Incidental Mutation 'R6429:Dstyk'
ID 518409
Institutional Source Beutler Lab
Gene Symbol Dstyk
Ensembl Gene ENSMUSG00000042046
Gene Name dual serine/threonine and tyrosine protein kinase
Synonyms A930019K20Rik, C430014H23Rik
MMRRC Submission 044567-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.267) question?
Stock # R6429 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 132345293-132394696 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 132377542 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 383 (Q383*)
Ref Sequence ENSEMBL: ENSMUSP00000139652 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045110] [ENSMUST00000188389]
AlphaFold Q6XUX1
Predicted Effect probably null
Transcript: ENSMUST00000045110
AA Change: Q383*
SMART Domains Protein: ENSMUSP00000035358
Gene: ENSMUSG00000042046
AA Change: Q383*

DomainStartEndE-ValueType
low complexity region 15 22 N/A INTRINSIC
low complexity region 57 73 N/A INTRINSIC
low complexity region 127 142 N/A INTRINSIC
low complexity region 285 299 N/A INTRINSIC
low complexity region 630 641 N/A INTRINSIC
Pfam:Pkinase_Tyr 651 904 6.9e-37 PFAM
Pfam:Pkinase 651 905 5.1e-37 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000187092
AA Change: Q136*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188006
Predicted Effect probably null
Transcript: ENSMUST00000188389
AA Change: Q383*
SMART Domains Protein: ENSMUSP00000139652
Gene: ENSMUSG00000042046
AA Change: Q383*

DomainStartEndE-ValueType
low complexity region 15 22 N/A INTRINSIC
low complexity region 57 73 N/A INTRINSIC
low complexity region 127 142 N/A INTRINSIC
low complexity region 285 299 N/A INTRINSIC
low complexity region 630 641 N/A INTRINSIC
S_TKc 650 859 2e-13 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
PHENOTYPE: Homozygous knockout results in impaired spatial learning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb G A 5: 114,366,652 (GRCm39) E1565K probably damaging Het
Amy1 T C 3: 113,363,158 (GRCm39) N63S probably damaging Het
Arhgef15 G T 11: 68,838,622 (GRCm39) N591K probably damaging Het
AW551984 A G 9: 39,511,910 (GRCm39) S34P probably damaging Het
C2cd3 A G 7: 100,081,298 (GRCm39) D127G probably damaging Het
Ccdc87 T A 19: 4,891,263 (GRCm39) V585E probably benign Het
Cemip2 T C 19: 21,779,272 (GRCm39) C361R probably benign Het
Cul2 T C 18: 3,421,345 (GRCm39) I223T probably damaging Het
Dgkq C T 5: 108,801,574 (GRCm39) V495M probably damaging Het
Dpp10 A G 1: 123,295,330 (GRCm39) I570T possibly damaging Het
Emilin2 C A 17: 71,617,951 (GRCm39) probably benign Het
Fnip1 A G 11: 54,406,393 (GRCm39) I1163M probably damaging Het
Fryl C T 5: 73,248,094 (GRCm39) E1008K possibly damaging Het
Gm35315 A T 5: 110,226,525 (GRCm39) Y305N possibly damaging Het
Grhl3 T A 4: 135,284,507 (GRCm39) D195V probably damaging Het
Ift56 T A 6: 38,375,248 (GRCm39) S250T possibly damaging Het
Il33 T C 19: 29,929,400 (GRCm39) F41S probably benign Het
Il4 A G 11: 53,504,736 (GRCm39) S15P possibly damaging Het
Inf2 C T 12: 112,570,690 (GRCm39) P410S probably benign Het
Kalrn T A 16: 34,152,534 (GRCm39) D349V possibly damaging Het
Krt4 A G 15: 101,831,229 (GRCm39) M224T probably benign Het
Lrp2 C T 2: 69,291,631 (GRCm39) S3516N probably damaging Het
Macf1 A T 4: 123,295,387 (GRCm39) probably null Het
Msr1 G A 8: 40,068,858 (GRCm39) P213S probably damaging Het
Nptx1 G T 11: 119,435,547 (GRCm39) C256* probably null Het
Nr1d1 T C 11: 98,662,840 (GRCm39) Y51C probably damaging Het
Or4c11c G A 2: 88,661,869 (GRCm39) R136Q probably benign Het
Panx3 T C 9: 37,572,461 (GRCm39) D363G probably damaging Het
Pira13 A T 7: 3,825,345 (GRCm39) H432Q possibly damaging Het
Prkag1 A G 15: 98,712,404 (GRCm39) F143L probably damaging Het
Ptger4 T C 15: 5,272,478 (GRCm39) K72R possibly damaging Het
Pvrig-ps A G 5: 138,340,312 (GRCm39) T28A probably benign Het
Rhod C T 19: 4,476,133 (GRCm39) C206Y probably benign Het
Rngtt C A 4: 33,320,606 (GRCm39) S51* probably null Het
Rreb1 T G 13: 38,116,105 (GRCm39) S1155A probably benign Het
Scn9a A C 2: 66,357,307 (GRCm39) I998S possibly damaging Het
Sfmbt1 T A 14: 30,495,868 (GRCm39) F50L probably damaging Het
Six4 A T 12: 73,150,247 (GRCm39) V766D probably damaging Het
Smpd1 T C 7: 105,206,135 (GRCm39) I421T probably damaging Het
Son T A 16: 91,455,054 (GRCm39) M1267K probably benign Het
Styk1 T A 6: 131,287,027 (GRCm39) D156V possibly damaging Het
Supt3 A G 17: 45,430,030 (GRCm39) E361G probably benign Het
Tbx3 T A 5: 119,812,256 (GRCm39) Y185* probably null Het
Trpm1 A T 7: 63,918,252 (GRCm39) T531S probably benign Het
Tspan32 T A 7: 142,572,479 (GRCm39) W172R possibly damaging Het
Urb1 A T 16: 90,559,318 (GRCm39) probably null Het
Vmn2r70 T A 7: 85,208,276 (GRCm39) I734F probably damaging Het
Vwa7 A G 17: 35,243,175 (GRCm39) T618A probably benign Het
Wac T A 18: 7,920,163 (GRCm39) V339E probably damaging Het
Wrn G A 8: 33,833,024 (GRCm39) T156M probably damaging Het
Zeb1 T A 18: 5,770,498 (GRCm39) C884S probably damaging Het
Zfp747l1 T C 7: 126,984,214 (GRCm39) probably benign Het
Zmpste24 A G 4: 120,952,867 (GRCm39) V10A probably damaging Het
Other mutations in Dstyk
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00950:Dstyk APN 1 132,387,726 (GRCm39) missense probably damaging 1.00
IGL01753:Dstyk APN 1 132,390,677 (GRCm39) missense probably damaging 1.00
IGL02156:Dstyk APN 1 132,377,664 (GRCm39) missense probably benign 0.27
IGL02175:Dstyk APN 1 132,377,129 (GRCm39) nonsense probably null
IGL02721:Dstyk APN 1 132,377,054 (GRCm39) missense probably benign 0.03
IGL03194:Dstyk APN 1 132,384,054 (GRCm39) splice site probably benign
PIT4305001:Dstyk UTSW 1 132,383,634 (GRCm39) nonsense probably null
PIT4791001:Dstyk UTSW 1 132,377,665 (GRCm39) missense probably benign 0.00
R0135:Dstyk UTSW 1 132,390,672 (GRCm39) missense probably damaging 1.00
R0309:Dstyk UTSW 1 132,384,602 (GRCm39) splice site probably benign
R0399:Dstyk UTSW 1 132,380,818 (GRCm39) splice site probably benign
R0781:Dstyk UTSW 1 132,381,063 (GRCm39) splice site probably benign
R1110:Dstyk UTSW 1 132,381,063 (GRCm39) splice site probably benign
R1138:Dstyk UTSW 1 132,391,224 (GRCm39) missense probably benign 0.00
R1300:Dstyk UTSW 1 132,377,651 (GRCm39) missense probably benign 0.02
R1330:Dstyk UTSW 1 132,377,618 (GRCm39) missense probably benign 0.25
R1509:Dstyk UTSW 1 132,384,084 (GRCm39) missense probably damaging 1.00
R1667:Dstyk UTSW 1 132,384,657 (GRCm39) missense probably damaging 1.00
R1728:Dstyk UTSW 1 132,384,722 (GRCm39) missense probably damaging 1.00
R1729:Dstyk UTSW 1 132,384,722 (GRCm39) missense probably damaging 1.00
R1730:Dstyk UTSW 1 132,384,722 (GRCm39) missense probably damaging 1.00
R1739:Dstyk UTSW 1 132,384,722 (GRCm39) missense probably damaging 1.00
R1757:Dstyk UTSW 1 132,361,832 (GRCm39) splice site probably benign
R1762:Dstyk UTSW 1 132,384,722 (GRCm39) missense probably damaging 1.00
R1783:Dstyk UTSW 1 132,384,722 (GRCm39) missense probably damaging 1.00
R1784:Dstyk UTSW 1 132,384,722 (GRCm39) missense probably damaging 1.00
R1785:Dstyk UTSW 1 132,384,722 (GRCm39) missense probably damaging 1.00
R1829:Dstyk UTSW 1 132,377,333 (GRCm39) missense probably benign 0.06
R2031:Dstyk UTSW 1 132,380,929 (GRCm39) missense probably damaging 0.99
R2124:Dstyk UTSW 1 132,380,857 (GRCm39) missense possibly damaging 0.64
R2132:Dstyk UTSW 1 132,377,222 (GRCm39) missense probably null
R2143:Dstyk UTSW 1 132,391,113 (GRCm39) missense probably damaging 1.00
R2144:Dstyk UTSW 1 132,391,113 (GRCm39) missense probably damaging 1.00
R2145:Dstyk UTSW 1 132,391,113 (GRCm39) missense probably damaging 1.00
R3804:Dstyk UTSW 1 132,377,464 (GRCm39) missense probably damaging 1.00
R4277:Dstyk UTSW 1 132,383,151 (GRCm39) splice site probably null
R4504:Dstyk UTSW 1 132,362,127 (GRCm39) missense possibly damaging 0.81
R4674:Dstyk UTSW 1 132,391,128 (GRCm39) missense probably benign 0.42
R4697:Dstyk UTSW 1 132,377,225 (GRCm39) missense probably damaging 0.98
R4828:Dstyk UTSW 1 132,361,875 (GRCm39) missense probably benign
R4940:Dstyk UTSW 1 132,380,844 (GRCm39) missense probably damaging 0.96
R5029:Dstyk UTSW 1 132,377,062 (GRCm39) missense probably benign 0.01
R5678:Dstyk UTSW 1 132,381,029 (GRCm39) missense probably benign
R5900:Dstyk UTSW 1 132,384,717 (GRCm39) missense probably damaging 1.00
R5935:Dstyk UTSW 1 132,381,875 (GRCm39) missense probably damaging 0.99
R5973:Dstyk UTSW 1 132,362,149 (GRCm39) missense probably damaging 0.99
R6217:Dstyk UTSW 1 132,387,677 (GRCm39) missense probably damaging 1.00
R6381:Dstyk UTSW 1 132,384,503 (GRCm39) splice site probably null
R7038:Dstyk UTSW 1 132,381,847 (GRCm39) missense probably benign 0.32
R7240:Dstyk UTSW 1 132,381,861 (GRCm39) missense probably benign 0.02
R7411:Dstyk UTSW 1 132,345,404 (GRCm39) missense probably benign 0.01
R7714:Dstyk UTSW 1 132,384,614 (GRCm39) missense possibly damaging 0.93
R8805:Dstyk UTSW 1 132,361,963 (GRCm39) missense probably damaging 1.00
R9564:Dstyk UTSW 1 132,362,023 (GRCm39) missense probably damaging 1.00
R9785:Dstyk UTSW 1 132,381,038 (GRCm39) missense probably damaging 0.96
R9789:Dstyk UTSW 1 132,381,859 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGACCAGGACTGTAAAGCTCAG -3'
(R):5'- AAGAGAGTCCTAGAGTGCCAGC -3'

Sequencing Primer
(F):5'- CTCAGAGCATGTTGGTGGAGC -3'
(R):5'- GCACTCCAGAAGCTCGCTAG -3'
Posted On 2018-05-24