Incidental Mutation 'R6474:Zfp871'
ID 516748
Institutional Source Beutler Lab
Gene Symbol Zfp871
Ensembl Gene ENSMUSG00000024298
Gene Name zinc finger protein 871
Synonyms 9030612M13Rik
MMRRC Submission 044607-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6474 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 32984470-33007261 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 32994647 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 157 (D157G)
Ref Sequence ENSEMBL: ENSMUSP00000050501 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057501] [ENSMUST00000159086]
AlphaFold G5E905
Predicted Effect possibly damaging
Transcript: ENSMUST00000057501
AA Change: D157G

PolyPhen 2 Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000050501
Gene: ENSMUSG00000024298
AA Change: D157G

DomainStartEndE-ValueType
KRAB 1 42 1.32e0 SMART
ZnF_C2H2 174 196 5.9e-3 SMART
ZnF_C2H2 202 224 6.32e-3 SMART
ZnF_C2H2 230 252 1.47e-3 SMART
ZnF_C2H2 258 280 3.63e-3 SMART
ZnF_C2H2 286 308 1.79e-2 SMART
ZnF_C2H2 314 336 4.79e-3 SMART
ZnF_C2H2 342 364 1.69e-3 SMART
ZnF_C2H2 370 392 2.79e-4 SMART
ZnF_C2H2 398 420 1.23e-5 SMART
ZnF_C2H2 426 448 1.2e-3 SMART
ZnF_C2H2 454 476 5.42e-2 SMART
ZnF_C2H2 482 504 8.6e-5 SMART
ZnF_C2H2 510 532 5.21e-4 SMART
ZnF_C2H2 538 560 3.11e-2 SMART
ZnF_C2H2 566 588 2.86e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159086
AA Change: D176G

PolyPhen 2 Score 0.438 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000127178
Gene: ENSMUSG00000024298
AA Change: D176G

DomainStartEndE-ValueType
KRAB 4 61 2.18e-15 SMART
ZnF_C2H2 193 215 5.9e-3 SMART
ZnF_C2H2 221 243 6.32e-3 SMART
ZnF_C2H2 249 271 1.47e-3 SMART
ZnF_C2H2 277 299 3.63e-3 SMART
ZnF_C2H2 305 327 1.79e-2 SMART
ZnF_C2H2 333 355 4.79e-3 SMART
ZnF_C2H2 361 383 1.69e-3 SMART
ZnF_C2H2 389 411 2.79e-4 SMART
ZnF_C2H2 417 439 1.23e-5 SMART
ZnF_C2H2 445 467 1.2e-3 SMART
ZnF_C2H2 473 495 5.42e-2 SMART
ZnF_C2H2 501 523 8.6e-5 SMART
ZnF_C2H2 529 551 5.21e-4 SMART
ZnF_C2H2 557 579 3.11e-2 SMART
ZnF_C2H2 585 607 2.86e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168337
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 92.0%
Validation Efficiency 100% (35/35)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd8 T A 8: 71,914,359 (GRCm39) N90Y probably damaging Het
Alkal1 T C 1: 6,459,670 (GRCm39) V82A probably damaging Het
Ascc3 T C 10: 50,624,932 (GRCm39) S1607P probably benign Het
Ccny A T 18: 9,345,427 (GRCm39) L149H probably damaging Het
Clptm1 T C 7: 19,369,762 (GRCm39) N383D possibly damaging Het
Clrn2 T A 5: 45,621,074 (GRCm39) M156K probably benign Het
Coro2b T A 9: 62,333,910 (GRCm39) H328L probably benign Het
Echs1 A T 7: 139,688,055 (GRCm39) M250K probably benign Het
Ecsit A G 9: 21,985,981 (GRCm39) V145A possibly damaging Het
Fas G A 19: 34,293,969 (GRCm39) G108D probably damaging Het
Folh1 A G 7: 86,424,964 (GRCm39) W2R probably damaging Het
Gba1 C T 3: 89,111,388 (GRCm39) P51L probably benign Het
Grik2 C T 10: 49,008,776 (GRCm39) M770I probably benign Het
Hcst T C 7: 30,117,250 (GRCm39) N74S probably damaging Het
Hdac9 T A 12: 34,481,990 (GRCm39) probably null Het
Hsfy2 T A 1: 56,676,150 (GRCm39) D129V probably damaging Het
Htt T C 5: 34,982,239 (GRCm39) V941A probably benign Het
Naip5 A G 13: 100,351,171 (GRCm39) V1279A possibly damaging Het
Neb T A 2: 52,170,624 (GRCm39) M1683L probably benign Het
Nudt21 C T 8: 94,746,282 (GRCm39) V139I probably benign Het
Or5e1 T C 7: 108,354,236 (GRCm39) Y58H probably damaging Het
Pex2 A G 3: 5,626,191 (GRCm39) F206S probably damaging Het
Plek2 C A 12: 78,943,065 (GRCm39) R77L probably benign Het
Ppfia1 A T 7: 144,059,942 (GRCm39) D623E possibly damaging Het
Ppm1l T A 3: 69,460,374 (GRCm39) I317N probably damaging Het
Prkacb T A 3: 146,461,479 (GRCm39) T36S probably damaging Het
Sphkap T A 1: 83,256,544 (GRCm39) I115F probably damaging Het
Sprtn G T 8: 125,625,873 (GRCm39) E95* probably null Het
St3gal1 A G 15: 66,983,195 (GRCm39) V187A possibly damaging Het
Tcap C A 11: 98,275,003 (GRCm39) Q46K probably benign Het
Thada T C 17: 84,751,339 (GRCm39) I546V possibly damaging Het
Tubal3 T A 13: 3,983,107 (GRCm39) S296T probably benign Het
Ube3a A G 7: 58,936,772 (GRCm39) N683D probably damaging Het
Vmn2r82 T G 10: 79,214,871 (GRCm39) L285V possibly damaging Het
Other mutations in Zfp871
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00849:Zfp871 APN 17 32,994,873 (GRCm39) missense probably benign
IGL00963:Zfp871 APN 17 32,993,726 (GRCm39) missense probably benign 0.25
IGL01687:Zfp871 APN 17 32,994,618 (GRCm39) missense probably benign 0.00
IGL02170:Zfp871 APN 17 32,994,662 (GRCm39) missense possibly damaging 0.72
IGL02399:Zfp871 APN 17 32,993,329 (GRCm39) missense probably benign 0.18
R0304:Zfp871 UTSW 17 32,993,408 (GRCm39) missense probably damaging 0.99
R1215:Zfp871 UTSW 17 32,994,946 (GRCm39) missense possibly damaging 0.70
R1444:Zfp871 UTSW 17 32,993,900 (GRCm39) missense possibly damaging 0.85
R1754:Zfp871 UTSW 17 32,994,308 (GRCm39) missense probably damaging 1.00
R1913:Zfp871 UTSW 17 32,994,891 (GRCm39) missense possibly damaging 0.53
R2018:Zfp871 UTSW 17 32,993,751 (GRCm39) missense probably damaging 1.00
R2180:Zfp871 UTSW 17 32,994,275 (GRCm39) missense probably damaging 1.00
R2881:Zfp871 UTSW 17 32,994,407 (GRCm39) missense probably damaging 1.00
R4422:Zfp871 UTSW 17 32,993,808 (GRCm39) missense probably benign 0.37
R4422:Zfp871 UTSW 17 32,993,807 (GRCm39) missense probably benign 0.39
R4979:Zfp871 UTSW 17 32,994,829 (GRCm39) missense probably damaging 0.99
R5564:Zfp871 UTSW 17 32,994,842 (GRCm39) missense possibly damaging 0.70
R6228:Zfp871 UTSW 17 32,994,858 (GRCm39) missense possibly damaging 0.50
R6232:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R6233:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R6234:Zfp871 UTSW 17 32,994,494 (GRCm39) frame shift probably null
R7237:Zfp871 UTSW 17 32,994,289 (GRCm39) missense probably damaging 1.00
R7809:Zfp871 UTSW 17 32,993,826 (GRCm39) missense probably damaging 1.00
R8830:Zfp871 UTSW 17 32,993,901 (GRCm39) missense probably benign 0.03
R9219:Zfp871 UTSW 17 32,993,914 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TTTCGCAACTGAATCCAACG -3'
(R):5'- AAGTGTACTTCTTAAACCTGACCC -3'

Sequencing Primer
(F):5'- ATGAGCGAAGGTTTTCCCAC -3'
(R):5'- TGACCCAAAGCATGAATCGTG -3'
Posted On 2018-05-21