Incidental Mutation 'R6457:Tnik'
| ID |
516509 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnik
|
| Ensembl Gene |
ENSMUSG00000027692 |
| Gene Name |
TRAF2 and NCK interacting kinase |
| Synonyms |
C530008O15Rik, 4831440I19Rik, 1500031A17Rik, C630040K21Rik |
| MMRRC Submission |
044592-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6457 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
28317362-28724734 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 28593597 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 151
(H151L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124726
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000160934]
[ENSMUST00000161964]
[ENSMUST00000162485]
[ENSMUST00000162777]
|
| AlphaFold |
P83510 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159236
AA Change: H151L
PolyPhen 2
Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
AA Change: H151L
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000159308
AA Change: H151L
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
AA Change: H151L
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000159680
AA Change: H151L
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
AA Change: H151L
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160307
AA Change: H151L
|
| SMART Domains |
Protein: ENSMUSP00000125081
Gene: ENSMUSG00000027692
AA Change: H151L
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
|
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160518
AA Change: H151L
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
AA Change: H151L
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160934
AA Change: H151L
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000123859
Gene: ENSMUSG00000027692
AA Change: H151L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
|
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161423
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000161964
AA Change: H151L
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
AA Change: H151L
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000162485
AA Change: H151L
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
AA Change: H151L
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162777
AA Change: H151L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
AA Change: H151L
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193721
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.3%
|
| Validation Efficiency |
97% (63/65) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
T |
A |
3: 137,772,383 (GRCm39) |
V524E |
probably damaging |
Het |
| Acer2 |
T |
A |
4: 86,818,808 (GRCm39) |
M152K |
probably damaging |
Het |
| Actn3 |
T |
C |
19: 4,921,876 (GRCm39) |
D130G |
probably damaging |
Het |
| Ank1 |
T |
A |
8: 23,577,983 (GRCm39) |
F211Y |
probably damaging |
Het |
| Ankfn1 |
C |
T |
11: 89,282,670 (GRCm39) |
A326T |
probably benign |
Het |
| Ankrd11 |
G |
A |
8: 123,635,503 (GRCm39) |
R44C |
probably damaging |
Het |
| Ankrd46 |
A |
G |
15: 36,484,217 (GRCm39) |
|
probably benign |
Het |
| Aurkb |
G |
A |
11: 68,939,172 (GRCm39) |
E132K |
possibly damaging |
Het |
| Bsdc1 |
C |
T |
4: 129,359,069 (GRCm39) |
T9I |
possibly damaging |
Het |
| Card14 |
C |
T |
11: 119,230,428 (GRCm39) |
R767* |
probably null |
Het |
| Ccdc82 |
T |
A |
9: 13,272,745 (GRCm39) |
F411L |
possibly damaging |
Het |
| Col12a1 |
C |
T |
9: 79,552,973 (GRCm39) |
G2106D |
probably damaging |
Het |
| Col27a1 |
T |
A |
4: 63,237,701 (GRCm39) |
|
probably benign |
Het |
| Cox10 |
A |
G |
11: 63,855,198 (GRCm39) |
L361P |
probably damaging |
Het |
| Cox18 |
A |
G |
5: 90,371,548 (GRCm39) |
I84T |
probably benign |
Het |
| Dhrs3 |
T |
C |
4: 144,646,522 (GRCm39) |
S125P |
probably damaging |
Het |
| Fbxl15 |
A |
G |
19: 46,317,765 (GRCm39) |
H149R |
probably benign |
Het |
| Flg2 |
T |
A |
3: 93,127,789 (GRCm39) |
S2234T |
unknown |
Het |
| Gtf2e1 |
A |
C |
16: 37,356,698 (GRCm39) |
|
probably null |
Het |
| H2-Q7 |
A |
T |
17: 35,658,655 (GRCm39) |
S98C |
probably damaging |
Het |
| Hcn2 |
G |
T |
10: 79,569,607 (GRCm39) |
E536* |
probably null |
Het |
| Kat6b |
A |
T |
14: 21,720,748 (GRCm39) |
H1700L |
probably damaging |
Het |
| Klhl3 |
C |
T |
13: 58,248,192 (GRCm39) |
V35I |
probably benign |
Het |
| Krt34 |
A |
T |
11: 99,930,916 (GRCm39) |
L162Q |
probably damaging |
Het |
| Ly9 |
A |
G |
1: 171,416,663 (GRCm39) |
S644P |
probably damaging |
Het |
| Magi1 |
A |
T |
6: 93,676,620 (GRCm39) |
V685E |
probably damaging |
Het |
| Malrd1 |
A |
G |
2: 15,531,408 (GRCm39) |
|
probably benign |
Het |
| Malrd1 |
A |
T |
2: 15,672,740 (GRCm39) |
H599L |
probably benign |
Het |
| Matn2 |
T |
A |
15: 34,426,380 (GRCm39) |
C631S |
probably damaging |
Het |
| Megf8 |
A |
T |
7: 25,049,120 (GRCm39) |
D1739V |
probably damaging |
Het |
| Mlf1 |
G |
A |
3: 67,300,277 (GRCm39) |
R98Q |
probably benign |
Het |
| Mprip |
T |
A |
11: 59,649,815 (GRCm39) |
I1173K |
possibly damaging |
Het |
| Mrc1 |
A |
G |
2: 14,275,016 (GRCm39) |
D439G |
probably damaging |
Het |
| Mroh5 |
A |
T |
15: 73,662,691 (GRCm39) |
W208R |
probably damaging |
Het |
| Ms4a5 |
T |
G |
19: 11,256,646 (GRCm39) |
I84L |
probably benign |
Het |
| Myt1 |
G |
A |
2: 181,405,218 (GRCm39) |
|
probably null |
Het |
| Nbea |
T |
A |
3: 55,907,990 (GRCm39) |
H1374L |
probably damaging |
Het |
| Nbeal1 |
T |
A |
1: 60,292,633 (GRCm39) |
I1095K |
probably benign |
Het |
| Nolc1 |
A |
G |
19: 46,071,509 (GRCm39) |
|
probably benign |
Het |
| Nr5a2 |
A |
G |
1: 136,887,976 (GRCm39) |
L18P |
probably benign |
Het |
| Nup188 |
G |
T |
2: 30,212,199 (GRCm39) |
C562F |
probably damaging |
Het |
| Obscn |
A |
G |
11: 58,971,597 (GRCm39) |
V2415A |
probably damaging |
Het |
| Pacsin2 |
A |
T |
15: 83,263,879 (GRCm39) |
|
probably null |
Het |
| Pias3 |
A |
G |
3: 96,606,839 (GRCm39) |
H34R |
possibly damaging |
Het |
| Ppfia2 |
T |
C |
10: 106,729,361 (GRCm39) |
V903A |
probably damaging |
Het |
| Pramel1 |
T |
A |
4: 143,123,275 (GRCm39) |
L84Q |
probably damaging |
Het |
| Pramel6 |
G |
A |
2: 87,339,782 (GRCm39) |
C182Y |
probably damaging |
Het |
| Prdm4 |
A |
G |
10: 85,743,896 (GRCm39) |
Y120H |
probably damaging |
Het |
| Prss28 |
A |
G |
17: 25,530,331 (GRCm39) |
M212V |
probably benign |
Het |
| Rbp3 |
G |
T |
14: 33,677,224 (GRCm39) |
G391* |
probably null |
Het |
| Rc3h2 |
C |
T |
2: 37,301,151 (GRCm39) |
|
probably null |
Het |
| Ret |
A |
G |
6: 118,150,582 (GRCm39) |
F645L |
probably benign |
Het |
| Saxo5 |
T |
C |
8: 3,529,268 (GRCm39) |
L251P |
probably damaging |
Het |
| Sgsm2 |
A |
G |
11: 74,755,995 (GRCm39) |
S402P |
possibly damaging |
Het |
| Shc3 |
T |
A |
13: 51,636,915 (GRCm39) |
|
probably null |
Het |
| Slc25a16 |
A |
G |
10: 62,776,938 (GRCm39) |
N246S |
probably benign |
Het |
| Snrpd1 |
T |
A |
18: 10,623,694 (GRCm39) |
H26Q |
probably benign |
Het |
| Thsd1 |
A |
G |
8: 22,733,363 (GRCm39) |
T137A |
probably damaging |
Het |
| Tns1 |
T |
A |
1: 73,957,209 (GRCm39) |
K1725N |
probably damaging |
Het |
| Tomm40l |
T |
A |
1: 171,048,161 (GRCm39) |
T147S |
probably damaging |
Het |
| Tomm6 |
G |
T |
17: 47,998,932 (GRCm39) |
|
probably benign |
Het |
| Trp53 |
G |
A |
11: 69,480,440 (GRCm39) |
C272Y |
probably damaging |
Het |
| Trpm7 |
A |
T |
2: 126,649,214 (GRCm39) |
V1492E |
probably benign |
Het |
| Tsen2 |
G |
A |
6: 115,536,592 (GRCm39) |
R116H |
probably benign |
Het |
| Uvrag |
A |
G |
7: 98,555,726 (GRCm39) |
F456S |
probably damaging |
Het |
| Vmn1r86 |
A |
T |
7: 12,836,279 (GRCm39) |
M199K |
possibly damaging |
Het |
| Vmn2r4 |
C |
T |
3: 64,317,378 (GRCm39) |
C120Y |
probably damaging |
Het |
|
| Other mutations in Tnik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Tnik
|
APN |
3 |
28,708,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00726:Tnik
|
APN |
3 |
28,587,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01022:Tnik
|
APN |
3 |
28,679,377 (GRCm39) |
splice site |
probably null |
|
|
IGL01145:Tnik
|
APN |
3 |
28,658,316 (GRCm39) |
intron |
probably benign |
|
|
IGL01664:Tnik
|
APN |
3 |
28,692,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01843:Tnik
|
APN |
3 |
28,625,007 (GRCm39) |
splice site |
probably null |
|
|
IGL02378:Tnik
|
APN |
3 |
28,692,608 (GRCm39) |
nonsense |
probably null |
|
|
IGL02448:Tnik
|
APN |
3 |
28,675,226 (GRCm39) |
missense |
probably null |
0.01 |
|
IGL02756:Tnik
|
APN |
3 |
28,596,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Tnik
|
APN |
3 |
28,720,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
delightful
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hottie
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
Knockout
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Looker
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
Lovely
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
Usher
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0135:Tnik
|
UTSW |
3 |
28,661,394 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0418:Tnik
|
UTSW |
3 |
28,625,029 (GRCm39) |
nonsense |
probably null |
|
|
R0540:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0549:Tnik
|
UTSW |
3 |
28,625,069 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0556:Tnik
|
UTSW |
3 |
28,679,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0586:Tnik
|
UTSW |
3 |
28,631,510 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0842:Tnik
|
UTSW |
3 |
28,648,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1068:Tnik
|
UTSW |
3 |
28,587,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1171:Tnik
|
UTSW |
3 |
28,587,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1597:Tnik
|
UTSW |
3 |
28,658,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Tnik
|
UTSW |
3 |
28,719,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1652:Tnik
|
UTSW |
3 |
28,658,442 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1996:Tnik
|
UTSW |
3 |
28,719,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2333:Tnik
|
UTSW |
3 |
28,587,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Tnik
|
UTSW |
3 |
28,700,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Tnik
|
UTSW |
3 |
28,722,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3774:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3775:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4007:Tnik
|
UTSW |
3 |
28,658,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4119:Tnik
|
UTSW |
3 |
28,720,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4209:Tnik
|
UTSW |
3 |
28,413,214 (GRCm39) |
splice site |
probably benign |
|
|
R4441:Tnik
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4611:Tnik
|
UTSW |
3 |
28,596,249 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4714:Tnik
|
UTSW |
3 |
28,648,226 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4772:Tnik
|
UTSW |
3 |
28,661,359 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4829:Tnik
|
UTSW |
3 |
28,593,690 (GRCm39) |
intron |
probably benign |
|
|
R4839:Tnik
|
UTSW |
3 |
28,650,224 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4898:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5029:Tnik
|
UTSW |
3 |
28,719,993 (GRCm39) |
splice site |
probably null |
|
|
R5278:Tnik
|
UTSW |
3 |
28,704,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5307:Tnik
|
UTSW |
3 |
28,596,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tnik
|
UTSW |
3 |
28,596,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5375:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5459:Tnik
|
UTSW |
3 |
28,715,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Tnik
|
UTSW |
3 |
28,666,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5749:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5780:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5837:Tnik
|
UTSW |
3 |
28,722,202 (GRCm39) |
unclassified |
probably benign |
|
|
R5969:Tnik
|
UTSW |
3 |
28,675,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6244:Tnik
|
UTSW |
3 |
28,704,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Tnik
|
UTSW |
3 |
28,631,649 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6464:Tnik
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6473:Tnik
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R6737:Tnik
|
UTSW |
3 |
28,650,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7049:Tnik
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
R7237:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7267:Tnik
|
UTSW |
3 |
28,700,776 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7445:Tnik
|
UTSW |
3 |
28,718,058 (GRCm39) |
splice site |
probably null |
|
|
R7499:Tnik
|
UTSW |
3 |
28,684,743 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7629:Tnik
|
UTSW |
3 |
28,715,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7654:Tnik
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7886:Tnik
|
UTSW |
3 |
28,720,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8096:Tnik
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8210:Tnik
|
UTSW |
3 |
28,658,482 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8233:Tnik
|
UTSW |
3 |
28,609,086 (GRCm39) |
missense |
unknown |
|
|
R8386:Tnik
|
UTSW |
3 |
28,317,823 (GRCm39) |
missense |
unknown |
|
|
R8399:Tnik
|
UTSW |
3 |
28,548,159 (GRCm39) |
missense |
unknown |
|
|
R8490:Tnik
|
UTSW |
3 |
28,650,321 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8539:Tnik
|
UTSW |
3 |
28,596,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8751:Tnik
|
UTSW |
3 |
28,666,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8804:Tnik
|
UTSW |
3 |
28,648,202 (GRCm39) |
missense |
unknown |
|
|
R8966:Tnik
|
UTSW |
3 |
28,587,044 (GRCm39) |
missense |
unknown |
|
|
R8998:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8999:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Tnik
|
UTSW |
3 |
28,692,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9284:Tnik
|
UTSW |
3 |
28,593,570 (GRCm39) |
missense |
unknown |
|
|
R9290:Tnik
|
UTSW |
3 |
28,675,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Tnik
|
UTSW |
3 |
28,684,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Tnik
|
UTSW |
3 |
28,649,093 (GRCm39) |
missense |
unknown |
|
|
X0022:Tnik
|
UTSW |
3 |
28,722,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnik
|
UTSW |
3 |
28,661,477 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Tnik
|
UTSW |
3 |
28,658,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTCAGCATACAGTCATGTG -3'
(R):5'- CTTTCATCTTTGGGGAAATGCC -3'
Sequencing Primer
(F):5'- ATAGTGGCCTGTAGCTCAGCTC -3'
(R):5'- GGAAATGCCCCACCCCC -3'
|
| Posted On |
2018-05-21 |
Incidental Mutation