Incidental Mutation 'R6436:Plk2'
ID 518785
Institutional Source Beutler Lab
Gene Symbol Plk2
Ensembl Gene ENSMUSG00000021701
Gene Name polo like kinase 2
Synonyms Snk
MMRRC Submission 044574-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6436 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 110531580-110537378 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 110532570 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 95 (E95*)
Ref Sequence ENSEMBL: ENSMUSP00000022212 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022212]
AlphaFold P53351
Predicted Effect probably null
Transcript: ENSMUST00000022212
AA Change: E95*
SMART Domains Protein: ENSMUSP00000022212
Gene: ENSMUSG00000021701
AA Change: E95*

DomainStartEndE-ValueType
low complexity region 54 62 N/A INTRINSIC
S_TKc 79 331 7.08e-97 SMART
Blast:STYKc 335 383 9e-7 BLAST
low complexity region 448 464 N/A INTRINSIC
Pfam:POLO_box 508 569 2.5e-19 PFAM
Pfam:POLO_box 604 673 1.3e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223756
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224489
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225156
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225340
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.7%
  • 10x: 98.1%
  • 20x: 93.5%
Validation Efficiency 100% (33/33)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
PHENOTYPE: Inactivation of this gene results in impaired embryonic growth and placental defects due to increased cell proliferation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arc C A 15: 74,544,098 (GRCm39) V42L possibly damaging Het
Clip1 C T 5: 123,779,848 (GRCm39) E433K probably damaging Het
Cmya5 T C 13: 93,225,723 (GRCm39) T3122A probably damaging Het
Ctf2 G T 7: 127,318,603 (GRCm39) A92E probably damaging Het
Ctsw G T 19: 5,516,322 (GRCm39) R184S possibly damaging Het
D130043K22Rik A G 13: 25,061,918 (GRCm39) E629G probably damaging Het
Dmbt1 T C 7: 130,718,370 (GRCm39) V1523A probably benign Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Fanci T C 7: 79,090,446 (GRCm39) I982T probably benign Het
Fnbp1 T C 2: 30,986,139 (GRCm39) D3G probably damaging Het
Gm10770 G A 2: 150,020,830 (GRCm39) T229I probably benign Het
Gm35315 G A 5: 110,226,578 (GRCm39) T287I probably benign Het
Itgb3 T A 11: 104,524,318 (GRCm39) D151E probably damaging Het
Lcn8 A T 2: 25,544,990 (GRCm39) probably null Het
Ninl A G 2: 150,808,098 (GRCm39) L310P probably damaging Het
Nop2 A G 6: 125,114,274 (GRCm39) D215G probably benign Het
Or4d10c T C 19: 12,065,299 (GRCm39) T286A probably benign Het
Or6c3 A G 10: 129,308,773 (GRCm39) T71A probably damaging Het
Parg T C 14: 31,993,634 (GRCm39) W289R probably damaging Het
Pdcd4 A G 19: 53,915,362 (GRCm39) probably null Het
Pold1 G A 7: 44,188,202 (GRCm39) R559C probably damaging Het
Ptprc T C 1: 138,011,377 (GRCm39) D560G possibly damaging Het
Rasal3 T C 17: 32,616,478 (GRCm39) Y290C probably damaging Het
Rcsd1 T A 1: 165,485,184 (GRCm39) S90C probably damaging Het
Rttn T C 18: 89,128,853 (GRCm39) L1935P probably damaging Het
Smc1b C T 15: 84,976,232 (GRCm39) R825Q probably benign Het
Srsf11 C T 3: 157,728,981 (GRCm39) probably benign Homo
Tmc3 T C 7: 83,247,695 (GRCm39) Y230H probably damaging Het
Tnfrsf25 A T 4: 152,204,084 (GRCm39) probably null Het
Ubl7 T C 9: 57,827,793 (GRCm39) L160P probably damaging Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Zfp646 T A 7: 127,479,113 (GRCm39) V430E probably benign Het
Other mutations in Plk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00513:Plk2 APN 13 110,535,298 (GRCm39) missense probably benign 0.18
IGL00586:Plk2 APN 13 110,532,912 (GRCm39) missense possibly damaging 0.61
IGL00798:Plk2 APN 13 110,534,568 (GRCm39) missense probably benign 0.00
IGL01450:Plk2 APN 13 110,532,858 (GRCm39) missense probably damaging 1.00
IGL01722:Plk2 APN 13 110,535,976 (GRCm39) missense probably benign 0.00
IGL01937:Plk2 APN 13 110,535,588 (GRCm39) missense possibly damaging 0.80
IGL01945:Plk2 APN 13 110,535,588 (GRCm39) missense possibly damaging 0.80
IGL01993:Plk2 APN 13 110,535,731 (GRCm39) missense probably damaging 1.00
IGL02231:Plk2 APN 13 110,536,603 (GRCm39) missense probably benign 0.01
IGL03059:Plk2 APN 13 110,535,668 (GRCm39) missense probably benign 0.42
Mite UTSW 13 110,532,570 (GRCm39) nonsense probably null
R0189:Plk2 UTSW 13 110,535,997 (GRCm39) missense probably damaging 1.00
R0324:Plk2 UTSW 13 110,534,242 (GRCm39) missense probably benign 0.08
R1108:Plk2 UTSW 13 110,536,023 (GRCm39) missense probably damaging 0.99
R1422:Plk2 UTSW 13 110,536,023 (GRCm39) missense probably damaging 0.99
R1513:Plk2 UTSW 13 110,536,622 (GRCm39) missense probably benign 0.45
R2987:Plk2 UTSW 13 110,534,243 (GRCm39) missense probably benign 0.03
R4050:Plk2 UTSW 13 110,536,400 (GRCm39) missense probably damaging 1.00
R4211:Plk2 UTSW 13 110,532,871 (GRCm39) missense probably damaging 0.98
R4278:Plk2 UTSW 13 110,532,637 (GRCm39) missense probably benign 0.15
R4777:Plk2 UTSW 13 110,534,307 (GRCm39) missense probably benign
R5121:Plk2 UTSW 13 110,535,958 (GRCm39) missense probably benign 0.01
R5677:Plk2 UTSW 13 110,535,591 (GRCm39) missense possibly damaging 0.83
R6240:Plk2 UTSW 13 110,536,568 (GRCm39) missense probably damaging 1.00
R6240:Plk2 UTSW 13 110,536,008 (GRCm39) missense probably damaging 1.00
R6596:Plk2 UTSW 13 110,534,296 (GRCm39) missense probably benign 0.37
R6776:Plk2 UTSW 13 110,536,325 (GRCm39) missense probably benign
R6938:Plk2 UTSW 13 110,533,214 (GRCm39) nonsense probably null
R7556:Plk2 UTSW 13 110,533,122 (GRCm39) splice site probably null
R8927:Plk2 UTSW 13 110,535,750 (GRCm39) missense probably damaging 1.00
R8928:Plk2 UTSW 13 110,535,750 (GRCm39) missense probably damaging 1.00
R9043:Plk2 UTSW 13 110,533,194 (GRCm39) missense probably damaging 0.97
R9063:Plk2 UTSW 13 110,532,920 (GRCm39) missense possibly damaging 0.67
R9512:Plk2 UTSW 13 110,536,673 (GRCm39) missense probably damaging 0.96
R9546:Plk2 UTSW 13 110,535,301 (GRCm39) missense possibly damaging 0.84
Z1177:Plk2 UTSW 13 110,531,793 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- CTAGGAATGTGCTGCCCTTC -3'
(R):5'- TCTGGAAAGGCAGTGCTTAC -3'

Sequencing Primer
(F):5'- ATGTGCTGCCCTTCCTGAAAAAC -3'
(R):5'- GTGCTTACACATGCAGAAGAC -3'
Posted On 2018-05-24