Incidental Mutation 'R6350:Prl2c5'
ID |
514164 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Prl2c5
|
Ensembl Gene |
ENSMUSG00000055360 |
Gene Name |
prolactin family 2, subfamily c, member 5 |
Synonyms |
MRP-4, Mrpplf4, PLF-4 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.079)
|
Stock # |
R6350 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
13 |
Chromosomal Location |
13357300-13366508 bp(+) (GRCm39) |
Type of Mutation |
critical splice donor site (2 bp from exon) |
DNA Base Change (assembly) |
T to C
at 13357631 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000115024
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021778]
[ENSMUST00000126540]
[ENSMUST00000151144]
|
AlphaFold |
Q9JLV9 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000021778
|
SMART Domains |
Protein: ENSMUSP00000021778 Gene: ENSMUSG00000055360
Domain | Start | End | E-Value | Type |
Pfam:Hormone_1
|
16 |
222 |
2.7e-70 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000126540
|
SMART Domains |
Protein: ENSMUSP00000115024 Gene: ENSMUSG00000055360
Domain | Start | End | E-Value | Type |
Pfam:Hormone_1
|
19 |
225 |
1.5e-73 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143335
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000151144
|
SMART Domains |
Protein: ENSMUSP00000117522 Gene: ENSMUSG00000055360
Domain | Start | End | E-Value | Type |
Pfam:Hormone_1
|
16 |
172 |
3.5e-51 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.5%
- 20x: 95.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 31 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930407I10Rik |
A |
G |
15: 81,947,764 (GRCm39) |
K554E |
possibly damaging |
Het |
Acsf2 |
T |
C |
11: 94,449,156 (GRCm39) |
M609V |
probably benign |
Het |
Acsm3 |
A |
G |
7: 119,367,256 (GRCm39) |
T30A |
probably benign |
Het |
Adam32 |
T |
C |
8: 25,353,445 (GRCm39) |
K715E |
possibly damaging |
Het |
Cdk5r1 |
T |
C |
11: 80,369,068 (GRCm39) |
L245P |
probably damaging |
Het |
Cntn3 |
A |
G |
6: 102,147,579 (GRCm39) |
V926A |
probably damaging |
Het |
Csf2rb |
G |
A |
15: 78,229,752 (GRCm39) |
D440N |
probably damaging |
Het |
D3Ertd751e |
T |
A |
3: 41,708,278 (GRCm39) |
H138Q |
probably damaging |
Het |
D630003M21Rik |
A |
G |
2: 158,062,415 (GRCm39) |
L35P |
probably damaging |
Het |
Faap100 |
A |
T |
11: 120,265,406 (GRCm39) |
V490E |
probably damaging |
Het |
Il3ra |
A |
G |
14: 14,348,903 (GRCm38) |
D99G |
probably benign |
Het |
Kcnmb1 |
A |
G |
11: 33,914,711 (GRCm39) |
K4R |
probably damaging |
Het |
Larp1 |
T |
A |
11: 57,940,657 (GRCm39) |
D594E |
probably benign |
Het |
Lnpep |
G |
T |
17: 17,783,071 (GRCm39) |
H577N |
probably benign |
Het |
Mief1 |
T |
C |
15: 80,133,804 (GRCm39) |
I287T |
probably damaging |
Het |
Mras |
T |
C |
9: 99,293,560 (GRCm39) |
S27G |
probably damaging |
Het |
Myh7b |
T |
A |
2: 155,470,680 (GRCm39) |
C1043S |
probably benign |
Het |
N4bp1 |
T |
C |
8: 87,588,596 (GRCm39) |
D114G |
probably damaging |
Het |
Nsmce4a |
A |
T |
7: 130,140,829 (GRCm39) |
I219K |
probably damaging |
Het |
Nynrin |
A |
T |
14: 56,105,533 (GRCm39) |
I848F |
probably benign |
Het |
Or2p2 |
T |
C |
13: 21,256,775 (GRCm39) |
E232G |
probably benign |
Het |
Or4f62 |
T |
A |
2: 111,986,542 (GRCm39) |
I82N |
probably damaging |
Het |
Patj |
T |
A |
4: 98,293,855 (GRCm39) |
S36T |
probably benign |
Het |
Pcdhb15 |
G |
A |
18: 37,608,414 (GRCm39) |
V549M |
probably damaging |
Het |
Ptbp3 |
A |
T |
4: 59,482,624 (GRCm39) |
D386E |
probably damaging |
Het |
Ptpra |
T |
C |
2: 130,382,512 (GRCm39) |
L451P |
probably damaging |
Het |
Repin1 |
A |
G |
6: 48,574,562 (GRCm39) |
D497G |
probably damaging |
Het |
Ryr2 |
A |
G |
13: 11,776,282 (GRCm39) |
F1085S |
probably damaging |
Het |
Slc6a18 |
G |
A |
13: 73,826,044 (GRCm39) |
A2V |
possibly damaging |
Het |
Wee2 |
C |
T |
6: 40,432,039 (GRCm39) |
R203C |
probably damaging |
Het |
Zmynd15 |
T |
C |
11: 70,355,257 (GRCm39) |
V388A |
probably damaging |
Het |
|
Other mutations in Prl2c5 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00910:Prl2c5
|
APN |
13 |
13,364,061 (GRCm39) |
critical splice donor site |
probably null |
|
IGL01874:Prl2c5
|
APN |
13 |
13,365,362 (GRCm39) |
missense |
probably benign |
|
IGL01878:Prl2c5
|
APN |
13 |
13,360,402 (GRCm39) |
missense |
probably benign |
0.00 |
R0178:Prl2c5
|
UTSW |
13 |
13,366,390 (GRCm39) |
missense |
probably damaging |
0.98 |
R0276:Prl2c5
|
UTSW |
13 |
13,357,634 (GRCm39) |
intron |
probably benign |
|
R0373:Prl2c5
|
UTSW |
13 |
13,357,609 (GRCm39) |
intron |
probably benign |
|
R0539:Prl2c5
|
UTSW |
13 |
13,363,906 (GRCm39) |
splice site |
probably null |
|
R1037:Prl2c5
|
UTSW |
13 |
13,360,492 (GRCm39) |
nonsense |
probably null |
|
R1296:Prl2c5
|
UTSW |
13 |
13,364,009 (GRCm39) |
missense |
probably damaging |
1.00 |
R1458:Prl2c5
|
UTSW |
13 |
13,365,310 (GRCm39) |
missense |
probably benign |
0.40 |
R1557:Prl2c5
|
UTSW |
13 |
13,365,265 (GRCm39) |
missense |
possibly damaging |
0.52 |
R1850:Prl2c5
|
UTSW |
13 |
13,360,377 (GRCm39) |
missense |
probably benign |
0.40 |
R1866:Prl2c5
|
UTSW |
13 |
13,365,358 (GRCm39) |
splice site |
probably null |
|
R1894:Prl2c5
|
UTSW |
13 |
13,366,263 (GRCm39) |
missense |
probably benign |
0.04 |
R2060:Prl2c5
|
UTSW |
13 |
13,365,238 (GRCm39) |
missense |
probably damaging |
0.99 |
R2330:Prl2c5
|
UTSW |
13 |
13,366,378 (GRCm39) |
missense |
possibly damaging |
0.67 |
R4755:Prl2c5
|
UTSW |
13 |
13,363,970 (GRCm39) |
missense |
probably benign |
|
R5229:Prl2c5
|
UTSW |
13 |
13,360,441 (GRCm39) |
missense |
probably damaging |
1.00 |
R5364:Prl2c5
|
UTSW |
13 |
13,357,627 (GRCm39) |
missense |
probably benign |
0.01 |
R6307:Prl2c5
|
UTSW |
13 |
13,365,175 (GRCm39) |
missense |
probably benign |
0.01 |
R6927:Prl2c5
|
UTSW |
13 |
13,357,503 (GRCm39) |
splice site |
probably null |
|
R7397:Prl2c5
|
UTSW |
13 |
13,366,327 (GRCm39) |
missense |
probably benign |
0.01 |
R7965:Prl2c5
|
UTSW |
13 |
13,360,469 (GRCm39) |
missense |
probably benign |
0.01 |
R8084:Prl2c5
|
UTSW |
13 |
13,360,539 (GRCm39) |
missense |
probably benign |
0.20 |
R8959:Prl2c5
|
UTSW |
13 |
13,365,392 (GRCm39) |
intron |
probably benign |
|
R8980:Prl2c5
|
UTSW |
13 |
13,360,470 (GRCm39) |
missense |
probably benign |
0.12 |
R9258:Prl2c5
|
UTSW |
13 |
13,365,297 (GRCm39) |
missense |
probably damaging |
0.97 |
R9465:Prl2c5
|
UTSW |
13 |
13,360,531 (GRCm39) |
missense |
probably benign |
0.42 |
RF020:Prl2c5
|
UTSW |
13 |
13,360,497 (GRCm39) |
missense |
probably benign |
0.28 |
X0025:Prl2c5
|
UTSW |
13 |
13,366,339 (GRCm39) |
missense |
probably benign |
0.03 |
|
Predicted Primers |
PCR Primer
(F):5'- AATTATATTGCAGAGGTGGTGGAC -3'
(R):5'- AACATCCTCGTGAAGACAGG -3'
Sequencing Primer
(F):5'- ATATTGCAGAGGTGGTGGACAGTTAG -3'
(R):5'- CTCGTGAAGACAGGGGCTTG -3'
|
Posted On |
2018-04-27 |