Incidental Mutation 'R6377:Vmn2r109'
| ID |
515080 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r109
|
| Ensembl Gene |
ENSMUSG00000090572 |
| Gene Name |
vomeronasal 2, receptor 109 |
| Synonyms |
EG627814 |
| MMRRC Submission |
044527-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
R6377 (G1)
|
| Quality Score |
224.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20760779-20785018 bp(-) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
A to C
at 20784796 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132641
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167093]
|
| AlphaFold |
K7N747 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000167093
|
| SMART Domains |
Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
1.4e-35 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
596 |
831 |
7.4e-52 |
PFAM |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 97.8%
|
| Validation Efficiency |
94% (59/63) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ankib1 |
A |
G |
5: 3,743,855 (GRCm39) |
S812P |
possibly damaging |
Het |
| Atp2c2 |
A |
G |
8: 120,453,093 (GRCm39) |
E159G |
probably benign |
Het |
| Atrn |
A |
G |
2: 130,821,889 (GRCm39) |
I861V |
probably damaging |
Het |
| Clip1 |
A |
G |
5: 123,741,717 (GRCm39) |
V1053A |
possibly damaging |
Het |
| Cngb1 |
C |
A |
8: 95,975,608 (GRCm39) |
G629C |
probably damaging |
Het |
| Cntn5 |
A |
T |
9: 9,743,657 (GRCm39) |
F540Y |
probably damaging |
Het |
| Cpb1 |
A |
C |
3: 20,329,748 (GRCm39) |
|
probably null |
Het |
| Cyp4a14 |
A |
G |
4: 115,353,280 (GRCm39) |
Y11H |
probably benign |
Het |
| Dact2 |
A |
G |
17: 14,419,450 (GRCm39) |
S103P |
probably damaging |
Het |
| Dcstamp |
A |
T |
15: 39,618,317 (GRCm39) |
Y242F |
probably benign |
Het |
| Drd3 |
G |
T |
16: 43,641,670 (GRCm39) |
G329* |
probably null |
Het |
| Duxf1 |
T |
C |
10: 58,059,494 (GRCm39) |
|
probably benign |
Het |
| Dysf |
T |
A |
6: 83,985,945 (GRCm39) |
S17T |
probably benign |
Het |
| Eno1 |
A |
T |
4: 150,333,009 (GRCm39) |
K366N |
possibly damaging |
Het |
| Ffar2 |
C |
T |
7: 30,518,971 (GRCm39) |
V190I |
probably benign |
Het |
| Fkbp15 |
T |
C |
4: 62,242,429 (GRCm39) |
T508A |
probably damaging |
Het |
| Fndc1 |
A |
G |
17: 7,988,567 (GRCm39) |
V1165A |
unknown |
Het |
| Foxj3 |
A |
T |
4: 119,430,945 (GRCm39) |
|
probably null |
Het |
| Gabarap |
T |
C |
11: 69,882,630 (GRCm39) |
|
probably null |
Het |
| Gm19410 |
T |
A |
8: 36,270,736 (GRCm39) |
L1221* |
probably null |
Het |
| Gpat2 |
G |
C |
2: 127,273,838 (GRCm39) |
G294R |
possibly damaging |
Het |
| Igf1r |
A |
T |
7: 67,850,998 (GRCm39) |
Y931F |
probably benign |
Het |
| Il23r |
A |
T |
6: 67,400,636 (GRCm39) |
S565T |
probably damaging |
Het |
| Ipo8 |
A |
T |
6: 148,717,995 (GRCm39) |
Y209* |
probably null |
Het |
| Jph2 |
C |
T |
2: 163,181,632 (GRCm39) |
G511R |
probably benign |
Het |
| Khdrbs1 |
C |
A |
4: 129,635,890 (GRCm39) |
D22Y |
probably damaging |
Het |
| Kif5b |
A |
T |
18: 6,212,562 (GRCm39) |
L754Q |
probably damaging |
Het |
| Ksr1 |
C |
T |
11: 78,927,320 (GRCm39) |
|
probably null |
Het |
| L3mbtl4 |
G |
T |
17: 69,084,918 (GRCm39) |
V610F |
probably benign |
Het |
| Lars2 |
A |
G |
9: 123,283,825 (GRCm39) |
T698A |
probably benign |
Het |
| Lonp1 |
A |
G |
17: 56,928,961 (GRCm39) |
V267A |
possibly damaging |
Het |
| Loxhd1 |
T |
A |
18: 77,468,128 (GRCm39) |
D925E |
probably damaging |
Het |
| Lsg1 |
A |
G |
16: 30,393,386 (GRCm39) |
L187P |
possibly damaging |
Het |
| Mki67 |
A |
T |
7: 135,298,050 (GRCm39) |
V2328E |
possibly damaging |
Het |
| Mlh3 |
A |
G |
12: 85,315,271 (GRCm39) |
I305T |
probably damaging |
Het |
| Mtbp |
A |
G |
15: 55,421,016 (GRCm39) |
M1V |
probably null |
Het |
| Myadml2 |
C |
A |
11: 120,538,538 (GRCm39) |
C99F |
probably benign |
Het |
| Ncbp1 |
A |
G |
4: 46,150,703 (GRCm39) |
Y185C |
probably damaging |
Het |
| Ndufaf7 |
A |
T |
17: 79,250,739 (GRCm39) |
Q222L |
probably null |
Het |
| Nlrp4b |
A |
T |
7: 10,449,339 (GRCm39) |
Y147F |
probably benign |
Het |
| Or4c11c |
C |
T |
2: 88,661,613 (GRCm39) |
R51* |
probably null |
Het |
| Pet100 |
T |
C |
8: 3,672,370 (GRCm39) |
V15A |
probably benign |
Het |
| Pot1a |
A |
G |
6: 25,778,869 (GRCm39) |
V75A |
probably benign |
Het |
| Ptprs |
A |
T |
17: 56,725,935 (GRCm39) |
M1043K |
probably damaging |
Het |
| Rnf31 |
A |
G |
14: 55,832,984 (GRCm39) |
T413A |
probably damaging |
Het |
| Rsf1 |
ATGGCG |
ATGGCGACGGTGGCG |
7: 97,229,111 (GRCm39) |
|
probably benign |
Homo |
| Rsf1 |
CG |
CGACGGCGGTG |
7: 97,229,115 (GRCm39) |
|
probably benign |
Het |
| Rubcnl |
A |
T |
14: 75,287,635 (GRCm39) |
|
probably null |
Het |
| Ryr3 |
A |
T |
2: 112,462,530 (GRCm39) |
C4839S |
probably damaging |
Het |
| Scai |
A |
C |
2: 38,992,340 (GRCm39) |
D379E |
probably benign |
Het |
| Scd2 |
G |
T |
19: 44,288,198 (GRCm39) |
G197* |
probably null |
Het |
| Sdr39u1 |
A |
C |
14: 56,135,166 (GRCm39) |
I259S |
probably benign |
Het |
| Slco1a5 |
A |
T |
6: 142,187,906 (GRCm39) |
|
probably null |
Het |
| Sp1 |
A |
T |
15: 102,339,318 (GRCm39) |
T733S |
probably benign |
Het |
| Tecta |
A |
G |
9: 42,255,051 (GRCm39) |
S1711P |
probably damaging |
Het |
| Tedc1 |
G |
T |
12: 113,124,975 (GRCm39) |
W240L |
probably damaging |
Het |
| Trarg1 |
T |
C |
11: 76,571,355 (GRCm39) |
S124P |
probably damaging |
Het |
| Trim50 |
A |
G |
5: 135,382,454 (GRCm39) |
K102R |
probably benign |
Het |
| Utrn |
A |
G |
10: 12,619,827 (GRCm39) |
Y278H |
probably damaging |
Het |
| Vinac1 |
T |
A |
2: 128,878,731 (GRCm39) |
D1065V |
unknown |
Het |
| Zbed5 |
T |
C |
5: 129,932,210 (GRCm39) |
S720P |
possibly damaging |
Het |
| Zc3h3 |
A |
G |
15: 75,711,304 (GRCm39) |
S386P |
probably damaging |
Het |
| Zscan4-ps1 |
C |
T |
7: 10,802,418 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn2r109 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01313:Vmn2r109
|
APN |
17 |
20,770,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01383:Vmn2r109
|
APN |
17 |
20,761,383 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01469:Vmn2r109
|
APN |
17 |
20,761,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01762:Vmn2r109
|
APN |
17 |
20,774,654 (GRCm39) |
missense |
probably benign |
|
|
IGL01864:Vmn2r109
|
APN |
17 |
20,761,396 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02028:Vmn2r109
|
APN |
17 |
20,761,342 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02074:Vmn2r109
|
APN |
17 |
20,774,603 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02162:Vmn2r109
|
APN |
17 |
20,774,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02474:Vmn2r109
|
APN |
17 |
20,761,150 (GRCm39) |
missense |
probably benign |
|
|
IGL02490:Vmn2r109
|
APN |
17 |
20,761,246 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02604:Vmn2r109
|
APN |
17 |
20,760,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02669:Vmn2r109
|
APN |
17 |
20,774,518 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02705:Vmn2r109
|
APN |
17 |
20,774,062 (GRCm39) |
missense |
probably benign |
|
|
IGL02745:Vmn2r109
|
APN |
17 |
20,761,512 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4142001:Vmn2r109
|
UTSW |
17 |
20,774,839 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0389:Vmn2r109
|
UTSW |
17 |
20,761,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0470:Vmn2r109
|
UTSW |
17 |
20,773,148 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0570:Vmn2r109
|
UTSW |
17 |
20,760,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0855:Vmn2r109
|
UTSW |
17 |
20,761,670 (GRCm39) |
nonsense |
probably null |
|
|
R0882:Vmn2r109
|
UTSW |
17 |
20,774,842 (GRCm39) |
splice site |
probably benign |
|
|
R1241:Vmn2r109
|
UTSW |
17 |
20,775,503 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1587:Vmn2r109
|
UTSW |
17 |
20,761,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1931:Vmn2r109
|
UTSW |
17 |
20,774,072 (GRCm39) |
nonsense |
probably null |
|
|
R1957:Vmn2r109
|
UTSW |
17 |
20,784,969 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1962:Vmn2r109
|
UTSW |
17 |
20,774,185 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2020:Vmn2r109
|
UTSW |
17 |
20,761,448 (GRCm39) |
nonsense |
probably null |
|
|
R2073:Vmn2r109
|
UTSW |
17 |
20,784,974 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2436:Vmn2r109
|
UTSW |
17 |
20,774,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3123:Vmn2r109
|
UTSW |
17 |
20,761,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3839:Vmn2r109
|
UTSW |
17 |
20,774,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4019:Vmn2r109
|
UTSW |
17 |
20,774,074 (GRCm39) |
missense |
probably benign |
|
|
R4428:Vmn2r109
|
UTSW |
17 |
20,773,286 (GRCm39) |
missense |
probably benign |
|
|
R4584:Vmn2r109
|
UTSW |
17 |
20,774,820 (GRCm39) |
nonsense |
probably null |
|
|
R4652:Vmn2r109
|
UTSW |
17 |
20,761,656 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r109
|
UTSW |
17 |
20,761,605 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4823:Vmn2r109
|
UTSW |
17 |
20,774,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4831:Vmn2r109
|
UTSW |
17 |
20,761,494 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4907:Vmn2r109
|
UTSW |
17 |
20,770,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5011:Vmn2r109
|
UTSW |
17 |
20,775,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r109
|
UTSW |
17 |
20,774,603 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5600:Vmn2r109
|
UTSW |
17 |
20,761,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5602:Vmn2r109
|
UTSW |
17 |
20,760,933 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5652:Vmn2r109
|
UTSW |
17 |
20,760,781 (GRCm39) |
makesense |
probably null |
|
|
R5702:Vmn2r109
|
UTSW |
17 |
20,774,407 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5706:Vmn2r109
|
UTSW |
17 |
20,774,567 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5714:Vmn2r109
|
UTSW |
17 |
20,773,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Vmn2r109
|
UTSW |
17 |
20,761,318 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6008:Vmn2r109
|
UTSW |
17 |
20,760,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6334:Vmn2r109
|
UTSW |
17 |
20,761,440 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6738:Vmn2r109
|
UTSW |
17 |
20,774,785 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6857:Vmn2r109
|
UTSW |
17 |
20,760,932 (GRCm39) |
missense |
probably benign |
0.45 |
|
R6953:Vmn2r109
|
UTSW |
17 |
20,760,973 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7108:Vmn2r109
|
UTSW |
17 |
20,785,006 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7229:Vmn2r109
|
UTSW |
17 |
20,761,225 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7238:Vmn2r109
|
UTSW |
17 |
20,761,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7244:Vmn2r109
|
UTSW |
17 |
20,760,945 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7292:Vmn2r109
|
UTSW |
17 |
20,761,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7354:Vmn2r109
|
UTSW |
17 |
20,761,043 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7357:Vmn2r109
|
UTSW |
17 |
20,761,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7522:Vmn2r109
|
UTSW |
17 |
20,774,665 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7596:Vmn2r109
|
UTSW |
17 |
20,760,942 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7728:Vmn2r109
|
UTSW |
17 |
20,773,117 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7859:Vmn2r109
|
UTSW |
17 |
20,761,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7871:Vmn2r109
|
UTSW |
17 |
20,760,782 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8113:Vmn2r109
|
UTSW |
17 |
20,774,729 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8153:Vmn2r109
|
UTSW |
17 |
20,784,969 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8977:Vmn2r109
|
UTSW |
17 |
20,774,531 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R9687:Vmn2r109
|
UTSW |
17 |
20,775,332 (GRCm39) |
missense |
|
|
|
Z1176:Vmn2r109
|
UTSW |
17 |
20,773,256 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCAACAAAGTCAGGCTGAGATTAAG -3'
(R):5'- AGATTCCCAAACTTGTCTCTGC -3'
Sequencing Primer
(F):5'- TATCATTTCATTCCCCCTGAGAGAGG -3'
(R):5'- AACTTGTCTCTGCCTTTATAACTATG -3'
|
| Posted On |
2018-05-04 |
Incidental Mutation