Incidental Mutation 'IGL01113:Igkv6-25'
ID 51335
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igkv6-25
Ensembl Gene ENSMUSG00000094930
Gene Name immunoglobulin kappa chain variable 6-25
Synonyms Gm16943
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.338) question?
Stock # IGL01113
Quality Score
Status
Chromosome 6
Chromosomal Location 70192417-70192941 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 70192772 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 60 (P60S)
Ref Sequence ENSEMBL: ENSMUSP00000100184 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103383] [ENSMUST00000103384]
AlphaFold A0A140T8N7
Predicted Effect possibly damaging
Transcript: ENSMUST00000103383
AA Change: P60S

PolyPhen 2 Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000100184
Gene: ENSMUSG00000094930
AA Change: P60S

DomainStartEndE-ValueType
IGv 38 110 3.24e-21 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000103384
SMART Domains Protein: ENSMUSP00000100185
Gene: ENSMUSG00000076583

DomainStartEndE-ValueType
IGv 38 116 1.21e-20 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196786
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930544L04Rik A G 7: 134,998,871 (GRCm39) noncoding transcript Het
Adam34l T C 8: 44,079,189 (GRCm39) H345R probably damaging Het
Adgrv1 A T 13: 81,637,147 (GRCm39) F3431L probably benign Het
Adk A G 14: 21,142,461 (GRCm39) N21S probably damaging Het
Cacna2d3 A G 14: 29,022,688 (GRCm39) probably benign Het
Camk2d C A 3: 126,574,061 (GRCm39) A156E probably damaging Het
Ccdc171 G T 4: 83,580,047 (GRCm39) W598L probably damaging Het
Cep85 C T 4: 133,876,072 (GRCm39) V445I possibly damaging Het
Cftr A G 6: 18,270,252 (GRCm39) Y814C probably damaging Het
Dctn1 T C 6: 83,156,879 (GRCm39) S9P probably benign Het
Dmxl1 A G 18: 50,045,818 (GRCm39) K2409R probably benign Het
Dnaaf1 T A 8: 120,309,317 (GRCm39) I135N probably damaging Het
Eif3d G A 15: 77,847,515 (GRCm39) T241M probably damaging Het
Etv1 T C 12: 38,831,791 (GRCm39) probably benign Het
Gdpd3 C A 7: 126,366,997 (GRCm39) S182R probably benign Het
Gm12888 C A 4: 121,175,521 (GRCm39) C87F probably damaging Het
Gml C A 15: 74,685,576 (GRCm39) M136I probably benign Het
Habp2 A G 19: 56,298,548 (GRCm39) T137A probably benign Het
Mak A T 13: 41,195,619 (GRCm39) W396R probably damaging Het
Mast4 C A 13: 102,910,744 (GRCm39) C441F probably damaging Het
Medag T C 5: 149,353,372 (GRCm39) I189T probably benign Het
Myh1 A G 11: 67,093,006 (GRCm39) T71A probably benign Het
Nin G T 12: 70,078,553 (GRCm39) L1678M probably damaging Het
Nol6 T C 4: 41,115,749 (GRCm39) D1081G probably damaging Het
Or1j4 A T 2: 36,740,631 (GRCm39) D191V probably damaging Het
Or6f1 A T 7: 85,970,361 (GRCm39) D266E probably benign Het
Ppp1r10 T A 17: 36,240,451 (GRCm39) N580K probably damaging Het
Rpgrip1l T C 8: 91,987,367 (GRCm39) probably benign Het
Serpinb3a G A 1: 106,978,789 (GRCm39) Q57* probably null Het
Thumpd3 T C 6: 113,037,021 (GRCm39) S307P probably benign Het
Upf1 A C 8: 70,790,934 (GRCm39) D577E probably benign Het
Vmn2r99 T C 17: 19,614,518 (GRCm39) V746A probably benign Het
Wscd2 T C 5: 113,708,800 (GRCm39) V268A probably damaging Het
Other mutations in Igkv6-25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02098:Igkv6-25 APN 6 70,192,719 (GRCm39) missense probably damaging 0.98
IGL02929:Igkv6-25 APN 6 70,192,929 (GRCm39) missense probably damaging 1.00
R4399:Igkv6-25 UTSW 6 70,192,694 (GRCm39) missense possibly damaging 0.70
R5030:Igkv6-25 UTSW 6 70,192,426 (GRCm39) nonsense probably null
R7161:Igkv6-25 UTSW 6 70,192,762 (GRCm39) nonsense probably null
RF003:Igkv6-25 UTSW 6 70,192,762 (GRCm39) nonsense probably null
RF004:Igkv6-25 UTSW 6 70,192,647 (GRCm39) frame shift probably null
Posted On 2013-06-21