Incidental Mutation 'IGL01096:Wee2'
ID |
51302 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Wee2
|
Ensembl Gene |
ENSMUSG00000037159 |
Gene Name |
WEE1 homolog 2 (S. pombe) |
Synonyms |
Wee1b, LOC381759 |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL01096
|
Quality Score |
|
Status
|
|
Chromosome |
6 |
Chromosomal Location |
40416022-40443747 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 40440187 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glycine
at position 445
(E445G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000038754
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000038907]
|
AlphaFold |
Q66JT0 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000038907
AA Change: E445G
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
SMART Domains |
Protein: ENSMUSP00000038754 Gene: ENSMUSG00000037159 AA Change: E445G
Domain | Start | End | E-Value | Type |
low complexity region
|
117 |
128 |
N/A |
INTRINSIC |
Pfam:Pkinase
|
208 |
481 |
3.6e-51 |
PFAM |
Pfam:Pkinase_Tyr
|
209 |
478 |
9.6e-25 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 34 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adgrg3 |
A |
T |
8: 95,766,221 (GRCm39) |
M351L |
possibly damaging |
Het |
Alk |
T |
C |
17: 72,228,891 (GRCm39) |
K725E |
possibly damaging |
Het |
Castor1 |
A |
C |
11: 4,171,850 (GRCm39) |
E309A |
probably damaging |
Het |
Dspp |
T |
A |
5: 104,323,233 (GRCm39) |
H125Q |
possibly damaging |
Het |
Elmo2 |
A |
T |
2: 165,138,907 (GRCm39) |
|
probably benign |
Het |
Erg |
A |
G |
16: 95,190,912 (GRCm39) |
|
probably benign |
Het |
Fam20c |
A |
G |
5: 138,794,910 (GRCm39) |
E513G |
possibly damaging |
Het |
Gm9839 |
G |
T |
1: 32,559,917 (GRCm39) |
T55N |
possibly damaging |
Het |
Gpd2 |
A |
T |
2: 57,228,879 (GRCm39) |
M228L |
probably damaging |
Het |
Hp |
A |
T |
8: 110,302,033 (GRCm39) |
M305K |
probably benign |
Het |
Ifng |
T |
A |
10: 118,281,174 (GRCm39) |
|
probably benign |
Het |
Igkv9-123 |
T |
C |
6: 67,931,449 (GRCm39) |
D39G |
possibly damaging |
Het |
Melk |
T |
A |
4: 44,347,262 (GRCm39) |
F431I |
probably benign |
Het |
Or10ak12 |
A |
G |
4: 118,666,653 (GRCm39) |
V136A |
probably damaging |
Het |
Or12j5 |
A |
T |
7: 140,084,097 (GRCm39) |
S92T |
probably damaging |
Het |
Or4p19 |
A |
G |
2: 88,242,135 (GRCm39) |
M289T |
probably damaging |
Het |
Or51k1 |
A |
C |
7: 103,661,321 (GRCm39) |
L196W |
probably damaging |
Het |
Or8g27 |
G |
A |
9: 39,129,412 (GRCm39) |
G253D |
probably damaging |
Het |
Pappa |
T |
C |
4: 65,107,553 (GRCm39) |
Y655H |
probably damaging |
Het |
Prss58 |
A |
T |
6: 40,872,399 (GRCm39) |
I208N |
probably damaging |
Het |
Ryr2 |
T |
A |
13: 11,718,430 (GRCm39) |
I2720F |
probably damaging |
Het |
Slc13a1 |
G |
T |
6: 24,104,076 (GRCm39) |
T322K |
probably damaging |
Het |
Spag17 |
T |
C |
3: 99,970,691 (GRCm39) |
F1292L |
probably benign |
Het |
Tbx5 |
A |
G |
5: 120,021,091 (GRCm39) |
T366A |
probably benign |
Het |
Tmeff2 |
G |
A |
1: 50,969,705 (GRCm39) |
|
probably benign |
Het |
Tmem101 |
C |
A |
11: 102,045,378 (GRCm39) |
|
probably null |
Het |
Tpp2 |
C |
A |
1: 44,000,048 (GRCm39) |
P389T |
probably damaging |
Het |
Tyk2 |
A |
G |
9: 21,020,159 (GRCm39) |
Y1000H |
probably damaging |
Het |
Ush2a |
C |
A |
1: 188,410,574 (GRCm39) |
N2407K |
probably damaging |
Het |
Vmn1r94 |
C |
T |
7: 19,901,561 (GRCm39) |
V248I |
probably damaging |
Het |
Vmn2r12 |
T |
A |
5: 109,234,125 (GRCm39) |
I696F |
probably damaging |
Het |
Vmn2r83 |
A |
G |
10: 79,313,662 (GRCm39) |
E90G |
probably damaging |
Het |
Washc5 |
T |
C |
15: 59,222,060 (GRCm39) |
|
probably benign |
Het |
Zfp518b |
T |
C |
5: 38,830,131 (GRCm39) |
T625A |
probably benign |
Het |
|
Other mutations in Wee2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00335:Wee2
|
APN |
6 |
40,438,995 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01978:Wee2
|
APN |
6 |
40,432,087 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03026:Wee2
|
APN |
6 |
40,438,915 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03091:Wee2
|
APN |
6 |
40,438,968 (GRCm39) |
missense |
probably benign |
0.02 |
IGL03350:Wee2
|
APN |
6 |
40,426,665 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03352:Wee2
|
APN |
6 |
40,429,589 (GRCm39) |
critical splice donor site |
probably null |
|
R0420:Wee2
|
UTSW |
6 |
40,433,929 (GRCm39) |
missense |
probably benign |
0.04 |
R0506:Wee2
|
UTSW |
6 |
40,440,187 (GRCm39) |
missense |
probably benign |
0.04 |
R1205:Wee2
|
UTSW |
6 |
40,420,875 (GRCm39) |
start gained |
probably benign |
|
R1702:Wee2
|
UTSW |
6 |
40,441,135 (GRCm39) |
missense |
probably benign |
0.04 |
R3982:Wee2
|
UTSW |
6 |
40,432,175 (GRCm39) |
missense |
possibly damaging |
0.86 |
R3983:Wee2
|
UTSW |
6 |
40,432,175 (GRCm39) |
missense |
possibly damaging |
0.86 |
R5946:Wee2
|
UTSW |
6 |
40,440,146 (GRCm39) |
missense |
probably null |
1.00 |
R6020:Wee2
|
UTSW |
6 |
40,426,554 (GRCm39) |
splice site |
probably null |
|
R6127:Wee2
|
UTSW |
6 |
40,426,701 (GRCm39) |
missense |
probably damaging |
1.00 |
R6189:Wee2
|
UTSW |
6 |
40,426,617 (GRCm39) |
missense |
probably damaging |
1.00 |
R6342:Wee2
|
UTSW |
6 |
40,421,189 (GRCm39) |
missense |
probably benign |
0.05 |
R6347:Wee2
|
UTSW |
6 |
40,432,039 (GRCm39) |
missense |
probably damaging |
1.00 |
R6350:Wee2
|
UTSW |
6 |
40,432,039 (GRCm39) |
missense |
probably damaging |
1.00 |
R6513:Wee2
|
UTSW |
6 |
40,429,553 (GRCm39) |
missense |
probably benign |
0.00 |
R7091:Wee2
|
UTSW |
6 |
40,438,936 (GRCm39) |
missense |
probably benign |
0.00 |
R8258:Wee2
|
UTSW |
6 |
40,421,114 (GRCm39) |
missense |
probably benign |
0.00 |
R8259:Wee2
|
UTSW |
6 |
40,421,114 (GRCm39) |
missense |
probably benign |
0.00 |
R8463:Wee2
|
UTSW |
6 |
40,420,914 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
R8853:Wee2
|
UTSW |
6 |
40,441,200 (GRCm39) |
missense |
probably benign |
0.07 |
R9028:Wee2
|
UTSW |
6 |
40,421,189 (GRCm39) |
missense |
probably benign |
|
R9170:Wee2
|
UTSW |
6 |
40,437,977 (GRCm39) |
missense |
probably benign |
0.07 |
R9231:Wee2
|
UTSW |
6 |
40,440,089 (GRCm39) |
missense |
probably damaging |
1.00 |
R9394:Wee2
|
UTSW |
6 |
40,433,878 (GRCm39) |
missense |
probably damaging |
0.96 |
R9474:Wee2
|
UTSW |
6 |
40,432,044 (GRCm39) |
nonsense |
probably null |
|
R9493:Wee2
|
UTSW |
6 |
40,421,057 (GRCm39) |
missense |
probably benign |
0.39 |
|
Posted On |
2013-06-21 |