Incidental Mutation 'R6437:Klk10'
ID 518813
Institutional Source Beutler Lab
Gene Symbol Klk10
Ensembl Gene ENSMUSG00000030693
Gene Name kallikrein related-peptidase 10
Synonyms 2300002A13Rik, PRSSL1, NES1
MMRRC Submission 044575-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R6437 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 43430478-43434834 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43432241 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 58 (H58R)
Ref Sequence ENSEMBL: ENSMUSP00000014058 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000014058] [ENSMUST00000080211] [ENSMUST00000171458]
AlphaFold Q99M20
Predicted Effect probably benign
Transcript: ENSMUST00000014058
AA Change: H58R

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000014058
Gene: ENSMUSG00000030693
AA Change: H58R

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
Tryp_SPc 46 271 1.35e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000080211
SMART Domains Protein: ENSMUSP00000079101
Gene: ENSMUSG00000067616

DomainStartEndE-ValueType
low complexity region 22 37 N/A INTRINSIC
Tryp_SPc 47 269 5.14e-95 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000171458
SMART Domains Protein: ENSMUSP00000132721
Gene: ENSMUSG00000067616

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Tryp_SPc 20 242 5.14e-95 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181454
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205415
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205566
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206165
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg2a T A 3: 37,582,347 (GRCm39) V794E probably damaging Het
Agrn C T 4: 156,261,235 (GRCm39) V514I probably damaging Het
Atg16l1 T C 1: 87,718,370 (GRCm39) L545P probably damaging Het
Ces3b T A 8: 105,819,238 (GRCm39) D431E probably damaging Het
Cracr2a A G 6: 127,608,794 (GRCm39) D291G probably damaging Het
Csmd2 T G 4: 127,881,893 (GRCm39) C11G probably benign Het
Cstdc3 A G 16: 36,132,999 (GRCm39) E92G probably damaging Het
Dido1 A G 2: 180,316,806 (GRCm39) I127T probably damaging Het
Dpp8 A T 9: 64,981,860 (GRCm39) Y714F probably benign Het
Efcab5 G A 11: 77,028,728 (GRCm39) A201V probably benign Het
Eif3h C T 15: 51,662,660 (GRCm39) V129I probably benign Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Fars2 G A 13: 36,388,846 (GRCm39) V112I probably benign Het
Fbn2 T G 18: 58,246,435 (GRCm39) D489A probably damaging Het
Frmd4b G T 6: 97,273,228 (GRCm39) S675R probably damaging Het
Fsip2 C T 2: 82,813,836 (GRCm39) S3385F possibly damaging Het
Gtpbp10 A G 5: 5,607,406 (GRCm39) Y12H probably damaging Het
Kcng3 A G 17: 83,938,558 (GRCm39) S164P probably damaging Het
Kifap3 T A 1: 163,685,095 (GRCm39) L483Q probably damaging Het
Kntc1 T G 5: 123,907,754 (GRCm39) W452G probably damaging Het
Krt87 C T 15: 101,336,273 (GRCm39) D127N possibly damaging Het
Ldaf1 A T 7: 119,715,584 (GRCm39) probably null Het
Lipm A G 19: 34,098,657 (GRCm39) Y377C probably damaging Het
Mrc2 G A 11: 105,240,669 (GRCm39) R1453H probably damaging Het
Nat1 T C 8: 67,944,388 (GRCm39) F255L possibly damaging Het
Neb C T 2: 52,147,569 (GRCm39) probably null Het
Nek5 T A 8: 22,575,476 (GRCm39) D491V possibly damaging Het
Nynrin T C 14: 56,109,227 (GRCm39) S1445P probably benign Het
Oog2 T A 4: 143,921,678 (GRCm39) probably null Het
Or2j6 C T 7: 139,980,434 (GRCm39) C175Y probably damaging Het
Pafah1b1 T C 11: 74,568,557 (GRCm39) T391A probably benign Het
Pcdhb7 T C 18: 37,475,743 (GRCm39) L293P probably damaging Het
Plce1 A T 19: 38,513,576 (GRCm39) T292S probably benign Het
Pold1 G A 7: 44,188,202 (GRCm39) R559C probably damaging Het
Rfx7 A G 9: 72,525,768 (GRCm39) Q986R possibly damaging Het
Rrp9 G T 9: 106,360,150 (GRCm39) R186L probably benign Het
Samm50 T A 15: 84,088,298 (GRCm39) probably null Het
Scoc T C 8: 84,164,616 (GRCm39) D7G probably benign Het
Smad9 C T 3: 54,693,505 (GRCm39) P145S probably benign Het
Smc1b C T 15: 84,976,232 (GRCm39) R825Q probably benign Het
Snrk A G 9: 121,995,879 (GRCm39) R553G probably damaging Het
Srcap T A 7: 127,127,722 (GRCm39) probably null Het
Syne2 T A 12: 76,037,188 (GRCm39) V3789E possibly damaging Het
Thsd7b T C 1: 129,744,419 (GRCm39) I769T probably damaging Het
Ttc7 A G 17: 87,637,534 (GRCm39) K430E probably damaging Het
Ubr4 T A 4: 139,124,525 (GRCm39) probably null Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Vmn2r37 G T 7: 9,220,850 (GRCm39) Q338K probably damaging Het
Yod1 T C 1: 130,646,885 (GRCm39) V254A probably damaging Het
Zfpm2 T C 15: 40,962,793 (GRCm39) S152P probably benign Het
Zmym2 T A 14: 57,140,461 (GRCm39) L100H probably damaging Het
Other mutations in Klk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01488:Klk10 APN 7 43,434,400 (GRCm39) missense probably damaging 1.00
IGL01657:Klk10 APN 7 43,431,013 (GRCm39) missense possibly damaging 0.49
IGL02049:Klk10 APN 7 43,433,882 (GRCm39) splice site probably benign
IGL02725:Klk10 APN 7 43,431,044 (GRCm39) missense probably damaging 1.00
IGL03382:Klk10 APN 7 43,433,883 (GRCm39) splice site probably benign
R0433:Klk10 UTSW 7 43,430,989 (GRCm39) missense possibly damaging 0.51
R1521:Klk10 UTSW 7 43,432,304 (GRCm39) missense probably benign 0.00
R1580:Klk10 UTSW 7 43,432,286 (GRCm39) missense probably damaging 1.00
R4825:Klk10 UTSW 7 43,433,022 (GRCm39) missense probably damaging 1.00
R5969:Klk10 UTSW 7 43,434,409 (GRCm39) missense probably damaging 1.00
R6641:Klk10 UTSW 7 43,434,324 (GRCm39) missense possibly damaging 0.94
R7589:Klk10 UTSW 7 43,433,051 (GRCm39) missense probably benign 0.00
R7599:Klk10 UTSW 7 43,433,851 (GRCm39) missense probably benign 0.03
R7902:Klk10 UTSW 7 43,432,942 (GRCm39) missense probably benign 0.34
R8519:Klk10 UTSW 7 43,432,239 (GRCm39) nonsense probably null
R9560:Klk10 UTSW 7 43,433,746 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACGGCTTACTACTCAGCTGC -3'
(R):5'- CTCTTGTAGAATGGCTGCCAC -3'

Sequencing Primer
(F):5'- ACTACTCAGCTGCGCCCC -3'
(R):5'- TGTAGAATGGCTGCCACCCTTAAC -3'
Posted On 2018-05-24