Incidental Mutation 'R6401:Olfr1465'
ID516185
Institutional Source Beutler Lab
Gene Symbol Olfr1465
Ensembl Gene ENSMUSG00000062199
Gene Nameolfactory receptor 1465
SynonymsMOR202-28, GA_x6K02T2RE5P-3645346-3644423
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock #R6401 (G1)
Quality Score225.009
Status Validated
Chromosome19
Chromosomal Location13312768-13315541 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 13313514 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 257 (Y257C)
Ref Sequence ENSEMBL: ENSMUSP00000146645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080142] [ENSMUST00000207340]
Predicted Effect probably damaging
Transcript: ENSMUST00000080142
AA Change: Y257C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079039
Gene: ENSMUSG00000062199
AA Change: Y257C

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 7.4e-47 PFAM
Pfam:7tm_1 39 288 3.7e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207340
AA Change: Y257C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency 93% (41/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano3 T A 2: 110,775,114 N249I probably benign Het
Ap3s1 A C 18: 46,758,007 I56L probably benign Het
Cngb1 A G 8: 95,303,739 probably benign Het
Col2a1 T C 15: 97,985,892 T570A unknown Het
Cyp3a16 T C 5: 145,440,364 E471G probably damaging Het
D930020B18Rik A G 10: 121,641,857 N14D possibly damaging Het
Ext1 T C 15: 53,106,097 E365G possibly damaging Het
Fbn1 C A 2: 125,346,450 V1490F probably damaging Het
Fsip2 A G 2: 82,990,086 T5388A possibly damaging Het
Gm4869 A T 5: 140,456,943 T80S possibly damaging Het
Gm5431 T A 11: 48,888,709 N740I probably benign Het
Ifi209 T C 1: 173,644,703 M370T probably damaging Het
Ighv2-4 G T 12: 113,653,462 P60Q probably damaging Het
Ldb3 A T 14: 34,577,334 L111Q probably benign Het
Mcmbp G T 7: 128,707,059 L413I possibly damaging Het
Mib1 T A 18: 10,795,802 M721K probably benign Het
Nos3 A G 5: 24,379,811 T738A probably benign Het
Notch3 T A 17: 32,158,623 I160L probably benign Het
Nrxn3 C A 12: 89,255,000 N516K possibly damaging Het
Nt5c2 A G 19: 46,889,811 Y496H probably benign Het
Olfr275 A C 4: 52,826,242 T282P probably damaging Het
Olfr351 A T 2: 36,860,165 L61* probably null Het
Polm A T 11: 5,829,491 W436R probably damaging Het
Prex2 T A 1: 11,186,727 I1221N probably benign Het
Rfpl4b T C 10: 38,820,945 H220R possibly damaging Het
Rgs12 T C 5: 35,020,332 F79L probably damaging Het
Rxfp2 A G 5: 150,043,130 D111G probably benign Het
Smg7 A G 1: 152,840,136 probably null Het
Spata22 T C 11: 73,333,354 S34P probably damaging Het
St7 T A 6: 17,855,318 probably null Het
Stk31 A G 6: 49,423,438 E399G probably damaging Het
Tcp10b C A 17: 13,073,579 N296K probably damaging Het
Tonsl T C 15: 76,633,666 Y645C probably damaging Het
Ttn A T 2: 76,969,862 M334K probably benign Het
Vcpkmt C A 12: 69,582,845 V48F probably damaging Het
Vmn2r112 T A 17: 22,603,551 Y403* probably null Het
Vwa7 G A 17: 35,017,310 probably null Het
Wisp2 T C 2: 163,829,026 I151T probably benign Het
Wscd2 A T 5: 113,588,145 *572C probably null Het
Xpo7 A G 14: 70,682,347 L676P probably damaging Het
Zbtb32 A C 7: 30,591,819 L17W probably damaging Het
Other mutations in Olfr1465
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01296:Olfr1465 APN 19 13314126 missense probably damaging 1.00
IGL01548:Olfr1465 APN 19 13313986 missense possibly damaging 0.95
IGL02548:Olfr1465 APN 19 13313938 missense probably damaging 0.98
IGL02663:Olfr1465 APN 19 13313379 missense probably benign 0.01
PIT4651001:Olfr1465 UTSW 19 13314192 missense probably benign 0.12
R0563:Olfr1465 UTSW 19 13313748 missense probably benign 0.28
R1803:Olfr1465 UTSW 19 13314171 missense possibly damaging 0.90
R2146:Olfr1465 UTSW 19 13314121 missense probably benign 0.23
R4674:Olfr1465 UTSW 19 13313814 missense probably benign 0.17
R4697:Olfr1465 UTSW 19 13313717 missense probably benign 0.39
R4825:Olfr1465 UTSW 19 13314320 intron probably null
R4884:Olfr1465 UTSW 19 13313670 missense probably benign 0.28
R5647:Olfr1465 UTSW 19 13314189 missense probably damaging 1.00
R6913:Olfr1465 UTSW 19 13313634 missense probably benign 0.01
R6996:Olfr1465 UTSW 19 13313672 missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- GCAGGAATACGAGAATCCCTTC -3'
(R):5'- GATAGACATGTTAGTGAGCTGGTTC -3'

Sequencing Primer
(F):5'- CCTTCTAGAATTTAATTGCATGTGGC -3'
(R):5'- TTATGTAGGGAGCTTCAGTA -3'
Posted On2018-05-04