Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01072:Fbxw26'

51872

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fbxw26

Ensembl Gene

ENSMUSG00000059547

Gene Name

F-box and WD-40 domain protein 26

Synonyms

Gm5163

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01072

Quality Score

Status

Chromosome

Chromosomal Location

109546634-109575157 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 109552905 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 290 (F290I)

Ref Sequence

ENSEMBL: ENSMUSP00000071811 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071917]

AlphaFold

Q8BI58

Predicted Effect

probably damaging
Transcript: ENSMUST00000071917
AA Change: F290I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000071811
Gene: ENSMUSG00000059547
AA Change: F290I

Domain	Start	End	E-Value	Type
FBOX	5	45	2.54e-6	SMART
SCOP:d1tbga_	128	249	1e-5	SMART
Blast:WD40	137	176	4e-7	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ccdc65	A	T	15: 98,606,277 (GRCm39)	M1L	unknown	Het
Cyp3a44	T	C	5: 145,728,438 (GRCm39)	D262G	probably benign	Het
Dmbt1	C	T	7: 130,687,098 (GRCm39)		probably benign	Het
Dnmt3l	A	G	10: 77,888,605 (GRCm39)	N169S	probably benign	Het
Foxj3	A	G	4: 119,467,226 (GRCm39)	M190V	probably benign	Het
Gm7275	T	C	16: 47,894,519 (GRCm39)		noncoding transcript	Het
Ly75	T	A	2: 60,184,840 (GRCm39)	D438V	probably damaging	Het
Lzts3	T	C	2: 130,477,365 (GRCm39)	E475G	probably damaging	Het
Mon2	A	T	10: 122,846,444 (GRCm39)	Y1375*	probably null	Het
Ndufc2	T	A	7: 97,049,490 (GRCm39)	V32D	probably damaging	Het
Nf2	A	C	11: 4,739,713 (GRCm39)	L431R	probably null	Het
Niban2	T	C	2: 32,802,427 (GRCm39)		probably benign	Het
Ptpn9	C	T	9: 56,943,987 (GRCm39)	T287I	possibly damaging	Het
Rictor	A	G	15: 6,819,043 (GRCm39)	D1422G	probably damaging	Het
Rpp40	C	A	13: 36,086,017 (GRCm39)	G115C	probably damaging	Het
Rps6ka5	A	G	12: 100,540,157 (GRCm39)	V522A	probably benign	Het
Scgb1b24	A	T	7: 33,443,434 (GRCm39)	D31V	probably damaging	Het
Trrap	C	A	5: 144,721,065 (GRCm39)		probably benign	Het
Vmn1r214	T	C	13: 23,219,300 (GRCm39)	Y265H	possibly damaging	Het

Other mutations in Fbxw26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00589:Fbxw26	APN	9	109,547,016 (GRCm39)	utr 3 prime	probably benign
IGL01151:Fbxw26	APN	9	109,550,848 (GRCm39)	missense	possibly damaging	0.50
IGL01394:Fbxw26	APN	9	109,547,057 (GRCm39)	missense	probably benign	0.00
IGL01432:Fbxw26	APN	9	109,547,043 (GRCm39)	missense	probably benign	0.32
IGL02559:Fbxw26	APN	9	109,551,232 (GRCm39)	missense	probably benign	0.34
IGL02981:Fbxw26	APN	9	109,573,862 (GRCm39)	missense	probably benign	0.09
IGL03370:Fbxw26	APN	9	109,575,087 (GRCm39)	missense	probably damaging	1.00
R0023:Fbxw26	UTSW	9	109,547,079 (GRCm39)	missense	probably benign	0.01
R0087:Fbxw26	UTSW	9	109,554,006 (GRCm39)	missense	probably benign
R0369:Fbxw26	UTSW	9	109,552,780 (GRCm39)	critical splice donor site	probably null
R0446:Fbxw26	UTSW	9	109,572,788 (GRCm39)	missense	probably benign	0.03
R1844:Fbxw26	UTSW	9	109,553,946 (GRCm39)	missense	probably benign	0.42
R1891:Fbxw26	UTSW	9	109,551,232 (GRCm39)	missense	probably benign	0.34
R2042:Fbxw26	UTSW	9	109,561,772 (GRCm39)	missense	probably damaging	1.00
R3615:Fbxw26	UTSW	9	109,572,828 (GRCm39)	nonsense	probably null
R3616:Fbxw26	UTSW	9	109,572,828 (GRCm39)	nonsense	probably null
R4659:Fbxw26	UTSW	9	109,573,939 (GRCm39)	missense	probably damaging	0.97
R4785:Fbxw26	UTSW	9	109,553,868 (GRCm39)	missense	possibly damaging	0.50
R4898:Fbxw26	UTSW	9	109,547,037 (GRCm39)	missense	possibly damaging	0.95
R5791:Fbxw26	UTSW	9	109,574,221 (GRCm39)	missense	probably damaging	1.00
R5818:Fbxw26	UTSW	9	109,561,634 (GRCm39)	missense	probably benign
R5921:Fbxw26	UTSW	9	109,575,086 (GRCm39)	missense	probably damaging	1.00
R5983:Fbxw26	UTSW	9	109,547,033 (GRCm39)	missense	possibly damaging	0.49
R6145:Fbxw26	UTSW	9	109,561,691 (GRCm39)	missense	probably benign	0.09
R6209:Fbxw26	UTSW	9	109,547,033 (GRCm39)	missense	possibly damaging	0.49
R6412:Fbxw26	UTSW	9	109,561,715 (GRCm39)	missense	probably damaging	0.97
R6842:Fbxw26	UTSW	9	109,553,988 (GRCm39)	missense	probably damaging	1.00
R7228:Fbxw26	UTSW	9	109,554,012 (GRCm39)	missense	possibly damaging	0.93
R7451:Fbxw26	UTSW	9	109,561,691 (GRCm39)	missense	probably benign	0.03
R7467:Fbxw26	UTSW	9	109,561,765 (GRCm39)	missense	probably benign	0.00
R8397:Fbxw26	UTSW	9	109,561,715 (GRCm39)	missense	probably damaging	0.99
R8912:Fbxw26	UTSW	9	109,561,717 (GRCm39)	missense	probably damaging	1.00
R9284:Fbxw26	UTSW	9	109,550,962 (GRCm39)	intron	probably benign
R9479:Fbxw26	UTSW	9	109,561,625 (GRCm39)	missense	probably damaging	0.99
R9694:Fbxw26	UTSW	9	109,575,135 (GRCm39)	start gained	probably benign
X0020:Fbxw26	UTSW	9	109,561,700 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21