Incidental Mutation 'R6398:Or5b98'
ID 516084
Institutional Source Beutler Lab
Gene Symbol Or5b98
Ensembl Gene ENSMUSG00000062892
Gene Name olfactory receptor family 5 subfamily B member 98
Synonyms Olfr1450, GA_x6K02T2RE5P-3283121-3284098, MOR202-33
MMRRC Submission 044381-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R6398 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 12930955-12931932 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 12931681 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 243 (S243P)
Ref Sequence ENSEMBL: ENSMUSP00000150243 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082006] [ENSMUST00000213587] [ENSMUST00000213925]
AlphaFold Q8VF19
Predicted Effect probably damaging
Transcript: ENSMUST00000082006
AA Change: S243P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000080666
Gene: ENSMUSG00000062892
AA Change: S243P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.8e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.5e-6 PFAM
Pfam:7tm_1 41 290 2.1e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213587
AA Change: S243P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000213925
AA Change: S243P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ago1 T A 4: 126,342,601 (GRCm39) Q514L probably benign Het
Alpi G C 1: 87,027,184 (GRCm39) T365S probably damaging Het
Cbx4 A T 11: 118,971,908 (GRCm39) V489E probably damaging Het
Ccdc162 T C 10: 41,503,145 (GRCm39) D999G probably damaging Het
Clspn A G 4: 126,457,740 (GRCm39) E88G probably damaging Het
D6Ertd527e C G 6: 87,088,506 (GRCm39) T223S unknown Het
Ddx1 A T 12: 13,295,721 (GRCm39) I33N probably damaging Het
Diaph3 G A 14: 87,103,922 (GRCm39) L821F probably damaging Het
Duox2 C T 2: 122,126,851 (GRCm39) M221I probably benign Het
Gm15130 A T 2: 110,965,787 (GRCm39) M154K unknown Het
Gm3233 G T 10: 77,595,249 (GRCm39) probably benign Het
Heg1 A C 16: 33,587,145 (GRCm39) I1327L probably damaging Het
Ifnar1 G A 16: 91,302,303 (GRCm39) probably null Het
Itpr1 C T 6: 108,482,864 (GRCm39) L2310F probably damaging Het
Pcdhb7 A G 18: 37,476,487 (GRCm39) N541S possibly damaging Het
Prelp A G 1: 133,842,479 (GRCm39) L222P probably damaging Het
Prl8a8 A G 13: 27,692,412 (GRCm39) I193T probably damaging Het
Prpf4b G T 13: 35,084,354 (GRCm39) R914L probably damaging Het
Ptbp2 G C 3: 119,514,484 (GRCm39) Q448E probably benign Het
Rsf1 GCG GCGACGGCGACG 7: 97,229,114 (GRCm39) probably benign Het
Slc9a9 A T 9: 94,552,280 (GRCm39) M56L probably benign Het
Slfn4 A G 11: 83,078,000 (GRCm39) I263V possibly damaging Het
Taar2 A G 10: 23,817,177 (GRCm39) N239S probably benign Het
Trrap T A 5: 144,727,680 (GRCm39) I467N possibly damaging Het
Ttc28 T C 5: 111,424,142 (GRCm39) Y1439H probably damaging Het
Usp34 A G 11: 23,438,666 (GRCm39) I3409M probably benign Het
Zbbx G T 3: 74,985,872 (GRCm39) N388K probably damaging Het
Znhit2 A G 19: 6,112,287 (GRCm39) N344S probably damaging Het
Other mutations in Or5b98
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01978:Or5b98 APN 19 12,931,406 (GRCm39) missense probably benign 0.00
IGL02378:Or5b98 APN 19 12,931,747 (GRCm39) missense probably benign 0.01
IGL02405:Or5b98 APN 19 12,931,823 (GRCm39) missense probably damaging 1.00
IGL02493:Or5b98 APN 19 12,931,138 (GRCm39) missense probably benign 0.12
IGL02496:Or5b98 APN 19 12,931,556 (GRCm39) missense possibly damaging 0.86
IGL02866:Or5b98 APN 19 12,931,719 (GRCm39) missense possibly damaging 0.81
IGL02886:Or5b98 APN 19 12,931,882 (GRCm39) missense probably benign 0.00
IGL03223:Or5b98 APN 19 12,931,268 (GRCm39) missense probably benign 0.00
IGL03286:Or5b98 APN 19 12,931,532 (GRCm39) missense probably benign 0.05
IGL03396:Or5b98 APN 19 12,931,184 (GRCm39) missense probably damaging 1.00
R0106:Or5b98 UTSW 19 12,931,720 (GRCm39) missense probably benign 0.10
R0106:Or5b98 UTSW 19 12,931,720 (GRCm39) missense probably benign 0.10
R0544:Or5b98 UTSW 19 12,931,066 (GRCm39) missense possibly damaging 0.79
R1660:Or5b98 UTSW 19 12,931,055 (GRCm39) missense probably damaging 1.00
R2020:Or5b98 UTSW 19 12,931,696 (GRCm39) missense possibly damaging 0.61
R4292:Or5b98 UTSW 19 12,931,520 (GRCm39) missense possibly damaging 0.83
R4647:Or5b98 UTSW 19 12,931,441 (GRCm39) missense probably benign 0.00
R5964:Or5b98 UTSW 19 12,931,895 (GRCm39) missense probably benign 0.03
R6681:Or5b98 UTSW 19 12,931,823 (GRCm39) missense probably damaging 1.00
R7129:Or5b98 UTSW 19 12,931,478 (GRCm39) missense possibly damaging 0.94
R7399:Or5b98 UTSW 19 12,931,811 (GRCm39) missense probably damaging 1.00
R7561:Or5b98 UTSW 19 12,931,403 (GRCm39) missense probably benign 0.00
R7692:Or5b98 UTSW 19 12,931,006 (GRCm39) missense possibly damaging 0.59
R8094:Or5b98 UTSW 19 12,931,366 (GRCm39) missense probably benign 0.00
R8258:Or5b98 UTSW 19 12,931,727 (GRCm39) missense possibly damaging 0.58
R8259:Or5b98 UTSW 19 12,931,727 (GRCm39) missense possibly damaging 0.58
R9522:Or5b98 UTSW 19 12,931,377 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGCTGAATCTTCTGTCTATACTGGG -3'
(R):5'- TGGTGTTGAGCAGACTTCAAC -3'

Sequencing Primer
(F):5'- TCTGCCATTCTAATGTGATTCATC -3'
(R):5'- GAGCAGACTTCAACTTCTCAATGG -3'
Posted On 2018-05-04