Incidental Mutation 'R6386:Or4d10b'
ID 515622
Institutional Source Beutler Lab
Gene Symbol Or4d10b
Ensembl Gene ENSMUSG00000067528
Gene Name olfactory receptor family 4 subfamily D member 10B
Synonyms GA_x6K02T2RE5P-2418550-2417609, MOR239-2, Olfr1424
MMRRC Submission 044535-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R6386 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 12036173-12037114 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 12036920 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 65 (N65K)
Ref Sequence ENSEMBL: ENSMUSP00000146552 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087830] [ENSMUST00000207681]
AlphaFold Q8VFV1
Predicted Effect probably damaging
Transcript: ENSMUST00000087830
AA Change: N65K

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000085132
Gene: ENSMUSG00000067528
AA Change: N65K

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 2.4e-47 PFAM
Pfam:7tm_1 41 306 2.8e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207681
AA Change: N65K

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 96.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ak6 TGACGA TGA 13: 100,792,311 (GRCm39) probably benign Het
Arap2 A T 5: 62,761,865 (GRCm39) N1620K possibly damaging Het
Atf6b T C 17: 34,870,825 (GRCm39) S396P probably damaging Het
Cc2d1a A G 8: 84,865,166 (GRCm39) M469T probably damaging Het
Ceacam3 A G 7: 16,892,144 (GRCm39) N296D probably benign Het
Cep57l1 A T 10: 41,619,128 (GRCm39) S80T probably damaging Het
Clip4 C A 17: 72,141,189 (GRCm39) Y514* probably null Het
Cop1 T C 1: 159,116,601 (GRCm39) I125T probably damaging Het
Cstf1 T C 2: 172,219,816 (GRCm39) V309A probably damaging Het
Cyp4a29 T G 4: 115,104,272 (GRCm39) probably null Het
F830045P16Rik G A 2: 129,314,738 (GRCm39) H180Y probably damaging Het
Foxp4 T C 17: 48,189,387 (GRCm39) K237E unknown Het
Fstl5 A T 3: 76,229,373 (GRCm39) H58L probably benign Het
Gje1 A G 10: 14,592,365 (GRCm39) F139S probably damaging Het
Gpatch1 T C 7: 34,991,265 (GRCm39) D593G probably damaging Het
Inpp5d T A 1: 87,627,397 (GRCm39) L566Q probably damaging Het
Mtch2 A G 2: 90,679,739 (GRCm39) T38A probably benign Het
Mvb12b A T 2: 33,717,754 (GRCm39) I129N probably damaging Het
Npffr2 T C 5: 89,730,556 (GRCm39) V162A probably benign Het
Or5p61 A T 7: 107,758,409 (GRCm39) Y224N probably damaging Het
Pkhd1 G A 1: 20,621,244 (GRCm39) R805C probably damaging Het
Ppp4r4 T C 12: 103,559,364 (GRCm39) L406P probably damaging Het
Prl3d2 A G 13: 27,311,286 (GRCm39) D186G probably damaging Het
Rfc5 T C 5: 117,523,463 (GRCm39) T112A probably benign Het
Rnf148 A G 6: 23,654,483 (GRCm39) L171P probably damaging Het
Rps24 G A 14: 24,542,116 (GRCm39) G71S possibly damaging Het
Slco2a1 G A 9: 102,954,187 (GRCm39) V453I probably benign Het
Spidr T C 16: 15,786,424 (GRCm39) K440E probably benign Het
Syndig1 C A 2: 149,741,496 (GRCm39) N27K probably damaging Het
Tmem62 C T 2: 120,829,595 (GRCm39) T316I probably benign Het
Tpgs2 A T 18: 25,272,081 (GRCm39) I258N possibly damaging Het
Vmn2r78 A T 7: 86,571,545 (GRCm39) R452* probably null Het
Wasf3 A T 5: 146,390,227 (GRCm39) I124F possibly damaging Het
Wbp11 T C 6: 136,797,523 (GRCm39) T299A probably benign Het
Wdr25 T C 12: 108,990,991 (GRCm39) S41P probably damaging Het
Zfp874b T C 13: 67,622,962 (GRCm39) D116G possibly damaging Het
Other mutations in Or4d10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02045:Or4d10b APN 19 12,036,253 (GRCm39) missense possibly damaging 0.96
IGL02095:Or4d10b APN 19 12,036,913 (GRCm39) missense probably benign 0.00
IGL02743:Or4d10b APN 19 12,036,811 (GRCm39) missense probably damaging 1.00
IGL02745:Or4d10b APN 19 12,036,565 (GRCm39) missense probably benign 0.05
R0834:Or4d10b UTSW 19 12,036,979 (GRCm39) missense probably benign 0.00
R1474:Or4d10b UTSW 19 12,036,844 (GRCm39) missense probably benign 0.30
R5590:Or4d10b UTSW 19 12,036,642 (GRCm39) missense probably benign 0.01
R6864:Or4d10b UTSW 19 12,036,777 (GRCm39) missense probably damaging 1.00
R8207:Or4d10b UTSW 19 12,036,222 (GRCm39) missense possibly damaging 0.94
R8213:Or4d10b UTSW 19 12,036,456 (GRCm39) missense probably benign 0.32
R9284:Or4d10b UTSW 19 12,036,273 (GRCm39) missense probably damaging 0.98
R9773:Or4d10b UTSW 19 12,036,939 (GRCm39) missense possibly damaging 0.94
Z1088:Or4d10b UTSW 19 12,036,493 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TCGATCTAGAGCCATCACAGAC -3'
(R):5'- AGGAGCTTCTGAATTGTGCCC -3'

Sequencing Primer
(F):5'- GAGCCATCACAGACAGAGAAAATGC -3'
(R):5'- TCTGAATTGTGCCCTAAGAGC -3'
Posted On 2018-05-04