Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01140:Zfp128'

51648

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp128

Ensembl Gene

ENSMUSG00000060397

Gene Name

zinc finger protein 128

Synonyms

mZnf8, 9630016P15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

IGL01140

Quality Score

Status

Chromosome

Chromosomal Location

12615105-12627349 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 12624949 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 439 (Y439C)

Ref Sequence

ENSEMBL: ENSMUSP00000115378 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000144578]

AlphaFold

Q8BGV5

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000081891

Predicted Effect

probably benign
Transcript: ENSMUST00000144578
AA Change: Y439C

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000115378
Gene: ENSMUSG00000060397
AA Change: Y439C

Domain	Start	End	E-Value	Type
KRAB	25	85	2.51e-38	SMART
ZnF_C2H2	254	276	8.47e-4	SMART
ZnF_C2H2	282	304	5.21e-4	SMART
ZnF_C2H2	310	332	4.17e-3	SMART
ZnF_C2H2	338	360	3.89e-3	SMART
ZnF_C2H2	366	388	1.47e-3	SMART
ZnF_C2H2	394	416	8.47e-4	SMART
ZnF_C2H2	464	486	3.39e-3	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afm	A	G	5: 90,672,726 (GRCm39)	E187G	probably damaging	Het
Asap2	T	C	12: 21,256,317 (GRCm39)	V205A	probably damaging	Het
Atg16l1	A	G	1: 87,702,575 (GRCm39)	I279V	probably benign	Het
Atp2b2	C	T	6: 113,766,932 (GRCm39)	V436I	possibly damaging	Het
Cald1	T	A	6: 34,739,196 (GRCm39)	S640T	possibly damaging	Het
Cdc23	A	G	18: 34,769,385 (GRCm39)	Y460H	probably benign	Het
Cenpk	T	A	13: 104,372,742 (GRCm39)		probably benign	Het
Ctss	A	G	3: 95,446,036 (GRCm39)	E52G	probably damaging	Het
Cuzd1	A	T	7: 130,913,523 (GRCm39)	C365S	probably damaging	Het
Cyp2c55	T	C	19: 39,007,093 (GRCm39)	L163P	probably benign	Het
Cyp4f37	T	C	17: 32,848,027 (GRCm39)	S182P	probably benign	Het
Flt4	G	T	11: 49,525,770 (GRCm39)	E740*	probably null	Het
Galntl6	T	A	8: 58,411,356 (GRCm39)	R291S	probably damaging	Het
Hydin	G	A	8: 111,124,694 (GRCm39)	V568I	probably benign	Het
Ift70a1	A	G	2: 75,810,259 (GRCm39)	V608A	probably benign	Het
Kcnab3	A	G	11: 69,220,705 (GRCm39)	K145R	probably benign	Het
Lama1	T	C	17: 68,109,928 (GRCm39)	V2183A	probably benign	Het
Lrmda	C	T	14: 22,646,585 (GRCm39)	A75V	possibly damaging	Het
Mbtd1	A	G	11: 93,815,258 (GRCm39)	E282G	probably damaging	Het
Muc19	A	T	15: 91,783,593 (GRCm39)		noncoding transcript	Het
Mug1	A	G	6: 121,859,693 (GRCm39)	T1231A	probably benign	Het
Nkpd1	A	G	7: 19,257,387 (GRCm39)	T389A	possibly damaging	Het
Nudt19	A	G	7: 35,247,336 (GRCm39)	*358Q	probably null	Het
Nup160	G	T	2: 90,530,909 (GRCm39)	M522I	possibly damaging	Het
Obsl1	T	A	1: 75,466,400 (GRCm39)		probably benign	Het
Or4m1	T	A	14: 50,557,732 (GRCm39)	I187F	probably damaging	Het
Or5ak24	T	C	2: 85,260,484 (GRCm39)	T230A	probably benign	Het
Or5b119	G	A	19: 13,457,151 (GRCm39)	T137I	possibly damaging	Het
Osbpl10	C	T	9: 115,005,070 (GRCm39)	P341S	probably benign	Het
Papola	C	A	12: 105,775,856 (GRCm39)	C7*	probably null	Het
Pld1	C	A	3: 28,132,386 (GRCm39)	L525I	probably benign	Het
Prom2	T	C	2: 127,373,125 (GRCm39)		probably benign	Het
Psmb5	G	A	14: 54,855,264 (GRCm39)	T62I	possibly damaging	Het
Sag	A	G	1: 87,751,086 (GRCm39)	E184G	probably benign	Het
Slc16a10	T	C	10: 39,952,921 (GRCm39)	Y191C	probably damaging	Het
Slc22a22	T	C	15: 57,126,734 (GRCm39)	T93A	probably damaging	Het
Ssx2ip	A	G	3: 146,133,598 (GRCm39)	Y231C	probably benign	Het
Trib1	A	G	15: 59,523,476 (GRCm39)	Y170C	probably damaging	Het
Trmt10a	G	A	3: 137,862,459 (GRCm39)		probably benign	Het
Troap	G	T	15: 98,980,027 (GRCm39)	Q402H	probably damaging	Het
Vmn2r70	G	A	7: 85,214,379 (GRCm39)	Q258*	probably null	Het
Zmym1	A	G	4: 126,943,435 (GRCm39)	F318L	probably damaging	Het
Zswim2	A	G	2: 83,745,672 (GRCm39)	S589P	probably benign	Het

Other mutations in Zfp128

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01293:Zfp128	APN	7	12,625,351 (GRCm39)	makesense	probably null
IGL02067:Zfp128	APN	7	12,618,977 (GRCm39)	missense	possibly damaging	0.86
IGL02146:Zfp128	APN	7	12,623,959 (GRCm39)	missense	possibly damaging	0.72
IGL02654:Zfp128	APN	7	12,618,606 (GRCm39)	missense	possibly damaging	0.95
IGL03066:Zfp128	APN	7	12,624,044 (GRCm39)	missense	probably benign	0.00
IGL03076:Zfp128	APN	7	12,618,636 (GRCm39)	missense	possibly damaging	0.95
IGL03113:Zfp128	APN	7	12,624,314 (GRCm39)	missense	probably benign	0.00
IGL03237:Zfp128	APN	7	12,624,953 (GRCm39)	missense	probably benign	0.28
prayer	UTSW	7	12,624,563 (GRCm39)	nonsense	probably null
R0783:Zfp128	UTSW	7	12,624,199 (GRCm39)	missense	probably damaging	1.00
R1686:Zfp128	UTSW	7	12,624,563 (GRCm39)	nonsense	probably null
R1806:Zfp128	UTSW	7	12,624,949 (GRCm39)	missense	probably benign	0.00
R2021:Zfp128	UTSW	7	12,623,956 (GRCm39)	missense	possibly damaging	0.96
R3792:Zfp128	UTSW	7	12,618,659 (GRCm39)	missense	probably damaging	0.98
R4105:Zfp128	UTSW	7	12,618,667 (GRCm39)	missense	probably damaging	0.99
R4167:Zfp128	UTSW	7	12,624,289 (GRCm39)	missense	probably benign	0.28
R4168:Zfp128	UTSW	7	12,624,289 (GRCm39)	missense	probably benign	0.28
R5743:Zfp128	UTSW	7	12,618,654 (GRCm39)	missense	probably damaging	1.00
R6266:Zfp128	UTSW	7	12,624,897 (GRCm39)	missense	possibly damaging	0.80
R6799:Zfp128	UTSW	7	12,624,826 (GRCm39)	missense	possibly damaging	0.93
R7102:Zfp128	UTSW	7	12,624,399 (GRCm39)	missense	probably damaging	1.00
R7313:Zfp128	UTSW	7	12,624,461 (GRCm39)	missense	possibly damaging	0.94
R7428:Zfp128	UTSW	7	12,624,289 (GRCm39)	missense	probably benign	0.28
R7504:Zfp128	UTSW	7	12,624,405 (GRCm39)	missense	probably damaging	0.99
R7539:Zfp128	UTSW	7	12,624,479 (GRCm39)	nonsense	probably null
R7636:Zfp128	UTSW	7	12,624,039 (GRCm39)	missense	probably benign
R7755:Zfp128	UTSW	7	12,624,240 (GRCm39)	nonsense	probably null
R7820:Zfp128	UTSW	7	12,624,949 (GRCm39)	missense	probably benign	0.00
R8269:Zfp128	UTSW	7	12,624,663 (GRCm39)	missense	probably damaging	1.00
R8932:Zfp128	UTSW	7	12,625,113 (GRCm39)	missense	possibly damaging	0.91
R9361:Zfp128	UTSW	7	12,624,364 (GRCm39)	missense	probably damaging	0.99
R9381:Zfp128	UTSW	7	12,624,897 (GRCm39)	missense	possibly damaging	0.80

Posted On

2013-06-21