Incidental Mutation 'R6410:Or7e177'
ID 514579
Institutional Source Beutler Lab
Gene Symbol Or7e177
Ensembl Gene ENSMUSG00000049028
Gene Name olfactory receptor family 7 subfamily E member 177
Synonyms Olfr873, GA_x6K02T2PVTD-14040245-14041204, MOR145-2
MMRRC Submission 044383-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R6410 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 20211507-20212466 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 20211748 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 84 (I84N)
Ref Sequence ENSEMBL: ENSMUSP00000153816 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053919] [ENSMUST00000075717] [ENSMUST00000215540]
AlphaFold E9PX82
Predicted Effect probably damaging
Transcript: ENSMUST00000053919
AA Change: I81N

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000054778
Gene: ENSMUSG00000049028
AA Change: I81N

DomainStartEndE-ValueType
Pfam:7tm_4 41 317 1.7e-52 PFAM
Pfam:7TM_GPCR_Srsx 45 315 1.6e-8 PFAM
Pfam:7tm_1 51 300 3e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000075717
AA Change: I85N

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000075135
Gene: ENSMUSG00000049028
AA Change: I85N

DomainStartEndE-ValueType
Pfam:7tm_4 45 321 6.2e-43 PFAM
Pfam:7TM_GPCR_Srsx 49 309 3e-8 PFAM
Pfam:7tm_1 55 304 1.5e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212793
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213445
Predicted Effect probably damaging
Transcript: ENSMUST00000215540
AA Change: I84N

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216567
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217193
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahdc1 C T 4: 132,790,210 (GRCm39) R484W probably damaging Het
Arhgap24 T A 5: 103,040,017 (GRCm39) I411N probably benign Het
Armt1 A G 10: 4,403,826 (GRCm39) S304G probably benign Het
Atg9b T A 5: 24,591,108 (GRCm39) N774I possibly damaging Het
C1s1 C T 6: 124,508,117 (GRCm39) C624Y probably damaging Het
Camsap2 C A 1: 136,273,182 (GRCm39) probably benign Het
Cd109 T C 9: 78,564,798 (GRCm39) S248P probably benign Het
Cd28 A T 1: 60,804,442 (GRCm39) H140L probably benign Het
Csmd3 G A 15: 48,536,803 (GRCm39) T133I probably damaging Het
D430041D05Rik A T 2: 103,998,548 (GRCm39) probably null Het
Defb47 T C 14: 63,238,442 (GRCm39) V56A probably benign Het
Fxyd5 T C 7: 30,734,831 (GRCm39) E132G probably damaging Het
H2-M2 A G 17: 37,794,104 (GRCm39) V40A probably damaging Het
H2-Q7 T C 17: 35,659,152 (GRCm39) L201P probably benign Het
Klra9 T G 6: 130,155,957 (GRCm39) D266A probably damaging Het
Meioc A G 11: 102,565,860 (GRCm39) N492S probably benign Het
Nmt2 A G 2: 3,317,215 (GRCm39) E341G probably damaging Het
Nutm1 A C 2: 112,079,074 (GRCm39) V947G possibly damaging Het
Oga T C 19: 45,764,484 (GRCm39) probably null Het
Pm20d1 G A 1: 131,726,334 (GRCm39) G57D probably benign Het
Pnpla5 A G 15: 84,004,880 (GRCm39) I157T probably damaging Het
Rsrc1 C T 3: 66,901,982 (GRCm39) P44L unknown Het
Sv2b A T 7: 74,789,857 (GRCm39) I392N probably benign Het
Wfdc8 T A 2: 164,439,663 (GRCm39) I240F probably benign Het
Other mutations in Or7e177
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02122:Or7e177 APN 9 20,211,880 (GRCm39) missense probably damaging 1.00
IGL02268:Or7e177 APN 9 20,211,588 (GRCm39) missense probably damaging 1.00
IGL02416:Or7e177 APN 9 20,211,541 (GRCm39) missense probably benign 0.01
IGL03124:Or7e177 APN 9 20,212,459 (GRCm39) missense probably benign 0.00
R0147:Or7e177 UTSW 9 20,212,387 (GRCm39) missense probably damaging 1.00
R0148:Or7e177 UTSW 9 20,212,387 (GRCm39) missense probably damaging 1.00
R0266:Or7e177 UTSW 9 20,212,454 (GRCm39) missense probably benign 0.01
R0831:Or7e177 UTSW 9 20,211,861 (GRCm39) missense probably benign 0.20
R1456:Or7e177 UTSW 9 20,212,134 (GRCm39) missense probably benign 0.35
R1894:Or7e177 UTSW 9 20,211,633 (GRCm39) missense probably benign 0.23
R1928:Or7e177 UTSW 9 20,212,354 (GRCm39) missense probably benign 0.12
R2135:Or7e177 UTSW 9 20,211,593 (GRCm39) missense probably benign 0.00
R2379:Or7e177 UTSW 9 20,211,963 (GRCm39) missense possibly damaging 0.87
R2911:Or7e177 UTSW 9 20,211,775 (GRCm39) missense possibly damaging 0.60
R3788:Or7e177 UTSW 9 20,211,666 (GRCm39) missense probably benign 0.13
R4657:Or7e177 UTSW 9 20,211,919 (GRCm39) missense probably damaging 1.00
R5754:Or7e177 UTSW 9 20,212,390 (GRCm39) missense probably damaging 1.00
R6291:Or7e177 UTSW 9 20,211,899 (GRCm39) missense probably damaging 1.00
R7014:Or7e177 UTSW 9 20,211,959 (GRCm39) nonsense probably null
R7521:Or7e177 UTSW 9 20,212,036 (GRCm39) missense probably benign 0.00
R8201:Or7e177 UTSW 9 20,212,317 (GRCm39) missense probably damaging 1.00
R8355:Or7e177 UTSW 9 20,211,715 (GRCm39) missense probably damaging 1.00
R8455:Or7e177 UTSW 9 20,211,715 (GRCm39) missense probably damaging 1.00
R8523:Or7e177 UTSW 9 20,212,093 (GRCm39) missense probably benign 0.10
R8874:Or7e177 UTSW 9 20,212,069 (GRCm39) missense possibly damaging 0.95
R9283:Or7e177 UTSW 9 20,212,419 (GRCm39) missense possibly damaging 0.61
R9397:Or7e177 UTSW 9 20,211,748 (GRCm39) missense possibly damaging 0.50
R9595:Or7e177 UTSW 9 20,211,661 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGTCTCAGAATTCCATCTCATGAG -3'
(R):5'- CACAGAGGCGAGGATTCATG -3'

Sequencing Primer
(F):5'- GAGAATCTCTGATGATCCAGAACTGC -3'
(R):5'- ATTCATGATGAGTGAGTAATGCAGTG -3'
Posted On 2018-05-04