Incidental Mutation 'R6391:Zfp959'
ID |
515785 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp959
|
Ensembl Gene |
ENSMUSG00000003198 |
Gene Name |
zinc finger protein 959 |
Synonyms |
BC011426 |
MMRRC Submission |
044540-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.057)
|
Stock # |
R6391 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
56199093-56205928 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 56202854 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Leucine
at position 10
(F10L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000153698
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054780]
[ENSMUST00000224379]
|
AlphaFold |
Q91VM8 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000054780
AA Change: F13L
PolyPhen 2
Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000053979 Gene: ENSMUSG00000003198 AA Change: F13L
Domain | Start | End | E-Value | Type |
KRAB
|
4 |
66 |
5.28e-14 |
SMART |
ZnF_C2H2
|
155 |
177 |
2.57e2 |
SMART |
ZnF_C2H2
|
287 |
309 |
1.1e-2 |
SMART |
ZnF_C2H2
|
315 |
337 |
4.17e-3 |
SMART |
ZnF_C2H2
|
343 |
365 |
1.47e-3 |
SMART |
ZnF_C2H2
|
371 |
393 |
5.14e-3 |
SMART |
ZnF_C2H2
|
399 |
421 |
1.82e-3 |
SMART |
ZnF_C2H2
|
427 |
449 |
1.98e-4 |
SMART |
ZnF_C2H2
|
455 |
477 |
2.57e-3 |
SMART |
ZnF_C2H2
|
483 |
505 |
7.26e-3 |
SMART |
ZnF_C2H2
|
511 |
533 |
1.72e-4 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224294
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000224379
AA Change: F10L
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 98.2%
|
Validation Efficiency |
98% (40/41) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 41 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Bcl7b |
G |
T |
5: 135,208,879 (GRCm39) |
S114I |
probably damaging |
Het |
Cct8 |
A |
T |
16: 87,284,566 (GRCm39) |
M207K |
probably benign |
Het |
Cnga1 |
A |
G |
5: 72,769,702 (GRCm39) |
|
probably null |
Het |
Cst13 |
T |
C |
2: 148,670,111 (GRCm39) |
C94R |
probably damaging |
Het |
Cyp8b1 |
G |
T |
9: 121,744,864 (GRCm39) |
S156* |
probably null |
Het |
Dip2b |
T |
C |
15: 100,049,157 (GRCm39) |
S184P |
probably damaging |
Het |
Dmbt1 |
T |
C |
7: 130,659,984 (GRCm39) |
W516R |
probably damaging |
Het |
Dock8 |
A |
T |
19: 25,072,914 (GRCm39) |
Y398F |
possibly damaging |
Het |
Drosha |
T |
A |
15: 12,889,803 (GRCm39) |
C890* |
probably null |
Het |
Eed |
A |
G |
7: 89,626,149 (GRCm39) |
S75P |
probably benign |
Het |
Efcab3 |
T |
C |
11: 104,885,143 (GRCm39) |
L4134S |
possibly damaging |
Het |
Etaa1 |
A |
C |
11: 17,896,833 (GRCm39) |
I428S |
probably benign |
Het |
F5 |
A |
T |
1: 164,021,062 (GRCm39) |
D1179V |
probably damaging |
Het |
Fat1 |
T |
C |
8: 45,405,379 (GRCm39) |
V710A |
possibly damaging |
Het |
Fmo4 |
G |
A |
1: 162,621,538 (GRCm39) |
Q558* |
probably null |
Het |
Gm7361 |
A |
G |
5: 26,463,960 (GRCm39) |
I72V |
probably benign |
Het |
Grm4 |
A |
G |
17: 27,654,294 (GRCm39) |
V552A |
probably benign |
Het |
Krt13 |
T |
A |
11: 100,010,202 (GRCm39) |
I260F |
probably damaging |
Het |
Krtap3-3 |
T |
C |
11: 99,441,490 (GRCm39) |
D49G |
probably damaging |
Het |
Lpin1 |
T |
C |
12: 16,614,554 (GRCm39) |
E409G |
probably benign |
Het |
Ly9 |
A |
G |
1: 171,428,576 (GRCm39) |
V238A |
possibly damaging |
Het |
Map2k6 |
T |
C |
11: 110,381,703 (GRCm39) |
|
probably null |
Het |
Mylk2 |
T |
C |
2: 152,759,315 (GRCm39) |
L362P |
probably damaging |
Het |
Or4c120 |
T |
A |
2: 89,000,942 (GRCm39) |
I205F |
probably benign |
Het |
Or4c3 |
A |
G |
2: 89,851,975 (GRCm39) |
V145A |
probably benign |
Het |
Or51a6 |
T |
A |
7: 102,604,622 (GRCm39) |
Y69F |
possibly damaging |
Het |
Pcdha9 |
G |
A |
18: 37,130,972 (GRCm39) |
V14M |
probably benign |
Het |
Pdzrn4 |
A |
T |
15: 92,578,418 (GRCm39) |
E380D |
probably damaging |
Het |
Piezo2 |
A |
G |
18: 63,239,364 (GRCm39) |
Y739H |
possibly damaging |
Het |
Pigk |
A |
G |
3: 152,446,486 (GRCm39) |
H195R |
probably benign |
Het |
Plin2 |
T |
C |
4: 86,580,236 (GRCm39) |
D175G |
probably null |
Het |
Plk4 |
T |
A |
3: 40,763,408 (GRCm39) |
H526Q |
probably benign |
Het |
Pom121l12 |
A |
T |
11: 14,549,489 (GRCm39) |
D65V |
probably damaging |
Het |
Prb1a |
T |
C |
6: 132,184,139 (GRCm39) |
Y498C |
unknown |
Het |
Sh3bp2 |
G |
A |
5: 34,718,947 (GRCm39) |
V495I |
probably damaging |
Het |
Slx4ip |
T |
A |
2: 136,888,669 (GRCm39) |
C117S |
probably damaging |
Het |
Tmtc2 |
A |
T |
10: 105,409,551 (GRCm39) |
S20R |
probably benign |
Het |
Unc79 |
A |
G |
12: 102,987,269 (GRCm39) |
Y186C |
probably damaging |
Het |
Vmn2r106 |
C |
T |
17: 20,488,725 (GRCm39) |
C558Y |
probably damaging |
Het |
Vmn2r26 |
T |
C |
6: 124,038,348 (GRCm39) |
L641P |
probably damaging |
Het |
Wdr17 |
A |
T |
8: 55,114,495 (GRCm39) |
S674T |
probably benign |
Het |
|
Other mutations in Zfp959 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00698:Zfp959
|
APN |
17 |
56,204,565 (GRCm39) |
missense |
possibly damaging |
0.91 |
IGL02731:Zfp959
|
APN |
17 |
56,202,956 (GRCm39) |
splice site |
probably benign |
|
IGL03206:Zfp959
|
APN |
17 |
56,204,613 (GRCm39) |
missense |
possibly damaging |
0.78 |
R0141:Zfp959
|
UTSW |
17 |
56,205,139 (GRCm39) |
missense |
probably benign |
0.41 |
R0347:Zfp959
|
UTSW |
17 |
56,204,180 (GRCm39) |
nonsense |
probably null |
|
R0522:Zfp959
|
UTSW |
17 |
56,203,201 (GRCm39) |
missense |
probably null |
1.00 |
R1692:Zfp959
|
UTSW |
17 |
56,205,299 (GRCm39) |
missense |
probably damaging |
0.99 |
R1771:Zfp959
|
UTSW |
17 |
56,204,677 (GRCm39) |
splice site |
probably null |
|
R1891:Zfp959
|
UTSW |
17 |
56,204,604 (GRCm39) |
missense |
probably damaging |
1.00 |
R1945:Zfp959
|
UTSW |
17 |
56,204,231 (GRCm39) |
nonsense |
probably null |
|
R1959:Zfp959
|
UTSW |
17 |
56,204,404 (GRCm39) |
missense |
probably damaging |
0.98 |
R2317:Zfp959
|
UTSW |
17 |
56,204,326 (GRCm39) |
missense |
possibly damaging |
0.59 |
R4726:Zfp959
|
UTSW |
17 |
56,205,260 (GRCm39) |
splice site |
probably null |
|
R4869:Zfp959
|
UTSW |
17 |
56,204,228 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5436:Zfp959
|
UTSW |
17 |
56,204,626 (GRCm39) |
missense |
probably benign |
|
R6235:Zfp959
|
UTSW |
17 |
56,204,427 (GRCm39) |
missense |
probably damaging |
1.00 |
R6365:Zfp959
|
UTSW |
17 |
56,204,785 (GRCm39) |
missense |
probably damaging |
1.00 |
R6417:Zfp959
|
UTSW |
17 |
56,205,094 (GRCm39) |
missense |
probably damaging |
1.00 |
R6420:Zfp959
|
UTSW |
17 |
56,205,094 (GRCm39) |
missense |
probably damaging |
1.00 |
R7114:Zfp959
|
UTSW |
17 |
56,205,501 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7380:Zfp959
|
UTSW |
17 |
56,205,551 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7437:Zfp959
|
UTSW |
17 |
56,205,334 (GRCm39) |
missense |
probably damaging |
1.00 |
R7568:Zfp959
|
UTSW |
17 |
56,204,886 (GRCm39) |
missense |
probably benign |
0.01 |
R8114:Zfp959
|
UTSW |
17 |
56,205,496 (GRCm39) |
missense |
probably benign |
0.09 |
R8197:Zfp959
|
UTSW |
17 |
56,204,677 (GRCm39) |
missense |
probably damaging |
1.00 |
R8389:Zfp959
|
UTSW |
17 |
56,204,299 (GRCm39) |
missense |
probably benign |
|
R8970:Zfp959
|
UTSW |
17 |
56,204,836 (GRCm39) |
missense |
possibly damaging |
0.72 |
R9063:Zfp959
|
UTSW |
17 |
56,204,221 (GRCm39) |
missense |
probably benign |
0.18 |
R9504:Zfp959
|
UTSW |
17 |
56,204,793 (GRCm39) |
missense |
probably benign |
0.06 |
R9648:Zfp959
|
UTSW |
17 |
56,204,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
R9733:Zfp959
|
UTSW |
17 |
56,204,866 (GRCm39) |
missense |
probably benign |
0.06 |
Z1088:Zfp959
|
UTSW |
17 |
56,205,135 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Predicted Primers |
PCR Primer
(F):5'- ATGCCTTATTCATCATGAACAGAAGT -3'
(R):5'- TTGCAGTCTTCCCACATGTAGC -3'
Sequencing Primer
(F):5'- AGTGAGAGGCATGATTCTCCTTTAC -3'
(R):5'- CTGTGAACTTTAGAACAGTGCCC -3'
|
Posted On |
2018-05-04 |