Incidental Mutation 'R6420:Map3k10'
ID 518146
Institutional Source Beutler Lab
Gene Symbol Map3k10
Ensembl Gene ENSMUSG00000040390
Gene Name mitogen-activated protein kinase kinase kinase 10
Synonyms Mlk2, mixed lineage kinase 2, MKN28 derived nonreceptor_type, MKN28 kinase, serine/threonine kinase
MMRRC Submission 044562-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6420 (G1)
Quality Score 168.009
Status Validated
Chromosome 7
Chromosomal Location 27355800-27374023 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 27362709 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 459 (F459S)
Ref Sequence ENSEMBL: ENSMUSP00000103978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036453] [ENSMUST00000108341] [ENSMUST00000138243]
AlphaFold Q66L42
Predicted Effect probably damaging
Transcript: ENSMUST00000036453
AA Change: F459S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000037725
Gene: ENSMUSG00000040390
AA Change: F459S

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
SH3 19 80 6e-20 SMART
Pfam:Pkinase 98 357 7.4e-59 PFAM
Pfam:Pkinase_Tyr 98 357 3.8e-62 PFAM
coiled coil region 378 449 N/A INTRINSIC
low complexity region 501 511 N/A INTRINSIC
low complexity region 524 550 N/A INTRINSIC
low complexity region 665 676 N/A INTRINSIC
low complexity region 761 778 N/A INTRINSIC
low complexity region 835 847 N/A INTRINSIC
low complexity region 870 881 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000108341
AA Change: F459S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000103978
Gene: ENSMUSG00000040390
AA Change: F459S

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
SH3 19 80 6e-20 SMART
Pfam:Pkinase_Tyr 98 357 2e-62 PFAM
Pfam:Pkinase 98 358 4.8e-59 PFAM
coiled coil region 378 449 N/A INTRINSIC
low complexity region 501 511 N/A INTRINSIC
low complexity region 524 550 N/A INTRINSIC
low complexity region 665 676 N/A INTRINSIC
low complexity region 761 778 N/A INTRINSIC
low complexity region 837 849 N/A INTRINSIC
low complexity region 872 883 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133551
Predicted Effect probably benign
Transcript: ENSMUST00000138243
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152032
Meta Mutation Damage Score 0.4554 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.5%
Validation Efficiency 100% (38/38)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit normal development, reproduction and lifespan. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530064D06Rik A T 17: 48,473,566 (GRCm39) I117N probably damaging Het
Abca15 A G 7: 119,996,351 (GRCm39) K1426E possibly damaging Het
Arhgef17 A G 7: 100,579,269 (GRCm39) S560P probably damaging Het
Asb13 G A 13: 3,693,574 (GRCm39) V111I probably damaging Het
Dhx16 A G 17: 36,193,906 (GRCm39) E367G possibly damaging Het
Epc2 T C 2: 49,341,912 (GRCm39) V32A probably damaging Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Hdlbp T C 1: 93,358,726 (GRCm39) E275G probably damaging Het
Kdm7a T C 6: 39,142,102 (GRCm39) D392G probably damaging Het
Lgmn T A 12: 102,389,978 (GRCm39) R4* probably null Het
Lrrk2 C T 15: 91,696,549 (GRCm39) R2446C probably benign Het
Mup1 C G 4: 60,457,758 (GRCm39) E31Q possibly damaging Het
Nckap1l G C 15: 103,399,893 (GRCm39) G1025A possibly damaging Het
Or4d10 T G 19: 12,051,324 (GRCm39) K224T probably benign Het
Or5b24 A C 19: 12,912,584 (GRCm39) T161P probably damaging Het
Or8b39 T A 9: 37,996,890 (GRCm39) S253T probably benign Het
Or8b41 T G 9: 38,054,611 (GRCm39) L55R probably damaging Het
Or8k38 A T 2: 86,488,510 (GRCm39) C97* probably null Het
Pik3r5 G A 11: 68,366,250 (GRCm39) W42* probably null Het
Pkd1l2 C T 8: 117,740,638 (GRCm39) C2153Y probably damaging Het
Rad1 T C 15: 10,488,098 (GRCm39) V74A probably benign Het
Scara3 C T 14: 66,175,701 (GRCm39) G22D possibly damaging Het
Scn1a A G 2: 66,103,542 (GRCm39) I1906T probably damaging Het
Sema5b T A 16: 35,483,516 (GRCm39) D1051E probably benign Het
Slc16a12 T C 19: 34,650,097 (GRCm39) probably null Het
Slc25a23 T C 17: 57,359,780 (GRCm39) I324V probably damaging Het
Sord A T 2: 122,094,602 (GRCm39) K330M possibly damaging Het
Spag9 T C 11: 93,977,128 (GRCm39) V78A probably damaging Het
St3gal1 A G 15: 66,983,195 (GRCm39) V187A possibly damaging Het
Tnrc6a A G 7: 122,770,297 (GRCm39) T696A probably benign Het
Ttn A G 2: 76,542,619 (GRCm39) Y33456H possibly damaging Het
Unc45a C G 7: 79,989,400 (GRCm39) E23Q probably benign Het
Urb2 C T 8: 124,773,938 (GRCm39) R1490W probably damaging Het
Zfp62 A T 11: 49,107,340 (GRCm39) N477I probably damaging Het
Zfp846 T C 9: 20,505,007 (GRCm39) L289P probably damaging Het
Zfp959 G A 17: 56,205,094 (GRCm39) G377D probably damaging Het
Zswim3 G A 2: 164,662,653 (GRCm39) V378M probably damaging Het
Other mutations in Map3k10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Map3k10 APN 7 27,367,894 (GRCm39) missense probably damaging 1.00
IGL00672:Map3k10 APN 7 27,361,026 (GRCm39) missense probably damaging 0.98
IGL00913:Map3k10 APN 7 27,362,640 (GRCm39) unclassified probably benign
IGL01383:Map3k10 APN 7 27,357,424 (GRCm39) missense probably benign 0.15
IGL02683:Map3k10 APN 7 27,358,362 (GRCm39) missense probably damaging 1.00
R0039:Map3k10 UTSW 7 27,357,523 (GRCm39) missense possibly damaging 0.95
R0219:Map3k10 UTSW 7 27,356,156 (GRCm39) missense probably damaging 1.00
R0285:Map3k10 UTSW 7 27,373,325 (GRCm39) missense probably benign 0.00
R0368:Map3k10 UTSW 7 27,362,785 (GRCm39) missense probably damaging 0.98
R0724:Map3k10 UTSW 7 27,367,780 (GRCm39) missense probably damaging 1.00
R0729:Map3k10 UTSW 7 27,360,992 (GRCm39) missense probably damaging 1.00
R1734:Map3k10 UTSW 7 27,357,540 (GRCm39) missense probably damaging 1.00
R1847:Map3k10 UTSW 7 27,360,981 (GRCm39) splice site probably null
R2395:Map3k10 UTSW 7 27,373,418 (GRCm39) missense unknown
R2517:Map3k10 UTSW 7 27,362,688 (GRCm39) missense possibly damaging 0.92
R3841:Map3k10 UTSW 7 27,357,789 (GRCm39) missense possibly damaging 0.91
R4749:Map3k10 UTSW 7 27,357,786 (GRCm39) missense possibly damaging 0.78
R5269:Map3k10 UTSW 7 27,357,957 (GRCm39) missense probably benign 0.01
R5822:Map3k10 UTSW 7 27,356,159 (GRCm39) missense probably damaging 1.00
R6059:Map3k10 UTSW 7 27,356,247 (GRCm39) missense probably damaging 0.99
R6417:Map3k10 UTSW 7 27,362,709 (GRCm39) missense probably damaging 1.00
R7903:Map3k10 UTSW 7 27,357,382 (GRCm39) missense probably damaging 0.99
R8118:Map3k10 UTSW 7 27,372,842 (GRCm39) missense possibly damaging 0.91
R8191:Map3k10 UTSW 7 27,362,671 (GRCm39) missense probably damaging 0.99
R8336:Map3k10 UTSW 7 27,372,884 (GRCm39) missense probably benign 0.25
R8697:Map3k10 UTSW 7 27,362,784 (GRCm39) missense probably benign 0.13
R8699:Map3k10 UTSW 7 27,367,780 (GRCm39) missense probably damaging 0.99
R9237:Map3k10 UTSW 7 27,357,842 (GRCm39) nonsense probably null
R9526:Map3k10 UTSW 7 27,364,434 (GRCm39) missense probably damaging 1.00
X0020:Map3k10 UTSW 7 27,363,887 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGAAAACCACCTTGCCAAG -3'
(R):5'- ATGTGAACTCAGAGCCGATG -3'

Sequencing Primer
(F):5'- TTGCCAAGCACACACAATAATTATC -3'
(R):5'- AGCTAAGCCCTACCTCTGG -3'
Posted On 2018-05-24