Mutagenetix > Incidental Mutation

Incidental Mutation 'R6461:Mup10'

517602

Institutional Source

Beutler Lab

Gene Symbol

Mup10

Ensembl Gene

ENSMUSG00000078680

Gene Name

major urinary protein 10

Synonyms

2610016E04Rik

MMRRC Submission

044390-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R6461 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

60534259-60538198 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 60538078 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 4 (M4L)

Ref Sequence

ENSEMBL: ENSMUSP00000095655 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098047]

AlphaFold

A2BIN1

Predicted Effect

unknown
Transcript: ENSMUST00000098047
AA Change: M4L

SMART Domains

Protein: ENSMUSP00000095655
Gene: ENSMUSG00000078680
AA Change: M4L

Domain	Start	End	E-Value	Type
low complexity region	5	16	N/A	INTRINSIC
Pfam:Lipocalin	34	173	5.6e-34	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148302

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.7%
20x: 93.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abtb3	T	A	10: 85,476,428 (GRCm39)	I903N	probably damaging	Het
Atp12a	C	T	14: 56,610,695 (GRCm39)	R280C	probably damaging	Het
Dnmbp	A	G	19: 43,855,964 (GRCm39)		probably null	Het
Enpp5	G	A	17: 44,396,155 (GRCm39)	G356S	probably damaging	Het
Fbxo40	T	C	16: 36,790,390 (GRCm39)	E240G	probably benign	Het
Gne	T	C	4: 44,060,078 (GRCm39)	D105G	probably damaging	Het
Grin2c	A	T	11: 115,146,522 (GRCm39)	M494K	possibly damaging	Het
Hnrnpk	A	G	13: 58,541,008 (GRCm39)		probably null	Het
Irf6	G	C	1: 192,849,779 (GRCm39)	G234R	probably damaging	Het
Lman2	A	G	13: 55,494,728 (GRCm39)	F347L	probably damaging	Het
Mcfd2	G	A	17: 87,565,494 (GRCm39)	T3I	probably benign	Het
Mon1b	A	G	8: 114,365,170 (GRCm39)	D166G	probably damaging	Het
Or13c7b	T	C	4: 43,821,355 (GRCm39)	E2G	probably benign	Het
Or2h1b	C	T	17: 37,462,362 (GRCm39)	C167Y	probably damaging	Het
Or51s1	T	A	7: 102,558,235 (GRCm39)	R270S	possibly damaging	Het
Papln	A	G	12: 83,828,587 (GRCm39)		probably null	Het
Pelp1	A	T	11: 70,287,132 (GRCm39)	V522E	probably damaging	Het
Scn1a	T	C	2: 66,156,466 (GRCm39)	D481G	probably null	Het
Scube1	G	A	15: 83,496,628 (GRCm39)	T791I	probably damaging	Het
Sec24a	T	C	11: 51,604,373 (GRCm39)	I748V	possibly damaging	Het
Slc29a2	A	G	19: 5,077,768 (GRCm39)	T236A	probably benign	Het
Smarca4	T	A	9: 21,590,316 (GRCm39)	I1152N	probably damaging	Het
Syngap1	A	G	17: 27,183,822 (GRCm39)	I1026V	probably damaging	Het
Tnxb	G	T	17: 34,890,872 (GRCm39)	R405L	probably damaging	Het
Zbtb11	G	A	16: 55,827,234 (GRCm39)	R900H	probably damaging	Het
Zfp142	T	C	1: 74,606,344 (GRCm39)	K1639R	probably damaging	Het

Other mutations in Mup10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R7253:Mup10	UTSW	4	60,538,077 (GRCm39)	missense	unknown
R8236:Mup10	UTSW	4	60,537,562 (GRCm39)	missense	probably damaging	0.99
R8930:Mup10	UTSW	4	60,536,708 (GRCm39)	missense	possibly damaging	0.96
R8932:Mup10	UTSW	4	60,536,708 (GRCm39)	missense	possibly damaging	0.96

Predicted Primers

PCR Primer
(F):5'- TGTCTAAGAGATTGGGGCACTATAC -3'
(R):5'- TCCACAAAGCCTGACTGAGG -3'

Sequencing Primer
(F):5'- GGCACTATACCCATCCCCTC -3'
(R):5'- CCTGACTGAGGTAGAGGAGACCC -3'

Posted On

2018-05-21