Incidental Mutation 'IGL01111:Cyp2a22'
ID 51561
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2a22
Ensembl Gene ENSMUSG00000091867
Gene Name cytochrome P450, family 2, subfamily a, polypeptide 22
Synonyms EG233005
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # IGL01111
Quality Score
Status
Chromosome 7
Chromosomal Location 26631056-26638809 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 26635883 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 227 (K227E)
Ref Sequence ENSEMBL: ENSMUSP00000128030 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170227]
AlphaFold B2RXZ2
Predicted Effect probably damaging
Transcript: ENSMUST00000170227
AA Change: K227E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128030
Gene: ENSMUSG00000091867
AA Change: K227E

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
Pfam:p450 33 489 7.4e-148 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206638
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206957
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ammecr1l T A 18: 31,905,123 (GRCm39) Y121* probably null Het
Apc C T 18: 34,448,189 (GRCm39) T1661I possibly damaging Het
Ccdc13 T C 9: 121,639,150 (GRCm39) probably benign Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Cpt1c T C 7: 44,614,978 (GRCm39) H325R possibly damaging Het
Ddx10 T C 9: 53,071,248 (GRCm39) K682E possibly damaging Het
Dlg2 T C 7: 91,098,971 (GRCm39) Y123H possibly damaging Het
Dnaaf9 G T 2: 130,578,518 (GRCm39) D655E possibly damaging Het
Dnah11 A T 12: 118,106,669 (GRCm39) probably benign Het
Dpysl2 T C 14: 67,071,681 (GRCm39) E153G probably damaging Het
Edrf1 T A 7: 133,260,282 (GRCm39) Y64* probably null Het
Ephb2 A T 4: 136,384,721 (GRCm39) S897T probably benign Het
Flt1 A G 5: 147,515,146 (GRCm39) I1092T probably damaging Het
Gabra4 T C 5: 71,790,972 (GRCm39) Y290C probably damaging Het
Hectd2 A T 19: 36,574,520 (GRCm39) H67L probably damaging Het
Itgb2 T C 10: 77,377,834 (GRCm39) L11P probably damaging Het
Jmy T C 13: 93,577,529 (GRCm39) R880G probably damaging Het
Klhl2 A G 8: 65,202,081 (GRCm39) C532R probably damaging Het
Kpna1 A G 16: 35,833,259 (GRCm39) probably benign Het
L3mbtl2 T C 15: 81,569,099 (GRCm39) V591A possibly damaging Het
Ldc1 T A 4: 130,115,518 (GRCm39) D10V probably benign Het
Lepr A T 4: 101,671,852 (GRCm39) N959Y possibly damaging Het
Man1a A T 10: 53,853,109 (GRCm39) probably benign Het
Mov10 A T 3: 104,708,721 (GRCm39) S431T possibly damaging Het
Mx2 A T 16: 97,359,919 (GRCm39) Q563L probably benign Het
Nrap A T 19: 56,333,990 (GRCm39) Y874N probably damaging Het
Nup160 T C 2: 90,563,553 (GRCm39) I1373T probably benign Het
Nwd2 A T 5: 63,964,643 (GRCm39) D1409V probably damaging Het
Obsl1 A T 1: 75,473,789 (GRCm39) V744E possibly damaging Het
Or51l4 T A 7: 103,404,580 (GRCm39) T71S probably benign Het
Pgap1 T C 1: 54,570,102 (GRCm39) K315R probably benign Het
Rab8a T C 8: 72,929,700 (GRCm39) V114A probably damaging Het
Sh2d6 T C 6: 72,496,812 (GRCm39) T73A probably benign Het
Shroom1 A G 11: 53,354,875 (GRCm39) E265G probably damaging Het
Slc8b1 G A 5: 120,671,000 (GRCm39) V529M probably damaging Het
Srbd1 G T 17: 86,405,961 (GRCm39) A613E probably benign Het
Stat1 G A 1: 52,182,120 (GRCm39) probably null Het
Tbck A G 3: 132,400,168 (GRCm39) H73R probably damaging Het
Thg1l A T 11: 45,839,051 (GRCm39) D220E probably damaging Het
Ttn C T 2: 76,608,667 (GRCm39) G16037D probably damaging Het
Unc13b A G 4: 43,096,927 (GRCm39) E100G possibly damaging Het
Vmn2r81 T A 10: 79,083,831 (GRCm39) D68E probably benign Het
Xpo6 T C 7: 125,728,740 (GRCm39) T505A probably benign Het
Zfp976 T C 7: 42,265,711 (GRCm39) K25E probably damaging Het
Other mutations in Cyp2a22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00156:Cyp2a22 APN 7 26,637,163 (GRCm39) missense probably benign 0.09
IGL01388:Cyp2a22 APN 7 26,637,217 (GRCm39) missense probably benign 0.02
IGL01449:Cyp2a22 APN 7 26,632,978 (GRCm39) missense probably benign 0.01
IGL01642:Cyp2a22 APN 7 26,638,184 (GRCm39) missense possibly damaging 0.81
IGL02253:Cyp2a22 APN 7 26,637,662 (GRCm39) splice site probably benign
IGL02327:Cyp2a22 APN 7 26,634,206 (GRCm39) missense probably damaging 0.99
IGL02673:Cyp2a22 APN 7 26,637,525 (GRCm39) missense probably benign 0.00
IGL02813:Cyp2a22 APN 7 26,635,859 (GRCm39) missense probably benign 0.19
IGL02896:Cyp2a22 APN 7 26,635,886 (GRCm39) missense probably damaging 0.98
IGL03193:Cyp2a22 APN 7 26,635,846 (GRCm39) missense probably benign 0.00
IGL03350:Cyp2a22 APN 7 26,634,279 (GRCm39) missense possibly damaging 0.88
R1648:Cyp2a22 UTSW 7 26,631,793 (GRCm39) missense probably damaging 0.98
R1679:Cyp2a22 UTSW 7 26,635,736 (GRCm39) nonsense probably null
R1733:Cyp2a22 UTSW 7 26,634,187 (GRCm39) missense possibly damaging 0.78
R2001:Cyp2a22 UTSW 7 26,634,197 (GRCm39) missense probably damaging 1.00
R2858:Cyp2a22 UTSW 7 26,633,687 (GRCm39) missense probably damaging 0.99
R3054:Cyp2a22 UTSW 7 26,638,254 (GRCm39) missense probably damaging 1.00
R4528:Cyp2a22 UTSW 7 26,634,194 (GRCm39) missense possibly damaging 0.95
R4623:Cyp2a22 UTSW 7 26,632,916 (GRCm39) missense probably damaging 1.00
R4669:Cyp2a22 UTSW 7 26,637,280 (GRCm39) missense possibly damaging 0.88
R4690:Cyp2a22 UTSW 7 26,638,634 (GRCm39) nonsense probably null
R4840:Cyp2a22 UTSW 7 26,631,949 (GRCm39) missense probably benign 0.13
R4915:Cyp2a22 UTSW 7 26,637,195 (GRCm39) missense probably benign 0.33
R5071:Cyp2a22 UTSW 7 26,631,906 (GRCm39) missense probably benign 0.01
R5072:Cyp2a22 UTSW 7 26,631,906 (GRCm39) missense probably benign 0.01
R5074:Cyp2a22 UTSW 7 26,631,906 (GRCm39) missense probably benign 0.01
R5147:Cyp2a22 UTSW 7 26,635,750 (GRCm39) missense probably damaging 1.00
R5363:Cyp2a22 UTSW 7 26,635,858 (GRCm39) missense probably damaging 0.99
R5705:Cyp2a22 UTSW 7 26,638,640 (GRCm39) missense probably benign 0.05
R6014:Cyp2a22 UTSW 7 26,638,605 (GRCm39) splice site probably null
R6042:Cyp2a22 UTSW 7 26,633,664 (GRCm39) missense probably damaging 1.00
R6253:Cyp2a22 UTSW 7 26,633,657 (GRCm39) missense probably benign 0.18
R6757:Cyp2a22 UTSW 7 26,638,629 (GRCm39) missense probably benign 0.00
R6994:Cyp2a22 UTSW 7 26,638,606 (GRCm39) critical splice donor site probably null
R7581:Cyp2a22 UTSW 7 26,637,573 (GRCm39) missense possibly damaging 0.87
R8212:Cyp2a22 UTSW 7 26,637,205 (GRCm39) missense possibly damaging 0.89
R9225:Cyp2a22 UTSW 7 26,637,202 (GRCm39) missense possibly damaging 0.81
R9749:Cyp2a22 UTSW 7 26,638,715 (GRCm39) missense probably null 0.41
Posted On 2013-06-21