Incidental Mutation 'R6410:Armt1'
| ID |
514581 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Armt1
|
| Ensembl Gene |
ENSMUSG00000061759 |
| Gene Name |
acidic residue methyltransferase 1 |
| Synonyms |
1700052N19Rik |
| MMRRC Submission |
044383-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.152)
|
| Stock # |
R6410 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
4382572-4405140 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 4403826 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 304
(S304G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000093581
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095893]
[ENSMUST00000118544]
[ENSMUST00000152294]
|
| AlphaFold |
A6H630 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095893
AA Change: S304G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000093581
Gene: ENSMUSG00000061759
AA Change: S304G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF89
|
20 |
417 |
1.3e-125 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118544
|
| SMART Domains |
Protein: ENSMUSP00000114073
Gene: ENSMUSG00000061759
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF89
|
20 |
187 |
1.2e-33 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143037
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152294
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 97.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ahdc1 |
C |
T |
4: 132,790,210 (GRCm39) |
R484W |
probably damaging |
Het |
| Arhgap24 |
T |
A |
5: 103,040,017 (GRCm39) |
I411N |
probably benign |
Het |
| Atg9b |
T |
A |
5: 24,591,108 (GRCm39) |
N774I |
possibly damaging |
Het |
| C1s1 |
C |
T |
6: 124,508,117 (GRCm39) |
C624Y |
probably damaging |
Het |
| Camsap2 |
C |
A |
1: 136,273,182 (GRCm39) |
|
probably benign |
Het |
| Cd109 |
T |
C |
9: 78,564,798 (GRCm39) |
S248P |
probably benign |
Het |
| Cd28 |
A |
T |
1: 60,804,442 (GRCm39) |
H140L |
probably benign |
Het |
| Csmd3 |
G |
A |
15: 48,536,803 (GRCm39) |
T133I |
probably damaging |
Het |
| D430041D05Rik |
A |
T |
2: 103,998,548 (GRCm39) |
|
probably null |
Het |
| Defb47 |
T |
C |
14: 63,238,442 (GRCm39) |
V56A |
probably benign |
Het |
| Fxyd5 |
T |
C |
7: 30,734,831 (GRCm39) |
E132G |
probably damaging |
Het |
| H2-M2 |
A |
G |
17: 37,794,104 (GRCm39) |
V40A |
probably damaging |
Het |
| H2-Q7 |
T |
C |
17: 35,659,152 (GRCm39) |
L201P |
probably benign |
Het |
| Klra9 |
T |
G |
6: 130,155,957 (GRCm39) |
D266A |
probably damaging |
Het |
| Meioc |
A |
G |
11: 102,565,860 (GRCm39) |
N492S |
probably benign |
Het |
| Nmt2 |
A |
G |
2: 3,317,215 (GRCm39) |
E341G |
probably damaging |
Het |
| Nutm1 |
A |
C |
2: 112,079,074 (GRCm39) |
V947G |
possibly damaging |
Het |
| Oga |
T |
C |
19: 45,764,484 (GRCm39) |
|
probably null |
Het |
| Or7e177 |
T |
A |
9: 20,211,748 (GRCm39) |
I84N |
probably damaging |
Het |
| Pm20d1 |
G |
A |
1: 131,726,334 (GRCm39) |
G57D |
probably benign |
Het |
| Pnpla5 |
A |
G |
15: 84,004,880 (GRCm39) |
I157T |
probably damaging |
Het |
| Rsrc1 |
C |
T |
3: 66,901,982 (GRCm39) |
P44L |
unknown |
Het |
| Sv2b |
A |
T |
7: 74,789,857 (GRCm39) |
I392N |
probably benign |
Het |
| Wfdc8 |
T |
A |
2: 164,439,663 (GRCm39) |
I240F |
probably benign |
Het |
|
| Other mutations in Armt1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00907:Armt1
|
APN |
10 |
4,454,051 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
IGL01018:Armt1
|
APN |
10 |
4,404,237 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01018:Armt1
|
APN |
10 |
4,400,732 (GRCm39) |
missense |
probably benign |
|
|
IGL02198:Armt1
|
APN |
10 |
4,404,064 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02980:Armt1
|
APN |
10 |
4,400,643 (GRCm39) |
splice site |
probably benign |
|
|
IGL03104:Armt1
|
APN |
10 |
4,389,615 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0620:Armt1
|
UTSW |
10 |
4,382,689 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4248:Armt1
|
UTSW |
10 |
4,389,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5709:Armt1
|
UTSW |
10 |
4,384,903 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6058:Armt1
|
UTSW |
10 |
4,403,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6318:Armt1
|
UTSW |
10 |
4,400,859 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6998:Armt1
|
UTSW |
10 |
4,403,937 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7242:Armt1
|
UTSW |
10 |
4,403,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7268:Armt1
|
UTSW |
10 |
4,400,855 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7432:Armt1
|
UTSW |
10 |
4,382,706 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7640:Armt1
|
UTSW |
10 |
4,403,572 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7715:Armt1
|
UTSW |
10 |
4,400,751 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8877:Armt1
|
UTSW |
10 |
4,400,864 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8968:Armt1
|
UTSW |
10 |
4,404,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8973:Armt1
|
UTSW |
10 |
4,389,550 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9096:Armt1
|
UTSW |
10 |
4,384,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9404:Armt1
|
UTSW |
10 |
4,400,848 (GRCm39) |
frame shift |
probably null |
|
|
R9405:Armt1
|
UTSW |
10 |
4,400,848 (GRCm39) |
frame shift |
probably null |
|
|
R9408:Armt1
|
UTSW |
10 |
4,400,848 (GRCm39) |
frame shift |
probably null |
|
|
R9563:Armt1
|
UTSW |
10 |
4,400,848 (GRCm39) |
frame shift |
probably null |
|
|
R9785:Armt1
|
UTSW |
10 |
4,389,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACAGTAGAAACGCCCGTAG -3'
(R):5'- TGGAACGGAAAGGTGAACTTCC -3'
Sequencing Primer
(F):5'- CGCCCGTAGTTAGAGTAGACATTG -3'
(R):5'- CGGAAAGGTGAACTTCCATTTTCTG -3'
|
| Posted On |
2018-05-04 |
Incidental Mutation