Mutagenetix > Incidental Mutation

Incidental Mutation 'R6405:Vmn2r106'

516273

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r106

Ensembl Gene

ENSMUSG00000091656

Gene Name

vomeronasal 2, receptor 106

Synonyms

EG224576

MMRRC Submission

044550-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

R6405 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20487809-20505692 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 20499361 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 183 (S183R)

Ref Sequence

ENSEMBL: ENSMUSP00000126534 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167464]

AlphaFold

E9PY92

Predicted Effect

probably benign
Transcript: ENSMUST00000167464
AA Change: S183R

PolyPhen 2 Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: S183R

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	471	3.8e-37	PFAM
Pfam:NCD3G	514	567	5.7e-22	PFAM
Pfam:7tm_3	596	835	1.3e-49	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 98.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930562C15Rik	T	C	16: 4,669,742 (GRCm39)	V769A	probably damaging	Het
Abca4	A	G	3: 121,967,311 (GRCm39)		probably null	Het
Ahnak2	A	T	12: 112,739,771 (GRCm39)	S628T	probably damaging	Het
Ano8	T	C	8: 71,935,674 (GRCm39)	T315A	probably damaging	Het
Arhgap32	T	A	9: 32,159,784 (GRCm39)	V267E	probably benign	Het
Asnsd1	A	T	1: 53,387,154 (GRCm39)	S158T	probably damaging	Het
Asxl2	T	A	12: 3,543,758 (GRCm39)	V309E	probably damaging	Het
Bhlhe40	TG	TGG	6: 108,641,818 (GRCm39)	254	probably null	Het
Ccdc110	T	A	8: 46,394,734 (GRCm39)	Y208*	probably null	Het
Cfap157	G	T	2: 32,671,408 (GRCm39)	Q133K	probably damaging	Het
Cfap53	A	G	18: 74,492,677 (GRCm39)	E467G	probably damaging	Het
Csmd3	T	C	15: 47,683,767 (GRCm39)	I1688M	probably damaging	Het
Cyp3a11	A	T	5: 145,799,230 (GRCm39)	L319Q	probably damaging	Het
Dchs2	A	G	3: 83,261,570 (GRCm39)	I2613V	probably benign	Het
Dhx35	T	A	2: 158,636,839 (GRCm39)	W11R	probably damaging	Het
Dscam	C	T	16: 96,479,625 (GRCm39)	G1174D	probably damaging	Het
Fan1	T	A	7: 64,022,234 (GRCm39)	N340Y	probably damaging	Het
Fsip2	A	G	2: 82,820,430 (GRCm39)	T5388A	possibly damaging	Het
Gm10549	C	A	18: 33,597,358 (GRCm39)		probably benign	Het
Greb1l	T	A	18: 10,501,076 (GRCm39)	I402K	probably benign	Het
Hectd3	A	T	4: 116,857,821 (GRCm39)	M585L	probably benign	Het
Inpp5k	T	C	11: 75,524,004 (GRCm39)		probably null	Het
Lalba	T	G	15: 98,378,632 (GRCm39)		probably null	Het
Lgals9	C	A	11: 78,862,211 (GRCm39)	V125L	probably benign	Het
Ncbp2	CGTCTGGATG	CG	16: 31,775,161 (GRCm39)		probably null	Het
Or2g25	A	G	17: 37,971,014 (GRCm39)	I70T	possibly damaging	Het
Peg10	C	CTCG	6: 4,756,453 (GRCm39)		probably benign	Het
Rab4b	T	A	7: 26,872,379 (GRCm39)	D94V	probably damaging	Het
Rhpn2	A	G	7: 35,071,864 (GRCm39)	E243G	probably benign	Het
Rp1	T	C	1: 4,415,994 (GRCm39)	D1706G	probably damaging	Het
Slc29a3	A	T	10: 60,551,805 (GRCm39)	I413N	probably damaging	Het
Slc7a9	T	C	7: 35,154,064 (GRCm39)	L229P	probably damaging	Het
Tenm2	T	C	11: 36,755,686 (GRCm39)	H104R	probably benign	Het
Tmem87a	A	G	2: 120,210,231 (GRCm39)	Y241H	probably damaging	Het
Trpv5	G	T	6: 41,651,602 (GRCm39)	T192K	probably damaging	Het
Unc79	T	C	12: 103,134,595 (GRCm39)	V2189A	probably damaging	Het
Vmn2r112	G	T	17: 22,837,216 (GRCm39)	C559F	probably damaging	Het
Wdhd1	T	C	14: 47,481,324 (GRCm39)	D1031G	possibly damaging	Het
Wnt5b	T	C	6: 119,410,457 (GRCm39)	S328G	probably benign	Het
Zcchc7	T	C	4: 44,926,032 (GRCm39)	Y344H	probably damaging	Het

Other mutations in Vmn2r106

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00979:Vmn2r106	APN	17	20,497,837 (GRCm39)	missense	possibly damaging	0.90
IGL01313:Vmn2r106	APN	17	20,498,651 (GRCm39)	missense	probably damaging	0.99
IGL01419:Vmn2r106	APN	17	20,499,807 (GRCm39)	missense	probably benign	0.06
IGL01574:Vmn2r106	APN	17	20,488,572 (GRCm39)	missense	possibly damaging	0.94
IGL01796:Vmn2r106	APN	17	20,488,314 (GRCm39)	missense	possibly damaging	0.79
IGL01893:Vmn2r106	APN	17	20,497,730 (GRCm39)	missense	probably benign	0.06
IGL01895:Vmn2r106	APN	17	20,499,227 (GRCm39)	missense	probably benign	0.02
IGL02378:Vmn2r106	APN	17	20,497,791 (GRCm39)	missense	probably damaging	1.00
IGL02430:Vmn2r106	APN	17	20,499,158 (GRCm39)	missense	probably benign	0.38
IGL02664:Vmn2r106	APN	17	20,488,344 (GRCm39)	missense	possibly damaging	0.88
IGL03308:Vmn2r106	APN	17	20,498,785 (GRCm39)	nonsense	probably null
IGL03384:Vmn2r106	APN	17	20,488,405 (GRCm39)	missense	probably damaging	0.99
R0401:Vmn2r106	UTSW	17	20,499,281 (GRCm39)	missense	possibly damaging	0.86
R0842:Vmn2r106	UTSW	17	20,488,465 (GRCm39)	missense	probably damaging	1.00
R0964:Vmn2r106	UTSW	17	20,487,859 (GRCm39)	missense	probably benign	0.00
R1235:Vmn2r106	UTSW	17	20,499,741 (GRCm39)	missense	probably benign	0.00
R1709:Vmn2r106	UTSW	17	20,499,373 (GRCm39)	missense	probably benign	0.12
R1712:Vmn2r106	UTSW	17	20,498,997 (GRCm39)	missense	probably benign	0.01
R1770:Vmn2r106	UTSW	17	20,488,560 (GRCm39)	missense	probably damaging	0.99
R2049:Vmn2r106	UTSW	17	20,488,566 (GRCm39)	missense	possibly damaging	0.90
R2245:Vmn2r106	UTSW	17	20,488,423 (GRCm39)	missense	probably benign	0.13
R2336:Vmn2r106	UTSW	17	20,488,470 (GRCm39)	missense	probably benign	0.18
R2910:Vmn2r106	UTSW	17	20,498,946 (GRCm39)	missense	probably damaging	1.00
R3025:Vmn2r106	UTSW	17	20,499,147 (GRCm39)	missense	probably benign	0.00
R3944:Vmn2r106	UTSW	17	20,487,913 (GRCm39)	missense	probably damaging	1.00
R4081:Vmn2r106	UTSW	17	20,487,818 (GRCm39)	nonsense	probably null
R4153:Vmn2r106	UTSW	17	20,488,080 (GRCm39)	missense	probably damaging	1.00
R4356:Vmn2r106	UTSW	17	20,499,910 (GRCm39)	missense	probably benign	0.06
R4426:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.00
R4590:Vmn2r106	UTSW	17	20,497,728 (GRCm39)	missense	probably damaging	0.99
R4661:Vmn2r106	UTSW	17	20,487,885 (GRCm39)	missense	probably benign	0.10
R5106:Vmn2r106	UTSW	17	20,499,395 (GRCm39)	critical splice acceptor site	probably null
R5341:Vmn2r106	UTSW	17	20,497,788 (GRCm39)	missense	probably benign	0.00
R5509:Vmn2r106	UTSW	17	20,498,684 (GRCm39)	missense	probably damaging	0.99
R5826:Vmn2r106	UTSW	17	20,499,133 (GRCm39)	missense	probably benign
R5859:Vmn2r106	UTSW	17	20,505,583 (GRCm39)	missense	possibly damaging	0.72
R5937:Vmn2r106	UTSW	17	20,505,667 (GRCm39)	nonsense	probably null
R5972:Vmn2r106	UTSW	17	20,498,738 (GRCm39)	missense	probably benign
R6056:Vmn2r106	UTSW	17	20,487,806 (GRCm39)	splice site	probably null
R6108:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6114:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6115:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6132:Vmn2r106	UTSW	17	20,488,666 (GRCm39)	missense	probably benign
R6208:Vmn2r106	UTSW	17	20,488,591 (GRCm39)	missense	probably damaging	0.99
R6217:Vmn2r106	UTSW	17	20,488,501 (GRCm39)	missense	probably benign	0.10
R6289:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6378:Vmn2r106	UTSW	17	20,498,667 (GRCm39)	missense	probably benign	0.19
R6390:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6391:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6392:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6427:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6428:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6435:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6436:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6437:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6511:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6512:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6587:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6703:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6730:Vmn2r106	UTSW	17	20,499,096 (GRCm39)	missense	possibly damaging	0.64
R6961:Vmn2r106	UTSW	17	20,488,646 (GRCm39)	nonsense	probably null
R7054:Vmn2r106	UTSW	17	20,499,182 (GRCm39)	missense	probably damaging	0.96
R7379:Vmn2r106	UTSW	17	20,488,037 (GRCm39)	missense	possibly damaging	0.75
R7402:Vmn2r106	UTSW	17	20,487,883 (GRCm39)	missense	probably damaging	0.99
R7497:Vmn2r106	UTSW	17	20,488,201 (GRCm39)	missense	probably damaging	1.00
R7692:Vmn2r106	UTSW	17	20,505,490 (GRCm39)	missense	possibly damaging	0.96
R8539:Vmn2r106	UTSW	17	20,499,271 (GRCm39)	missense	probably benign	0.00
R8827:Vmn2r106	UTSW	17	20,487,868 (GRCm39)	missense	probably benign	0.05
R8872:Vmn2r106	UTSW	17	20,488,401 (GRCm39)	missense	probably benign	0.19
R9118:Vmn2r106	UTSW	17	20,505,667 (GRCm39)	missense	probably benign	0.00
R9254:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9379:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9571:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.17

Predicted Primers

PCR Primer
(F):5'- AAATGTGAAGTCCAGGTGGC -3'
(R):5'- GTAGTTCTTTGAAACTAACAGGCTAGG -3'

Sequencing Primer
(F):5'- CCAGGTGGCAGGGATCATTTTAAC -3'
(R):5'- ACAGGCTAGGCAGGAATTTTTC -3'

Posted On

2018-05-04