Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01066:Or5p79'

51430

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5p79

Ensembl Gene

ENSMUSG00000061000

Gene Name

olfactory receptor family 5 subfamily P member 79

Synonyms

Olfr507, GA_x6K02T2PBJ9-10951546-10952496, MOR204-7

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.132) question?

Stock #

IGL01066

Quality Score

Status

Chromosome

Chromosomal Location

108221021-108221971 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 108221064 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 15 (F15S)

Ref Sequence

ENSEMBL: ENSMUSP00000078926 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080014]

AlphaFold

Q8VG13

Predicted Effect

probably damaging
Transcript: ENSMUST00000080014
AA Change: F15S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000078926
Gene: ENSMUSG00000061000
AA Change: F15S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	313	6.1e-52	PFAM
Pfam:7tm_1	44	295	1e-20	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,834,475 (GRCm39)	V124I	probably damaging	Het
2300003K06Rik	T	A	11: 99,728,454 (GRCm39)	R130*	probably null	Het
Abca12	T	A	1: 71,392,889 (GRCm39)	R117W	possibly damaging	Het
Agrn	A	G	4: 156,261,800 (GRCm39)	S497P	probably benign	Het
Alpk1	A	T	3: 127,473,874 (GRCm39)	S710T	probably benign	Het
Anapc4	T	A	5: 53,014,551 (GRCm39)	N471K	probably benign	Het
Ano3	A	T	2: 110,491,790 (GRCm39)	M879K	probably null	Het
Apoe	A	G	7: 19,430,525 (GRCm39)	L239P	probably damaging	Het
Ash1l	T	C	3: 88,891,942 (GRCm39)	Y1274H	probably damaging	Het
B3glct	C	T	5: 149,632,890 (GRCm39)	T80I	possibly damaging	Het
Ccdc146	T	C	5: 21,524,540 (GRCm39)	T271A	probably benign	Het
Chd8	T	A	14: 52,455,223 (GRCm39)	N1088I	probably damaging	Het
Csnk1g2	T	C	10: 80,470,481 (GRCm39)		probably benign	Het
Daxx	T	A	17: 34,132,867 (GRCm39)	V627D	probably benign	Het
Dnai7	C	T	6: 145,121,948 (GRCm39)	G624S	probably damaging	Het
Dpy19l3	A	G	7: 35,392,192 (GRCm39)		probably benign	Het
Enc1	A	G	13: 97,381,822 (GRCm39)	I111V	probably benign	Het
Ep400	A	G	5: 110,816,065 (GRCm39)		probably benign	Het
Fig4	T	C	10: 41,161,413 (GRCm39)		probably benign	Het
Fkbp7	A	T	2: 76,503,252 (GRCm39)	L36*	probably null	Het
Fxn	A	T	19: 24,244,662 (GRCm39)		probably benign	Het
Gm10152	C	T	7: 144,316,993 (GRCm39)	P16L	unknown	Het
Hivep2	T	C	10: 14,024,768 (GRCm39)	V2194A	possibly damaging	Het
Hook3	T	G	8: 26,538,326 (GRCm39)	E525A	probably damaging	Het
Icam1	A	G	9: 20,927,401 (GRCm39)		probably null	Het
Ifngr1	C	T	10: 19,484,946 (GRCm39)	T315I	probably damaging	Het
Igsf10	A	G	3: 59,235,203 (GRCm39)		probably null	Het
Irag2	T	C	6: 145,106,681 (GRCm39)	S222P	probably damaging	Het
Krt87	A	G	15: 101,336,266 (GRCm39)		probably null	Het
Lama1	T	A	17: 68,050,321 (GRCm39)	C311S	probably damaging	Het
Lig3	T	A	11: 82,688,141 (GRCm39)	M714K	possibly damaging	Het
Lypd5	C	T	7: 24,052,910 (GRCm39)	T189I	probably benign	Het
Mapk8ip3	C	T	17: 25,120,692 (GRCm39)	G807D	probably benign	Het
Met	T	C	6: 17,535,104 (GRCm39)		probably null	Het
Nlrp4g	C	A	9: 124,349,526 (GRCm38)		noncoding transcript	Het
Nlrp6	T	A	7: 140,501,709 (GRCm39)	V62D	possibly damaging	Het
Nme7	A	G	1: 164,172,999 (GRCm39)		probably null	Het
Or2y1f	T	C	11: 49,184,457 (GRCm39)	I103T	possibly damaging	Het
Or5m9	A	G	2: 85,877,602 (GRCm39)	R259G	probably damaging	Het
Pcnx1	G	A	12: 82,038,795 (GRCm39)	R2020Q	possibly damaging	Het
Pdzd2	T	A	15: 12,402,718 (GRCm39)		probably benign	Het
Pi4ka	A	G	16: 17,166,637 (GRCm39)		probably benign	Het
Pkdrej	T	G	15: 85,700,360 (GRCm39)	I1859L	probably benign	Het
Plcg1	A	T	2: 160,596,318 (GRCm39)	H638L	probably damaging	Het
Polr1b	C	T	2: 128,961,072 (GRCm39)	S677L	probably damaging	Het
Ppef2	A	G	5: 92,382,096 (GRCm39)	L533P	probably damaging	Het
Sh3rf1	T	A	8: 61,782,370 (GRCm39)	W171R	probably damaging	Het
Son	T	C	16: 91,457,024 (GRCm39)		probably benign	Het
Sycp1	A	G	3: 102,827,950 (GRCm39)	S266P	probably damaging	Het
Tedc1	A	G	12: 113,126,770 (GRCm39)	E344G	probably damaging	Het
Tkfc	T	C	19: 10,571,892 (GRCm39)	I381M	probably benign	Het
Tmprss6	T	C	15: 78,326,634 (GRCm39)	D1G	probably null	Het
Ttn	T	C	2: 76,582,770 (GRCm39)	T22708A	probably damaging	Het
Ubtf	T	C	11: 102,199,710 (GRCm39)		probably benign	Het
Vps35l	T	A	7: 118,372,234 (GRCm39)		probably null	Het
Vwc2l	T	C	1: 70,768,070 (GRCm39)	F45L	probably damaging	Het
Xpo7	T	C	14: 70,939,195 (GRCm39)	T154A	probably benign	Het
Yars2	C	T	16: 16,124,406 (GRCm39)	R338*	probably null	Het

Other mutations in Or5p79

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01979:Or5p79	APN	7	108,221,648 (GRCm39)	missense	probably benign	0.09
IGL02373:Or5p79	APN	7	108,221,310 (GRCm39)	missense	probably benign	0.11
IGL02754:Or5p79	APN	7	108,221,880 (GRCm39)	missense	possibly damaging	0.94
IGL03008:Or5p79	APN	7	108,221,490 (GRCm39)	missense	probably damaging	0.99
R0305:Or5p79	UTSW	7	108,221,792 (GRCm39)	missense	probably benign	0.01
R0584:Or5p79	UTSW	7	108,221,622 (GRCm39)	missense	probably benign	0.00
R0611:Or5p79	UTSW	7	108,221,494 (GRCm39)	missense	possibly damaging	0.72
R0947:Or5p79	UTSW	7	108,221,879 (GRCm39)	missense	probably benign	0.02
R1488:Or5p79	UTSW	7	108,221,696 (GRCm39)	missense	probably damaging	1.00
R1808:Or5p79	UTSW	7	108,221,817 (GRCm39)	missense	possibly damaging	0.87
R3763:Or5p79	UTSW	7	108,221,924 (GRCm39)	missense	probably damaging	1.00
R4367:Or5p79	UTSW	7	108,221,096 (GRCm39)	missense	probably benign	0.27
R4369:Or5p79	UTSW	7	108,221,096 (GRCm39)	missense	probably benign	0.27
R4371:Or5p79	UTSW	7	108,221,096 (GRCm39)	missense	probably benign	0.27
R4609:Or5p79	UTSW	7	108,221,711 (GRCm39)	missense	probably benign	0.35
R5389:Or5p79	UTSW	7	108,221,924 (GRCm39)	missense	probably damaging	1.00
R6499:Or5p79	UTSW	7	108,221,713 (GRCm39)	missense	probably benign	0.02
R6684:Or5p79	UTSW	7	108,221,141 (GRCm39)	missense	probably damaging	0.98
R7531:Or5p79	UTSW	7	108,221,269 (GRCm39)	missense	probably benign	0.06
R7555:Or5p79	UTSW	7	108,221,933 (GRCm39)	missense	probably damaging	1.00
R7893:Or5p79	UTSW	7	108,221,844 (GRCm39)	missense	probably damaging	1.00
R8415:Or5p79	UTSW	7	108,221,163 (GRCm39)	missense	probably damaging	1.00
R8444:Or5p79	UTSW	7	108,221,027 (GRCm39)	missense	probably benign	0.00
R8904:Or5p79	UTSW	7	108,221,919 (GRCm39)	missense	probably damaging	0.98
R9635:Or5p79	UTSW	7	108,221,654 (GRCm39)	missense	probably benign	0.00
R9795:Or5p79	UTSW	7	108,221,869 (GRCm39)	missense	probably benign	0.39

Posted On

2013-06-21