Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01068:Rnf225'

51445

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rnf225

Ensembl Gene

ENSMUSG00000033967

Gene Name

ring finger protein 225

Synonyms

2310014L17Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01068

Quality Score

Status

Chromosome

Chromosomal Location

12661343-12664999 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to C at 12662827 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000118798 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000004554] [ENSMUST00000045870] [ENSMUST00000108539] [ENSMUST00000137329] [ENSMUST00000147435]

AlphaFold

Q9D7D1

Predicted Effect

probably benign
Transcript: ENSMUST00000004554

SMART Domains

Protein: ENSMUSP00000004554
Gene: ENSMUSG00000012848

Domain	Start	End	E-Value	Type
Pfam:Ribosomal_S7	49	204	3.5e-44	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000045870

SMART Domains

Protein: ENSMUSP00000042816
Gene: ENSMUSG00000033967

Domain	Start	End	E-Value	Type
low complexity region	14	27	N/A	INTRINSIC
low complexity region	35	47	N/A	INTRINSIC
RING	63	110	2.91e-6	SMART
low complexity region	150	170	N/A	INTRINSIC
low complexity region	175	196	N/A	INTRINSIC
transmembrane domain	202	224	N/A	INTRINSIC
low complexity region	266	278	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000083072

Predicted Effect

probably benign
Transcript: ENSMUST00000108539

SMART Domains

Protein: ENSMUSP00000104179
Gene: ENSMUSG00000012848

Domain	Start	End	E-Value	Type
Pfam:Ribosomal_S7	51	204	1.8e-40	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000137329

SMART Domains

Protein: ENSMUSP00000121961
Gene: ENSMUSG00000012848

Domain	Start	End	E-Value	Type
Pfam:Ribosomal_S7	49	182	1.2e-34	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139349

Predicted Effect

probably benign
Transcript: ENSMUST00000147435

SMART Domains

Protein: ENSMUSP00000118798
Gene: ENSMUSG00000012848

Domain	Start	End	E-Value	Type
Pfam:Ribosomal_S7	49	182	1.2e-34	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931406B18Rik	T	C	7: 43,153,599 (GRCm39)		probably benign	Het
Adgra1	A	G	7: 139,425,541 (GRCm39)	E18G	probably damaging	Het
Aen	G	A	7: 78,557,050 (GRCm39)	M299I	probably damaging	Het
Atg16l1	C	T	1: 87,702,546 (GRCm39)	S269L	probably damaging	Het
Atp8a1	A	G	5: 67,824,680 (GRCm39)	V853A	probably benign	Het
Bicral	T	C	17: 47,136,317 (GRCm39)	I298V	probably damaging	Het
Cad	A	G	5: 31,219,114 (GRCm39)		probably benign	Het
Chd9	A	T	8: 91,768,744 (GRCm39)	Y2448F	probably benign	Het
Clstn3	A	G	6: 124,439,098 (GRCm39)	L16S	probably damaging	Het
Cmtr2	G	A	8: 110,949,501 (GRCm39)	V604M	possibly damaging	Het
Ctcf	A	T	8: 106,408,117 (GRCm39)		probably benign	Het
Eif2ak2	A	G	17: 79,172,800 (GRCm39)	I295T	probably damaging	Het
Foxm1	G	A	6: 128,347,930 (GRCm39)	R284H	possibly damaging	Het
Gabra2	T	C	5: 71,119,415 (GRCm39)	I362M	probably benign	Het
Hivep1	C	A	13: 42,313,460 (GRCm39)	P1900Q	probably benign	Het
Klhl25	G	T	7: 75,515,897 (GRCm39)	E268*	probably null	Het
Klk1b16	T	C	7: 43,790,102 (GRCm39)	L124P	probably damaging	Het
Ltf	A	T	9: 110,864,880 (GRCm39)		probably null	Het
Mpped2	T	A	2: 106,695,091 (GRCm39)	H248Q	probably damaging	Het
Mrpl1	T	A	5: 96,371,895 (GRCm39)		probably benign	Het
Mthfd1l	T	A	10: 3,978,428 (GRCm39)	S429R	probably damaging	Het
Myl2	G	A	5: 122,244,767 (GRCm39)	V146I	probably benign	Het
Myo10	T	A	15: 25,739,395 (GRCm39)	I527N	possibly damaging	Het
Ncoa3	T	C	2: 165,894,715 (GRCm39)	S333P	probably damaging	Het
Or1j4	T	G	2: 36,740,282 (GRCm39)	S75A	probably damaging	Het
Or4k47	T	G	2: 111,451,685 (GRCm39)	T245P	probably damaging	Het
Oxct1	T	C	15: 4,083,246 (GRCm39)	F155S	probably damaging	Het
P4ha1	T	C	10: 59,175,157 (GRCm39)	V39A	probably damaging	Het
Padi6	G	T	4: 140,458,264 (GRCm39)	T514N	possibly damaging	Het
Pgm2	G	A	5: 64,265,139 (GRCm39)	V387I	probably damaging	Het
Ppt1	G	A	4: 122,737,800 (GRCm39)	C46Y	probably damaging	Het
Rpl26	T	C	11: 68,793,224 (GRCm39)	Y42H	probably benign	Het
Rundc1	A	G	11: 101,324,968 (GRCm39)	N558S	probably damaging	Het
Sema3e	T	G	5: 14,283,732 (GRCm39)		probably null	Het
Slc8a1	T	C	17: 81,696,371 (GRCm39)	I888V	probably benign	Het
Thsd7b	T	C	1: 129,523,883 (GRCm39)	C306R	probably damaging	Het
Tmem209	A	C	6: 30,502,085 (GRCm39)	L197R	probably benign	Het
Tmem38b	T	G	4: 53,849,024 (GRCm39)	V119G	probably damaging	Het
Trpc1	T	C	9: 95,608,547 (GRCm39)	D82G	probably damaging	Het
Zfp292	A	G	4: 34,806,763 (GRCm39)	F2094L	probably damaging	Het
Zfp638	C	T	6: 83,911,976 (GRCm39)	R453W	probably damaging	Het

Other mutations in Rnf225

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0033:Rnf225	UTSW	7	12,662,085 (GRCm39)	missense	probably damaging	1.00
R4541:Rnf225	UTSW	7	12,662,520 (GRCm39)	splice site	probably null
R4741:Rnf225	UTSW	7	12,661,857 (GRCm39)	missense	probably benign	0.02
R5388:Rnf225	UTSW	7	12,661,932 (GRCm39)	missense	probably damaging	1.00
R7128:Rnf225	UTSW	7	12,661,911 (GRCm39)	missense	probably benign	0.03
Z1177:Rnf225	UTSW	7	12,662,172 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-06-21