Incidental Mutation 'R6434:Or5w1'
ID 518675
Institutional Source Beutler Lab
Gene Symbol Or5w1
Ensembl Gene ENSMUSG00000111747
Gene Name olfactory receptor family 5 subfamily W member 1
Synonyms MOR176-1, Olfr1134, GA_x6K02T2Q125-49162076-49161138
MMRRC Submission 044572-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R6434 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 87486269-87488801 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 87486558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 236 (K236*)
Ref Sequence ENSEMBL: ENSMUSP00000150358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099857] [ENSMUST00000135875] [ENSMUST00000213939]
AlphaFold Q7TR43
Predicted Effect probably null
Transcript: ENSMUST00000099857
AA Change: K236*
SMART Domains Protein: ENSMUSP00000097443
Gene: ENSMUSG00000111747
AA Change: K236*

DomainStartEndE-ValueType
GHB 123 190 1.21e0 SMART
Predicted Effect probably null
Transcript: ENSMUST00000135875
AA Change: K236*
Predicted Effect probably null
Transcript: ENSMUST00000213939
AA Change: K236*
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.8%
Validation Efficiency 98% (57/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alcam A C 16: 52,109,190 (GRCm39) probably null Het
Ankle2 A G 5: 110,401,759 (GRCm39) Y807C probably damaging Het
Arhgef26 A C 3: 62,336,335 (GRCm39) M625L probably damaging Het
Aspdh G A 7: 44,116,474 (GRCm39) A86T probably damaging Het
Atl1 G T 12: 70,006,199 (GRCm39) E502* probably null Het
Atp6v1c1 T C 15: 38,677,790 (GRCm39) F105S probably damaging Het
Auh C A 13: 53,083,446 (GRCm39) G17C probably benign Het
Ccdc81 T C 7: 89,525,352 (GRCm39) Y474C probably damaging Het
Ccdc82 T C 9: 13,251,659 (GRCm39) probably benign Het
Ccdc96 T G 5: 36,643,707 (GRCm39) V571G probably damaging Het
Col6a5 C A 9: 105,814,544 (GRCm39) E489D unknown Het
Dchs2 T A 3: 83,176,577 (GRCm39) I845N probably damaging Het
Dnajc11 T C 4: 152,063,751 (GRCm39) V449A probably damaging Het
Ect2 A T 3: 27,193,268 (GRCm39) Y269* probably null Het
Egfr T C 11: 16,819,294 (GRCm39) Y275H probably benign Het
Fan1 T A 7: 64,004,129 (GRCm39) D779V probably damaging Het
Fancm T C 12: 65,123,942 (GRCm39) V200A probably damaging Het
Frem1 A G 4: 82,884,253 (GRCm39) I1214T probably benign Het
Gm3415 T A 5: 146,494,752 (GRCm39) F138L probably benign Het
Gtse1 C A 15: 85,759,370 (GRCm39) T626K probably benign Het
Herc1 T A 9: 66,393,464 (GRCm39) H4114Q probably damaging Het
Ifi44 T A 3: 151,454,826 (GRCm39) N133I probably benign Het
Ilf3 A G 9: 21,314,447 (GRCm39) probably benign Het
Inpp4a A G 1: 37,437,919 (GRCm39) T593A probably damaging Het
Iqgap2 A T 13: 95,819,441 (GRCm39) W634R possibly damaging Het
Kcnh4 T A 11: 100,641,105 (GRCm39) N448I probably damaging Het
Klhl33 G A 14: 51,130,564 (GRCm39) A310V probably damaging Het
Klra9 G T 6: 130,155,995 (GRCm39) Y253* probably null Het
Lrig2 T C 3: 104,398,863 (GRCm39) K222E possibly damaging Het
Manba G A 3: 135,217,734 (GRCm39) probably null Het
Mga A T 2: 119,754,419 (GRCm39) Q976L probably damaging Het
Mtmr4 A G 11: 87,504,309 (GRCm39) D1086G probably damaging Het
Muc20 A G 16: 32,615,176 (GRCm39) V67A probably benign Het
Myh3 T A 11: 66,973,193 (GRCm39) L97Q probably damaging Het
Nars1 T C 18: 64,640,872 (GRCm39) T195A probably benign Het
Npat A T 9: 53,474,739 (GRCm39) I844L possibly damaging Het
Nrxn3 T C 12: 88,762,285 (GRCm39) F111L probably benign Het
Obp2b T C 2: 25,628,599 (GRCm39) Y118H probably damaging Het
Or7e170 A T 9: 19,795,141 (GRCm39) Y153* probably null Het
Patj A G 4: 98,379,866 (GRCm39) D215G probably damaging Het
Pex1 T A 5: 3,680,196 (GRCm39) Y979* probably null Het
Septin3 G A 15: 82,163,804 (GRCm39) V54I possibly damaging Het
Shc3 A G 13: 51,603,326 (GRCm39) Y260H probably damaging Het
Simc1 A G 13: 54,674,477 (GRCm39) T942A probably benign Het
Slco1c1 T C 6: 141,493,576 (GRCm39) S371P probably damaging Het
Snrnp200 T A 2: 127,080,574 (GRCm39) I2029N probably damaging Het
Syne1 A G 10: 5,268,422 (GRCm39) V2089A probably benign Het
Syne2 T C 12: 76,088,230 (GRCm39) S5016P probably damaging Het
Tril G C 6: 53,795,493 (GRCm39) D576E probably damaging Het
Tubb2b C T 13: 34,311,561 (GRCm39) A411T probably damaging Het
Ubr4 T C 4: 139,156,949 (GRCm39) Y2325H probably damaging Het
Utp20 A T 10: 88,608,395 (GRCm39) C1547* probably null Het
Utrn A T 10: 12,401,171 (GRCm39) W98R probably damaging Het
Vps35 C T 8: 86,000,124 (GRCm39) D501N possibly damaging Het
Wdr48 T C 9: 119,745,879 (GRCm39) S421P possibly damaging Het
Yju2b A G 8: 84,989,630 (GRCm39) I63T probably damaging Het
Zfp719 C A 7: 43,240,412 (GRCm39) H667N probably damaging Het
Other mutations in Or5w1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Or5w1 APN 2 87,486,582 (GRCm39) missense probably benign 0.01
IGL01397:Or5w1 APN 2 87,487,249 (GRCm39) missense probably damaging 0.99
IGL01583:Or5w1 APN 2 87,486,757 (GRCm39) nonsense probably null
IGL01655:Or5w1 APN 2 87,486,773 (GRCm39) missense probably damaging 1.00
IGL02184:Or5w1 APN 2 87,487,136 (GRCm39) missense probably damaging 0.99
IGL02263:Or5w1 APN 2 87,486,543 (GRCm39) missense probably damaging 1.00
IGL02964:Or5w1 APN 2 87,487,058 (GRCm39) missense probably damaging 1.00
IGL03391:Or5w1 APN 2 87,487,032 (GRCm39) missense possibly damaging 0.93
R5171:Or5w1 UTSW 2 87,486,888 (GRCm39) missense possibly damaging 0.95
R7466:Or5w1 UTSW 2 87,486,740 (GRCm39) missense possibly damaging 0.73
R7770:Or5w1 UTSW 2 87,486,813 (GRCm39) missense not run
R8810:Or5w1 UTSW 2 87,486,591 (GRCm39) missense possibly damaging 0.54
R9249:Or5w1 UTSW 2 87,486,660 (GRCm39) missense probably benign 0.10
R9572:Or5w1 UTSW 2 87,486,914 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- ACCCAGGCCACAAGTTAATATTG -3'
(R):5'- GTGACATCCCACCCTTACTG -3'

Sequencing Primer
(F):5'- CAGGCCACAAGTTAATATTGATTGCC -3'
(R):5'- GGCCCTCTCCTGCTCAGATAC -3'
Posted On 2018-05-24