Incidental Mutation 'R6385:Apon'
ID 515562
Institutional Source Beutler Lab
Gene Symbol Apon
Ensembl Gene ENSMUSG00000051716
Gene Name apolipoprotein N
Synonyms D10Ucla2
MMRRC Submission 044534-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R6385 (G1)
Quality Score 133.008
Status Not validated
Chromosome 10
Chromosomal Location 128090000-128091770 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) A to G at 128090223 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151553 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055539] [ENSMUST00000060782] [ENSMUST00000105242] [ENSMUST00000105244] [ENSMUST00000105245] [ENSMUST00000218722]
AlphaFold G3X9D6
Predicted Effect probably benign
Transcript: ENSMUST00000055539
SMART Domains Protein: ENSMUSP00000058021
Gene: ENSMUSG00000039994

DomainStartEndE-ValueType
Pfam:TIMELESS 21 285 2.2e-102 PFAM
low complexity region 381 395 N/A INTRINSIC
low complexity region 528 537 N/A INTRINSIC
low complexity region 653 682 N/A INTRINSIC
Pfam:TIMELESS_C 722 1197 1.9e-186 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000060782
SMART Domains Protein: ENSMUSP00000059142
Gene: ENSMUSG00000051716

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:Apolipo_F 50 247 2.1e-75 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000105240
Predicted Effect probably benign
Transcript: ENSMUST00000105242
SMART Domains Protein: ENSMUSP00000100876
Gene: ENSMUSG00000039994

DomainStartEndE-ValueType
Pfam:TIMELESS 21 285 2.1e-102 PFAM
low complexity region 381 395 N/A INTRINSIC
low complexity region 528 537 N/A INTRINSIC
low complexity region 653 682 N/A INTRINSIC
Pfam:TIMELESS_C 722 1196 4.4e-187 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105244
SMART Domains Protein: ENSMUSP00000100878
Gene: ENSMUSG00000039994

DomainStartEndE-ValueType
Pfam:TIMELESS 21 285 2.3e-103 PFAM
low complexity region 381 395 N/A INTRINSIC
low complexity region 528 537 N/A INTRINSIC
low complexity region 653 682 N/A INTRINSIC
Pfam:TIMELESS_C 722 1196 5e-187 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105245
SMART Domains Protein: ENSMUSP00000100879
Gene: ENSMUSG00000039994

DomainStartEndE-ValueType
Pfam:TIMELESS 24 284 1.1e-81 PFAM
low complexity region 381 395 N/A INTRINSIC
low complexity region 528 537 N/A INTRINSIC
low complexity region 653 682 N/A INTRINSIC
Pfam:TIMELESS_C 722 1197 1.9e-186 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000218722
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136854
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129147
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145710
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.4%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T A 14: 32,383,236 (GRCm39) M910L probably benign Het
Abca9 T A 11: 110,025,080 (GRCm39) I988F probably damaging Het
Adgra2 A T 8: 27,608,878 (GRCm39) S92C probably damaging Het
Arap3 G A 18: 38,130,084 (GRCm39) R26* probably null Het
Btnl6 T G 17: 34,727,343 (GRCm39) I396L probably benign Het
Catsper3 G T 13: 55,934,239 (GRCm39) Q53H probably damaging Het
Cep164 T G 9: 45,691,081 (GRCm39) E372A probably damaging Het
Cln3 A T 7: 126,174,207 (GRCm39) C339S probably null Het
Cntnap2 G A 6: 46,833,114 (GRCm39) D776N probably benign Het
Cttnbp2nl A G 3: 104,912,952 (GRCm39) F311L probably benign Het
Daam2 C T 17: 49,770,964 (GRCm39) A918T probably damaging Het
Dst T C 1: 34,346,549 (GRCm39) V7353A possibly damaging Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Fanca A T 8: 124,032,606 (GRCm39) probably null Het
Filip1 G T 9: 79,727,813 (GRCm39) Q269K possibly damaging Het
Fut9 G A 4: 25,620,328 (GRCm39) S162L probably damaging Het
Gtf2ird1 A T 5: 134,433,544 (GRCm39) H294Q probably benign Het
Gucy1a1 A G 3: 82,016,313 (GRCm39) I225T probably benign Het
H2-DMb1 T A 17: 34,374,576 (GRCm39) N75K probably benign Het
Helz2 C T 2: 180,875,260 (GRCm39) E1745K probably damaging Het
Hes1 A G 16: 29,884,424 (GRCm39) M6V possibly damaging Het
Hydin A T 8: 111,038,856 (GRCm39) H198L possibly damaging Het
Iars1 T C 13: 49,855,371 (GRCm39) L266P probably damaging Het
Ifna11 A G 4: 88,738,386 (GRCm39) E64G probably damaging Het
Inpp5d T A 1: 87,627,397 (GRCm39) L566Q probably damaging Het
Kcnh3 T C 15: 99,125,822 (GRCm39) S160P probably benign Het
Lama5 T C 2: 179,838,326 (GRCm39) T850A probably damaging Het
Lgi3 A G 14: 70,768,610 (GRCm39) T36A possibly damaging Het
Lrp2 T C 2: 69,326,128 (GRCm39) S1810G probably benign Het
Lypd10 A T 7: 24,413,535 (GRCm39) I184F probably damaging Het
Msln T A 17: 25,970,115 (GRCm39) D280V probably benign Het
Myh4 A T 11: 67,146,663 (GRCm39) I1513F probably damaging Het
Ncf2 A T 1: 152,706,173 (GRCm39) M262L probably benign Het
Neb G T 2: 52,075,311 (GRCm39) A218D probably damaging Het
Notch4 C A 17: 34,792,788 (GRCm39) Q640K probably null Het
Or4f7 T C 2: 111,644,964 (GRCm39) I36V probably benign Het
Or52e19b A T 7: 103,033,104 (GRCm39) V35D possibly damaging Het
Or6k6 A T 1: 173,944,862 (GRCm39) F240Y probably damaging Het
Pear1 G T 3: 87,661,506 (GRCm39) H562N probably benign Het
Poli C A 18: 70,663,072 (GRCm39) probably benign Het
Ppp3r2 A G 4: 49,681,767 (GRCm39) I61T possibly damaging Het
Rfc5 T C 5: 117,523,463 (GRCm39) T112A probably benign Het
Serhl A G 15: 82,985,823 (GRCm39) T5A probably benign Het
Shank3 T C 15: 89,405,578 (GRCm39) probably null Het
Slc22a28 A G 19: 8,078,844 (GRCm39) S282P probably damaging Het
Slc2a12 C T 10: 22,569,929 (GRCm39) T540I possibly damaging Het
Slurp2 T C 15: 74,618,524 (GRCm39) M1V probably null Het
St3gal1 A G 15: 66,983,195 (GRCm39) V187A possibly damaging Het
Tln2 C T 9: 67,185,411 (GRCm39) A700T probably benign Het
Ttn C T 2: 76,748,192 (GRCm39) V4286I probably benign Het
Ube2u A G 4: 100,389,341 (GRCm39) K214R possibly damaging Het
Vmn1r46 A G 6: 89,953,427 (GRCm39) H92R probably damaging Het
Wdr90 A G 17: 26,067,504 (GRCm39) I1486T probably damaging Het
Zc3h11a A T 1: 133,565,192 (GRCm39) S236T possibly damaging Het
Zfp318 A G 17: 46,721,932 (GRCm39) K1312E probably damaging Het
Zfp930 A G 8: 69,681,283 (GRCm39) Y326C probably damaging Het
Zfp972 G T 2: 177,563,588 (GRCm39) D8E probably damaging Het
Other mutations in Apon
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02535:Apon APN 10 128,090,823 (GRCm39) missense probably damaging 1.00
IGL03340:Apon APN 10 128,090,847 (GRCm39) missense probably benign 0.01
R1704:Apon UTSW 10 128,090,865 (GRCm39) missense probably damaging 1.00
R2178:Apon UTSW 10 128,090,634 (GRCm39) missense probably benign 0.01
R4853:Apon UTSW 10 128,090,951 (GRCm39) missense probably benign 0.13
R5323:Apon UTSW 10 128,090,907 (GRCm39) missense probably damaging 1.00
R7354:Apon UTSW 10 128,090,607 (GRCm39) missense probably benign 0.18
R7567:Apon UTSW 10 128,090,922 (GRCm39) missense possibly damaging 0.73
R7759:Apon UTSW 10 128,090,384 (GRCm39) missense probably benign 0.00
R7858:Apon UTSW 10 128,090,328 (GRCm39) missense probably benign 0.07
R8467:Apon UTSW 10 128,091,002 (GRCm39) missense probably benign
R8680:Apon UTSW 10 128,090,428 (GRCm39) missense probably benign 0.00
R9187:Apon UTSW 10 128,090,832 (GRCm39) missense probably benign 0.00
R9779:Apon UTSW 10 128,091,065 (GRCm39) missense probably benign 0.44
Predicted Primers
Posted On 2018-05-04