Incidental Mutation 'R6386:Zfp874b'
ID 515614
Institutional Source Beutler Lab
Gene Symbol Zfp874b
Ensembl Gene ENSMUSG00000059839
Gene Name zinc finger protein 874b
Synonyms 9630025I21Rik
MMRRC Submission 044535-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R6386 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 67619632-67632377 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 67622962 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 116 (D116G)
Ref Sequence ENSEMBL: ENSMUSP00000153242 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019572] [ENSMUST00000223868]
AlphaFold Q7M6X2
Predicted Effect probably benign
Transcript: ENSMUST00000019572
AA Change: D112G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000019572
Gene: ENSMUSG00000059839
AA Change: D112G

DomainStartEndE-ValueType
KRAB 5 65 4.48e-26 SMART
ZnF_C2H2 136 158 5.9e-3 SMART
ZnF_C2H2 164 186 3.16e-3 SMART
ZnF_C2H2 192 214 6.78e-3 SMART
ZnF_C2H2 220 242 2.4e-3 SMART
ZnF_C2H2 248 268 1.88e2 SMART
ZnF_C2H2 276 298 6.42e-4 SMART
ZnF_C2H2 304 326 2.12e-4 SMART
ZnF_C2H2 332 354 1.28e-3 SMART
ZnF_C2H2 360 382 8.47e-4 SMART
ZnF_C2H2 388 410 1.79e-2 SMART
ZnF_C2H2 416 438 1.47e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223711
Predicted Effect possibly damaging
Transcript: ENSMUST00000223868
AA Change: D116G

PolyPhen 2 Score 0.697 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223925
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224308
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225027
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 96.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ak6 TGACGA TGA 13: 100,792,311 (GRCm39) probably benign Het
Arap2 A T 5: 62,761,865 (GRCm39) N1620K possibly damaging Het
Atf6b T C 17: 34,870,825 (GRCm39) S396P probably damaging Het
Cc2d1a A G 8: 84,865,166 (GRCm39) M469T probably damaging Het
Ceacam3 A G 7: 16,892,144 (GRCm39) N296D probably benign Het
Cep57l1 A T 10: 41,619,128 (GRCm39) S80T probably damaging Het
Clip4 C A 17: 72,141,189 (GRCm39) Y514* probably null Het
Cop1 T C 1: 159,116,601 (GRCm39) I125T probably damaging Het
Cstf1 T C 2: 172,219,816 (GRCm39) V309A probably damaging Het
Cyp4a29 T G 4: 115,104,272 (GRCm39) probably null Het
F830045P16Rik G A 2: 129,314,738 (GRCm39) H180Y probably damaging Het
Foxp4 T C 17: 48,189,387 (GRCm39) K237E unknown Het
Fstl5 A T 3: 76,229,373 (GRCm39) H58L probably benign Het
Gje1 A G 10: 14,592,365 (GRCm39) F139S probably damaging Het
Gpatch1 T C 7: 34,991,265 (GRCm39) D593G probably damaging Het
Inpp5d T A 1: 87,627,397 (GRCm39) L566Q probably damaging Het
Mtch2 A G 2: 90,679,739 (GRCm39) T38A probably benign Het
Mvb12b A T 2: 33,717,754 (GRCm39) I129N probably damaging Het
Npffr2 T C 5: 89,730,556 (GRCm39) V162A probably benign Het
Or4d10b A T 19: 12,036,920 (GRCm39) N65K probably damaging Het
Or5p61 A T 7: 107,758,409 (GRCm39) Y224N probably damaging Het
Pkhd1 G A 1: 20,621,244 (GRCm39) R805C probably damaging Het
Ppp4r4 T C 12: 103,559,364 (GRCm39) L406P probably damaging Het
Prl3d2 A G 13: 27,311,286 (GRCm39) D186G probably damaging Het
Rfc5 T C 5: 117,523,463 (GRCm39) T112A probably benign Het
Rnf148 A G 6: 23,654,483 (GRCm39) L171P probably damaging Het
Rps24 G A 14: 24,542,116 (GRCm39) G71S possibly damaging Het
Slco2a1 G A 9: 102,954,187 (GRCm39) V453I probably benign Het
Spidr T C 16: 15,786,424 (GRCm39) K440E probably benign Het
Syndig1 C A 2: 149,741,496 (GRCm39) N27K probably damaging Het
Tmem62 C T 2: 120,829,595 (GRCm39) T316I probably benign Het
Tpgs2 A T 18: 25,272,081 (GRCm39) I258N possibly damaging Het
Vmn2r78 A T 7: 86,571,545 (GRCm39) R452* probably null Het
Wasf3 A T 5: 146,390,227 (GRCm39) I124F possibly damaging Het
Wbp11 T C 6: 136,797,523 (GRCm39) T299A probably benign Het
Wdr25 T C 12: 108,990,991 (GRCm39) S41P probably damaging Het
Other mutations in Zfp874b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02172:Zfp874b APN 13 67,622,135 (GRCm39) missense probably damaging 1.00
R0432:Zfp874b UTSW 13 67,629,955 (GRCm39) missense probably damaging 1.00
R0653:Zfp874b UTSW 13 67,623,052 (GRCm39) missense possibly damaging 0.69
R0727:Zfp874b UTSW 13 67,622,831 (GRCm39) missense probably damaging 1.00
R1475:Zfp874b UTSW 13 67,622,211 (GRCm39) splice site probably null
R1726:Zfp874b UTSW 13 67,622,839 (GRCm39) missense probably damaging 1.00
R5484:Zfp874b UTSW 13 67,629,373 (GRCm39) missense possibly damaging 0.76
R7029:Zfp874b UTSW 13 67,622,392 (GRCm39) missense probably damaging 0.98
R7150:Zfp874b UTSW 13 67,622,622 (GRCm39) nonsense probably null
R7726:Zfp874b UTSW 13 67,621,975 (GRCm39) missense probably benign 0.01
R7778:Zfp874b UTSW 13 67,622,093 (GRCm39) missense probably benign 0.03
R7824:Zfp874b UTSW 13 67,622,093 (GRCm39) missense probably benign 0.03
R7918:Zfp874b UTSW 13 67,622,279 (GRCm39) missense possibly damaging 0.74
R7939:Zfp874b UTSW 13 67,622,622 (GRCm39) nonsense probably null
R8053:Zfp874b UTSW 13 67,622,217 (GRCm39) missense probably damaging 0.96
R8881:Zfp874b UTSW 13 67,622,141 (GRCm39) missense probably damaging 0.99
X0028:Zfp874b UTSW 13 67,622,179 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- CCTTTATGCTGGTTAAGAAAGAAAGC -3'
(R):5'- ACTAGAAGGATAGATCAGATCAGCTAC -3'

Sequencing Primer
(F):5'- GAAGAAAGGCTTTGTCACACTC -3'
(R):5'- CTTGCTCAACAGGAACAAC -3'
Posted On 2018-05-04