Incidental Mutation 'R6391:Zfp959'
ID 515785
Institutional Source Beutler Lab
Gene Symbol Zfp959
Ensembl Gene ENSMUSG00000003198
Gene Name zinc finger protein 959
Synonyms BC011426
MMRRC Submission 044540-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R6391 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 56199093-56205928 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 56202854 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 10 (F10L)
Ref Sequence ENSEMBL: ENSMUSP00000153698 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054780] [ENSMUST00000224379]
AlphaFold Q91VM8
Predicted Effect possibly damaging
Transcript: ENSMUST00000054780
AA Change: F13L

PolyPhen 2 Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000053979
Gene: ENSMUSG00000003198
AA Change: F13L

DomainStartEndE-ValueType
KRAB 4 66 5.28e-14 SMART
ZnF_C2H2 155 177 2.57e2 SMART
ZnF_C2H2 287 309 1.1e-2 SMART
ZnF_C2H2 315 337 4.17e-3 SMART
ZnF_C2H2 343 365 1.47e-3 SMART
ZnF_C2H2 371 393 5.14e-3 SMART
ZnF_C2H2 399 421 1.82e-3 SMART
ZnF_C2H2 427 449 1.98e-4 SMART
ZnF_C2H2 455 477 2.57e-3 SMART
ZnF_C2H2 483 505 7.26e-3 SMART
ZnF_C2H2 511 533 1.72e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224294
Predicted Effect probably damaging
Transcript: ENSMUST00000224379
AA Change: F10L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 98% (40/41)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcl7b G T 5: 135,208,879 (GRCm39) S114I probably damaging Het
Cct8 A T 16: 87,284,566 (GRCm39) M207K probably benign Het
Cnga1 A G 5: 72,769,702 (GRCm39) probably null Het
Cst13 T C 2: 148,670,111 (GRCm39) C94R probably damaging Het
Cyp8b1 G T 9: 121,744,864 (GRCm39) S156* probably null Het
Dip2b T C 15: 100,049,157 (GRCm39) S184P probably damaging Het
Dmbt1 T C 7: 130,659,984 (GRCm39) W516R probably damaging Het
Dock8 A T 19: 25,072,914 (GRCm39) Y398F possibly damaging Het
Drosha T A 15: 12,889,803 (GRCm39) C890* probably null Het
Eed A G 7: 89,626,149 (GRCm39) S75P probably benign Het
Efcab3 T C 11: 104,885,143 (GRCm39) L4134S possibly damaging Het
Etaa1 A C 11: 17,896,833 (GRCm39) I428S probably benign Het
F5 A T 1: 164,021,062 (GRCm39) D1179V probably damaging Het
Fat1 T C 8: 45,405,379 (GRCm39) V710A possibly damaging Het
Fmo4 G A 1: 162,621,538 (GRCm39) Q558* probably null Het
Gm7361 A G 5: 26,463,960 (GRCm39) I72V probably benign Het
Grm4 A G 17: 27,654,294 (GRCm39) V552A probably benign Het
Krt13 T A 11: 100,010,202 (GRCm39) I260F probably damaging Het
Krtap3-3 T C 11: 99,441,490 (GRCm39) D49G probably damaging Het
Lpin1 T C 12: 16,614,554 (GRCm39) E409G probably benign Het
Ly9 A G 1: 171,428,576 (GRCm39) V238A possibly damaging Het
Map2k6 T C 11: 110,381,703 (GRCm39) probably null Het
Mylk2 T C 2: 152,759,315 (GRCm39) L362P probably damaging Het
Or4c120 T A 2: 89,000,942 (GRCm39) I205F probably benign Het
Or4c3 A G 2: 89,851,975 (GRCm39) V145A probably benign Het
Or51a6 T A 7: 102,604,622 (GRCm39) Y69F possibly damaging Het
Pcdha9 G A 18: 37,130,972 (GRCm39) V14M probably benign Het
Pdzrn4 A T 15: 92,578,418 (GRCm39) E380D probably damaging Het
Piezo2 A G 18: 63,239,364 (GRCm39) Y739H possibly damaging Het
Pigk A G 3: 152,446,486 (GRCm39) H195R probably benign Het
Plin2 T C 4: 86,580,236 (GRCm39) D175G probably null Het
Plk4 T A 3: 40,763,408 (GRCm39) H526Q probably benign Het
Pom121l12 A T 11: 14,549,489 (GRCm39) D65V probably damaging Het
Prb1a T C 6: 132,184,139 (GRCm39) Y498C unknown Het
Sh3bp2 G A 5: 34,718,947 (GRCm39) V495I probably damaging Het
Slx4ip T A 2: 136,888,669 (GRCm39) C117S probably damaging Het
Tmtc2 A T 10: 105,409,551 (GRCm39) S20R probably benign Het
Unc79 A G 12: 102,987,269 (GRCm39) Y186C probably damaging Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Vmn2r26 T C 6: 124,038,348 (GRCm39) L641P probably damaging Het
Wdr17 A T 8: 55,114,495 (GRCm39) S674T probably benign Het
Other mutations in Zfp959
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00698:Zfp959 APN 17 56,204,565 (GRCm39) missense possibly damaging 0.91
IGL02731:Zfp959 APN 17 56,202,956 (GRCm39) splice site probably benign
IGL03206:Zfp959 APN 17 56,204,613 (GRCm39) missense possibly damaging 0.78
R0141:Zfp959 UTSW 17 56,205,139 (GRCm39) missense probably benign 0.41
R0347:Zfp959 UTSW 17 56,204,180 (GRCm39) nonsense probably null
R0522:Zfp959 UTSW 17 56,203,201 (GRCm39) missense probably null 1.00
R1692:Zfp959 UTSW 17 56,205,299 (GRCm39) missense probably damaging 0.99
R1771:Zfp959 UTSW 17 56,204,677 (GRCm39) splice site probably null
R1891:Zfp959 UTSW 17 56,204,604 (GRCm39) missense probably damaging 1.00
R1945:Zfp959 UTSW 17 56,204,231 (GRCm39) nonsense probably null
R1959:Zfp959 UTSW 17 56,204,404 (GRCm39) missense probably damaging 0.98
R2317:Zfp959 UTSW 17 56,204,326 (GRCm39) missense possibly damaging 0.59
R4726:Zfp959 UTSW 17 56,205,260 (GRCm39) splice site probably null
R4869:Zfp959 UTSW 17 56,204,228 (GRCm39) missense possibly damaging 0.95
R5436:Zfp959 UTSW 17 56,204,626 (GRCm39) missense probably benign
R6235:Zfp959 UTSW 17 56,204,427 (GRCm39) missense probably damaging 1.00
R6365:Zfp959 UTSW 17 56,204,785 (GRCm39) missense probably damaging 1.00
R6417:Zfp959 UTSW 17 56,205,094 (GRCm39) missense probably damaging 1.00
R6420:Zfp959 UTSW 17 56,205,094 (GRCm39) missense probably damaging 1.00
R7114:Zfp959 UTSW 17 56,205,501 (GRCm39) missense possibly damaging 0.94
R7380:Zfp959 UTSW 17 56,205,551 (GRCm39) missense possibly damaging 0.94
R7437:Zfp959 UTSW 17 56,205,334 (GRCm39) missense probably damaging 1.00
R7568:Zfp959 UTSW 17 56,204,886 (GRCm39) missense probably benign 0.01
R8114:Zfp959 UTSW 17 56,205,496 (GRCm39) missense probably benign 0.09
R8197:Zfp959 UTSW 17 56,204,677 (GRCm39) missense probably damaging 1.00
R8389:Zfp959 UTSW 17 56,204,299 (GRCm39) missense probably benign
R8970:Zfp959 UTSW 17 56,204,836 (GRCm39) missense possibly damaging 0.72
R9063:Zfp959 UTSW 17 56,204,221 (GRCm39) missense probably benign 0.18
R9504:Zfp959 UTSW 17 56,204,793 (GRCm39) missense probably benign 0.06
R9648:Zfp959 UTSW 17 56,204,212 (GRCm39) missense possibly damaging 0.70
R9733:Zfp959 UTSW 17 56,204,866 (GRCm39) missense probably benign 0.06
Z1088:Zfp959 UTSW 17 56,205,135 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- ATGCCTTATTCATCATGAACAGAAGT -3'
(R):5'- TTGCAGTCTTCCCACATGTAGC -3'

Sequencing Primer
(F):5'- AGTGAGAGGCATGATTCTCCTTTAC -3'
(R):5'- CTGTGAACTTTAGAACAGTGCCC -3'
Posted On 2018-05-04