Incidental Mutation 'R6345:Selplg'
ID 514100
Institutional Source Beutler Lab
Gene Symbol Selplg
Ensembl Gene ENSMUSG00000048163
Gene Name selectin, platelet (p-selectin) ligand
Synonyms Psgl-1, CD162, Psgl1
MMRRC Submission 044499-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R6345 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 113956597-113970705 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 113958210 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 32 (P32L)
Ref Sequence ENSEMBL: ENSMUSP00000098436 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100874] [ENSMUST00000199109]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000100874
AA Change: P32L

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000098436
Gene: ENSMUSG00000048163
AA Change: P32L

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
low complexity region 102 115 N/A INTRINSIC
internal_repeat_2 130 182 2.38e-13 PROSPERO
internal_repeat_1 133 186 5.75e-16 PROSPERO
internal_repeat_1 193 246 5.75e-16 PROSPERO
internal_repeat_2 200 252 2.38e-13 PROSPERO
transmembrane domain 328 350 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198920
Predicted Effect probably benign
Transcript: ENSMUST00000199109
AA Change: P32L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000201194
Predicted Effect probably benign
Transcript: ENSMUST00000201931
Predicted Effect probably benign
Transcript: ENSMUST00000202555
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.5%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
PHENOTYPE: Mice homozygous for a null allele exhibit neutrophillia and impaired leukocyte adhesion and rolling. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik T C 10: 87,061,913 (GRCm39) I121T probably benign Het
4921524L21Rik T A 18: 6,626,399 (GRCm39) M137K possibly damaging Het
Angpt4 C A 2: 151,771,354 (GRCm39) N223K probably benign Het
Ankrd6 T C 4: 32,810,266 (GRCm39) R437G probably damaging Het
Atp9a C T 2: 168,518,093 (GRCm39) S264N probably damaging Het
AY358078 A C 14: 52,063,749 (GRCm39) Y465S probably damaging Het
Bin3 G A 14: 70,374,676 (GRCm39) R235Q probably benign Het
Bsn G A 9: 107,984,554 (GRCm39) P3167S unknown Het
Camk2g G A 14: 20,787,443 (GRCm39) R274C probably damaging Het
Ccdc61 A T 7: 18,643,914 (GRCm39) probably null Het
Ccnjl A T 11: 43,476,165 (GRCm39) T263S probably benign Het
Col17a1 G T 19: 47,641,818 (GRCm39) P944T possibly damaging Het
Cyp2c39 A T 19: 39,501,615 (GRCm39) probably null Het
Cyp2c39 G T 19: 39,501,616 (GRCm39) probably null Het
Cyp4a32 T C 4: 115,459,560 (GRCm39) V98A possibly damaging Het
Dnah9 A G 11: 65,928,519 (GRCm39) V2050A probably damaging Het
F5 A G 1: 164,019,520 (GRCm39) N665S probably benign Het
Fbxl6 A T 15: 76,420,054 (GRCm39) C520S probably damaging Het
Fscn2 C A 11: 120,252,853 (GRCm39) H107N probably damaging Het
Gfm2 C T 13: 97,299,461 (GRCm39) T367M probably damaging Het
Gle1 C G 2: 29,826,127 (GRCm39) P69A probably benign Het
Gpr156 A T 16: 37,807,881 (GRCm39) D176V probably damaging Het
Grip2 A G 6: 91,742,369 (GRCm39) S895P possibly damaging Het
Hfm1 C T 5: 106,989,504 (GRCm39) G1404D probably benign Het
Ifit1bl1 G A 19: 34,571,570 (GRCm39) R296* probably null Het
Ighv1-39 C T 12: 114,878,479 (GRCm39) V31M possibly damaging Het
Itgav A G 2: 83,632,380 (GRCm39) E956G probably damaging Het
Katnip C A 7: 125,352,159 (GRCm39) D26E probably damaging Het
Lsm8 A G 6: 18,853,644 (GRCm39) D86G probably damaging Het
Mdh1b T G 1: 63,754,398 (GRCm39) H390P possibly damaging Het
Mtrf1l A T 10: 5,767,468 (GRCm39) I216N possibly damaging Het
Muc16 G A 9: 18,566,222 (GRCm39) T2099I unknown Het
Myh7 T C 14: 55,221,149 (GRCm39) R925G probably damaging Het
Myo1h T A 5: 114,489,769 (GRCm39) I658N probably damaging Het
Myo5a A T 9: 75,097,195 (GRCm39) D81V possibly damaging Het
Nell1 G A 7: 49,625,171 (GRCm39) C12Y possibly damaging Het
Obscn T C 11: 58,944,522 (GRCm39) Y4724C probably damaging Het
Or8k53 A G 2: 86,177,892 (GRCm39) Y73H probably damaging Het
Pah G A 10: 87,412,049 (GRCm39) D315N probably damaging Het
Per2 A G 1: 91,376,444 (GRCm39) V143A probably damaging Het
Plcxd1 T C 5: 110,248,165 (GRCm39) V38A probably benign Het
Pld1 A G 3: 28,184,896 (GRCm39) probably benign Het
Plekhh2 A G 17: 84,883,215 (GRCm39) N761S probably benign Het
Polh T C 17: 46,493,664 (GRCm39) I318V probably benign Het
Prex1 T C 2: 166,414,880 (GRCm39) Q1323R probably null Het
Rb1cc1 T A 1: 6,333,481 (GRCm39) S1440T probably benign Het
Rbm19 G T 5: 120,265,105 (GRCm39) W382L possibly damaging Het
Rchy1 T C 5: 92,105,801 (GRCm39) D49G probably benign Het
Ric1 A G 19: 29,581,485 (GRCm39) D1402G probably benign Het
S1pr3 G T 13: 51,573,067 (GRCm39) A83S probably damaging Het
S1pr3 C A 13: 51,573,068 (GRCm39) A83D probably damaging Het
Serpinb9c T C 13: 33,333,978 (GRCm39) R355G probably damaging Het
Slx4 G C 16: 3,808,714 (GRCm39) Q409E probably benign Het
Sntg1 A C 1: 8,653,508 (GRCm39) L243R possibly damaging Het
Specc1l G T 10: 75,084,322 (GRCm39) D682Y probably damaging Het
Spen C T 4: 141,198,944 (GRCm39) V3228I possibly damaging Het
Strip1 T C 3: 107,535,516 (GRCm39) E69G probably damaging Het
Tasp1 C A 2: 139,793,457 (GRCm39) V240L probably damaging Het
Tdrd9 T A 12: 112,001,042 (GRCm39) F787L probably damaging Het
Vmn1r228 A G 17: 20,997,144 (GRCm39) S125P probably damaging Het
Wdhd1 A G 14: 47,489,379 (GRCm39) M718T probably damaging Het
Other mutations in Selplg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01412:Selplg APN 5 113,957,529 (GRCm39) missense probably damaging 1.00
IGL01488:Selplg APN 5 113,957,697 (GRCm39) missense possibly damaging 0.78
IGL02355:Selplg APN 5 113,957,467 (GRCm39) missense probably benign 0.00
IGL02362:Selplg APN 5 113,957,467 (GRCm39) missense probably benign 0.00
PIT4142001:Selplg UTSW 5 113,957,689 (GRCm39) missense probably benign 0.00
R0375:Selplg UTSW 5 113,958,069 (GRCm39) missense probably damaging 0.99
R1222:Selplg UTSW 5 113,957,434 (GRCm39) missense possibly damaging 0.95
R1840:Selplg UTSW 5 113,957,905 (GRCm39) missense possibly damaging 0.66
R2925:Selplg UTSW 5 113,958,240 (GRCm39) missense possibly damaging 0.92
R4512:Selplg UTSW 5 113,957,124 (GRCm39) missense probably benign 0.05
R4702:Selplg UTSW 5 113,957,094 (GRCm39) missense probably benign 0.31
R4703:Selplg UTSW 5 113,957,094 (GRCm39) missense probably benign 0.31
R4704:Selplg UTSW 5 113,957,094 (GRCm39) missense probably benign 0.31
R4968:Selplg UTSW 5 113,957,787 (GRCm39) missense possibly damaging 0.93
R5075:Selplg UTSW 5 113,958,045 (GRCm39) missense probably benign 0.00
R6159:Selplg UTSW 5 113,957,162 (GRCm39) missense probably benign 0.02
R6550:Selplg UTSW 5 113,958,210 (GRCm39) missense probably benign 0.03
R6554:Selplg UTSW 5 113,958,210 (GRCm39) missense probably benign 0.03
R6997:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7050:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7094:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7235:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7481:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7604:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7674:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7846:Selplg UTSW 5 113,957,481 (GRCm39) missense probably damaging 1.00
R7887:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R8051:Selplg UTSW 5 113,957,502 (GRCm39) missense probably damaging 0.99
R8823:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R8834:Selplg UTSW 5 113,957,691 (GRCm39) missense possibly damaging 0.64
R8955:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9036:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9152:Selplg UTSW 5 113,957,467 (GRCm39) missense probably benign 0.00
R9241:Selplg UTSW 5 113,957,647 (GRCm39) missense possibly damaging 0.83
R9249:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9361:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9381:Selplg UTSW 5 113,957,917 (GRCm39) missense probably benign 0.05
R9434:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9446:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9482:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9670:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9779:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
Z1177:Selplg UTSW 5 113,957,412 (GRCm39) missense probably benign 0.30
Predicted Primers PCR Primer
(F):5'- GTGGCAATCTTCTCAGTGGCTC -3'
(R):5'- AACTCAGGAGATGTCTGCCG -3'

Sequencing Primer
(F):5'- TTCCAGCGCTCGTGGAATC -3'
(R):5'- AGATGTCTGCCGCCACC -3'
Posted On 2018-04-27