Incidental Mutation 'R6354:Vmn2r65'
ID |
512964 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r65
|
Ensembl Gene |
ENSMUSG00000066372 |
Gene Name |
vomeronasal 2, receptor 65 |
Synonyms |
ENSMUSG00000070600 |
MMRRC Submission |
044506-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.071)
|
Stock # |
R6354 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
84589377-84613217 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 84589574 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Phenylalanine
at position 781
(I781F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000036551
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044583]
|
AlphaFold |
G3X931 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000044583
AA Change: I781F
PolyPhen 2
Score 0.349 (Sensitivity: 0.90; Specificity: 0.89)
|
SMART Domains |
Protein: ENSMUSP00000036551 Gene: ENSMUSG00000066372 AA Change: I781F
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
73 |
435 |
5.6e-41 |
PFAM |
Pfam:NCD3G
|
501 |
553 |
1.3e-21 |
PFAM |
Pfam:7tm_3
|
584 |
821 |
2.3e-53 |
PFAM |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.8%
- 10x: 98.5%
- 20x: 95.3%
|
Validation Efficiency |
100% (56/56) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 56 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700012B07Rik |
T |
C |
11: 109,685,042 (GRCm39) |
K152E |
probably benign |
Het |
Adamts20 |
C |
A |
15: 94,245,691 (GRCm39) |
C537F |
probably damaging |
Het |
Apc |
A |
T |
18: 34,445,581 (GRCm39) |
T808S |
probably benign |
Het |
Atad3a |
A |
G |
4: 155,838,402 (GRCm39) |
I205T |
possibly damaging |
Het |
Casz1 |
G |
T |
4: 149,036,999 (GRCm39) |
G1754C |
unknown |
Het |
Ccdc62 |
C |
T |
5: 124,082,267 (GRCm39) |
A232V |
probably damaging |
Het |
Cdc27 |
C |
A |
11: 104,425,574 (GRCm39) |
D81Y |
probably damaging |
Het |
Cep126 |
A |
G |
9: 8,099,928 (GRCm39) |
S869P |
probably damaging |
Het |
Cfap251 |
C |
T |
5: 123,440,818 (GRCm39) |
T1125I |
probably damaging |
Het |
Ciita |
A |
T |
16: 10,341,610 (GRCm39) |
K983N |
probably damaging |
Het |
Cimap1a |
A |
G |
7: 140,430,527 (GRCm39) |
|
probably null |
Het |
Clstn1 |
A |
C |
4: 149,727,673 (GRCm39) |
Q523P |
probably benign |
Het |
Cpb2 |
T |
C |
14: 75,495,145 (GRCm39) |
|
probably null |
Het |
Crybg2 |
A |
G |
4: 133,818,447 (GRCm39) |
D1710G |
probably benign |
Het |
Csmd3 |
C |
T |
15: 47,744,885 (GRCm39) |
G1370D |
probably damaging |
Het |
Cwf19l1 |
G |
T |
19: 44,115,912 (GRCm39) |
D172E |
probably benign |
Het |
Cyp4a14 |
A |
G |
4: 115,344,441 (GRCm39) |
F475L |
probably damaging |
Het |
Fam98c |
C |
T |
7: 28,852,272 (GRCm39) |
V298M |
probably damaging |
Het |
Gcsh |
T |
C |
8: 117,710,582 (GRCm39) |
N127S |
probably benign |
Het |
Gimap4 |
T |
C |
6: 48,663,814 (GRCm39) |
F10S |
possibly damaging |
Het |
Gm4787 |
C |
T |
12: 81,424,755 (GRCm39) |
A468T |
probably damaging |
Het |
Gm5111 |
G |
A |
6: 48,567,268 (GRCm39) |
|
probably benign |
Het |
Gm7137 |
C |
A |
10: 77,623,481 (GRCm39) |
|
probably benign |
Het |
Inpp1 |
A |
G |
1: 52,836,224 (GRCm39) |
S81P |
probably damaging |
Het |
Iqce |
T |
C |
5: 140,662,090 (GRCm39) |
|
probably null |
Het |
Ivl |
CCTGCTGCTGCTGCT |
CCTGCTGCTGCT |
3: 92,479,217 (GRCm39) |
|
probably benign |
Het |
Krtap13 |
C |
A |
16: 88,548,131 (GRCm39) |
C119F |
probably damaging |
Het |
Lama2 |
G |
T |
10: 27,088,064 (GRCm39) |
D904E |
probably damaging |
Het |
Lrrc37a |
T |
A |
11: 103,355,213 (GRCm39) |
I2535F |
unknown |
Het |
Lrrc40 |
T |
A |
3: 157,766,901 (GRCm39) |
L452* |
probably null |
Het |
Meis1 |
A |
T |
11: 18,966,184 (GRCm39) |
M63K |
possibly damaging |
Het |
Mpo |
T |
A |
11: 87,688,172 (GRCm39) |
I277N |
possibly damaging |
Het |
Mtmr11 |
T |
A |
3: 96,075,992 (GRCm39) |
F406I |
probably benign |
Het |
Muc4 |
T |
C |
16: 32,575,476 (GRCm39) |
S1411P |
probably benign |
Het |
Or2y1b |
A |
T |
11: 49,208,465 (GRCm39) |
I31F |
probably damaging |
Het |
Or4c102 |
T |
A |
2: 88,422,478 (GRCm39) |
I110N |
probably damaging |
Het |
Or56a5 |
G |
A |
7: 104,792,915 (GRCm39) |
T195I |
probably benign |
Het |
Phf21a |
G |
A |
2: 92,179,282 (GRCm39) |
G298R |
probably damaging |
Het |
Phldb2 |
T |
C |
16: 45,645,477 (GRCm39) |
Y368C |
probably damaging |
Het |
Pik3cb |
G |
T |
9: 98,955,696 (GRCm39) |
T407K |
probably benign |
Het |
Robo3 |
A |
T |
9: 37,328,513 (GRCm39) |
|
probably benign |
Het |
Sgsm1 |
T |
G |
5: 113,430,522 (GRCm39) |
T288P |
probably damaging |
Het |
Slc5a7 |
A |
G |
17: 54,584,061 (GRCm39) |
S410P |
probably damaging |
Het |
Tmc6 |
A |
C |
11: 117,665,062 (GRCm39) |
C404G |
probably benign |
Het |
Tnrc6c |
A |
T |
11: 117,640,440 (GRCm39) |
Q1410L |
possibly damaging |
Het |
Trak1 |
A |
T |
9: 121,280,792 (GRCm39) |
T384S |
probably null |
Het |
Txlna |
A |
T |
4: 129,528,205 (GRCm39) |
L244Q |
probably damaging |
Het |
Ube3c |
T |
C |
5: 29,868,581 (GRCm39) |
F939L |
probably damaging |
Het |
Vmn2r72 |
A |
G |
7: 85,399,747 (GRCm39) |
|
probably null |
Het |
Vps36 |
T |
C |
8: 22,695,771 (GRCm39) |
S109P |
probably damaging |
Het |
Wrn |
T |
C |
8: 33,833,666 (GRCm39) |
I82M |
possibly damaging |
Het |
Zbtb49 |
T |
C |
5: 38,360,903 (GRCm39) |
R511G |
possibly damaging |
Het |
Zeb1 |
A |
G |
18: 5,772,743 (GRCm39) |
T1011A |
possibly damaging |
Het |
Zfhx4 |
T |
C |
3: 5,467,011 (GRCm39) |
S2390P |
probably benign |
Het |
Zfp619 |
C |
A |
7: 39,184,243 (GRCm39) |
T91K |
probably benign |
Het |
Zfp644 |
A |
G |
5: 106,784,619 (GRCm39) |
S643P |
probably benign |
Het |
|
Other mutations in Vmn2r65 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00942:Vmn2r65
|
APN |
7 |
84,592,761 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01104:Vmn2r65
|
APN |
7 |
84,589,996 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL01154:Vmn2r65
|
APN |
7 |
84,592,729 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01453:Vmn2r65
|
APN |
7 |
84,589,708 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01675:Vmn2r65
|
APN |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01748:Vmn2r65
|
APN |
7 |
84,589,507 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01997:Vmn2r65
|
APN |
7 |
84,589,978 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02527:Vmn2r65
|
APN |
7 |
84,595,724 (GRCm39) |
missense |
possibly damaging |
0.82 |
IGL02617:Vmn2r65
|
APN |
7 |
84,589,549 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02676:Vmn2r65
|
APN |
7 |
84,589,381 (GRCm39) |
missense |
possibly damaging |
0.86 |
IGL03084:Vmn2r65
|
APN |
7 |
84,592,354 (GRCm39) |
missense |
probably damaging |
1.00 |
A4554:Vmn2r65
|
UTSW |
7 |
84,595,791 (GRCm39) |
missense |
probably damaging |
0.96 |
PIT4651001:Vmn2r65
|
UTSW |
7 |
84,595,461 (GRCm39) |
missense |
probably benign |
0.12 |
R0322:Vmn2r65
|
UTSW |
7 |
84,595,756 (GRCm39) |
missense |
probably benign |
0.01 |
R0453:Vmn2r65
|
UTSW |
7 |
84,595,442 (GRCm39) |
missense |
probably benign |
0.03 |
R0862:Vmn2r65
|
UTSW |
7 |
84,592,853 (GRCm39) |
missense |
probably benign |
0.00 |
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
R1508:Vmn2r65
|
UTSW |
7 |
84,589,886 (GRCm39) |
missense |
probably benign |
0.00 |
R1687:Vmn2r65
|
UTSW |
7 |
84,590,026 (GRCm39) |
missense |
probably benign |
0.02 |
R1876:Vmn2r65
|
UTSW |
7 |
84,595,505 (GRCm39) |
missense |
probably damaging |
1.00 |
R2136:Vmn2r65
|
UTSW |
7 |
84,592,781 (GRCm39) |
missense |
probably damaging |
0.96 |
R2259:Vmn2r65
|
UTSW |
7 |
84,590,119 (GRCm39) |
missense |
possibly damaging |
0.86 |
R2338:Vmn2r65
|
UTSW |
7 |
84,590,051 (GRCm39) |
missense |
possibly damaging |
0.86 |
R2880:Vmn2r65
|
UTSW |
7 |
84,613,094 (GRCm39) |
missense |
probably damaging |
1.00 |
R3410:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
R3411:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
R3770:Vmn2r65
|
UTSW |
7 |
84,589,623 (GRCm39) |
missense |
probably damaging |
1.00 |
R3800:Vmn2r65
|
UTSW |
7 |
84,589,738 (GRCm39) |
missense |
possibly damaging |
0.93 |
R3850:Vmn2r65
|
UTSW |
7 |
84,595,859 (GRCm39) |
missense |
probably benign |
0.00 |
R4105:Vmn2r65
|
UTSW |
7 |
84,595,691 (GRCm39) |
missense |
probably benign |
0.03 |
R4568:Vmn2r65
|
UTSW |
7 |
84,596,677 (GRCm39) |
missense |
probably damaging |
1.00 |
R4677:Vmn2r65
|
UTSW |
7 |
84,613,082 (GRCm39) |
missense |
possibly damaging |
0.55 |
R4768:Vmn2r65
|
UTSW |
7 |
84,596,602 (GRCm39) |
missense |
probably damaging |
1.00 |
R4778:Vmn2r65
|
UTSW |
7 |
84,592,801 (GRCm39) |
missense |
possibly damaging |
0.47 |
R5057:Vmn2r65
|
UTSW |
7 |
84,589,819 (GRCm39) |
missense |
probably damaging |
1.00 |
R5279:Vmn2r65
|
UTSW |
7 |
84,589,849 (GRCm39) |
missense |
probably damaging |
1.00 |
R5280:Vmn2r65
|
UTSW |
7 |
84,595,542 (GRCm39) |
missense |
probably damaging |
0.99 |
R5394:Vmn2r65
|
UTSW |
7 |
84,595,862 (GRCm39) |
missense |
probably benign |
0.04 |
R5487:Vmn2r65
|
UTSW |
7 |
84,595,529 (GRCm39) |
missense |
possibly damaging |
0.76 |
R5580:Vmn2r65
|
UTSW |
7 |
84,596,802 (GRCm39) |
missense |
probably damaging |
0.99 |
R5638:Vmn2r65
|
UTSW |
7 |
84,590,047 (GRCm39) |
missense |
probably damaging |
1.00 |
R5673:Vmn2r65
|
UTSW |
7 |
84,596,615 (GRCm39) |
missense |
probably benign |
0.23 |
R5688:Vmn2r65
|
UTSW |
7 |
84,589,900 (GRCm39) |
missense |
probably benign |
0.00 |
R5935:Vmn2r65
|
UTSW |
7 |
84,592,869 (GRCm39) |
missense |
probably benign |
0.00 |
R6372:Vmn2r65
|
UTSW |
7 |
84,589,861 (GRCm39) |
missense |
probably damaging |
1.00 |
R6924:Vmn2r65
|
UTSW |
7 |
84,613,198 (GRCm39) |
missense |
probably benign |
0.20 |
R7021:Vmn2r65
|
UTSW |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
R7195:Vmn2r65
|
UTSW |
7 |
84,592,347 (GRCm39) |
critical splice donor site |
probably null |
|
R7422:Vmn2r65
|
UTSW |
7 |
84,595,569 (GRCm39) |
missense |
probably damaging |
0.99 |
R7654:Vmn2r65
|
UTSW |
7 |
84,590,261 (GRCm39) |
missense |
probably damaging |
1.00 |
R7686:Vmn2r65
|
UTSW |
7 |
84,589,744 (GRCm39) |
missense |
probably damaging |
0.99 |
R7691:Vmn2r65
|
UTSW |
7 |
84,592,851 (GRCm39) |
missense |
probably benign |
0.30 |
R7798:Vmn2r65
|
UTSW |
7 |
84,596,192 (GRCm39) |
missense |
probably damaging |
1.00 |
R7798:Vmn2r65
|
UTSW |
7 |
84,595,530 (GRCm39) |
missense |
probably benign |
0.00 |
R8103:Vmn2r65
|
UTSW |
7 |
84,595,919 (GRCm39) |
missense |
probably damaging |
1.00 |
R8272:Vmn2r65
|
UTSW |
7 |
84,596,817 (GRCm39) |
missense |
probably benign |
0.02 |
R8303:Vmn2r65
|
UTSW |
7 |
84,589,391 (GRCm39) |
nonsense |
probably null |
|
R8354:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
R8454:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
R8489:Vmn2r65
|
UTSW |
7 |
84,589,964 (GRCm39) |
missense |
possibly damaging |
0.85 |
R8554:Vmn2r65
|
UTSW |
7 |
84,595,960 (GRCm39) |
missense |
probably benign |
0.00 |
R8680:Vmn2r65
|
UTSW |
7 |
84,589,388 (GRCm39) |
missense |
probably benign |
0.00 |
R8731:Vmn2r65
|
UTSW |
7 |
84,589,447 (GRCm39) |
nonsense |
probably null |
|
R8839:Vmn2r65
|
UTSW |
7 |
84,595,489 (GRCm39) |
nonsense |
probably null |
|
R8847:Vmn2r65
|
UTSW |
7 |
84,590,212 (GRCm39) |
missense |
probably damaging |
1.00 |
R8916:Vmn2r65
|
UTSW |
7 |
84,595,665 (GRCm39) |
missense |
probably benign |
0.21 |
R9254:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
R9379:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
R9392:Vmn2r65
|
UTSW |
7 |
84,589,718 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9563:Vmn2r65
|
UTSW |
7 |
84,589,880 (GRCm39) |
nonsense |
probably null |
|
R9686:Vmn2r65
|
UTSW |
7 |
84,590,084 (GRCm39) |
missense |
probably benign |
0.45 |
X0067:Vmn2r65
|
UTSW |
7 |
84,590,113 (GRCm39) |
missense |
probably benign |
0.04 |
Z1088:Vmn2r65
|
UTSW |
7 |
84,592,473 (GRCm39) |
critical splice acceptor site |
probably null |
|
Z1177:Vmn2r65
|
UTSW |
7 |
84,590,234 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Predicted Primers |
PCR Primer
(F):5'- ATGTGTGTCACTGAACTTCTGAG -3'
(R):5'- GTGGAACATGGATAGGAACATCTCC -3'
Sequencing Primer
(F):5'- CACTGAACTTCTGAGTAAAATTCACC -3'
(R):5'- GATCCACACTTTGAACATGGTC -3'
|
Posted On |
2018-04-27 |