Incidental Mutation 'IGL01107:Tas2r105'
| ID |
51323 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r105
|
| Ensembl Gene |
ENSMUSG00000051153 |
| Gene Name |
taste receptor, type 2, member 105 |
| Synonyms |
T2r5, T2R05, mGR05, T2R9, mt2r5, Tas2r5 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.052)
|
| Stock # |
IGL01107
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
131663524-131664426 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 131664074 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 118
(V118A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000058006
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053652]
[ENSMUST00000072404]
[ENSMUST00000080619]
|
| AlphaFold |
Q9JKT4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053652
AA Change: V118A
PolyPhen 2
Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000058006
Gene: ENSMUSG00000051153
AA Change: V118A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
9.4e-109 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072404
|
| SMART Domains |
Protein: ENSMUSP00000072237
Gene: ENSMUSG00000061977
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
8.3e-102 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000080619
|
| SMART Domains |
Protein: ENSMUSP00000079453
Gene: ENSMUSG00000063478
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
8.1e-104 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null mutation respond normally to a variety of bitter, sweet, umami, salty and sour stimuli but show a striking and selective impairement in their ability to taste cycloheximide (a bitter tastant). In addition, homozygotes are no longer behaviorally averse to cycloheximide. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001O22Rik |
A |
T |
2: 30,687,948 (GRCm39) |
F215Y |
probably damaging |
Het |
| 2700049A03Rik |
T |
C |
12: 71,241,242 (GRCm39) |
|
probably null |
Het |
| Akip1 |
C |
T |
7: 109,311,045 (GRCm39) |
T195M |
probably damaging |
Het |
| Arhgef16 |
T |
C |
4: 154,364,701 (GRCm39) |
N631S |
probably benign |
Het |
| Brat1 |
C |
T |
5: 140,702,932 (GRCm39) |
S544L |
probably damaging |
Het |
| Cfap65 |
C |
T |
1: 74,958,342 (GRCm39) |
|
probably null |
Het |
| Defa22 |
T |
A |
8: 21,653,053 (GRCm39) |
|
probably null |
Het |
| Dnajc4 |
C |
T |
19: 6,966,869 (GRCm39) |
R153H |
probably benign |
Het |
| Dusp11 |
A |
G |
6: 85,929,352 (GRCm39) |
|
probably benign |
Het |
| E2f4 |
T |
A |
8: 106,030,809 (GRCm39) |
|
probably benign |
Het |
| Ece1 |
T |
A |
4: 137,665,969 (GRCm39) |
L271Q |
probably damaging |
Het |
| Fcgrt |
T |
C |
7: 44,742,752 (GRCm39) |
D343G |
probably damaging |
Het |
| Igsf10 |
T |
C |
3: 59,238,945 (GRCm39) |
E412G |
probably damaging |
Het |
| Il4ra |
G |
T |
7: 125,175,086 (GRCm39) |
L431F |
possibly damaging |
Het |
| Ilrun |
A |
T |
17: 28,005,043 (GRCm39) |
|
probably null |
Het |
| Krt86 |
T |
A |
15: 101,373,306 (GRCm39) |
L200Q |
probably damaging |
Het |
| Lpcat1 |
T |
A |
13: 73,642,947 (GRCm39) |
F126I |
probably damaging |
Het |
| Prag1 |
A |
G |
8: 36,567,085 (GRCm39) |
T79A |
probably benign |
Het |
| Pramel13 |
A |
T |
4: 144,119,664 (GRCm39) |
I301N |
probably benign |
Het |
| Psg29 |
G |
T |
7: 16,938,850 (GRCm39) |
L41F |
probably benign |
Het |
| Rai14 |
C |
T |
15: 10,599,797 (GRCm39) |
|
probably benign |
Het |
| Reg3a |
A |
G |
6: 78,360,228 (GRCm39) |
D136G |
probably benign |
Het |
| Rif1 |
A |
G |
2: 52,001,315 (GRCm39) |
T1590A |
probably benign |
Het |
| Rorb |
A |
T |
19: 18,934,692 (GRCm39) |
L300* |
probably null |
Het |
| Sin3b |
T |
C |
8: 73,457,733 (GRCm39) |
C150R |
possibly damaging |
Het |
| Smarcc1 |
C |
A |
9: 110,051,005 (GRCm39) |
H942N |
probably damaging |
Het |
| Tmem131 |
T |
C |
1: 36,868,662 (GRCm39) |
S388G |
probably damaging |
Het |
| Ttll9 |
C |
A |
2: 152,844,809 (GRCm39) |
|
probably benign |
Het |
| Ush1c |
A |
G |
7: 45,859,325 (GRCm39) |
L498P |
probably damaging |
Het |
| Vmn2r100 |
A |
G |
17: 19,741,618 (GRCm39) |
Y110C |
probably damaging |
Het |
| Zbtb11 |
T |
C |
16: 55,826,370 (GRCm39) |
Y800H |
probably damaging |
Het |
| Zdhhc20 |
T |
A |
14: 58,103,046 (GRCm39) |
E101V |
probably damaging |
Het |
|
| Other mutations in Tas2r105 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01148:Tas2r105
|
APN |
6 |
131,663,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02882:Tas2r105
|
APN |
6 |
131,664,143 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0833:Tas2r105
|
UTSW |
6 |
131,664,393 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0836:Tas2r105
|
UTSW |
6 |
131,664,393 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1429:Tas2r105
|
UTSW |
6 |
131,663,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2010:Tas2r105
|
UTSW |
6 |
131,664,365 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2418:Tas2r105
|
UTSW |
6 |
131,664,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4023:Tas2r105
|
UTSW |
6 |
131,663,789 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4026:Tas2r105
|
UTSW |
6 |
131,663,789 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4742:Tas2r105
|
UTSW |
6 |
131,663,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5497:Tas2r105
|
UTSW |
6 |
131,663,805 (GRCm39) |
splice site |
probably null |
|
|
R5812:Tas2r105
|
UTSW |
6 |
131,663,836 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7191:Tas2r105
|
UTSW |
6 |
131,663,945 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7236:Tas2r105
|
UTSW |
6 |
131,663,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7482:Tas2r105
|
UTSW |
6 |
131,663,972 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8783:Tas2r105
|
UTSW |
6 |
131,663,732 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8986:Tas2r105
|
UTSW |
6 |
131,663,913 (GRCm39) |
nonsense |
probably null |
|
|
R9250:Tas2r105
|
UTSW |
6 |
131,663,951 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9580:Tas2r105
|
UTSW |
6 |
131,663,699 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0067:Tas2r105
|
UTSW |
6 |
131,664,233 (GRCm39) |
missense |
probably benign |
0.29 |
|
| Posted On |
2013-06-21 |
Incidental Mutation