Incidental Mutation 'IGL01068:Klhl25'
ID 51444
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klhl25
Ensembl Gene ENSMUSG00000055652
Gene Name kelch-like 25
Synonyms 2810402K13Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.234) question?
Stock # IGL01068
Quality Score
Status
Chromosome 7
Chromosomal Location 75498086-75523881 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 75515897 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 268 (E268*)
Ref Sequence ENSEMBL: ENSMUSP00000146102 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092073] [ENSMUST00000171155] [ENSMUST00000205612] [ENSMUST00000205887] [ENSMUST00000206019]
AlphaFold Q8R2P1
Predicted Effect probably null
Transcript: ENSMUST00000092073
AA Change: E268*
SMART Domains Protein: ENSMUSP00000089707
Gene: ENSMUSG00000055652
AA Change: E268*

DomainStartEndE-ValueType
BTB 46 144 2.43e-28 SMART
BACK 149 251 1.06e-32 SMART
Blast:BTB 256 294 1e-9 BLAST
Kelch 296 340 1.4e0 SMART
Kelch 341 388 6.71e-10 SMART
Kelch 389 444 2.25e-11 SMART
Kelch 445 492 1.22e-1 SMART
Kelch 493 538 1.92e-5 SMART
Kelch 539 585 1.4e-7 SMART
Predicted Effect probably null
Transcript: ENSMUST00000171155
AA Change: E268*
SMART Domains Protein: ENSMUSP00000133175
Gene: ENSMUSG00000055652
AA Change: E268*

DomainStartEndE-ValueType
BTB 46 144 2.43e-28 SMART
BACK 149 251 1.06e-32 SMART
Blast:BTB 256 294 1e-9 BLAST
Kelch 296 340 1.4e0 SMART
Kelch 341 388 6.71e-10 SMART
Kelch 389 444 2.25e-11 SMART
Kelch 445 492 1.22e-1 SMART
Kelch 493 538 1.92e-5 SMART
Kelch 539 585 1.4e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205612
Predicted Effect probably benign
Transcript: ENSMUST00000205887
Predicted Effect probably null
Transcript: ENSMUST00000206019
AA Change: E268*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206418
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406B18Rik T C 7: 43,153,599 (GRCm39) probably benign Het
Adgra1 A G 7: 139,425,541 (GRCm39) E18G probably damaging Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Atg16l1 C T 1: 87,702,546 (GRCm39) S269L probably damaging Het
Atp8a1 A G 5: 67,824,680 (GRCm39) V853A probably benign Het
Bicral T C 17: 47,136,317 (GRCm39) I298V probably damaging Het
Cad A G 5: 31,219,114 (GRCm39) probably benign Het
Chd9 A T 8: 91,768,744 (GRCm39) Y2448F probably benign Het
Clstn3 A G 6: 124,439,098 (GRCm39) L16S probably damaging Het
Cmtr2 G A 8: 110,949,501 (GRCm39) V604M possibly damaging Het
Ctcf A T 8: 106,408,117 (GRCm39) probably benign Het
Eif2ak2 A G 17: 79,172,800 (GRCm39) I295T probably damaging Het
Foxm1 G A 6: 128,347,930 (GRCm39) R284H possibly damaging Het
Gabra2 T C 5: 71,119,415 (GRCm39) I362M probably benign Het
Hivep1 C A 13: 42,313,460 (GRCm39) P1900Q probably benign Het
Klk1b16 T C 7: 43,790,102 (GRCm39) L124P probably damaging Het
Ltf A T 9: 110,864,880 (GRCm39) probably null Het
Mpped2 T A 2: 106,695,091 (GRCm39) H248Q probably damaging Het
Mrpl1 T A 5: 96,371,895 (GRCm39) probably benign Het
Mthfd1l T A 10: 3,978,428 (GRCm39) S429R probably damaging Het
Myl2 G A 5: 122,244,767 (GRCm39) V146I probably benign Het
Myo10 T A 15: 25,739,395 (GRCm39) I527N possibly damaging Het
Ncoa3 T C 2: 165,894,715 (GRCm39) S333P probably damaging Het
Or1j4 T G 2: 36,740,282 (GRCm39) S75A probably damaging Het
Or4k47 T G 2: 111,451,685 (GRCm39) T245P probably damaging Het
Oxct1 T C 15: 4,083,246 (GRCm39) F155S probably damaging Het
P4ha1 T C 10: 59,175,157 (GRCm39) V39A probably damaging Het
Padi6 G T 4: 140,458,264 (GRCm39) T514N possibly damaging Het
Pgm2 G A 5: 64,265,139 (GRCm39) V387I probably damaging Het
Ppt1 G A 4: 122,737,800 (GRCm39) C46Y probably damaging Het
Rnf225 T C 7: 12,662,827 (GRCm39) probably benign Het
Rpl26 T C 11: 68,793,224 (GRCm39) Y42H probably benign Het
Rundc1 A G 11: 101,324,968 (GRCm39) N558S probably damaging Het
Sema3e T G 5: 14,283,732 (GRCm39) probably null Het
Slc8a1 T C 17: 81,696,371 (GRCm39) I888V probably benign Het
Thsd7b T C 1: 129,523,883 (GRCm39) C306R probably damaging Het
Tmem209 A C 6: 30,502,085 (GRCm39) L197R probably benign Het
Tmem38b T G 4: 53,849,024 (GRCm39) V119G probably damaging Het
Trpc1 T C 9: 95,608,547 (GRCm39) D82G probably damaging Het
Zfp292 A G 4: 34,806,763 (GRCm39) F2094L probably damaging Het
Zfp638 C T 6: 83,911,976 (GRCm39) R453W probably damaging Het
Other mutations in Klhl25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01142:Klhl25 APN 7 75,516,344 (GRCm39) missense probably damaging 1.00
IGL01295:Klhl25 APN 7 75,515,620 (GRCm39) missense probably benign 0.20
IGL02272:Klhl25 APN 7 75,516,368 (GRCm39) missense probably benign
IGL02721:Klhl25 APN 7 75,516,648 (GRCm39) missense probably damaging 1.00
R0196:Klhl25 UTSW 7 75,515,450 (GRCm39) missense probably damaging 1.00
R0365:Klhl25 UTSW 7 75,516,264 (GRCm39) missense probably damaging 1.00
R0828:Klhl25 UTSW 7 75,515,943 (GRCm39) missense probably damaging 0.99
R0881:Klhl25 UTSW 7 75,516,027 (GRCm39) missense probably damaging 1.00
R1061:Klhl25 UTSW 7 75,516,268 (GRCm39) nonsense probably null
R1228:Klhl25 UTSW 7 75,515,868 (GRCm39) missense probably benign
R1696:Klhl25 UTSW 7 75,516,591 (GRCm39) missense probably damaging 1.00
R1991:Klhl25 UTSW 7 75,516,480 (GRCm39) missense probably damaging 1.00
R2118:Klhl25 UTSW 7 75,516,480 (GRCm39) missense probably damaging 1.00
R4359:Klhl25 UTSW 7 75,516,480 (GRCm39) missense probably damaging 1.00
R4428:Klhl25 UTSW 7 75,515,162 (GRCm39) missense probably damaging 0.97
R4431:Klhl25 UTSW 7 75,515,162 (GRCm39) missense probably damaging 0.97
R4717:Klhl25 UTSW 7 75,516,528 (GRCm39) missense probably damaging 1.00
R4860:Klhl25 UTSW 7 75,516,798 (GRCm39) missense probably benign 0.03
R4860:Klhl25 UTSW 7 75,516,798 (GRCm39) missense probably benign 0.03
R5619:Klhl25 UTSW 7 75,516,602 (GRCm39) missense probably benign 0.22
R5637:Klhl25 UTSW 7 75,515,540 (GRCm39) splice site probably null
R5652:Klhl25 UTSW 7 75,515,895 (GRCm39) missense probably benign 0.06
R5840:Klhl25 UTSW 7 75,516,440 (GRCm39) missense possibly damaging 0.92
R6693:Klhl25 UTSW 7 75,516,561 (GRCm39) missense possibly damaging 0.91
R6723:Klhl25 UTSW 7 75,515,739 (GRCm39) missense possibly damaging 0.64
R6875:Klhl25 UTSW 7 75,516,090 (GRCm39) missense probably damaging 1.00
R7239:Klhl25 UTSW 7 75,516,516 (GRCm39) missense probably benign 0.25
R8535:Klhl25 UTSW 7 75,515,843 (GRCm39) missense probably benign
R8712:Klhl25 UTSW 7 75,515,420 (GRCm39) missense probably damaging 0.99
R8768:Klhl25 UTSW 7 75,516,359 (GRCm39) missense probably damaging 1.00
R8827:Klhl25 UTSW 7 75,516,391 (GRCm39) missense possibly damaging 0.70
R9033:Klhl25 UTSW 7 75,516,681 (GRCm39) missense probably damaging 0.98
R9046:Klhl25 UTSW 7 75,515,337 (GRCm39) missense probably damaging 1.00
R9404:Klhl25 UTSW 7 75,515,153 (GRCm39) missense probably benign 0.01
R9480:Klhl25 UTSW 7 75,516,120 (GRCm39) missense probably damaging 0.99
R9601:Klhl25 UTSW 7 75,515,757 (GRCm39) missense probably damaging 1.00
R9762:Klhl25 UTSW 7 75,516,741 (GRCm39) missense probably damaging 1.00
Z1177:Klhl25 UTSW 7 75,515,870 (GRCm39) missense possibly damaging 0.87
Posted On 2013-06-21