
Ensembl Gene ENSMUSG00000066372
Gene Name vomeronasal 2, receptor 65
Synonyms ENSMUSG00000070600
MMRRC Submission 044506-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R6354 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 84589377-84613217 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 84589574 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 781 (I781F)
Ref Sequence ENSEMBL: ENSMUSP00000036551 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044583]
AlphaFold G3X931
Predicted Effect probably benign
Transcript: ENSMUST00000044583
AA Change: I781F

PolyPhen 2 Score 0.349 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000036551
Gene: ENSMUSG00000066372
AA Change: I781F

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 73 435 5.6e-41 PFAM
Pfam:NCD3G 501 553 1.3e-21 PFAM
Pfam:7tm_3 584 821 2.3e-53 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.8%
  • 10x: 98.5%
  • 20x: 95.3%
Validation Efficiency 100% (56/56)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik T C 11: 109,685,042 (GRCm39) K152E probably benign Het
Adamts20 C A 15: 94,245,691 (GRCm39) C537F probably damaging Het
Apc A T 18: 34,445,581 (GRCm39) T808S probably benign Het
Atad3a A G 4: 155,838,402 (GRCm39) I205T possibly damaging Het
Casz1 G T 4: 149,036,999 (GRCm39) G1754C unknown Het
Ccdc62 C T 5: 124,082,267 (GRCm39) A232V probably damaging Het
Cdc27 C A 11: 104,425,574 (GRCm39) D81Y probably damaging Het
Cep126 A G 9: 8,099,928 (GRCm39) S869P probably damaging Het
Cfap251 C T 5: 123,440,818 (GRCm39) T1125I probably damaging Het
Ciita A T 16: 10,341,610 (GRCm39) K983N probably damaging Het
Cimap1a A G 7: 140,430,527 (GRCm39) probably null Het
Clstn1 A C 4: 149,727,673 (GRCm39) Q523P probably benign Het
Cpb2 T C 14: 75,495,145 (GRCm39) probably null Het
Crybg2 A G 4: 133,818,447 (GRCm39) D1710G probably benign Het
Csmd3 C T 15: 47,744,885 (GRCm39) G1370D probably damaging Het
Cwf19l1 G T 19: 44,115,912 (GRCm39) D172E probably benign Het
Cyp4a14 A G 4: 115,344,441 (GRCm39) F475L probably damaging Het
Fam98c C T 7: 28,852,272 (GRCm39) V298M probably damaging Het
Gcsh T C 8: 117,710,582 (GRCm39) N127S probably benign Het
Gimap4 T C 6: 48,663,814 (GRCm39) F10S possibly damaging Het
Gm4787 C T 12: 81,424,755 (GRCm39) A468T probably damaging Het
Gm5111 G A 6: 48,567,268 (GRCm39) probably benign Het
Gm7137 C A 10: 77,623,481 (GRCm39) probably benign Het
Inpp1 A G 1: 52,836,224 (GRCm39) S81P probably damaging Het
Iqce T C 5: 140,662,090 (GRCm39) probably null Het
Ivl CCTGCTGCTGCTGCT CCTGCTGCTGCT 3: 92,479,217 (GRCm39) probably benign Het
Krtap13 C A 16: 88,548,131 (GRCm39) C119F probably damaging Het
Lama2 G T 10: 27,088,064 (GRCm39) D904E probably damaging Het
Lrrc37a T A 11: 103,355,213 (GRCm39) I2535F unknown Het
Lrrc40 T A 3: 157,766,901 (GRCm39) L452* probably null Het
Meis1 A T 11: 18,966,184 (GRCm39) M63K possibly damaging Het
Mpo T A 11: 87,688,172 (GRCm39) I277N possibly damaging Het
Mtmr11 T A 3: 96,075,992 (GRCm39) F406I probably benign Het
Muc4 T C 16: 32,575,476 (GRCm39) S1411P probably benign Het
Or2y1b A T 11: 49,208,465 (GRCm39) I31F probably damaging Het
Or4c102 T A 2: 88,422,478 (GRCm39) I110N probably damaging Het
Or56a5 G A 7: 104,792,915 (GRCm39) T195I probably benign Het
Phf21a G A 2: 92,179,282 (GRCm39) G298R probably damaging Het
Phldb2 T C 16: 45,645,477 (GRCm39) Y368C probably damaging Het
Pik3cb G T 9: 98,955,696 (GRCm39) T407K probably benign Het
Robo3 A T 9: 37,328,513 (GRCm39) probably benign Het
Sgsm1 T G 5: 113,430,522 (GRCm39) T288P probably damaging Het
Slc5a7 A G 17: 54,584,061 (GRCm39) S410P probably damaging Het
Tmc6 A C 11: 117,665,062 (GRCm39) C404G probably benign Het
Tnrc6c A T 11: 117,640,440 (GRCm39) Q1410L possibly damaging Het
Trak1 A T 9: 121,280,792 (GRCm39) T384S probably null Het
Txlna A T 4: 129,528,205 (GRCm39) L244Q probably damaging Het
Ube3c T C 5: 29,868,581 (GRCm39) F939L probably damaging Het
Vmn2r72 A G 7: 85,399,747 (GRCm39) probably null Het
Vps36 T C 8: 22,695,771 (GRCm39) S109P probably damaging Het
Wrn T C 8: 33,833,666 (GRCm39) I82M possibly damaging Het
Zbtb49 T C 5: 38,360,903 (GRCm39) R511G possibly damaging Het
Zeb1 A G 18: 5,772,743 (GRCm39) T1011A possibly damaging Het
Zfhx4 T C 3: 5,467,011 (GRCm39) S2390P probably benign Het
Zfp619 C A 7: 39,184,243 (GRCm39) T91K probably benign Het
Zfp644 A G 5: 106,784,619 (GRCm39) S643P probably benign Het
Other mutations in Vmn2r65
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00942:Vmn2r65 APN 7 84,592,761 (GRCm39) missense probably damaging 0.99
IGL01104:Vmn2r65 APN 7 84,589,996 (GRCm39) missense possibly damaging 0.93
IGL01154:Vmn2r65 APN 7 84,592,729 (GRCm39) missense probably benign 0.00
IGL01453:Vmn2r65 APN 7 84,589,708 (GRCm39) missense probably damaging 1.00
IGL01675:Vmn2r65 APN 7 84,596,587 (GRCm39) missense probably benign 0.00
IGL01748:Vmn2r65 APN 7 84,589,507 (GRCm39) missense probably damaging 1.00
IGL01997:Vmn2r65 APN 7 84,589,978 (GRCm39) missense probably damaging 1.00
IGL02527:Vmn2r65 APN 7 84,595,724 (GRCm39) missense possibly damaging 0.82
IGL02617:Vmn2r65 APN 7 84,589,549 (GRCm39) missense probably damaging 1.00
IGL02676:Vmn2r65 APN 7 84,589,381 (GRCm39) missense possibly damaging 0.86
IGL03084:Vmn2r65 APN 7 84,592,354 (GRCm39) missense probably damaging 1.00
A4554:Vmn2r65 UTSW 7 84,595,791 (GRCm39) missense probably damaging 0.96
PIT4651001:Vmn2r65 UTSW 7 84,595,461 (GRCm39) missense probably benign 0.12
R0322:Vmn2r65 UTSW 7 84,595,756 (GRCm39) missense probably benign 0.01
R0453:Vmn2r65 UTSW 7 84,595,442 (GRCm39) missense probably benign 0.03
R0862:Vmn2r65 UTSW 7 84,592,853 (GRCm39) missense probably benign 0.00
R1392:Vmn2r65 UTSW 7 84,596,624 (GRCm39) missense probably benign 0.14
R1392:Vmn2r65 UTSW 7 84,596,624 (GRCm39) missense probably benign 0.14
R1508:Vmn2r65 UTSW 7 84,589,886 (GRCm39) missense probably benign 0.00
R1687:Vmn2r65 UTSW 7 84,590,026 (GRCm39) missense probably benign 0.02
R1876:Vmn2r65 UTSW 7 84,595,505 (GRCm39) missense probably damaging 1.00
R2136:Vmn2r65 UTSW 7 84,592,781 (GRCm39) missense probably damaging 0.96
R2259:Vmn2r65 UTSW 7 84,590,119 (GRCm39) missense possibly damaging 0.86
R2338:Vmn2r65 UTSW 7 84,590,051 (GRCm39) missense possibly damaging 0.86
R2880:Vmn2r65 UTSW 7 84,613,094 (GRCm39) missense probably damaging 1.00
R3410:Vmn2r65 UTSW 7 84,595,896 (GRCm39) missense probably benign 0.00
R3411:Vmn2r65 UTSW 7 84,595,896 (GRCm39) missense probably benign 0.00
R3770:Vmn2r65 UTSW 7 84,589,623 (GRCm39) missense probably damaging 1.00
R3800:Vmn2r65 UTSW 7 84,589,738 (GRCm39) missense possibly damaging 0.93
R3850:Vmn2r65 UTSW 7 84,595,859 (GRCm39) missense probably benign 0.00
R4105:Vmn2r65 UTSW 7 84,595,691 (GRCm39) missense probably benign 0.03
R4568:Vmn2r65 UTSW 7 84,596,677 (GRCm39) missense probably damaging 1.00
R4677:Vmn2r65 UTSW 7 84,613,082 (GRCm39) missense possibly damaging 0.55
R4768:Vmn2r65 UTSW 7 84,596,602 (GRCm39) missense probably damaging 1.00
R4778:Vmn2r65 UTSW 7 84,592,801 (GRCm39) missense possibly damaging 0.47
R5057:Vmn2r65 UTSW 7 84,589,819 (GRCm39) missense probably damaging 1.00
R5279:Vmn2r65 UTSW 7 84,589,849 (GRCm39) missense probably damaging 1.00
R5280:Vmn2r65 UTSW 7 84,595,542 (GRCm39) missense probably damaging 0.99
R5394:Vmn2r65 UTSW 7 84,595,862 (GRCm39) missense probably benign 0.04
R5487:Vmn2r65 UTSW 7 84,595,529 (GRCm39) missense possibly damaging 0.76
R5580:Vmn2r65 UTSW 7 84,596,802 (GRCm39) missense probably damaging 0.99
R5638:Vmn2r65 UTSW 7 84,590,047 (GRCm39) missense probably damaging 1.00
R5673:Vmn2r65 UTSW 7 84,596,615 (GRCm39) missense probably benign 0.23
R5688:Vmn2r65 UTSW 7 84,589,900 (GRCm39) missense probably benign 0.00
R5935:Vmn2r65 UTSW 7 84,592,869 (GRCm39) missense probably benign 0.00
R6372:Vmn2r65 UTSW 7 84,589,861 (GRCm39) missense probably damaging 1.00
R6924:Vmn2r65 UTSW 7 84,613,198 (GRCm39) missense probably benign 0.20
R7021:Vmn2r65 UTSW 7 84,596,587 (GRCm39) missense probably benign 0.00
R7195:Vmn2r65 UTSW 7 84,592,347 (GRCm39) critical splice donor site probably null
R7422:Vmn2r65 UTSW 7 84,595,569 (GRCm39) missense probably damaging 0.99
R7654:Vmn2r65 UTSW 7 84,590,261 (GRCm39) missense probably damaging 1.00
R7686:Vmn2r65 UTSW 7 84,589,744 (GRCm39) missense probably damaging 0.99
R7691:Vmn2r65 UTSW 7 84,592,851 (GRCm39) missense probably benign 0.30
R7798:Vmn2r65 UTSW 7 84,596,192 (GRCm39) missense probably damaging 1.00
R7798:Vmn2r65 UTSW 7 84,595,530 (GRCm39) missense probably benign 0.00
R8103:Vmn2r65 UTSW 7 84,595,919 (GRCm39) missense probably damaging 1.00
R8272:Vmn2r65 UTSW 7 84,596,817 (GRCm39) missense probably benign 0.02
R8303:Vmn2r65 UTSW 7 84,589,391 (GRCm39) nonsense probably null
R8354:Vmn2r65 UTSW 7 84,589,402 (GRCm39) missense possibly damaging 0.73
R8454:Vmn2r65 UTSW 7 84,589,402 (GRCm39) missense possibly damaging 0.73
R8489:Vmn2r65 UTSW 7 84,589,964 (GRCm39) missense possibly damaging 0.85
R8554:Vmn2r65 UTSW 7 84,595,960 (GRCm39) missense probably benign 0.00
R8680:Vmn2r65 UTSW 7 84,589,388 (GRCm39) missense probably benign 0.00
R8731:Vmn2r65 UTSW 7 84,589,447 (GRCm39) nonsense probably null
R8839:Vmn2r65 UTSW 7 84,595,489 (GRCm39) nonsense probably null
R8847:Vmn2r65 UTSW 7 84,590,212 (GRCm39) missense probably damaging 1.00
R8916:Vmn2r65 UTSW 7 84,595,665 (GRCm39) missense probably benign 0.21
R9254:Vmn2r65 UTSW 7 84,596,650 (GRCm39) missense probably damaging 0.99
R9379:Vmn2r65 UTSW 7 84,596,650 (GRCm39) missense probably damaging 0.99
R9392:Vmn2r65 UTSW 7 84,589,718 (GRCm39) missense possibly damaging 0.95
R9563:Vmn2r65 UTSW 7 84,589,880 (GRCm39) nonsense probably null
R9686:Vmn2r65 UTSW 7 84,590,084 (GRCm39) missense probably benign 0.45
X0067:Vmn2r65 UTSW 7 84,590,113 (GRCm39) missense probably benign 0.04
Z1088:Vmn2r65 UTSW 7 84,592,473 (GRCm39) critical splice acceptor site probably null
Z1177:Vmn2r65 UTSW 7 84,590,234 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- ATGTGTGTCACTGAACTTCTGAG -3'
(R):5'- GTGGAACATGGATAGGAACATCTCC -3'

Sequencing Primer
(F):5'- CACTGAACTTCTGAGTAAAATTCACC -3'
(R):5'- GATCCACACTTTGAACATGGTC -3'
Posted On 2018-04-27