Incidental Mutation 'R6380:Pald1'
ID 515277
Institutional Source Beutler Lab
Gene Symbol Pald1
Ensembl Gene ENSMUSG00000020092
Gene Name phosphatase domain containing, paladin 1
Synonyms paladin, X99384
MMRRC Submission 044529-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R6380 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 61155435-61219309 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 61186714 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 146 (F146L)
Ref Sequence ENSEMBL: ENSMUSP00000020289 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020289]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000020289
AA Change: F146L

PolyPhen 2 Score 0.855 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000020289
Gene: ENSMUSG00000020092
AA Change: F146L

DomainStartEndE-ValueType
low complexity region 2 37 N/A INTRINSIC
PTPlike_phytase 164 333 4.33e-53 SMART
low complexity region 428 441 N/A INTRINSIC
PTPlike_phytase 548 682 5.37e-49 SMART
low complexity region 757 768 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219132
Meta Mutation Damage Score 0.1881 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 96.5%
Validation Efficiency 100% (51/51)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik G A 6: 91,900,118 (GRCm39) G424D probably damaging Het
Aco1 T C 4: 40,185,028 (GRCm39) V566A probably benign Het
Adat1 G T 8: 112,704,704 (GRCm39) T414K probably benign Het
Alox12e A G 11: 70,211,927 (GRCm39) V194A probably benign Het
Anpep A G 7: 79,491,644 (GRCm39) V119A probably benign Het
Atat1 C A 17: 36,219,849 (GRCm39) probably null Het
Atp10a G A 7: 58,469,432 (GRCm39) W1094* probably null Het
Bcl11b T C 12: 107,969,360 (GRCm39) R15G probably benign Het
Bltp1 A G 3: 37,087,456 (GRCm39) D4019G probably benign Het
Btnl1 A G 17: 34,598,468 (GRCm39) E28G probably benign Het
Ccnd1 A G 7: 144,493,306 (GRCm39) V42A probably benign Het
Cdyl2 T A 8: 117,309,923 (GRCm39) K344N probably damaging Het
Cep68 A G 11: 20,180,498 (GRCm39) M711T probably benign Het
Cyp2j7 A G 4: 96,118,211 (GRCm39) probably null Het
Cyp3a25 A T 5: 145,935,357 (GRCm39) D86E probably damaging Het
Dclk1 G T 3: 55,154,615 (GRCm39) R15L probably damaging Het
Dpy19l1 T A 9: 24,393,341 (GRCm39) K143* probably null Het
Duox2 A G 2: 122,111,483 (GRCm39) V1405A probably benign Het
Filip1 T C 9: 79,726,906 (GRCm39) E571G probably damaging Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
Jph1 T C 1: 17,162,071 (GRCm39) N197S probably damaging Het
Kcnt2 T C 1: 140,437,322 (GRCm39) L535S probably damaging Het
Lepr C A 4: 101,622,151 (GRCm39) S361* probably null Het
Lfng T A 5: 140,600,151 (GRCm39) probably null Het
Lpcat2 G A 8: 93,613,209 (GRCm39) A250T probably benign Het
Mab21l4 G A 1: 93,088,613 (GRCm39) probably null Het
Map3k4 A T 17: 12,490,954 (GRCm39) M159K possibly damaging Het
Notch3 A T 17: 32,363,533 (GRCm39) C1177S probably damaging Het
Olfml2b C T 1: 170,496,800 (GRCm39) P477L probably benign Het
Or51a5 A T 7: 102,771,136 (GRCm39) F281Y probably benign Het
Or5k16 T A 16: 58,736,627 (GRCm39) I126L probably damaging Het
Or6c33 A T 10: 129,853,782 (GRCm39) H184L probably benign Het
Pcdhga1 A G 18: 37,796,022 (GRCm39) D342G probably damaging Het
Plcb2 T C 2: 118,545,949 (GRCm39) S579G probably damaging Het
Prdm16 A T 4: 154,425,824 (GRCm39) S654T probably benign Het
Rab3gap2 C A 1: 184,968,181 (GRCm39) L178I probably damaging Het
Rbfox1 C T 16: 7,042,214 (GRCm39) Q23* probably null Het
Slc14a2 T G 18: 78,190,190 (GRCm39) T920P probably benign Het
Slc17a6 G A 7: 51,317,211 (GRCm39) V411M probably benign Het
Stard6 G A 18: 70,609,459 (GRCm39) V33I probably benign Het
Syce1 A T 7: 140,358,978 (GRCm39) H178Q probably damaging Het
Syne2 T A 12: 76,151,754 (GRCm39) F1872I probably damaging Het
Tor1aip1 T C 1: 155,894,234 (GRCm39) E274G possibly damaging Het
Trpm1 A T 7: 63,918,045 (GRCm39) T462S probably benign Het
Ugt3a1 C T 15: 9,306,541 (GRCm39) A230V probably benign Het
Vmn1r178 A G 7: 23,592,984 (GRCm39) T11A possibly damaging Het
Vmn2r69 A T 7: 85,061,067 (GRCm39) N172K probably benign Het
Whrn G T 4: 63,336,829 (GRCm39) P136T possibly damaging Het
Zfhx4 A G 3: 5,478,170 (GRCm39) N3570S probably damaging Het
Zfp689 A G 7: 127,043,968 (GRCm39) S221P probably damaging Het
Other mutations in Pald1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02183:Pald1 APN 10 61,182,920 (GRCm39) splice site probably benign
IGL03068:Pald1 APN 10 61,156,963 (GRCm39) missense possibly damaging 0.94
IGL03106:Pald1 APN 10 61,182,884 (GRCm39) missense probably benign 0.41
R0331:Pald1 UTSW 10 61,176,708 (GRCm39) critical splice donor site probably null
R0497:Pald1 UTSW 10 61,177,094 (GRCm39) missense probably damaging 0.99
R1181:Pald1 UTSW 10 61,183,366 (GRCm39) splice site probably benign
R1437:Pald1 UTSW 10 61,177,064 (GRCm39) missense possibly damaging 0.63
R1466:Pald1 UTSW 10 61,184,304 (GRCm39) splice site probably benign
R1827:Pald1 UTSW 10 61,191,701 (GRCm39) small deletion probably benign
R2129:Pald1 UTSW 10 61,184,085 (GRCm39) critical splice donor site probably null
R2184:Pald1 UTSW 10 61,182,915 (GRCm39) missense possibly damaging 0.46
R2260:Pald1 UTSW 10 61,188,750 (GRCm39) missense probably damaging 1.00
R3051:Pald1 UTSW 10 61,182,542 (GRCm39) nonsense probably null
R3690:Pald1 UTSW 10 61,191,587 (GRCm39) splice site probably null
R3713:Pald1 UTSW 10 61,178,144 (GRCm39) missense possibly damaging 0.67
R3876:Pald1 UTSW 10 61,183,266 (GRCm39) missense probably damaging 0.97
R4261:Pald1 UTSW 10 61,179,471 (GRCm39) missense probably damaging 1.00
R4600:Pald1 UTSW 10 61,184,395 (GRCm39) missense probably benign 0.00
R4603:Pald1 UTSW 10 61,184,395 (GRCm39) missense probably benign 0.00
R5069:Pald1 UTSW 10 61,177,025 (GRCm39) missense possibly damaging 0.50
R5354:Pald1 UTSW 10 61,184,440 (GRCm39) missense probably damaging 1.00
R5590:Pald1 UTSW 10 61,179,489 (GRCm39) missense probably damaging 1.00
R5705:Pald1 UTSW 10 61,159,076 (GRCm39) missense possibly damaging 0.90
R5780:Pald1 UTSW 10 61,174,997 (GRCm39) missense probably damaging 1.00
R6239:Pald1 UTSW 10 61,156,910 (GRCm39) missense possibly damaging 0.59
R6812:Pald1 UTSW 10 61,178,701 (GRCm39) missense possibly damaging 0.53
R6891:Pald1 UTSW 10 61,184,311 (GRCm39) critical splice donor site probably null
R6949:Pald1 UTSW 10 61,156,996 (GRCm39) missense probably benign 0.23
R7038:Pald1 UTSW 10 61,175,078 (GRCm39) missense probably benign
R7051:Pald1 UTSW 10 61,159,125 (GRCm39) missense probably benign 0.26
R7188:Pald1 UTSW 10 61,182,845 (GRCm39) missense probably damaging 0.99
R7339:Pald1 UTSW 10 61,159,110 (GRCm39) missense possibly damaging 0.60
R7831:Pald1 UTSW 10 61,191,593 (GRCm39) missense probably damaging 1.00
R8000:Pald1 UTSW 10 61,183,218 (GRCm39) missense probably benign 0.00
R8710:Pald1 UTSW 10 61,183,232 (GRCm39) missense probably benign 0.03
R8903:Pald1 UTSW 10 61,182,815 (GRCm39) critical splice donor site probably null
R9255:Pald1 UTSW 10 61,176,989 (GRCm39) critical splice donor site probably null
R9414:Pald1 UTSW 10 61,178,932 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TCAGACCTTAGGCAGCTCTC -3'
(R):5'- CTGTCTGAGGAGAAACCCTGATTG -3'

Sequencing Primer
(F):5'- TTAGGCAGCTCTCAACAAGACAATG -3'
(R):5'- GAGAAACCCTGATTGACCTGCTG -3'
Posted On 2018-05-04