Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01154:Or51t4'

51692

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or51t4

Ensembl Gene

ENSMUSG00000045824

Gene Name

olfactory receptor family 51 subfamily T member 4

Synonyms

GA_x6K02T2PBJ9-5659738-5660748, MOR14-9, Olfr574

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.175) question?

Stock #

IGL01154

Quality Score

Status

Chromosome

Chromosomal Location

102597674-102598714 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 102598046 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 115 (S115P)

Ref Sequence

ENSEMBL: ENSMUSP00000147694 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052997] [ENSMUST00000211329] [ENSMUST00000213477] [ENSMUST00000216420]

AlphaFold

F8VQ18

Predicted Effect

probably damaging
Transcript: ENSMUST00000052997
AA Change: S125P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000095815
Gene: ENSMUSG00000045824
AA Change: S125P

Domain	Start	End	E-Value	Type
low complexity region	14	31	N/A	INTRINSIC
Pfam:7tm_4	44	323	3.8e-96	PFAM
Pfam:7TM_GPCR_Srsx	48	195	1.2e-8	PFAM
Pfam:7tm_1	54	305	2e-17	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000211329
AA Change: S115P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably benign
Transcript: ENSMUST00000213477

Predicted Effect

probably benign
Transcript: ENSMUST00000216420

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,834,475 (GRCm39)	V124I	probably damaging	Het
2210408I21Rik	T	G	13: 77,429,213 (GRCm39)	F767V	probably benign	Het
A2m	C	A	6: 121,650,501 (GRCm39)	S1203*	probably null	Het
Abcc3	T	C	11: 94,250,058 (GRCm39)		probably benign	Het
Adamts13	T	C	2: 26,896,206 (GRCm39)	Y1200H	probably benign	Het
Aldh1l2	T	C	10: 83,356,237 (GRCm39)	D51G	probably damaging	Het
Apc2	A	G	10: 80,148,903 (GRCm39)	E1319G	possibly damaging	Het
Arap3	A	T	18: 38,129,787 (GRCm39)	S125T	probably benign	Het
Atp2b1	T	A	10: 98,832,750 (GRCm39)	V417E	probably damaging	Het
Bpifa1	T	A	2: 153,985,920 (GRCm39)	D78E	probably benign	Het
Catsperb	C	A	12: 101,591,940 (GRCm39)	A1090E	possibly damaging	Het
Ceacam9	C	A	7: 16,457,886 (GRCm39)	T138K	probably damaging	Het
Cenpf	T	A	1: 189,412,530 (GRCm39)	E244D	probably benign	Het
Cep135	A	T	5: 76,754,643 (GRCm39)		probably benign	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Col15a1	A	C	4: 47,208,450 (GRCm39)	T6P	possibly damaging	Het
Cyp11b1	T	A	15: 74,710,383 (GRCm39)	Q306L	probably benign	Het
Defa22	T	A	8: 21,653,053 (GRCm39)		probably null	Het
Dnah5	A	T	15: 28,458,802 (GRCm39)	T4480S	possibly damaging	Het
Fastkd1	T	C	2: 69,520,404 (GRCm39)		probably null	Het
Flt1	A	G	5: 147,512,966 (GRCm39)	Y1124H	possibly damaging	Het
Fsd1l	A	G	4: 53,701,074 (GRCm39)	M469V	probably benign	Het
Fxr2	T	C	11: 69,532,259 (GRCm39)		probably benign	Het
Gm10801	A	T	2: 98,494,328 (GRCm39)	Y135F	probably benign	Het
Grm4	A	T	17: 27,653,711 (GRCm39)	C699*	probably null	Het
Hcn4	A	G	9: 58,766,362 (GRCm39)	T677A	unknown	Het
Igkv9-123	G	T	6: 67,931,518 (GRCm39)		probably benign	Het
Irf4	T	A	13: 30,941,404 (GRCm39)	H253Q	possibly damaging	Het
Jakmip2	T	C	18: 43,723,744 (GRCm39)		probably benign	Het
Kmt2c	A	G	5: 25,489,397 (GRCm39)	V1134A	probably damaging	Het
Limch1	G	T	5: 66,903,301 (GRCm39)	E17*	probably null	Het
Nap1l1	T	A	10: 111,322,536 (GRCm39)	N72K	probably damaging	Het
Or4x11	T	C	2: 89,867,812 (GRCm39)	L183P	probably damaging	Het
Otud6b	A	T	4: 14,811,732 (GRCm39)	Y304N	probably damaging	Het
Pdcd10	A	C	3: 75,448,540 (GRCm39)	M8R	probably damaging	Het
Ppip5k1	T	C	2: 121,173,660 (GRCm39)	T404A	probably damaging	Het
Ppp2r2d	C	T	7: 138,483,940 (GRCm39)	A197V	probably benign	Het
Psg25	C	T	7: 18,258,624 (GRCm39)	D351N	probably benign	Het
Sbno1	A	T	5: 124,548,312 (GRCm39)	I87N	probably damaging	Het
Stfa2l1	C	T	16: 35,980,307 (GRCm39)		probably benign	Het
Sugp2	T	A	8: 70,695,349 (GRCm39)	D107E	probably damaging	Het
Syne1	G	T	10: 5,310,848 (GRCm39)	F576L	probably damaging	Het
Syne3	A	G	12: 104,924,328 (GRCm39)	F357S	probably benign	Het
Tenm2	A	G	11: 35,932,371 (GRCm39)	L1741P	probably damaging	Het
Tgs1	A	T	4: 3,585,473 (GRCm39)	K117*	probably null	Het
Tram1	C	T	1: 13,649,673 (GRCm39)		probably null	Het
Trank1	T	A	9: 111,215,468 (GRCm39)	D1799E	probably benign	Het
Ttc14	A	T	3: 33,857,248 (GRCm39)	Y198F	probably benign	Het
Ube3b	A	G	5: 114,544,313 (GRCm39)	N570S	probably null	Het
Ube4b	A	G	4: 149,449,927 (GRCm39)	F412S	probably benign	Het
Vac14	T	C	8: 111,380,239 (GRCm39)		probably benign	Het
Vmn2r65	T	C	7: 84,592,729 (GRCm39)	T493A	probably benign	Het
Zfp408	T	C	2: 91,478,351 (GRCm39)		probably benign	Het
Zfp580	C	T	7: 5,056,267 (GRCm39)	T209I	possibly damaging	Het

Other mutations in Or51t4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01732:Or51t4	APN	7	102,598,446 (GRCm39)	missense	probably damaging	1.00
IGL02185:Or51t4	APN	7	102,597,721 (GRCm39)	missense	probably damaging	0.96
PIT4382001:Or51t4	UTSW	7	102,598,656 (GRCm39)	missense	probably benign
PIT4520001:Or51t4	UTSW	7	102,597,921 (GRCm39)	missense	probably damaging	1.00
R0765:Or51t4	UTSW	7	102,597,939 (GRCm39)	missense	probably damaging	1.00
R1616:Or51t4	UTSW	7	102,597,721 (GRCm39)	missense	probably damaging	0.96
R2041:Or51t4	UTSW	7	102,598,170 (GRCm39)	missense	probably damaging	0.98
R2079:Or51t4	UTSW	7	102,598,702 (GRCm39)	missense	probably benign	0.00
R2261:Or51t4	UTSW	7	102,598,464 (GRCm39)	missense	probably damaging	1.00
R2263:Or51t4	UTSW	7	102,598,464 (GRCm39)	missense	probably damaging	1.00
R2513:Or51t4	UTSW	7	102,598,700 (GRCm39)	missense	probably benign
R2903:Or51t4	UTSW	7	102,598,661 (GRCm39)	missense	probably benign	0.05
R4445:Or51t4	UTSW	7	102,598,005 (GRCm39)	missense	possibly damaging	0.93
R4512:Or51t4	UTSW	7	102,597,945 (GRCm39)	missense	probably damaging	1.00
R4513:Or51t4	UTSW	7	102,597,945 (GRCm39)	missense	probably damaging	1.00
R4528:Or51t4	UTSW	7	102,598,013 (GRCm39)	missense	probably damaging	1.00
R4904:Or51t4	UTSW	7	102,598,272 (GRCm39)	missense	probably damaging	1.00
R5935:Or51t4	UTSW	7	102,598,017 (GRCm39)	missense	probably benign	0.01
R6784:Or51t4	UTSW	7	102,597,722 (GRCm39)	missense	possibly damaging	0.91
R6889:Or51t4	UTSW	7	102,597,975 (GRCm39)	missense	possibly damaging	0.94
R7082:Or51t4	UTSW	7	102,598,455 (GRCm39)	missense	probably damaging	1.00
R7125:Or51t4	UTSW	7	102,598,386 (GRCm39)	missense	probably damaging	0.99
R7549:Or51t4	UTSW	7	102,597,798 (GRCm39)	missense	possibly damaging	0.92
R7564:Or51t4	UTSW	7	102,598,473 (GRCm39)	missense	probably damaging	1.00
R7947:Or51t4	UTSW	7	102,598,278 (GRCm39)	missense	probably damaging	1.00
R8460:Or51t4	UTSW	7	102,598,531 (GRCm39)	nonsense	probably null
R8518:Or51t4	UTSW	7	102,597,804 (GRCm39)	missense	probably damaging	1.00
R8859:Or51t4	UTSW	7	102,598,373 (GRCm39)	missense	probably damaging	1.00
R9116:Or51t4	UTSW	7	102,598,527 (GRCm39)	missense	possibly damaging	0.87
R9327:Or51t4	UTSW	7	102,597,687 (GRCm39)	missense	probably benign	0.00
R9408:Or51t4	UTSW	7	102,598,443 (GRCm39)	missense	probably damaging	1.00
Z1177:Or51t4	UTSW	7	102,597,959 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21