Incidental Mutation 'IGL01129:Vmn1r18'
ID51357
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r18
Ensembl Gene ENSMUSG00000091382
Gene Namevomeronasal 1 receptor 18
SynonymsV1rc26
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #IGL01129
Quality Score
Status
Chromosome6
Chromosomal Location57376660-57395783 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 57390497 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 24 (F24Y)
Ref Sequence ENSEMBL: ENSMUSP00000154497 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164732] [ENSMUST00000228574]
Predicted Effect probably benign
Transcript: ENSMUST00000164732
AA Change: F24Y

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000129827
Gene: ENSMUSG00000091382
AA Change: F24Y

DomainStartEndE-ValueType
Pfam:V1R 29 293 1.1e-59 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000228574
AA Change: F24Y

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933436I01Rik A T X: 67,920,604 F216L possibly damaging Het
Bace2 T G 16: 97,408,430 N181K probably damaging Het
Cc2d1a G T 8: 84,143,404 H161N probably benign Het
Ckap2 C T 8: 22,169,758 G569D probably damaging Het
Col11a1 T C 3: 114,185,873 probably benign Het
Col1a2 G A 6: 4,535,846 D939N unknown Het
Creb3l2 A T 6: 37,353,634 probably benign Het
Cuedc1 T A 11: 88,183,254 S205T possibly damaging Het
Cux1 G A 5: 136,304,718 probably benign Het
Cyp3a59 A G 5: 146,098,279 M256V probably benign Het
Gzf1 C A 2: 148,690,996 P690Q probably damaging Het
Lrch3 T A 16: 32,994,965 D575E probably benign Het
Lypd3 A G 7: 24,640,593 M362V probably benign Het
Mppe1 C A 18: 67,237,444 G61* probably null Het
Nr2c2 T A 6: 92,158,416 D328E probably benign Het
Olfr6 T C 7: 106,956,427 N170D probably damaging Het
Pfn4 T A 12: 4,775,505 V114E probably damaging Het
Rab14 T C 2: 35,183,386 probably benign Het
Slc30a9 G T 5: 67,342,143 G315C probably damaging Het
Spag16 A T 1: 69,896,522 S303C probably benign Het
Spata16 C T 3: 26,913,184 probably benign Het
Srcap T C 7: 127,521,651 V161A probably damaging Het
Srd5a3 A G 5: 76,149,746 probably benign Het
Vmn1r78 A T 7: 12,153,238 T259S probably benign Het
Zc3h13 G A 14: 75,335,999 D1527N probably damaging Het
Other mutations in Vmn1r18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01301:Vmn1r18 APN 6 57389667 utr 3 prime probably benign
IGL01996:Vmn1r18 APN 6 57390016 missense possibly damaging 0.80
IGL02017:Vmn1r18 APN 6 57389756 missense probably benign 0.01
R1908:Vmn1r18 UTSW 6 57390041 missense possibly damaging 0.77
R4200:Vmn1r18 UTSW 6 57390116 missense probably benign 0.01
R4288:Vmn1r18 UTSW 6 57390407 missense probably damaging 1.00
R4667:Vmn1r18 UTSW 6 57390084 missense probably benign 0.11
R6029:Vmn1r18 UTSW 6 57390466 missense possibly damaging 0.88
R6767:Vmn1r18 UTSW 6 57390221 missense probably damaging 1.00
R7174:Vmn1r18 UTSW 6 57389624 utr 3 prime probably null
R7229:Vmn1r18 UTSW 6 57390098 missense probably benign 0.14
R7332:Vmn1r18 UTSW 6 57390518 missense probably benign 0.06
R7425:Vmn1r18 UTSW 6 57390566 start codon destroyed probably null 1.00
Posted On2013-06-21