Incidental Mutation 'R6384:Or8g27'
ID 515508
Institutional Source Beutler Lab
Gene Symbol Or8g27
Ensembl Gene ENSMUSG00000096555
Gene Name olfactory receptor family 8 subfamily G member 27
Synonyms GA_x6K02T2PVTD-32914568-32915503, Olfr944, MOR171-19
MMRRC Submission 044533-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R6384 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 39128655-39129590 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39129274 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 207 (V207A)
Ref Sequence ENSEMBL: ENSMUSP00000150471 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079650] [ENSMUST00000213908] [ENSMUST00000215306]
AlphaFold Q9EQ91
Predicted Effect probably benign
Transcript: ENSMUST00000079650
AA Change: V207A

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000078595
Gene: ENSMUSG00000096555
AA Change: V207A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.5e-47 PFAM
Pfam:7tm_1 41 290 2.1e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213908
AA Change: V207A

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000215306
AA Change: V207A

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad10 T A 5: 121,790,066 (GRCm39) T97S probably benign Het
Adam34 T A 8: 44,103,836 (GRCm39) D603V probably benign Het
Adamts5 C T 16: 85,659,716 (GRCm39) V859I probably benign Het
Alb T A 5: 90,620,499 (GRCm39) D536E possibly damaging Het
Amz2 A G 11: 109,319,860 (GRCm39) Y82C probably damaging Het
Asxl1 T C 2: 153,233,744 (GRCm39) probably null Het
Bach1 C T 16: 87,516,745 (GRCm39) Q429* probably null Het
Bcl6 A G 16: 23,793,615 (GRCm39) Y111H probably damaging Het
Ccnj T C 19: 40,834,451 (GRCm39) V338A probably benign Het
Cdca3 C T 6: 124,809,382 (GRCm39) P174L probably damaging Het
Cdk17 T C 10: 93,047,827 (GRCm39) L25P probably damaging Het
Cdr2 G A 7: 120,581,351 (GRCm39) probably null Het
Cyp2c38 A T 19: 39,380,737 (GRCm39) probably null Het
Ednra T C 8: 78,415,723 (GRCm39) N175D probably damaging Het
Elp3 T C 14: 65,797,660 (GRCm39) Y337C probably damaging Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Eps15l1 A T 8: 73,122,554 (GRCm39) probably null Het
F11r A G 1: 171,288,508 (GRCm39) N117S probably benign Het
Foxp2 C T 6: 15,437,947 (GRCm39) T716I probably damaging Het
Gnaq A G 19: 16,293,377 (GRCm39) probably null Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
Gpr158 T C 2: 21,831,099 (GRCm39) M733T probably damaging Het
Hdac7 G A 15: 97,709,387 (GRCm39) Q48* probably null Het
Hmga2 G A 10: 120,206,612 (GRCm39) probably benign Het
Itgb7 A G 15: 102,132,886 (GRCm39) V142A probably benign Het
Kif5a T C 10: 127,078,644 (GRCm39) N334D probably damaging Het
Lrrc47 T C 4: 154,100,317 (GRCm39) S298P probably benign Het
Map3k1 A T 13: 111,887,064 (GRCm39) S1415R probably damaging Het
Mdn1 T A 4: 32,670,607 (GRCm39) L424Q probably damaging Het
Numb A C 12: 83,850,748 (GRCm39) L154R probably damaging Het
Or8k30 A G 2: 86,339,381 (GRCm39) K193E probably benign Het
Pdcd5 G T 7: 35,346,334 (GRCm39) A92E possibly damaging Het
Pdcl2 C T 5: 76,478,855 (GRCm39) probably null Het
Rbfa T C 18: 80,235,996 (GRCm39) Y251C probably damaging Het
Rgsl1 G A 1: 153,703,291 (GRCm39) T120I possibly damaging Het
Serpina3g A G 12: 104,206,655 (GRCm39) Q152R probably null Het
Setx T C 2: 29,063,570 (GRCm39) S2289P probably damaging Het
Slc6a16 A G 7: 44,907,017 (GRCm39) probably null Het
Slco1a6 C T 6: 142,055,105 (GRCm39) D280N probably benign Het
Syde2 T A 3: 145,704,568 (GRCm39) Y240N probably damaging Het
Synpo2 G A 3: 122,906,698 (GRCm39) Q873* probably null Het
Tlr2 A G 3: 83,744,301 (GRCm39) V594A probably benign Het
Ttc16 C T 2: 32,657,561 (GRCm39) A512T probably damaging Het
Tubb5 T C 17: 36,148,938 (GRCm39) E3G probably damaging Het
Vmn2r112 T C 17: 22,824,136 (GRCm39) Y464H probably damaging Het
Xcr1 T A 9: 123,684,847 (GRCm39) H305L probably damaging Het
Yars1 T G 4: 129,090,771 (GRCm39) probably null Het
Other mutations in Or8g27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01096:Or8g27 APN 9 39,129,412 (GRCm39) missense probably damaging 1.00
IGL01529:Or8g27 APN 9 39,129,427 (GRCm39) missense probably benign 0.30
IGL03307:Or8g27 APN 9 39,129,309 (GRCm39) missense probably benign 0.03
R0110:Or8g27 UTSW 9 39,129,024 (GRCm39) missense possibly damaging 0.50
R0413:Or8g27 UTSW 9 39,129,566 (GRCm39) missense probably benign 0.25
R0450:Or8g27 UTSW 9 39,129,024 (GRCm39) missense possibly damaging 0.50
R2108:Or8g27 UTSW 9 39,129,318 (GRCm39) missense probably damaging 0.99
R2112:Or8g27 UTSW 9 39,129,075 (GRCm39) missense probably benign 0.01
R4666:Or8g27 UTSW 9 39,129,142 (GRCm39) missense probably damaging 0.97
R5039:Or8g27 UTSW 9 39,129,410 (GRCm39) nonsense probably null
R8124:Or8g27 UTSW 9 39,128,967 (GRCm39) missense probably benign
R9104:Or8g27 UTSW 9 39,128,831 (GRCm39) missense probably damaging 1.00
R9290:Or8g27 UTSW 9 39,129,531 (GRCm39) missense probably damaging 1.00
R9328:Or8g27 UTSW 9 39,129,175 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TACAATTCTCTGATTTCGGGGTC -3'
(R):5'- AGGACACTTTTGCTTGGCCC -3'

Sequencing Primer
(F):5'- CTGATTTCGGGGTCATATATTTTTGC -3'
(R):5'- TGCTTGGCCCATAGAATTCAG -3'
Posted On 2018-05-04