Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01108:Vmn2r57'

51555

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r57

Ensembl Gene

ENSMUSG00000066537

Gene Name

vomeronasal 2, receptor 57

Synonyms

EG269902

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

IGL01108

Quality Score

Status

Chromosome

Chromosomal Location

41049156-41098065 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 41077008 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Lysine at position 386 (R386K)

Ref Sequence

ENSEMBL: ENSMUSP00000125817 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094532] [ENSMUST00000165029]

AlphaFold

L7N269

Predicted Effect

probably benign
Transcript: ENSMUST00000094532

Predicted Effect

probably benign
Transcript: ENSMUST00000165029
AA Change: R386K

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000125817
Gene: ENSMUSG00000066537
AA Change: R386K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	1.4e-44	PFAM
Pfam:NCD3G	514	567	2.7e-23	PFAM
Pfam:7tm_3	600	835	1.8e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Asah2	A	G	19: 31,986,081 (GRCm39)		probably benign	Het
Baz1a	A	G	12: 54,963,516 (GRCm39)	I856T	probably benign	Het
Cblb	T	A	16: 51,867,814 (GRCm39)		probably null	Het
Cpq	A	G	15: 33,497,433 (GRCm39)	Q391R	probably benign	Het
Dnah9	T	A	11: 65,740,806 (GRCm39)	T4127S	possibly damaging	Het
Dync2h1	A	G	9: 7,176,771 (GRCm39)	S63P	possibly damaging	Het
Ercc3	T	C	18: 32,397,638 (GRCm39)	V623A	probably damaging	Het
Fbxw9	A	G	8: 85,792,606 (GRCm39)		probably benign	Het
Gorasp2	T	A	2: 70,508,922 (GRCm39)	S133R	probably damaging	Het
Gtf2h1	G	A	7: 46,461,922 (GRCm39)	A307T	probably damaging	Het
Hk1	T	C	10: 62,132,487 (GRCm39)	K186R	probably benign	Het
Itga11	A	G	9: 62,664,903 (GRCm39)	E596G	probably benign	Het
Kcnj13	T	C	1: 87,314,659 (GRCm39)	I188V	probably benign	Het
Klhl18	A	T	9: 110,257,754 (GRCm39)	M492K	probably damaging	Het
Mctp2	T	C	7: 71,835,563 (GRCm39)	T545A	probably damaging	Het
Mgrn1	G	T	16: 4,734,019 (GRCm39)		probably null	Het
Mideas	T	C	12: 84,220,465 (GRCm39)	E163G	probably damaging	Het
Olfm4	T	C	14: 80,259,339 (GRCm39)	V529A	probably benign	Het
Or13f5	C	T	4: 52,825,727 (GRCm39)	T110I	probably damaging	Het
Parp4	T	G	14: 56,844,897 (GRCm39)	I596S	probably benign	Het
Plppr3	T	A	10: 79,703,355 (GRCm39)	D43V	probably damaging	Het
Prss51	A	T	14: 64,333,433 (GRCm39)	K14I	probably damaging	Het
Prss58	A	G	6: 40,874,278 (GRCm39)	C133R	probably damaging	Het
Recql5	A	T	11: 115,788,007 (GRCm39)	N437K	probably benign	Het
Samd10	A	G	2: 181,239,007 (GRCm39)	Y135H	probably damaging	Het
Scnn1b	G	T	7: 121,513,555 (GRCm39)		probably null	Het
Serpina7	C	T	X: 137,983,886 (GRCm39)	V58I	probably benign	Het
Slf1	A	T	13: 77,273,594 (GRCm39)		probably benign	Het
Tedc1	C	T	12: 113,126,808 (GRCm39)	R357*	probably null	Het
Urb1	C	T	16: 90,589,702 (GRCm39)	A360T	probably damaging	Het
Ush2a	G	T	1: 188,595,022 (GRCm39)	R3818L	probably benign	Het
Wnt3a	T	C	11: 59,147,135 (GRCm39)	N184D	probably benign	Het
Xpc	G	A	6: 91,469,987 (GRCm39)	R746W	probably damaging	Het

Other mutations in Vmn2r57

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Vmn2r57	APN	7	41,078,209 (GRCm39)	missense	probably benign
IGL01112:Vmn2r57	APN	7	41,074,467 (GRCm39)	missense	probably damaging	1.00
IGL01516:Vmn2r57	APN	7	41,049,370 (GRCm39)	missense	probably damaging	1.00
IGL01880:Vmn2r57	APN	7	41,049,619 (GRCm39)	missense	possibly damaging	0.73
IGL02117:Vmn2r57	APN	7	41,049,874 (GRCm39)	missense	probably benign	0.00
IGL02500:Vmn2r57	APN	7	41,077,650 (GRCm39)	missense	probably benign
IGL02801:Vmn2r57	APN	7	41,098,056 (GRCm39)	missense	probably benign	0.13
IGL02993:Vmn2r57	APN	7	41,077,498 (GRCm39)	missense	probably benign	0.04
IGL02996:Vmn2r57	APN	7	41,049,165 (GRCm39)	missense	probably benign	0.02
R0008:Vmn2r57	UTSW	7	41,050,076 (GRCm39)	missense	probably damaging	1.00
R0032:Vmn2r57	UTSW	7	41,049,157 (GRCm39)	splice site	probably null
R0305:Vmn2r57	UTSW	7	41,076,967 (GRCm39)	missense	probably benign	0.00
R0469:Vmn2r57	UTSW	7	41,077,216 (GRCm39)	missense	possibly damaging	0.58
R0510:Vmn2r57	UTSW	7	41,077,216 (GRCm39)	missense	possibly damaging	0.58
R0847:Vmn2r57	UTSW	7	41,078,225 (GRCm39)	missense	probably benign	0.00
R1025:Vmn2r57	UTSW	7	41,077,228 (GRCm39)	missense	probably benign	0.24
R1081:Vmn2r57	UTSW	7	41,077,635 (GRCm39)	missense	possibly damaging	0.47
R1479:Vmn2r57	UTSW	7	41,077,254 (GRCm39)	missense	possibly damaging	0.45
R1579:Vmn2r57	UTSW	7	41,049,548 (GRCm39)	missense	probably benign	0.38
R1764:Vmn2r57	UTSW	7	41,050,067 (GRCm39)	missense	probably damaging	1.00
R1848:Vmn2r57	UTSW	7	41,077,531 (GRCm39)	missense	probably damaging	1.00
R2006:Vmn2r57	UTSW	7	41,098,001 (GRCm39)	missense	probably benign	0.00
R2197:Vmn2r57	UTSW	7	41,078,249 (GRCm39)	critical splice acceptor site	probably null
R2242:Vmn2r57	UTSW	7	41,077,498 (GRCm39)	missense	probably benign	0.00
R2394:Vmn2r57	UTSW	7	41,049,619 (GRCm39)	missense	possibly damaging	0.73
R3937:Vmn2r57	UTSW	7	41,077,554 (GRCm39)	missense	probably damaging	0.97
R4193:Vmn2r57	UTSW	7	41,077,663 (GRCm39)	missense	probably benign
R4423:Vmn2r57	UTSW	7	41,076,064 (GRCm39)	missense	probably damaging	1.00
R4865:Vmn2r57	UTSW	7	41,049,892 (GRCm39)	missense	probably damaging	1.00
R4947:Vmn2r57	UTSW	7	41,049,919 (GRCm39)	missense	probably damaging	1.00
R5042:Vmn2r57	UTSW	7	41,078,086 (GRCm39)	missense	probably benign	0.06
R5084:Vmn2r57	UTSW	7	41,075,974 (GRCm39)	critical splice donor site	probably null
R5177:Vmn2r57	UTSW	7	41,049,664 (GRCm39)	missense	probably benign	0.31
R5192:Vmn2r57	UTSW	7	41,077,363 (GRCm39)	missense	probably damaging	0.96
R5289:Vmn2r57	UTSW	7	41,049,398 (GRCm39)	missense	probably damaging	0.99
R5745:Vmn2r57	UTSW	7	41,097,895 (GRCm39)	missense	possibly damaging	0.51
R6051:Vmn2r57	UTSW	7	41,097,896 (GRCm39)	missense	probably benign	0.00
R6155:Vmn2r57	UTSW	7	41,078,114 (GRCm39)	missense	probably benign	0.14
R6248:Vmn2r57	UTSW	7	41,049,284 (GRCm39)	missense	probably benign
R6381:Vmn2r57	UTSW	7	41,078,242 (GRCm39)	missense	probably benign	0.08
R7019:Vmn2r57	UTSW	7	41,078,089 (GRCm39)	missense	probably damaging	1.00
R7126:Vmn2r57	UTSW	7	41,049,218 (GRCm39)	missense	possibly damaging	0.93
R7146:Vmn2r57	UTSW	7	41,097,895 (GRCm39)	missense	possibly damaging	0.51
R7215:Vmn2r57	UTSW	7	41,049,710 (GRCm39)	missense	probably benign	0.00
R7432:Vmn2r57	UTSW	7	41,076,148 (GRCm39)	missense	probably benign	0.01
R7633:Vmn2r57	UTSW	7	41,074,513 (GRCm39)	missense	possibly damaging	0.76
R7811:Vmn2r57	UTSW	7	41,074,439 (GRCm39)	nonsense	probably null
R8025:Vmn2r57	UTSW	7	41,076,183 (GRCm39)	missense	probably benign	0.00
R8332:Vmn2r57	UTSW	7	41,049,677 (GRCm39)	missense	probably benign	0.01
R8345:Vmn2r57	UTSW	7	41,076,968 (GRCm39)	missense	possibly damaging	0.81
R8360:Vmn2r57	UTSW	7	41,049,640 (GRCm39)	missense	probably damaging	1.00
R8738:Vmn2r57	UTSW	7	41,077,020 (GRCm39)	missense	probably benign	0.00
R8758:Vmn2r57	UTSW	7	41,078,163 (GRCm39)	missense	probably damaging	1.00
R8955:Vmn2r57	UTSW	7	41,049,571 (GRCm39)	missense	possibly damaging	0.64
R8985:Vmn2r57	UTSW	7	41,049,259 (GRCm39)	missense	probably benign
R9108:Vmn2r57	UTSW	7	41,078,192 (GRCm39)	missense	possibly damaging	0.87
R9160:Vmn2r57	UTSW	7	41,076,159 (GRCm39)	missense	possibly damaging	0.48
R9354:Vmn2r57	UTSW	7	41,049,663 (GRCm39)	missense	probably benign	0.01
R9566:Vmn2r57	UTSW	7	41,077,089 (GRCm39)	missense	probably benign	0.32
R9633:Vmn2r57	UTSW	7	41,076,006 (GRCm39)	missense	probably benign	0.00
X0026:Vmn2r57	UTSW	7	41,077,985 (GRCm39)	missense	possibly damaging	0.91
X0026:Vmn2r57	UTSW	7	41,077,549 (GRCm39)	missense	probably benign	0.03
X0065:Vmn2r57	UTSW	7	41,077,395 (GRCm39)	missense	probably benign	0.09
Z1176:Vmn2r57	UTSW	7	41,049,922 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-06-21